EPISODE · Jan 5, 2026 · 9 MIN
Dr Flore Sicre de Fontbrune - La stratégie thérapeutique pour la prise en charge de l'HPN
from Podcasts HPN NEWS : La toute première chaîne de podcasts dédiés à l'HPN · host Alexion
FR/UNB-P/0200 - 1. Parker, C. et al., (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 2. Notaro, R., & Luzzatto, L. (2022). Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition. New England Journal of Medicine, 387(2), 160–166. https://doi.org/10.1056/nejmra2201664 3. PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.). 4. Kulasekararaj, A. G. et al., (2023). Biomarkers and laboratory assessments for monitoring the treatment of patients with paroxysmal nocturnal hemoglobinuria: Differences between terminal and proximal complement inhibition. In Blood Reviews (Vol. 59). Churchill Livingstone. https://doi.org/10.1016/j.blre.2023.101041 5. Hill A, et al., (2013). Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 21: 4985-4996. 6. Kulasekararaj, A. G. et al., (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 7. Hémoglobinurie paroxystique nocturne ©Orphanet Focus Handicap / Encyclopédie Orphanet du Handicap Hémoglobinurie paroxystique nocturne Synonymes : HPN / Maladie de MarchiafavaMicheli Encyclopédie Orphanet du Handicap. (n.d.). www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORP HA447.pdf 8. Fattizzo, B. et al., (2022). Managing Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Patient-Focused Perspective. In Journal of Blood Medicine (Vol. 13, pp. 327– 335). Dove Medical Press Ltd. https://doi.org/10.2147/JBM.S339660 9. Kelly, R. J. et al., (2024) Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 143, Issue 12, pp. 1157-1166. https://doi.org/10.1182/blood.2023021762 10.1182/blood.2023021762 10. Ricklin, D. et al., (2017). The renaissance of complement therapeutics. In Nature Reviews Nephrology (Vol. 14, Issue 1, pp. 26–47). Nature Publishing Group. 11. Avis du Haut Conseil de la Santé Publique en vigueur.
What this episode covers
FR/UNB-P/0200 - 1. Parker, C. et al., (2005). Diagnosis and management of paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 106, Issue 12, pp. 3699–3709). American Society of Hematology. https://doi.org/10.1182/blood-2005-04-1717 2. Notaro, R., & Luzzatto, L. (2022). Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition. New England Journal of Medicine, 387(2), 160–166. https://doi.org/10.1056/nejmra2201664 3. PROTOCOLE NATIONAL DE DIAGNOSTIC ET DE SOINS APLASIES MEDULLAIRES ACQUISES ET CONSTITUTIONNELLES. (n.d.). 4. Kulasekararaj, A. G. et al., (2023). Biomarkers and laboratory assessments for monitoring the treatment of patients with paroxysmal nocturnal hemoglobinuria: Differences between terminal and proximal complement inhibition. In Blood Reviews (Vol. 59). Churchill Livingstone. https://doi.org/10.1016/j.blre.2023.101041 5. Hill A, et al., (2013). Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood. 21: 4985-4996. 6. Kulasekararaj, A. G. et al., (2021). Monitoring of patients with paroxysmal nocturnal hemoglobinuria on a complement inhibitor. In American Journal of Hematology (Vol. 96, Issue 7, pp. E232–E235). John Wiley and Sons Inc. https://doi.org/10.1002/ajh.26176 7. Hémoglobinurie paroxystique nocturne ©Orphanet Focus Handicap / Encyclopédie Orphanet du Handicap Hémoglobinurie paroxystique nocturne Synonymes : HPN / Maladie de MarchiafavaMicheli Encyclopédie Orphanet du Handicap. (n.d.). www.orpha.net/data/patho/Han/Int/fr/HemoglobinurieParoxystiqueNocturne_FR_fr_HAN_ORP HA447.pdf 8. Fattizzo, B. et al., (2022). Managing Fatigue in Patients with Paroxysmal Nocturnal Hemoglobinuria: A Patient-Focused Perspective. In Journal of Blood Medicine (Vol. 13, pp. 327– 335). Dove Medical Press Ltd. https://doi.org/10.2147/JBM.S339660 9. Kelly, R. J. et al., (2024) Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria. In Blood (Vol. 143, Issue 12, pp. 1157-1166. https://doi.org/10.1182/blood.2023021762 10.1182/blood.2023021762 10. Ricklin, D. et al., (2017). The renaissance of complement therapeutics. In Nature Reviews Nephrology (Vol. 14, Issue 1, pp. 26–47). Nature Publishing Group. 11. Avis du Haut Conseil de la Santé Publique en vigueur.
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Dr Flore Sicre de Fontbrune - La stratégie thérapeutique pour la prise en charge de l'HPN
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