Myasthenia Gravis: High-Yield USMLE Topics You Must Know

Myasthenia Gravis is the most common neuromuscular junction disorder, and it’s high-yield for Step 1!Key Features:Fluctuating muscle weakness that worsens with activityPtosis, diplopia, dysphagia, and proximal weaknessMyasthenic crisis → Respiratory failure riskDiagnosis: Ice pack test improves ptosisACh receptor antibodies (highly specific)Chest CT to check for thymomaTreatment:Pyridostigmine (AChE inhibitor)Thymectomy if thymomaImmunotherapy for severe casesMyasthenic crisis → IVIG or plasmapheresisKnow how to differentiate it from Lambert-Eaton syndrome (which improves with use)!