Tony Schapira on GBA1 Parkinson's disease

from The Lancet Neurology in conversation with · host The Lancet Group

In this episode of In Conversation With, Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology, speaks with movement disorders specialist Tony Schapira from UCL’s Queen Square Institute of Neurology about GBA1-associated Parkinson’s disease. Together, they explore the genetic, clinical, and biochemical links between GBA1 variants, lysosomal function, Gaucher disease, alpha-synuclein pathology, and Parkinson’s progression. The conversation also highlights current challenges in risk prediction, biomarkers, genetic counselling, clinical management, and emerging therapeutic approaches aimed at modifying or even preventing disease. Click here to read the full article: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(26)00090-6/fulltext

What this episode covers

In this episode of In Conversation With, Elena Becker-Barroso, Editor-in-Chief of The Lancet Neurology, speaks with movement disorders specialist Tony Schapira from UCL’s Queen Square Institute of Neurology about GBA1-associated Parkinson’s disease.Together, they explore the genetic, clinical, and biochemical links between GBA1 variants, lysosomal function, Gaucher disease, alpha-synuclein pathology, and Parkinson’s progression. The conversation also highlights current challenges in risk prediction, biomarkers, genetic counselling, clinical management, and emerging therapeutic approaches aimed at modifying or even preventing disease. Click here to read the full article: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(26)00090-6/fulltext

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Tony Schapira on GBA1 Parkinson's disease

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This episode is 26 minutes long.

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This episode was published on June 16, 2026.

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