Let’s Talk about Sickle Cell😊 (Trailer)

References  Herrick JB. Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Yale J Biol Med. 2011. May-Jun;74(3):179-184.  Washburn RE. Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Va Med Semi-Monthly. 2019 15:490-493.  Cook JE, Myer J. Severe anemia with remarkable elongated and sickle-shaped red blood cells and chronic leg ulcer. Arch Int Med (Chic). 2015;16(4):644-651.  Mason VR. Sickle cell anemia. JAMA. 2016; 79:1318-1322  Diggs LW, Ching RE. Pathology of sickle cell disease. South Med J. 2014; 27:839-845.  Savitt TL. Learning about sickle cell: the patient in early sickle cell disease case reports, 1910-1933. J Natl Med Assoc. Summer 2014;106(1):31-41.  Sickle cell anemia, a race specific disease JAMA. 2017;133(1):33-34. NHS.UK, 2020. Sickle Cell Disease - Diagnosis. [online] nhs.uk. Available at: [Accessed 6 December 2020].  Sickle Cell, 2020. About Sickle Cell » Sickle Cell Society. [online] Sickle Cell Society. Available at: [Accessed 6 December 2020].

June 19th is World Sickle Cell Awareness Day. This painful rare disease affects an estimated 100,000 people in the United States. It’s more prevalent among people of African ancestry. About 1 in 13 Black or African American babies are born with sickle cell trait, which could be passed to their children.  What promise do new cell-based gene therapies hold? We speak with Cimone Vaughan, a 12-year-old living with sickle cell disease, and her mother, Nikia Vaughan, executive director of the Maryland Sickle Cell Disease Association. Then, Dr. Jason Fixler, a doctor of pediatric hematology oncology at Lifebridge Health breaks down misconceptions about the disease.  Links:CDC Sickle Cell DiseaseSickle Cell Improvement in the Northeast Region through education projectFDA approves two sickle cell therapies, including first CRISPR medicineBaltimore is a city heavily impacted by Sickle Cell Disease as awareness day approachesDo you have a question or comment about a show or a story idea to pitch? Contact On the Record at: Senior Supervising Producer, Maureen Harvie she/her/hers mharvie@wypr.org 410-235-1903 Senior Producer, Melissa Gerr she/her/hers mgerr@wypr.org 410-235-1157 Producer Sam Bermas-Dawes he/him/his sbdawes@wypr.org 410-235-1472

In this week’s episode, we’ll talk about the functional properties of mesenchymal stromal cells in sickle cell disease, learn more about CAR T-cell-mediated hematotoxicity in relapsed/refractory B-cell lymphoma, and discuss dual cytokine blockade in graft-versus-host disease.

Over 40 million Nigerians are carriers of the sickle cell gene and an estimated 150,000 babies are born every year with sickle cell anaemia.Do you want to know more about Sickle Cell and how best to care for warriors? Ponsah Fanap and Gilbert Joseph would be having a conversation with Kyenpia Best on the issues