Persica Pharmaceuticals is treating the cause of chronic lower back pain, not just the symptoms episode artwork

EPISODE · Jul 4, 2025 · 38 MIN

Persica Pharmaceuticals is treating the cause of chronic lower back pain, not just the symptoms

from Beyond Biotech - the podcast from Labiotech · host Labiotech

The World Health Organization reports that more than 600 million people suffer from lower back pain globally, making it the leading cause of disability worldwide. Chronic lower back pain – where the pain persists for more than 3 months – develops in between 5 and 10% of all lower back pain cases, with life-altering impacts for patients.And that’s where today’s guest, Steve Ruston, of Persica Pharmaceuticals comes in. Persica is developing a groundbreaking and transformative treatment for chronic Low Back Pain. Persica is targeting the cause of chronic lower back pain: the underlying bacterial infection. Unlike conventional approaches that manage symptoms, Persica’s drug enables the infection to clear, reducing inflammation, pain and disability at the source.1:20     Introducing Steve Ruston of Persica Pharmaceuticals3:53     Lessons learnt from developing blockbuster drugs6:35     Global experiences in the biopharma industry8:32     Persica Pharmaceuticals and its mission10:26   Collaborations with a network of partners11:48   A non-opioid approach to addressing lower back pain13:35   Treating the cause, not the symptoms15:05   How Persica’s treatment work18:59   Practical impacts of Persica’s treatment21:07   Identifying patients for cLBP treatment23:24   How Persica is changing the treatment landscape28:10   Regulatory hurdles to overcome34:37   Securing funding for Persica’s innovation36:16   The future of treating painInterested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: New non-opioid pain medication: How is the biotech industry fighting pain after the opioid crisis?Developing non-opioid pain drugsRedefining chronic pain treatment

The World Health Organization reports that more than 600 million people suffer from lower back pain globally, making it the leading cause of disability worldwide. Chronic lower back pain – where the pain persists for more than 3 months – develops in between 5 and 10% of all lower back pain cases, with life-altering impacts for patients. And that’s where today’s guest, Steve Ruston, of Persica Pharmaceuticals comes in. Persica is developing a groundbreaking and transformative treatment f...

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Persica Pharmaceuticals is treating the cause of chronic lower back pain, not just the symptoms

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This episode was published on July 4, 2025.

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The World Health Organization reports that more than 600 million people suffer from lower back pain globally, making it the leading cause of disability worldwide. Chronic lower back pain – where the pain persists for more than 3 months – develops in...

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