NFL Week 2 DraftKings Picks 2025 | Best DFS Lineups, Ownership & Pick’em Plays

NFL is back! In this video, Pat Mayo, Erik Beimfohr and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 2 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 2. Whether you’re entering GPPs or cash games, this guide has you covered. FREE WEEK + 25% OFF NFL BETTING TOOLS & PACKAGES at https://www.4for4.com/mayoUse code “MAYO” at underdog and make a $5 Pick’em entry and instantly get $50 in your accountGet a the PME Exclusive Boosts at Coolbet: https://shorturl.at/CHfyW Subscribe, Rate and ReviewApple: http://bit.ly/PMEiTunesSpotify: https://goo.gl/VboemH JOHNNIE WALKER — To claim a customized Blue Label Sunday Golf Bag by Devereux Go to johnniewalker.com/blue-in-waterBETTERHELP — Visit BetterHelp.com/PATMAYO today to get 10% off your first month.ZBIOTICS — Go to  https://zbiotics.com/PATMAYO and use PATMAYO at checkout for 15% off any first time orders of ZBiotics probiotics.POLICYGENIUS -- Secure your family’s future with Policygenius. Head to policygenius.com/MAYO to compare free life insurance quotes from top companies and see how much you could save.FOLLOW MAYO MEDIA NETWORK Newsletter: https://mayomedia.substack.com/Instagram: https://www.instagram.com/mayomedianetwork/TIK TOK: https://www.tiktok.com/discover/mayo-media-networkYOUTUBE:  https://bit.ly/YTMMN #NFL #NFLDFS #UDPartner #DraftKings #NFLPicks #FantasyFootball  #NFLWeek2 Show Index00:00 Intro00:54 Week 1 Recap8:03 Key Injuries13:28 Leverage/Ownership23:50 Optimal Lineup30:21 Cheap DST38:22 DAL/NYG50:01 CIN/JAX59:38 BAL/CLE1:16:37 BUF/NYJ1:227:01 OTHER GAME SKINNY STACKS Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.