Managing Acetate Accumulation in Recombinant E. coli Fed-Batch Processes

from Biomanufacturing & Fermentation Technology · host prasad ernala

This is particularly with recombinant Escherichia coli strains. Itdraws from a real-world case study of unexpected acetate, lactate, glycerol, or organic acidaccumulation during fed-batch operations, caused by feed strategy misalignment with cellular uptakekinetics. The focus is on a recombinant E. coli vaccine antigen process that failed GMP batches due toacetate toxicity at pilot scale

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This episode was published on December 18, 2025.

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