Platelet-Derived Exosomes in Aesthetics: Data, Safety, and Real-World Use Cases

Exosomes are becoming one of the most talked-about tools in regenerative medicine, but not all exosomes are created equal. In this episode of New Frontiers, Dr. Kara Fitzgerald talks with Alisa Lask, CEO of Plated Skin, about the science behind platelet-derived exosomes and why their signaling pathways matter for repair, renewal, and changes in skin appearance. We explore how discoveries in cardiology led to this technology, what early clinical studies are showing, and why source and preparation are critical when evaluating any exosome-based approach. A clear, grounded look at a fast-moving field for clinicians who want to understand what’s real, what’s emerging, and what deserves attention next. Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/ GUEST DETAILS Alisa Lask is the CEO of Rion Aesthetics, where she is driving innovation in regenerative aesthetics with platelet-derived exosomes and leading research in areas like hair restoration and skin appearance. She also oversees (plated)™ Skin Science, a medical-grade exosome skincare line distributed through aesthetic providers. Alisa previously held senior roles at Galderma, Allergan, Zimmer-Biomet, and Eli Lilly, and she serves on the Board of Directors for CollPlant. She holds an MBA from the University of Michigan and is also a nationally competitive show-jumping equestrian involved in dog rescue initiatives. THANKS TO OUR SPONSOR (plated)™ Skin Science: http://platedskinscience.com/ Plated Skin Science translates the discovery of Dr. Atta Behfar, M.D., Ph.D., Director of Mayo Clinic’s Van Cleve Cardiac Regenerative Medicine Program into the first shelf-stable skincare line using regenerative, platelet-derived exosomes. These aren’t generic exosomes; they’re a specific class shown in peer-reviewed trials to regenerate skin's appearance by improving the look of wrinkles, pigmentation, luminosity, and overall skin quality. It’s an elegant approach to visible signs of skin aging, recognized by Time as a Best Invention of 2024 and now used in more than 2,000 medical practices. Learn more at http://platedskinscience.com/ CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Practitioner Training Program: www.drkarafitzgerald.com/trainingyyi/ Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw