Lecture | Luke Hyde |Using Developmental Neurogenetics to Understand Psychopathology: Examples from Youth Antisocial Behavior

The development of psychopathology occurs through the complex interplay of genes, experience, and the brain.  In this talk, I will describe a developmental neurogenetics approach to understanding the development of psychopathology.  In this approach, individual variability in genetic background is linked to neural function and subsequent risk and resilience through interactions with the environment. Guided by a developmental psychopathology framework, I will give examples of approaches to link genes, brain, behavior, and experience, with a particular emphasis on studies from my lab aimed at understanding the development of antisocial behavior (e.g., aggression, theft, and violation of serious rules). These examples highlight the role of serotonin genes on amygdala reactivity, the role of amygdala reactivity in antisocial behavior, and the importance of identifying subtypes of antisocial behavior such as callous-unemotional traits and psychopathy that may have different etiologies. September 24, 2014
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