S01E04 The LIBERATE-D Trial: Conservative vs. Conventional Dialysis Strategies

Join us as we break down the LIBERATE-D trial, a provocative study questioning the default thrice-weekly dialysis schedule for AKI-D. We explore how a conservative, indications-only strategy (A-E-I-O-U—and sometimes “why”) was linked to higher kidney recovery at discharge in the unadjusted analysis, and why the accompanying editorial urges caution about robustness and real-world generalizability. Finally, we translate the findings into practical bedside decision-making for hemodynamically stable patients—and clarify who this does not apply to.Links (DOI + PubMed)Trial DOI: https://doi.org/10.1001/jama.2025.21530Trial PubMed: https://pubmed.ncbi.nlm.nih.gov/41201895/Editorial DOI: https://doi.org/10.1001/jama.2025.21618Editorial PubMed: https://pubmed.ncbi.nlm.nih.gov/41201902/