Phyto-Compounds
In episode 2 we're joined by Evan Stephens, Lead Scientific Advisor at Medibis, and Senior Research Fellow at the University of Queensland. We discuss the cannabis plant, the compounds produced by the plant, and how they are recognised as powerful medicin
First published
08/22/2022
Genres:
health
medicine
science
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Summary
In episode 2 we're joined by Evan Stephens, Lead Scientific Advisor at Medibis, and Senior Research Fellow at the University of Queensland. We discuss the cannabis plant, the compounds produced by the plant, and how they are recognised as powerful medicines.
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Parent Podcast
Phyting Words
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Phyting Words Season 1 Episode 3 – The Endocannabinoid System
Release Date: 11/02/2022
Authors: Medibis
Description: Hi, Welcome to the ECS Episode of the Medibis podcast series, Phyting Words. Angus Chapel – Medibis CEODr Evan Stephens – Medibis Scientific AdvisorDISCLAIMER – THIS IS NOT MEDICAL ADVICE – THIS IS SCIENTIFIC INFORMATION AND COMMUNICATIONECS (Endogenous Cannabinoid System) basicsAll of the systems throughout your body are constantly changing and working together to keep you in balance. Your body temperature is regulated using your skin, your breath and heart rate and modulated depending on the amount of energy you are using at any given time, your nervous system is modulated, the amount of adrenalin in your blood depends on your fight or flight response, your level of fear or excitement. All of these systems need to work together, and they do this very well considering there is no interference from the occupant of the body, it all happens innately.Research is showing that the ECS is playing a very important part in this process, perhaps even controlling, to a degree, all of the body’s systems. For a localised pain event for example, the ECS may produce higher levels of anandamide and have it delivered to the area of the body that has reported the pain response. It may also send 2AG if inflammation has been detected at an unacceptable level. Of course, there are limits to how much of these endocannabinoids can be manufactured by the body, the same as adrenalin for example. There must also be a consideration for the spill over effect into other systems of the body that, perhaps, may start to be compromised by excessive levels of a particular compound because at the end of the day, the body’s systems should be restored back to a balanced state.Using an integrated system of signalling, the ECS is able to not only monitor but also communicate through signalling to almost every other system in the body. This is fundamental to our homeostasis. All animals work this way, so it’s part of our magnificent design. Food and nutrients are some of the tools that the ECS uses to properly do this job, as are endo and phyto-cannabinoids and other phyto-compounds. It is microscopic and thus has evaded detected for many years and is a relatively new discovery.Because it has only been detected and recently understood, it doesn’t yet form part of the curriculum for a general practitioner, and there are few, if any, specialists for this system of the body. We have cardiovascular specialists, endocrine system specialists and almost all the other systems in the body except the ECS. It’s a huge discovery and a new frontier for science.So let’s go digging …….What is the ECS?CB1 and CB2 and Discuss specifics like TRPV1 and PPAR nuclear receptor proteins, FABP, etc.Also, enzymes e.g. FAAH, MAGL.TRPV1 - WikipediaInteractions by AEA, OD, AD.Peroxisome proliferator-activated receptor gamma - WikipediaFABP1 - Wikipediahttps://en.wikipedia.org/wiki/FABP1Fatty acid amide hydrolase - WikipediaMonoacylglycerol lipase - WikipediaMuch of the research started since the 1990s and 2000s.a 8 different dietary lipids. Mentioned the human genome project, and the genomics era (a preamble to later talking about the endo-cannabinoidome, and the tone of the ECS – hypo or hyper states) Master controllerTone of the ECS – how… biochemical factors, environmental factors, genetic factors – examples.ECS discovery. Why did it take so long to discover the ECS? What did we used to think was happening with homeostasis?Molecular biology tools (roughly from the 1980s, generally biology is much more complicated than chemistry)Hebrew University of Jerusalem, Israel. https://en.wikipedia.org/wiki/Raphael_MechoulamProfessor Raphael Mechoulam from the School of Pharmacology in the Faculty of Medicine at the Hebrew University of Jerusalem, is one of two winners of the esteemed Harvey Prize for his ground-breaking research in the world of medicinal cannabis. His studies in this field have given the entire world a new perspective on cannabis as a healing plant, rather than just a recreational drug.Prof. Mechoulam was born in Bulgaria (1930), where he studied chemical engineering. After immigrating to Israel he received his M.Sc. in biochemistry from the Hebrew University of Jerusalem and his Ph.D. at the Weizmann Institute and completed his postdoctoral studies at the Rockefeller Institute in New York. In 1960 he joined the junior staff of the Weizmann Institute, and in 1985 he became a professor at the Hebrew University.He is the first scientist to isolate plant cannabinoids, first CBD (cannabidiol) then THC (tetrahydrocannabinol) and he also is the first to discover the human endocannabinoid system, which is a complex cell-signalling system made up of receptors found throughout our entire bodies. These receptors react to plant cannabinoids to treat numerous conditions we suffer from. All living creatures except insects have an endocannabinoid system.David (Dedi) Meiri – Behind the smokescreen of medicinal cannabishttps://www.ted.com/talks/dedi_meiri_behind_the_smokescreen_of_medical_cannabis What does it do? How does it work? Activated dietary lipids and similarities to phyto-cannabinoidsTalking about stereochemistry and the Fischer lock and key principleDietary fats are long chains but these chains are quite flexibleCBD and ECS activation – complicated section – discuss. Metabolic disease – ECS toneScience reproducibility, and also should discuss reductionism versus confounding variables in the omics era. Genetic testing can be in the hundreds of dollars, but this was shortly after talking about whole genomesCannabinoidsHousing cannabinoids and 500+ compounds, cannabinoids, flavonoids and terpenoids.Aging, diet, and lifestyle effects.Senescent cells and SASPsQuality of lifeThe start low and go slow idea is not dissimilar to common dosing schedules, and this is to determine tolerability. There are some people in very low numbers who are unable to tolerate cannabis. We can measure this using genomic sequencing.Whilst THC has many cited medicinal applications, and replicates Anandamide throughout the ECS, the Side effect of THC can be intoxication or euphoria. What we know now through research is that we can improve the bioavailability of THC by adding CBD as this p...
Explicit: No
Patient Access
Release Date: 08/22/2022
Authors: Medibis
Description: In our first Phyting Words podcast episode - Patient Access, Angus Chapel, Managing Director, and Kristy Hunter, Marketing Manager, discuss the issues surrounding medicinal cannabis access in Australia. We also discuss how we hope to help solve some of them. Show links: Theraphttps://www.tga.gov.au/sites/default/files/tga-infographic-how-to-access-medicinal-cannabis.pdf https://www.tga.gov.au/community-qa/medicinal-cannabis-products-patient-information https://www.medigreenaustralia.com.au/ https://midispensary.com.au/ https://honahlee.com.au/ https://cannareviewsau.co/ https://cdaclinics.com.au/Medibis social media links:Facebook: https://www.facebook.com/medibispharmaceuticalInstagram: https://www.instagram.com/medibis_/LinkedIn: https://www.linkedin.com/company/74288335/admin/Produced By The Podcast Boss
Explicit: No
Words, Words, Words
Release Date: 07/01/2021
Description: In this episode, I discuss how being honest with yourself and your therapist affects your experience. I also shared two of the most important quotes I’ve ever come across in my adult life.
Explicit: No
Words, Words, Words
Release Date: 08/02/2022
Description: ATC Ep.39 Words, Words, WordsOn today’s episode we continue with our discussion on the way that words shape our thinking by highlighting the manipulation of words in current events.Questions, comments, and other words:Twitter:https://twitter.com/NShaneMillerLocals:https://nathanshanemiller.locals.comFacebook:https://www.facebook.com/nathanshanem…
Explicit: No
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