Liver Physiology and Glycation

In this episode of College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the liver’s central role in metabolic health and reveals how glycation and chronic inflammation quietly disrupt its vital functions. As the body’s primary metabolic hub, the liver is uniquely exposed to high concentrations of glucose and fructose, making it especially vulnerable to the formation of advanced glycation end products (AGEs). Dr. Reynolds breaks down how glycation alters liver enzymes, impairs insulin signaling, and initiates inflammatory cascades that ripple throughout the body.You’ll learn why fructose metabolism in the liver accelerates glycation through potent intermediates like methylglyoxal, how AGE–RAGE signaling drives fatty liver disease, fibrosis, and insulin resistance, and why the liver is both a victim and a driver of metabolic dysfunction. Grounded in peer-reviewed science, this episode provides a clear mechanistic framework for understanding fatty liver disease, diabetes, and systemic inflammation—and highlights why restoring liver health is one of the most powerful strategies for reclaiming metabolic resilience and long-term health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)