Metabolic and Endocrine System Physiology

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—kicks off a new physiology-focused series by exploring how glycation disrupts the metabolic and endocrine systems at the foundation of human health. Beginning with core concepts like insulin and glucagon signaling, fed versus fasted metabolism, and energy partitioning across liver, muscle, and adipose tissue, Dr. Reynolds builds a clear framework for understanding how the body normally regulates blood sugar and energy balance.From there, he reveals how non-enzymatic glycation and the accumulation of advanced glycation end products (AGEs) derail these systems through insulin resistance, chronic inflammation, and oxidative stress. By connecting molecular biochemistry to real-world conditions such as metabolic syndrome and type 2 diabetes, this episode shows why glycation is not just a complication of disease—but a driving force behind it. Whether you’re interested in physiology, metabolic health, or long-term disease prevention, this conversation lays the groundwork for understanding how sugar damage silently reshapes the body from the inside out.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)