Paroxysmal Nocturnal Hemoglobinuria (PNH): High-Yield USMLE Topics You Must Know!

from RD Medicine Podcast: Your Guide to a U.S. Medical Career · host RD Medicine ORG

Paroxysmal Nocturnal Hemoglobinuria (PNH) – YES, it shows up on Step 1, and you need to know the essentials!Here’s what you need to remember:- PIGA gene mutation in hematopoietic stem cells- Deficiency of CD55 and CD59- Complement-mediated intravascular hemolysis- Classic triad: hemolytic anemia, pancytopenia, and venous thrombosis (think Budd-Chiari syndrome)✅ Diagnosis: Flow cytometry✅ Treatment: Eculizumab💡 Exam clue: patient waking up with dark urine in the morning = think PNH!

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This episode was published on April 16, 2025.

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