פרשת השבוע- פרשת ויגש

Karakter-karakter di Dunia One Piece

Release Date: 01/16/2021

Description: Jika kalian mau menemukan karakter unik dan keren, One Piece adalah persinggahan yang kalian cari. Dibangun dengan kumpulan berbagai suku dan ras, dunia One Piece begitu kaya akan keberagaman tersebut. Mulai dari Ras manusia yang terdiri dari raksasa, kurcaci, bersayap, mata tiga, hingga manusia ikan. Ada juga Ras Oni atau iblis contohnya keturunan Oars. Begitupun suku-suku yang terdata seperti Suku tangan panjang, kaki panjang, leher panjang, Mink, Shandian dll. Gimana serunya pembahasan kita kali ini? Rugi kalau sampai dilewatkan! --- Support this podcast: https://podcasters.spotify.com/pod/show/podcast-d-ace42/support

Explicit: No

Sister Maki - Prayer / Ras Tamano - Judgement In The Rain

Release Date: 06/01/2021

Description: ARTIST: SISTER MAKI // TITLE: PRAYERS CAT. NR: DUB034 // GENRE: ROOTS REGGAE / DUB TRACKLIST: 01 - Prayer (Sister Maki) / 02 - Judgement in the Rain (Ras Tamano) 03 - 3x3 dub (Binghi-D) / 04 - Prayer Riddim / 05 - Judgement in the Rain Riddim New EP coming from the Land of the Rising Sun with Sister Maki on the Vocals. The Osaka reggae singer, known through her collaboration with Dub Cmd in 2020 on Way To Zion (Pt. I & II), returns with a new EP. This time she collaborates with some great artists from her homeland Japan. Produced by the multitalented Swe (producer, artist, event organiser, woodcrafter, Kette drum builder and landscape gardener), Prayers features Sister Maki, on the vocals, Ras Tamano from Nara the (member of the roots reggae band, Desanc and maker of reggae artists dolls) on the melodica and Binghi-D on the Kette Drum. CREDITS: Production & Riddims - Swe (JP) / Vocal & Lyrics (01) - Sister Maki (JP) / Melodica (02) - Ras Tamano (JP) / Kette Drum (03) - Binghi-D (JP) / Mixed & Mastered by Swe Rooting (JP) / Art Work by Mingalang

Explicit: No

Targeting Ras with Protein Engineering

Release Date: 11/28/2023

Description: BUFFALO, NY- November 27, 2023 – A recent #review paper was #published in Oncotarget's Volume 14 on July 1, 2023, entitled, “Targeting Ras with protein engineering.” Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy. Despite extensive efforts, targeting Ras proteins with small molecules has been extremely challenging due to Ras’s mostly flat surface and lack of small molecule-binding cavities. These challenges were recently overcome by the development of the first covalent small-molecule anti-Ras drug, sotorasib, highlighting the efficacy of Ras inhibition as a therapeutic strategy. However, this drug exclusively inhibits the Ras G12C mutant, which is not a prevalent mutation in most cancer types. Unlike the G12C variant, other Ras oncogenic mutants lack reactive cysteines, rendering them unsuitable for targeting via the same strategy. In this review, researchers Atilio Tomazini and Julia M. Shifman from The Hebrew University of Jerusalem discuss protein engineering as a promising emergent method to target Ras, since engineered proteins have the ability to recognize various surfaces with high affinity and specificity. “While the development of small-molecule Ras inhibitors has been reviewed elsewhere [40], we focus our review on protein-based Ras inhibitors, describing the methods for their engineering, various scaffolds used for inhibitor design, and prospects for delivery of the designed Ras inhibitors into the cellular cytoplasm, where Ras is located.” Over the past few years, scientists have engineered antibodies, natural Ras effectors, and novel binding domains to bind to Ras and counteract its carcinogenic activities via a variety of strategies. These include inhibiting Ras-effector interactions, disrupting Ras dimerization, interrupting Ras nucleotide exchange, stimulating Ras interaction with tumor suppressor genes, and promoting Ras degradation. In parallel, significant advancements have been made in intracellular protein delivery, enabling the delivery of the engineered anti-Ras agents into the cellular cytoplasm. “These advances offer a promising path for targeting Ras proteins and other challenging drug targets, opening up new opportunities for drug discovery and development.” DOI - https://doi.org/10.18632/oncotarget.28469 Correspondence to - Julia M. Shifman - [email protected] Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28469 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - Ras oncogene, anti-Ras therapeutics, Ras targeting, protein engineering, protein design About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact [email protected] 18009220957

Explicit: No

L’actualité avec Alexandre Dubé : moins de 1000 cas de COVID-19 au Québec

Release Date: 04/26/2021

Description: Benoit Dutrizac (mise à jour - 26 avril 12h00) Segment d’actualité avec Alexandre Dubé : le bilan COVID-19 du jour. La vaccination en entreprise commence. Grève des débardeurs au Port de Montréal. Le manoir d’un dirigeant de Pornhub incendié. Projet pilote des caméras portatives sur les policiers. Le trafic est de retour. Pour de l’information concernant l’utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

Explicit: No

Allo

Release Date: 04/27/2021

Authors: El Hassan Kharrata

Description: Ras

Explicit: No

RAS Weekly Update

Release Date: 03/23/2021

Authors: Lamont Trotter

Description: RAS

Explicit: No

rebel reggae intl./ rass kassa

Release Date: 03/26/2021

Authors: Rebel Reggae Intl.

Description: Ras Kassas Korner

Explicit: No

RMGI podcast

Release Date: 08/26/2020

Authors: Ras Maxim

Description: I am ras maxim, a music producer of reggae, dub and beyond.RMGI stands for Ras Maxim Global Industries

Explicit: No

RAS-ACS

Release Date: 08/17/2020

Authors: RAS-ACS

Description: Podcast by RAS-ACS

Explicit: No

Ras T Dubflex

Release Date: 03/26/2021

Authors: Ras T Dubflex

Description: Podcast by Ras T Dubflex

Explicit: No

RAS Talk

Release Date: 06/15/2021

Authors: RAStech Magazine

Description: RAS Talk is a podcast about Recirculating Aquaculture Systems (RAS) and land-based aquaculture. RAS Talk is hosted by Jean Ko Din, editor of RASTECH magazine, and Justin Henry, RAS consultant & expert. Each episode welcomes a new guest to discuss sustainable seafood production, technology developments and innovative ideas relevant to this rapidly expanding segment of the aquaculture industry.

Explicit: No

RAS

Release Date: 05/03/2021

Authors: Maria

Description: Organização das redes de atenção a saúde na pandemia

Explicit: No

RAS

Release Date: 08/12/2020

Authors: akroman syahida

Description: Bincang ringan tapi serius tentang konflik batin yang berkaitan dengan percintaan, pertemanan, keluarga atau semua hal yang kita temui di kehidupan sehari-hari.

Explicit: No

Dr. Anshuma Mishra

Release Date: 08/21/2020

Authors: Anushree Mishra

Description: Unleashing Bhakti ras in Hindi Rachna

Explicit: No

Réseau Anti Spin HD

Release Date: 03/26/2021

Authors: Réseau Anti Spin HD

Description: RAS HD: Nous sommes l'information maintenant

Explicit: No