Evidence-Based GI: An ACG Publication and Podcast

Leandro Sierra, MD is joined by Anna S. Lok, MD to discuss key points from the recent AASLD/ISDA Practice Guideline on treatment of chronic hepatitis B. (30:40)

Associate Editor Elie Al Kazzi, MD, MPH and Vasantham Chaudhary, MD discuss "Appendicectomy versus switching to a JAK inhibitor in inducing remission in patients with active ulcerative colitis after biologic therapy failure (COSTA): 1-year results of a multicentre, prospective, cohort study, by Visser E, Reijntjes MA, Heuthorst L, et al. Published in Lancet Gastroenterol Hepatol. 2026 Mar;11(3):190-203.

Leandro Sierra, MD is joined by author Jasmohan S. Bajaj, MD, MS, FACG to discuss the recent ACG Clinical Guideline on Hepatic Encephalopathy, published in the March 2026 issue of the American Journal of Gastroenterology.

Associate Editor Elie Al Kazzi, MD, MPH and Vasantham Chaudhary, MD discuss "Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease," by Mahadevan U, Seow CH, Barnes EL, et al. Published in Am J Gastroenterol, August 27, 2025.

Leandro Sierra, MD interviews author Zachary Fricker, MD on "ACG Clinical Guideline: Perioperative risk assessment and management in patients with cirrhosis," by Mahmud N, Fricker ZP, McElroy LM, Qayed E, Wong RJ, Ioannou GN. Published in Am J Gastroenterol, 2025;120:1968-1984.

Christopher Vélez, MD and Noor Syed, MD discuss "The Efficacy and Safety of Tacrolimus in Reducing Inflammation and Need for Dilation," by Kukreja K, Kumar A, Camisa C, Jacobs J, Richter JE. Published in Clin Transl Gastroenterol, 2024 Dec 1;15(12):e00752.

Vasantham Chaudhary, MD and Elie Al Kazzi, MD, MPH discuss "Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy – a multi-arm randomised controlled trial (HELIOS)," by Te Groen M, Wijnands AM, den Broeder N, et al. Published in Gut 2025;75:547-556.

Leandro Sierra, MD and Joseph Lim, MD discuss "Early antiviral treatment with tenofovir alafenamide to prevent serious clinical adverse events in adults with chronic hepatitis B and moderate or high viraemia (ATTENTION): interim results from a randomised controlled trial,” by Lim Y. S., Yu M. L., Choi J., et al. Published in Lancet Gastroenterol Hepatol 2025; 10(4):295-305.

Rachael Hagen, MD and Joseph C. Anderson, MD, FACG discuss "Optimizing Bowel Preparation Quality for Colonoscopy: Consensus Recommendations by the US Multi-Society Task Force on Colorectal Cancer,” by Jacobson BC, Anderson JC, Burke CA, Dominitz JA, Gross SA, May FP, Patel SG, Shaukat A, Robertson DJ. Published in Am J Gastroenterol. 2025: 120(4):738-764.

Ellen Axenfeld, MD and Elie Al Zazzi, MD, MPH discuss "Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis,” by Sands BE, Feagan BG, Peyrin-Biroulet L, et al and the ARTEMIS-UC Study Group. Published in N Engl J Med. 2024 Sep 26;391(12):1119-1129.

Editor-in-Chief Paul Y. Kwo, MD, FACG and Associate Editor Elie S. Al Kazzi, MD, MPH discuss "Tofacitinib in acute severe ulcerative colitis (TACOS): A randomized controlled trial," by Singh A, Goyal MK, Midha V, et al. Am J Gastroenterol 2024; 119 (7), 1365-1372.

Margaret J. Zhou, MD, MS and Timothy Yen, MD discuss "Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence," by O'Sullivan T, Mandarino FV, Gauci JL, et al. Gut. 2024 Dec 10;74(1):67-74.

Margaret J. Zhou, MD, MS and Timothy Yen, MD discuss "Germline CDH1 variants and lifetime cancer risk,” by Ryan CE, Fasaye G, Gallanis AF, et al. JAMA. 2024;332(9):722–729.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis,” by Sands BE, Feagan BG, Biroulet LP, et al. N Engl J Med. 2024; 391: 1119-29.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Cold Versus Hot Snare Endoscopic Resection of Large Nonpedunculated Colorectal Polyps: Randomized Controlled German CHRONICLE Trial,” by Steinbrück I, Ebigbo A, Kuellmer A, et al. Gastroenterology. 2024 Sep;167(4):764-777

Philip Schoenfeld, MD, MSEd, MSc (Epi) discusses “Combination of Carvedilol with Variceal Band Ligation in Prevention of First Variceal Bleed in Child-Turcotte-Pugh B and C Cirrhosis with High-Risk Oesophageal Varices: the ‘CAVARLY’ Trial,” by Tevethia HV, Pande A, Vijayaraghavan R, et al. Gut. 2024; 73: 1844-53.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MS discuss “Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial,” by Summarizing Rothenber M, Dellon E, Collins M, et al. Lancet Gastroenterol Hep. 2023; 9: 990-1004

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Elie S. Al Kazzi, MD, MPH discuss “Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY),” Gastroenterology. 2024;167:919–933.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Christopher Velez, MD discuss “Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease,” by Fass R, Vaezi M, Sharma P, et al. Aliment Pharmacol Ther. 2023 Nov;58(10):1016-1027.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Margaret Zhou, MD, MS discuss “Colonoscopy quality measures and adherence to follow-up guidelines among endoscopists participating in a U.S. endoscopy registry,” by Shapiro JA, Holub JL, Dominitz JA R, et al. Gastrointest Endosc. 2024 Aug 5:S0016-5107(24)03404-7.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Efficacy and Findings of a Blinded Randomized Reintroduction Phase for the Low FODMAP Diet in Irritable Bowel Syndrome,” by Van den Houte K, Colomier E, Routhiaux K, et al. Gastroenterology. 2024; 167: 333-42.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Douglas K. Rex, MD discuss “Quality Indicators for Colonoscopy,” by Rex DK, Anderson JC, Butterly LF, et al. Am J Gastroenterol. 2024;119:1754-80.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “Impact of longitudinal alcohol use patterns on long-term risk of cirrhosis among US veterans with steatotic liver disease,” by Wong RJ, Yang Z, Cheung R, et al. Gastroenterology. 2024; 166(6):1156-1165.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Stress ulcer prophylaxis during invasive mechanical ventilation,” by Cook D, Deane A, Lauzier F, et al. NEJM. 2024 July 4; 391(1):9-20.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Timothy Yen, MD discuss “Measuring size of colorectal polyps using a virtual scale endoscope or visual assessment: A randomized controlled trial,” by Taghiakbari M, Djinbachian R, Haumesser C, et al. Am J Gastroenterol. 2024 Jul 1;119(7):1309-1317.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Colin Howden, MD discuss “ACG Clinical Guideline: Treatment of Helicobacter pylori Infection,” by Chey W, Howden C, Moss S, et al. Am J Gastroenterol. 2024;119:1730-53.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Risankizumab for Ulcerative Colitis: Two Randomized Clinical Trials,” by Louis E, Schreiber S, Panaccione R, Bossuyt P, et al for the INSPIRE and COMMAND Study Group. JAMA. 2024 Jul 22:e2412414

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial,” by Meulen LWT, Bogie RMM, Siersema PD, et al. Gut. 2024 Apr 5;73(5):741-750

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MSCR discuss “Diagnostic Yield of Ambulatory Reflux Monitoring Systems for Evaluation of Chronic Laryngeal Symptoms,” by Krause AJ, Greytak M, Kaizer MA, et al. Am J Gastroenterol. 2024 Apr 1;119(4):627-634.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “Risankizumab versus Ustekinumab for Moderate-to-Severe Crohn's Disease,” by Peyrin-Biroulet L, Chapman JC, Colombel JF, et al. N Engl J Med 2024;391:213-223.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Christopher Velez, MD discuss “Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial,” by Laine L, Spechler S, and Yadlapati R et al. Clinical Gastroenterology and Hepatology 2024; In Press.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Margaret J. Zhou, MD, MS discuss “Extracorporeal Shock-Wave Lithotripsy and Endoscopy for the Treatment of Pain in Chronic Pancreatitis : A Sham-Controlled, Randomized Trial,” by Talukdar R, Olesen SS, Unnisa M et al. Ann Intern Med 2024 Jun;177(6):749-758.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Elie Al Kazzi, MD, MPH discuss “ACG Clinical Guideline: Gastroparesis,” by Camilleri M, Kuo B, Nguyen L, et al. Am J Gastroenterol 2022;117(8):1197-1220.

Philip Schoenfeld, MD, MSEd, MSc (Epi) discusses “Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis,” by Loomba R, Hartman ML, Lawitz EJ, et al. N Engl J Med June 8, 2024.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Comparison of vonoprazan vs intravenous proton pump inhibitor for prevention of high-risk peptic ulcers rebleeding after successful endoscopic hemostasis: a multicenter randomized noninferiority trial,” by Geeratragool T, Kaosombatwattana U, Boonchote A, et al. Gastroenterology 2024; In Press.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Efficacy and safety of ustekinumab for ulcerative colitis through 4 years: final results of the UNIFI long-term maintenance study,” by Afif W, Arasaradnam RP, Abreu MT, Danese S, et al. Am J Gastroenterol 2024 May 1;119(5):910-921.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Longer interval between first colonoscopy with negative findings for colorectal cancer and repeat colonoscopy,” by Liang Q, Mukama T, Sundquist K, et al. JAMA Oncology 2024; In Press.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Philip Okafor, MD, MPH discuss “Standard of care versus octreotide in angiodysplasia-related bleeding: a multicenter randomized control trial,” by Goltstein L, Grooteman KV, Bernts LH et al. Gastroenterology 2024; 155: 690-703):1649-1659.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Multitarget stool RNA for colorectal cancer screening,” by Barnell EK, Wurtzler EM, La Rocca J, et al. JAMA 2023; 330: 1760-68.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “The efficacy of metoclopramide for gastric visualization by endoscopy in patients with active upper gastrointestinal bleeding: double-blind randomized controlled trial,” by Vimonsuntirungsri T, Thungsuk R, Nopjaroonsri P, et al. Am J Gastroenterol 2024 May 1;119(5):846-855. PMID: 38059896.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Timothy Yen, MD discuss “Surveillance colonoscopy findings in older adults with a history of colorectal adenomas,” by Lee JK, Roy A, Jensen CD, et al. JAMA Network Open 2024; 7(4):e244611.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Swathi Eluri, MD, MSCR discuss “Budesonide oral suspension improves outcomes in patients with eosinophilic esophagitis: results from a phase 3 trial,” by Hirano I, Collins MH, Katzka DA, et al. Clin Gastroenterol Hepatol. 2022 Mar;20(3):525-534.e10

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “Next-generation multitarget stool DNA test for colorectal cancer screening,” by T, Porter K, Zella J, et al. N Engl J Med. 2024; 390: 984-93.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Ahmad Abu-Heija, MBBS discuss “Efficacy and safety of linaclotide in treating functional constipation in paediatric patients: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial,” by Di Lorenzo C, Khlevner J, Rodriguez-Araujo G, et al. Lancet Gastroenterol Hepatol. 2024 Mar;9(3):238-250.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Bharati Kochar, MD, MS discuss “A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn’s disease (PROFILE): a multicentre, open-label randomised controlled trial,” by Noor NM et al. Lancet Gastroenterol Hepatol. 2024; 9: 415-27.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jacqueline Gaulin discuss “A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening,” by Chung DC, Gray DM, Singh H, et al. N Engl J Med 2024; 390: 973-83.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Nicole Rich, MD, MSCS discuss “A phase 3, randomized controlled trial of resmetirom in NASH with liver fibrosis,” by Harrison SA, Bedossa P, Guy CD et al. NEJM 2024; 390(6): 497-509.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Sonali Paul, MD discuss “Association of Glucagon-Like Peptide-1 Receptor Agonists with Serious Liver Events among Patients with Type 2 Diabetes Mellitus: A Scandinavian Cohort Study,” Engstom A, Wintzell V, Melbye M, et al. Hepatology 2024; In Press.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Rahul Dalal, MD, MPH discuss “Maternal and Neonatal Outcomes in Vedolizumab and Ustekinumab Exposed Pregnancies: Results from the PIANO registry,” by Chugh R, Long MD, Jiang Y, Weaver KN, Beaulieu DB, Scherl EJ, Mahadevan U. Am J Gastroenterol. 2023 Oct 5. Epub ahead of print.

Philip Schoenfeld, MD, MSEd, MSc (Epi) and Jeffrey Lee, MD, MPH discuss “Endoscopic En Bloc Versus Piecemeal Resection of Large Nonpedunculated Colonic Adenomas: A Randomized Comparative Trial,” by Jacques J, Schaefer M, Wallenhorst T, et al. Ann Intern Med 2024; 177: 29-38.