New Immune Brake Discovered in Cancer

Scientists have uncovered a hidden immune brake: SLAMF6, a molecule on T cells that tells them to back off from attacking tumors — even without touching cancer cells. This self-activating brake weakens immune responses and accelerates T cell exhaustion. But new antibodies designed to block SLAMF6 dramatically boosted T cell activity in lab and mouse tests, reversing exhaustion and slashing tumor growth. Unlike current therapies that target tumors, this approach tackles the immune system’s internal sabotage — offering hope for patients who don’t respond to existing treatments. Human trials are next. Support the show:Get a discount at https://solipillow.com/discount/dnn. Advertise on DNN:[email protected] This is an automated, high-level news summary based on public reporting.Report issues to [email protected]. View sources & latest updates:https://sources.thednn.ai/98f0b0556e6b9faf