Ketones for Endurance Running: What's the Evidence? episode artwork

EPISODE · Sep 22, 2025 · 34 MIN

Ketones for Endurance Running: What's the Evidence?

from Sunday Dinner · host olinhacker

This week, we dive into the world of ketone supplementation.While ketones are already known to be beneficial in certain disease states and are commonly used by cyclists, we explore their potential to enhance running endurance performance, recovery, and cognitive function.Taken either acutely or chronically, ketone bodies act as an alternative fuel source — allowing the body to spare glucose during endurance exercise and potentially reduce protein breakdown during recovery. While the mechanisms are promising, the research so far is mixed.We discuss where ketone supplementation might be most effective, and which applications and research directions we're most excited about.If you're curious about using ketones to support your endurance training and performance, this episode gets into the key nuances and considerations you'll want to keep in mind.Contact us at [email protected] written and recorded by Tim GibsonArticles discussed:Perspective: Ketone Supplementation in Sports—Does It Work? Pedro L Valenzuela ,  Adrián Castillo-García , Javier S Morales , Alejandro Lucia Nutritional ketosis alters fuel preference and thereby endurance performance in athletes PJ Cox, T Kirk, T Ashmore, K Willerton, R Evans, A Smith, AJ Murray, B Stubbs, J West, SW McLure, et al.

This week, we dive into the world of ketone supplementation.While ketones are already known to be beneficial in certain disease states and are commonly used by cyclists, we explore their potential to enhance running endurance performance, recovery, and cognitive function.Taken either acutely or chronically, ketone bodies act as an alternative fuel source — allowing the body to spare glucose during endurance exercise and potentially reduce protein breakdown during recovery. While the mechanisms are promising, the research so far is mixed.We discuss where ketone supplementation might be most effective, and which applications and research directions we're most excited about.If you're curious about using ketones to support your endurance training and performance, this episode gets into the key nuances and considerations you'll want to keep in mind.Contact us at [email protected] written and recorded by Tim GibsonArticles discussed:Perspective: Ketone Supplementation in Sports—Does It Work? Pedro L Valenzuela ,  Adrián Castillo-García , Javier S Morales , Alejandro Lucia Nutritional ketosis alters fuel preference and thereby endurance performance in athletes PJ Cox, T Kirk, T Ashmore, K Willerton, R Evans, A Smith, AJ Murray, B Stubbs, J West, SW McLure, et al.

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Ketones for Endurance Running: What's the Evidence?

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This week, we dive into the world of ketone supplementation.While ketones are already known to be beneficial in certain disease states and are commonly used by cyclists, we explore their potential to enhance running endurance performance, recovery,...

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