EPISODE · Mar 9, 2026 · 49 MIN
Nikki Schultek – Chronic Infections & The Alzheimer’s Pathobiome: The Hidden Pathogens Driving Neurodegeneration
from Integrative Lyme Solutions with Dr. Karlfeldt · host Dr. Michael Karlfeldt
What if Alzheimer’s, multiple sclerosis, chronic fatigue, and even psychiatric symptoms are not random but driven by hidden infections? In this episode of Integrative Lyme Solutions, Dr. K sits down with research scientist and Lyme survivor Nikki Schultek to explore the infection hypothesis behind chronic disease. After battling years of misdiagnosed symptoms including asthma flares, interstitial cystitis, arrhythmias, neurological decline, and suspected MS, Nikki uncovered a complex web of infections including Borrelia, Bartonella, Babesia, Chlamydia pneumoniae, Epstein-Barr virus, and more. Now founder of the Alzheimer’s Pathobiome Initiative, Nikki is leading a global consortium investigating how stealth pathogens may trigger neurodegeneration, immune dysfunction, and dementia. This conversation dives into intracellular infections, the Herxheimer reaction, amyloid as an antimicrobial response, sterile brain autopsies, precision medicine, and why federal health agencies are finally acknowledging Lyme disease as a serious public health crisis. If you or someone you love is dealing with chronic Lyme, long COVID, autoimmune illness, or cognitive decline, this episode may change how you see disease. Key Takeaways: 0:00 Introduction 3:15 Asthma, air hunger, and early misdiagnoses 8:40 From interstitial cystitis to suspected multiple sclerosis 14:30 Discovering intracellular infections and Chlamydia pneumoniae 18:45 Lyme, Bartonella, Babesia and the whack-a-mole effect 24:10 The Pathobiome concept and microbial imbalance 27:30 Alzheimer’s disease and the infection hypothesis 32:00 Sterile brain autopsies and spinal fluid research 35:20 Amyloid plaque as an antimicrobial defense mechanism 41:00 APOE4, genetics, and infection susceptibility 44:30 Federal recognition of Lyme disease and future funding Resources Mentioned: Alzheimer’s Pathobiome Initiative - https://alzheimerspathobiome.org ILADS - https://www.ilads.org ILADS Education Foundation - https://www.iladef.org Philadelphia College of Osteopathic Medicine - https://www.pcom.edu Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. ____________________________________WORK WITH DR. KARLFELDT:The Karlfeldt Center offers the most cutting-edge and comprehensive Lyme therapies available. To schedule a Free 15-Minute Discovery Call with a Lyme Literate Naturopathic Doctor, contact us at:📞 208-338-8902📧 [email protected]🌐 TheKarlfeldtCenter.com____________________________________📖 FREE EBOOK: Breaking Free From Lyme: A Comprehensive Guide to Healing and RecoveryGet your copy at: store.thekarlfeldtcenter.com/products/breaking-free-from-lymeUse code LYMEPODCAST for 100% off____________________________________CONNECT WITH DR. KARLFELDT:Instagram: instagram.com/thekarlfeldtcenterFacebook: facebook.com/thekarlfeldtcenter____________________________________MORE PODCASTS FROM DR. KARLFELDT:🎙 The Dr. K Show — Integrative medicine, functional medicine, biohacking, and longevity for optimizing health and performance.🎙 Integrative Cancer Solutions — Evidence-based integrative therapies and real patient stories for those navigating a cancer diagnosis.Explore all shows on https://www.youtube.com/@KarlfeldtCenter____________________________________
What this episode covers
What if Alzheimer’s, multiple sclerosis, chronic fatigue, and even psychiatric symptoms are not random but driven by hidden infections? In this episode of Integrative Lyme Solutions, Dr. K sits down with research scientist and Lyme survivor Nikki Schultek to explore the infection hypothesis behind chronic disease. After battling years of misdiagnosed symptoms including asthma flares, interstitial cystitis, arrhythmias, neurological decline, and suspected MS, Nikki uncovered a complex web of infections including Borrelia, Bartonella, Babesia, Chlamydia pneumoniae, Epstein-Barr virus, and more. Now founder of the Alzheimer’s Pathobiome Initiative, Nikki is leading a global consortium investigating how stealth pathogens may trigger neurodegeneration, immune dysfunction, and dementia. This conversation dives into intracellular infections, the Herxheimer reaction, amyloid as an antimicrobial response, sterile brain autopsies, precision medicine, and why federal health agencies are finally acknowledging Lyme disease as a serious public health crisis. If you or someone you love is dealing with chronic Lyme, long COVID, autoimmune illness, or cognitive decline, this episode may change how you see disease. Key Takeaways: 0:00 Introduction 3:15 Asthma, air hunger, and early misdiagnoses 8:40 From interstitial cystitis to suspected multiple sclerosis 14:30 Discovering intracellular infections and Chlamydia pneumoniae 18:45 Lyme, Bartonella, Babesia and the whack-a-mole effect 24:10 The Pathobiome concept and microbial imbalance 27:30 Alzheimer’s disease and the infection hypothesis 32:00 Sterile brain autopsies and spinal fluid research 35:20 Amyloid plaque as an antimicrobial defense mechanism 41:00 APOE4, genetics, and infection susceptibility 44:30 Federal recognition of Lyme disease and future funding Resources Mentioned: Alzheimer’s Pathobiome Initiative - https://alzheimerspathobiome.org ILADS - https://www.ilads.org ILADS Education Foundation - https://www.iladef.org Philadelphia College of Osteopathic Medicine - https://www.pcom.edu Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. ____________________________________WORK WITH DR. KARLFELDT:The Karlfeldt Center offers the most cutting-edge and comprehensive Lyme therapies available. To schedule a Free 15-Minute Discovery Call with a Lyme Literate Naturopathic Doctor, contact us at:📞 208-338-8902📧 [email protected]🌐 TheKarlfeldtCenter.com____________________________________📖 FREE EBOOK: Breaking Free From Lyme: A Comprehensive Guide to Healing and RecoveryGet your copy at: store.thekarlfeldtcenter.com/products/breaking-free-from-lymeUse code LYMEPODCAST for 100% off____________________________________CONNECT WITH DR. KARLFELDT:Instagram: instagram.com/thekarlfeldtcenterFacebook: facebook.com/thekarlfeldtcenter____________________________________MORE PODCASTS FROM DR. KARLFELDT:🎙 The Dr. K Show — Integrative medicine, functional medicine, biohacking, and longevity for optimizing health and performance.🎙 Integrative Cancer Solutions — Evidence-based integrative therapies and real patient stories for those navigating a cancer diagnosis.Explore all shows on https://www.youtube.com/@KarlfeldtCenter____________________________________
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Nikki Schultek – Chronic Infections & The Alzheimer’s Pathobiome: The Hidden Pathogens Driving Neurodegeneration
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