MTHFD1, Choline and Methylation | SNPit #16

In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1. We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators.  Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is important in supplying methyl groups.  We highlight the impact of a negative MTHFD1 variant on choline usage and the potential consequences of choline deficiency, while also stressing the importance of considering other genes involved in methylation, not just MTHFR and MTHFD1. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/