Targeting Cancer Evolution

In this podcast episode, we recap a Forbeck Forum that explored how cancer’s rapid evolution makes it so difficult to treat. Experts from experimental, computational, and clinical backgrounds discussed the fundamental principles of cancer evolution and potential therapeutic vulnerabilities. Across four sessions—covering everything from genetic mutations to chromosome instability and tumor population dynamics—they examined how cancers evolve at multiple genomic scales and develop resistance to therapy. With insights from cutting-edge tools like CRISPR, long-read sequencing, and single-cell analysis, the discussions highlighted how basic biology and clinical applications intersect. This episode captures the key takeaways, new ideas, and collaborative approaches that emerged from this unique gathering of cancer researchers.