Rotations 2.0 Episode 52 Brain Immune Gut Axis

Send us Fan MailEpisode 52 Brain Immune Gut AxisShoot me any comments or questions @Rotation2ptoh  on XIntro Music: KI Instrumental (Rock Celtic) by Lyrium-2025Outro Music: Trap Beat (Dripin’ Sauce) by Alex GrohlCourtesy of Pixabay under Creative Commons non-commercial use.Produced by: Todd Fredricks DO MSS Edited by: Todd Fredricks DO MSSAnswers for Episode 51 Sprains and Strains 1) Acute management and expected outcomeA 24‑year‑old recreational basketball player presents 36 hours after an inversion injury. Examination is consistent with a grade II lateral ankle sprain; Ottawa ankle rules are negative. He asks what intervention is most likely to reduce his pain at rest over the next 1–2 weeks. Which is the best evidence‑based recommendation? A. Early, supervised physical therapy using a multimodal program (e.g., progressive exercise, stretching, thermotherapy/ultrasound or hydrotherapy, and functional training)2) Outcome interpretationA 19‑year‑old soccer player undergoes early physical therapy after a grade I ankle sprain. At follow‑up, the clinician reviews expected benefits from the literature. Which outcome did not show a significant difference between physical therapy and conventional treatment in the pooled analysis?C. Dorsiflexion range of motion (ROM)3) Evidence synthesis and methodologyIn the same review, Trial Sequential Analysis (TSA) showed the Z‑curve crossed the monitoring boundary and reached the required information size for the primary pain outcome. What is the best interpretation of this finding?A. The cumulative evidence is sufficient to conclude that physical therapy reduces pain versus conventional care while controlling for type I and type II errors Paper for Next Week:Jonathan J. Molina, Ana L. Flores-Mireles, CAUTIon – not all UTIs are the same, Nat Rev Urol. 2025 December ; 22(12): 799–814Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS.Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.