Healio Minute

In this edition, we look at rheumatology visits impacting reproductive health counseling, restrictive Medicare Part D coverage, and more. Read the full coverage here: Services targeting rheumatology visits increased reproductive health counseling rates 625% Medicare Part D coverage of certain rheumatoid arthritis drugs 'restrictive' DMARD treatment fails to mitigate osteoporosis in rheumatoid arthritis FDA to 'carefully shepherd' CAR T-cell therapy trials in autoimmune, rheumatic disease Low pay, longer training requirements hobble pediatric rheumatology workforce numbers References: Aritomi T, et al. Arthritis Rheumatol. 2026;doi:10.1002/art.70125. Healio interviews Healio interviews Kwon Y, et al. Arthritis Rheumatol. 2026;doi:10.1002/art.70132. Marcy D, et al. Arthritis Care Res. 2026;doi:10.1002/acr.80014.

In this edition, we look at the impact of GLP-1s on total joint replacement, the safety of NSAID's and more. Read the full coverage here: GLP-1s may have profound impact on total joint replacement NSAID use may be safe prior to total joint arthroplasty Complication risk may be lower for revision TJA when performed in ASC Despite improved function, patients with elbow dislocation often report long-term pain Osteochondral allograft transplant may treat pediatric elbow osteochondritis dissecans References: Acuña AJ, et al. Paper 33. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas. Foran JRH, et al. Paper 31. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas. Healio Interviews Perkins CA, et al. Am J Sports Med. 2025;doi:10.1177/03635465251366903. Plaisier N, et al. Paper 29. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 15-18, 2025; Phoenix.

In this edition, immunotherapy in advanced lung cancer, updates in EGFR-mutated lung cancer and more. Read the full coverage here: VIDEO: Immunotherapy in advanced lung cancer among highlights from ESMO 2025 VIDEO: Updates in EGFR-mutated lung cancer from ESMO 2025 VIDEO: DeLLphi-303 results show 'major jump in survival' for SCLC patients Emphysema found during lung cancer screening raises risk for mortality Q&A: More nonsmokers developing lung cancer due to radon exposure, air pollution References ·        González Gutiérrez J, et al. Radiology. 2025;doi:10.1148/radiol.250949. ·        Healio Interviews ·        Healio Interviews ·        Healio Interviews ·        Paulson KG, et al. Abstract OA13.01. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona.

In this edition, we look at robotic-assisted surgery, dislocation risk in fixed-bearing THA and more. Read the full coverage here: Higher head-to-cup ratio, robotic-assisted surgery may lower dislocation rate after THA Fully maximizing bearing diameter may reduce dislocation risk in fixed-bearing THA How may GLP-1s impact nutrition prior to orthopedic surgery? Medicare contractors propose coverage restriction of peripheral nerve block procedures Physician content on TikTok may guide patient education   References: Expert submission Healio Interviews Healio Interviews Kobayashi JK, et al. Paper 54. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas. Wang E, et al. Maximizing bearing diameter markedly lowers dislocations in primary total hip arthroplasty. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas.

In this edition, FDA warns complications following radiofrequency microneedling device use, chronic hand eczema considered "common" disease, and more. Read the full coverage here: Q&A: FDA warns of radiofrequency microneedling risks; here's what to know Chronic hand eczema now considered a 'common' skin disease in US 'Unproven' topical estrogens for the face may bring some risks FDA approves Restylane Lyft to treat receding chin References Chovatiya R, et al. Prevalence of self-reported physician diagnosis of chronic hand eczema in adults: A cross-sectional study of more than 10,000 participants in the general population – Results from the CHECK study in the United States. Presented at: Fall Clinical Dermatology Conference; Oct. 23-26, 2025; Las Vegas. Farkas E, et al J Am Acad Dermatol. 2025;doi:10.1016/j.jaad.2025.08.050. Healio Interviews Press Release

In this edition, we look at rehabilitation protocols, how AI can help patients with total knee arthroplasty, synthetic THC and more. Read the full coverage here: 'Quiet knee' rehabilitation protocol may reduce opioid exposure after TKA AI-enabled decision aid may improve TKA decision-making Synthetic THC may not reduce opioid intake after TKA Lorecivivint yields 'meaningful' improvements in knee osteoarthritis at 1 year Corticosteroid injections yield 'disappointing' response in knee osteoarthritis References: Baker J. Abstract 2624. Presented at: ACR Convergence 2025; Oct 24-29, 2025; Chicago. Bhatti P, et al. Poster 30. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas. Jayakumar P, et al. Paper 30. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas. Jennings JM, et al. Paper 10. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas. Yazici Y. Abstract 2626. Presented at: ACR Convergence 2025; Oct 24-29, 2025; Chicago.

In this edition, Congress reintroduces the Safe Step Act, an expert expresses doubt about the benefits of TrumpRx and more. Read the full coverage here: Congress reintroduces Safe Step Act to amend step therapy policies Q&A: TrumpRx, Pfizer deal sidestep health insurance companies Complete hair regrowth for some with alopecia after 3-year ritlecitinib treatment Waterproof bandages 'reasonable alternative' to petroleum-based wound care References ·       Bell MC, et al JAMA Dermatol. 2026;doi:10.1001/jamadermatol.2025.4051. ·       Healio Interviews ·       King B, et al. Abstract #LBA-335. Presented at: European Academy of Dermatology and Venereology Congress; Sept. 17-20, 2025; Paris.

In this edition, increased lung cancer screening improving outcomes, overall survival data from FLAURA2 trial and more. Read the full coverage here: Increased lung cancer screening improving outcomes, but rates 'still too low' VIDEO: Overall survival data from FLAURA2 trial presented at WCLC Updated NCCN guidelines on NSCLC put spotlight on biomarker testing 'Never too late': Smoking cessation after cancer diagnosis can extend survival New treatments worsened income-based survival disparities for lung cancer, melanoma References ·        American Lung Association 2025 State of Lung Cancer. ·        Khor S, et al. JCO Oncol Adv. 2025;doi:10.1200/OA-25-00026. ·        National Comprehensive Cancer Network.  ·        Planchard D, et al. Abstract PL02.06. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona. ·        Tohmasi S, et al. J Natl Compr Canc Netw. 2025;doi:10.6004/jnccn.2025.7059.

In this edition, we look at the first FDA approval of an oral therapy for chronic spontaneous urticaria, and more. Read the full coverage here: FDA approves first oral therapy for chronic spontaneous urticaria Denifanstat safe, effective in acne vulgaris treatment FDA approves Zoryve cream 0.05% for pediatric atopic dermatitis The 'Zoom boom' effect: Post-pandemic cost concerns for facial cosmetic procedures References: F Xiang, et al. Abstract #LBA-213. Presented at: European Academy of Dermatology and Venereology Congress; Sept. 17-20, 2025; Paris. Pecora V, et al. J Drugs Dermatol. 2025;doi:10.36849/JDD.9102. Press Release Press Release

In this edition, we look at how AI can help patients with total joint arthroplasty, the impact of opioid use on in-hospital sleep and more. Read the full coverage here: Custom-tailored AI platform may be feasible for addressing patient questions before TJA Opioid use may negatively affect in-hospital sleep, orthopedic trauma outcomes Polymicrobial infection may predict septic long bone nonunion repair reoperation Patients recognize importance of nutrition after surgery, need help with implementation GLP-1s may offer a 'protective effect' in shoulder surgery for patients with diabetes References: Barth K, et al. Paper 63. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 15-18, 2025; Phoenix. Martiono JA, et al. Paper 1. Presented at: American Shoulder and Elbow Surgeons Annual Meeting; Oct. 15-18, 2025; San Diego. Rizk AA, et al. Paper 4. Presented at: American Shoulder and Elbow Surgeons Annual Meeting; Oct. 15-18, 2025; San Diego. Schenker ML, et al. Paper 65. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 15-18, 2025; Phoenix. Zepeda KE, et al. Poster 13. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct. 23-26, 2025; Dallas.

In this edition we look at hip fracture surgery delays, how homelessness affects hip surgery outcomes and more. Read the full coverage here: Hip fracture surgery delay may increase mortality risk Homelessness may be a predictor of poor outcomes following hip fracture surgery Biological age, age acceleration may predict 1-year mortality after geriatric hip fracture Hip resurfacing device had low all-cause revision rate at 8-year follow-up Group cycling program leads to 'meaningful benefit' in hip osteoarthritis References: Cobb JP. Paper 11. Presented at: American Association of Hip and Knee Surgeons Annual Meeting; Oct 23-26, 2025; Dallas. Healio interviews Hoveidaei AH, et al. Paper 7. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 15-18, 2025; Phoenix. King SW, et al. Hip fracture surgery delayed by operating room capacity is an independent risk factor for 120-day mortality. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 15-18, 2025; Phoenix. Randall Z, et al. Paper 2. Presented at: Orthopaedic Trauma Association Annual Meeting; Oct. 15-18, 2025; Phoenix.

In this edition, FDA approves golimumab for pediatric ulcerative colitis, hospital affiliation linked to higher-cost care and more. Read the full coverage here: FDA approves golimumab for pediatric ulcerative colitis 'Tremendous implications': Hospital affiliation linked to higher-cost care 'Set a 2-TikTok limit': Smartphone use on toilet linked to higher risk for hemorrhoids APPs step up to fill GI care gaps, but scant on-the-job training fuels own burnout Rideshare 'potentially scalable intervention' to improve colonoscopy after abnormal FIT References: Expert Submission Issaka RB, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.30515. Kapoor DA et al. J Mark Access Health Policy. 2025;doi:10.3390/jmahp13030036. Press Release Ramprasad C, et al. PLoS One. 2025;doi:10.1371/journal.pone.0329983.

In this edition, radiation is a 'strong alternative' for surgery, FDA approves combination therapy for small cell lung cancer and more. Read the full coverage here: Radiation a 'strong alternative' to surgery for early-stage lung cancer FDA approves lurbinectedin, atezolizumab combination for small cell lung cancer Diagnostic yield high with robotic-assisted bronchoscopy in peripheral lung lesions Machine learning model predicts urgent care visits during lung cancer treatment Evidence is 'clear': Medicaid expansion significantly improves long-term cancer survival References: Gonzalez BD, et al. JCO Clin Cancer Inform. 2025;doi:10.1200/CCI-24-00315. Kleber T, et al. Abstract 268. Presented at: ASTRO Annual Meeting; Sept. 27-Oct. 1, 2025; San Francisco. Press Release Schafer EJ, et al. Cancer Discov. 2025;doi:10.1158/2159-8290.CD-25-1244. Steinack C, et al. OA1178: Robotic-assisted bronchoscopy with integrated cone-beam CT vs. conventional bronchoscopy for diagnosing peripheral pulmonary lesions: An open-label randomized controlled trial. Presented at: European Respiratory Society International Congress; Sept. 27-Oct. 1, 2025; Amsterdam.

In this edition, bioinductive implants for ACL reconstruction, osteochondral defects treatments and more. Read the full coverage here: ACL reconstruction with reinforced bioinductive implant may yield favorable outcomes Multiplug, single-plug techniques had comparable outcomes for osteochondral defects MRI-based clinical prediction model identified risk factors for patellar instability New technology, cost strategies continue to move robotic-assisted surgery forward Physician referral to physical therapy underutilized for patients with knee osteoarthritis References: Healio Interviews Khoja SS, et al. Arthritis Care Res. 2025;doi:10.1002/acr.25630. McMillan S, et al. Surg Technol Int. 2025;doi:10.52198/25.STI.45.OS1888. Mufti YN, et al. Am J Sports Med. 2025;doi:10.1177/03635465251352172. Nukala V, et al. Arthrosc Sports Med Rehabil. 2025;doi:10.1016/j.asmr.2025.101159.

In this edition, we look at AI bias, nonsurgical biologic therapies and more. Read the full coverage here: 'Math, not magic': Identify and combat bias in AI Orthobiologics: Commit to evidence-based practice, foster cautious optimism TJR indications expand, making it a young man's game Successful management of PJI occurred in about 50% of patients Risks of anteromedial tibial tubercle transfer are minimal and the benefits great   References: Expert Submission Healio Interviews Higuera Rueda C, et al. Paper 1409. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug. 1-2, 2025; Jersey City, N.J. Engagement Time: 18 minutes

In this edition, FDA approves subcutaneous chemotherapy for solid tumors, improvements to shared decision-making and more. Read the full coverage here: FDA approves Hernexeos as first oral therapy for NSCLC with HER2 mutations Communication, knowledge critical to improve shared decision-making for lung cancer Detection of ctDNA could help determine use of immunotherapy for small cell lung cancer Subcutaneous amivantamab plus lazertinib produces similar results to IV regimen in NSCLC Lung cancer screening guidance needed for certain never-smokers References: Bi N, et al. Abstract 2034. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona. Press Release Scott SC, et al. Abstract 1798. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona. Shum E, et al. Abstract 2172. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona. Villalon D, et al. Abstract 2368. Presented at IASLC World Conference on Lung Cancer; Sept. 6-9, 2025; Barcelona.

In this edition, ultra-processed grains linked to elevated risk for IBD, CTA use for GI bleeds increase and more. Read the full coverage here: Ultra-processed grains linked to elevated risk for IBD, especially ulcerative colitis 'Double whammy:' CTA use for GI bleeds rise, but diagnostic yield drops 'Another layer of benefit': GLP-1s linked to lower risk for peptic ulcer disease 'Simplified care models' needed for chronic HBV care to meet 2030 global elimination goals 'Stay vigilant': Routine exposure to AI may reduce ADR in standard colonoscopy References: Budzyń K, et al. Lancet Gastroenterol Hepatol. 2025;doi:10.1016/S2468-1253 (25) 00133-5. Narula N, et al. Am J Gastro. 2025;doi:10.14309/ajg.0000000000003700. Prasad S, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.29746. Seika P, et al. Clin Gastroenterol Hepatol. 2025;doi:10.1016/j.cgh.2025.08.015. Stockdale AJ, et al. Lancet Gastroenterol Hepatol. 2025;doi:10.1016/S2468-1253(25)00163-3.

In this edition, we look at labral reconstruction in adolescents, the risk of skipping breakfast on osteoporotic fractures and more. Read the full coverage here: Labral reconstruction yielded favorable outcomes among adolescent patients Skipping breakfast, eating late dinners may raise risk for major osteoporotic fractures AI may personalize patient care, identify surgical risks Surgical fixation for pickleball-related Achilles ruptures may improve quality of life Screening for osteoporosis, preventing fractures essential in diabetes care References: Chen C, et al. Paper 17. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn Domb BG, et al. Paper 50. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn. Kemmis K. Presentation D27. Presented at: ADCES25; Aug. 8-11, 2025; Phoenix. Nakajima H, et al. J Endocr Soc. 2025;doi:10.1210/jendso/bvaf127. Weight C. AI in the OR: Personalizing care, lowering complications and automating surgery. Presented at: Cleveland Clinic's A.I. Summit for Healthcare Professionals; July 11, 2025; Cleveland.

In this edition, we look at the risk orthopedic surgeons face from insufficient malpractice coverage, the role of AI in osteoporosis and more. Read the full coverage here: AI-assisted diagnostic system may identify osteopenia, osteoporosis Insufficient malpractice coverage may place surgeons caring for elite athletes at risk Psychological readiness, stress improved 2 years after ACL reconstruction Patella resurfacing reduced maltracking, had comparable outcomes as nonresurfacing Patellofemoral osteochondral allograft transplantation may effectively treat lesions References: Jolissaint JE, et al. Paper 1538. Presented at: Musculoskeletal Infection Society Annual Meeting; Aug. 1-2, 2025; Jersey City, N.J. Milewski MD, et al. Paper 57. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn. Moro T, et al. J Orthop Res. 2025;doi:10.1002/jor.70000. Ramkumar PN, et al. Paper 37. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-13, 2025; Nashville, Tenn. Wang T, et al. Paper 28. Presented at: American Orthopaedic Society for Sports Medicine Annual Meeting; July 10-12, 2025; Nashville, Tenn.

In this edition, FDA approves first oral therapy for NSCLC, interstitial lung disease diagnosis raises risk for lung cancer and more. Read the full coverage here: FDA approves Hernexeos as first oral therapy for NSCLC with HER2 mutations ILD diagnosis raises risk for lung cancer Uninsured patients benefit less from immune checkpoint inhibitors than privately insured Shared decision-making visit improves annual lung cancer screening adherence Indoor tobacco, e-cigarette use more common in rural vs. urban homes References: Chung Y, et al. CHEST. 2025;doi:10.1016/j.chest.2025.06.026. Press Release Steinberg AW, et al. Ann Am Thorac Soc. 2025;doi:10.1513/AnnalsATS.202504-419OC. Xu H, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.19630. Zhao J, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.19274.

In this edition, opioid deaths with GI issues tripled in the past decade, prophylactic vancomycin may reduce risk for recurrent C. difficile and more. Read the full coverage here: 'Deeply alarming': Opioid deaths with GI issues tripled in the past decade Prophylactic vancomycin may reduce risk for recurrent C. difficile CRC disparities in Black communities stem from access, not biology, experts say Mediterranean, plant-based diets linked to lower risk for chronic constipation Psychiatric disorders 'common' among patients with inflammatory bowel disease References: Appiah JK, et al. Cureus. 2025;doi:10.7759/cureus.86489. Cadogan K, et al. Crohns Colitis 360. 2025;doi:10.1093/crocol/otaf035. Keating JA, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.17834. May FP, et al. Nat Rev Gastroenterol Hepatol. 2025;doi: 10.1038/s41575-025-01087-3. Wang Y, et al. Gastroenterology. 2025;doi:10.1053/j.gastro.2025.06.020.

In this edition, we look at how state opioid cap laws impact total joint replacements, how nutrition affects orthopedic surgery and more. Read the full coverage here: State opioid cap laws may reduce opioid fills after total joint replacement Nutrition may be key to muscle, bone health after surgery Should malnutrition screening occur before orthopedic surgery? Pyrocarbon hemiarthroplasty with glenoid reaming may improve outcomes for young patients Physicians under pressure in name, image and likeness era References: Expert Submission Healio Interviews Healio Interviews Ranieri R, et al. J Shoulder Elbow Surg. 2025;doi:10.1016/j.jse.2024.06.028. Thirukumaran CP, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.4448.  

In this edition, we look at how testosterone and exercise affect older women with hip fracture, how vitamin C may be an effective alternative to glucocorticoids and more. Read the full coverage here: Function not improved with testosterone plus exercise after hip fracture in older women Vitamin C may be effective alternative to glucocorticoids in total hip arthroplasty Hip resurfacing may be effective for younger, active men with osteoarthritis Robotic-assisted THA may reduce opioid requirements vs. manual, computer-assisted THA One-stage exchange may provide alternative for chronic PJI References: Binder EF, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.10512. Expert Submission Giannakis P, et al. e-Poster 6833. Presented at: Anesthesiology and Acute Pain Medicine Meeting; May 1-3, 2025; Orlando. Jiang W, et al. J Bone Joint Surg Am. 2025;doi:10.2106/JBJS.24.01080. Zuke WA, et al. J Bone Joint Surg Am. 2025;doi:10.2106/JBJS.24.00926.

In this edition, light physical activity linked to lower cancer risk, lung lesion diagnostic yield from bronchoscopy and more. Read the full coverage here: 'Every bit of movement counts': Even light physical activity linked to lower cancer risk Robotic, electromagnetic navigation bronchoscopy have similar lung lesion diagnostic yield Women with history of adverse pregnancy outcomes face elevated risk for future COPD Long-term blood pressure lowering does not appear to impact risk for new-onset cancer Most patients with advanced cancer do not undergo next-generation sequencing testing References: Chehade CH, et al. Abstract 11014. Presented at: ASCO Annual Meeting; May 30-June 3, 2025; Chicago. Paez R, et al. Am J Respir Crit Care Med. 2025;doi:10.1164/rccm.202409-1846OC. Shreves AH, et al. Br J Sports Med. 2025;doi:10.1136/bjsports-2024-109360. Sridhar S, et al. Adverse pregnancy outcomes and future maternal risk of developing COPD: An analysis of the Women's Health Initiative. Presented at: American Thoracic Society International Conference; May 16-21, 2025; San Francisco. Zazarzadeh M, et al. JACC CardioOncol. 2025;doi:10.1016/j.jaccao.2025.03.005.

In this edition, IBD social risks linked to unplanned ED use, anal cancer screening for men with HIV may cut deaths by 65% and more. Read the full coverage here: Nearly two-thirds of adults with IBD experience social risks linked to unplanned ED use Anal cancer screening at age 35 for gay, bisexual men with HIV may cut deaths by 65% 'Not just a physical issue': CRC linked to adverse sexual health outcomes among women 'We need to take ownership': ACG guideline urges preventive care in IBD management Managing gut dysbiosis may offer 'therapeutic window' for severe alcoholic hepatitis References: Deshmukh AA, et al. Ann Intern Med. 2025;doi:10.7326/ANNALS-24-01426. Farraye FA, et al. Am J Gastroenterol. 2025;doi:10.14309/ajg.0000000000003541. Kim S, et al. Clin Gastroenterol Hepatol. 2025;doi:10.1016/j.cgh.2025.03.031. Oveisi N, et al. J Natl Cancer Inst. 2025;doi:10.1093/jnci/djaf120. Vaithiyam V, et al. Cureus. 2025;doi:10.7759/cureus.85516.

In this edition, we look at knee replacement survivorship, how DEI statements may lead to more women in sports medicine programs and more. Read the full coverage here: Public DEI statements may lead to more women faculty, fellows in sports medicine programs Knee replacements have high long-term survivorship in young patients Aragonite-based scaffold yielded similar outcomes between men, women with chondral defects Platelet-rich plasma may be inferior to corticosteroid injections for knee osteoarthritis Bioinductive collagen implant had similar outcomes as suture anchors in rotator cuff tears References: Hurley ET, et al. Clinical outcomes of bioinductive collagen implants for high-grade partial rotator cuff tears. Presented at: Arthroscopy Association of North America Annual Meeting; May 8-10, 2025; Washington, D.C Kon E, et al. Female patients report comparable results to males after the implantation of an aragonite scaffold. Presented at: Arthroscopy Association of North America Annual Meeting; May 8-10, 2025; Washington, D.C. Pai J, et al. Diversity, equity and inclusion initiatives and faculty roles in orthopedic sports fellowship. Presented at: Arthroscopy Association of North America Annual Meeting; May 8-10, 2025; Washington, D.C. Swartz GN, et al. Poster e251. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 10-14, 2025; San Diego. Weinblatt AI, et al. Paper 416. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 10-14, 2025; San Diego.

In this edition, DREAM program 'better than anything' available, maintenance regimen a potential new standard and more. Read the full coverage here: DREAM program 'better than anything' available for patients with advanced lung cancer Maintenance regimen a potential new standard in extensive-stage small cell lung cancer 'It can save their lives': Annual lung cancer screening improves cancer detection rate Assay predicts adjuvant chemotherapy benefit in early-stage non-small cell lung cancer High environmental burden has associations with incidence of multiple cancer types References: Kamarei AMA, et al. Abstract 11009. Presented at: ASCO Annual Meeting; May 30-June 3, 2025; Chicago. Kim RY, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.0942. Paz-Ares LG, et al. Abstract #8006. Presented at: ASCO Annual Meeting; May 30-June 3, 2025; Chicago. Press Release Spigel DR, et al. Abstract LBA8027. Presented at: ASCO Annual Meeting; May 30-June 3, 2025; Chicago.

In this edition, reduction efforts prevent 3.8 million lung cancer deaths since 1970, first-line combination should be 'new standard' in advanced lung cancer and more. Read the full coverage here: Smoking cessation, reduction efforts prevent 3.8 million lung cancer deaths since 1970 First-line combination should be 'new standard' in advanced lung cancer Only 1 in 5 people treated with immune checkpoint inhibitors respond to therapy 'It can save their lives': Annual lung cancer screening improves cancer detection rate 'Are we giving false hope?': Few hospitalized people with cancer benefit from immunotherapy References: Haslam A, et al. Int J Cancer. 2025;doi:10.1002/ijc.35347. Islami F, et al. CA Cancer J Clin. 2025;doi:10.3322/caac.70005. Kim RY, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.0942. Riaz F, et al. JCO Oncol Pract. 2025;doi:10.1200/OP-24-00788. Yang JCH, et al. Amivantamab plus lazertinib vs osimertinib in first-line EGFR-mutant advanced NSCLC. Presented at: European Lung Cancer Congress; March 26-29, 2025; Paris.

In this edition, reduction efforts prevent 3.8 million lung cancer deaths since 1970, first-line combination should be 'new standard' in advanced lung cancer and more. Read the full coverage here: Smoking cessation, reduction efforts prevent 3.8 million lung cancer deaths since 1970 First-line combination should be 'new standard' in advanced lung cancer Only 1 in 5 people treated with immune checkpoint inhibitors respond to therapy 'It can save their lives': Annual lung cancer screening improves cancer detection rate 'Are we giving false hope?': Few hospitalized people with cancer benefit from immunotherapy References: Haslam A, et al. Int J Cancer. 2025;doi:10.1002/ijc.35347. Islami F, et al. CA Cancer J Clin. 2025;doi:10.3322/caac.70005. Kim RY, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.0942. Riaz F, et al. JCO Oncol Pract. 2025;doi:10.1200/OP-24-00788. Yang JCH, et al. Amivantamab plus lazertinib vs osimertinib in first-line EGFR-mutant advanced NSCLC. Presented at: European Lung Cancer Congress; March 26-29, 2025; Paris.

In this edition, sick food service workers top driver of viral foodborne outbreaks in US, no weight loss benefit with semaglutide before bariatric surgery and more. Read the full coverage here: Sick food service workers remain top driver of viral foodborne outbreaks in US 'We have work to do': No weight loss benefit with semaglutide before bariatric surgery Mailed FIT outreach program boosts colorectal cancer screening in rural areas 'Distinct viral exposure patterns' found in patients with Crohn's years before diagnosis Mortality, dropout risk higher on liver transplant waitlist in low-density areas References: Coronado GD, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.0928. Holst MM, et al. MMWR Surveill Summ. 2025;doi:10.15585/mmwr.ss7401a1. Mathur V, et al. JAMA Surg. 2025;doi:10.1001/jamasurg.2025.0001. Nandy A, et al. Gastroenterology. 2025;doi:10.1053/j.gastro.2025.01.247 Tanaka T, et al. JAMA Netw Open. 2025;doi:10.1001/jamanetworkopen.2025.1759.

In this edition, recurrence-free survival estimates in less advanced lung cancer, bronchoscopy-guided microwave ablation safe in lung abnormality and more. Read the full coverage here: Recurrence-free survival estimates after surgery higher in less advanced lung cancer Electromagnetic navigation bronchoscopy-guided microwave ablation safe in lung abnormality High prevalence of atherosclerosis detected in patients entering lung cancer therapy Wood dust exposure negatively impacts lung function in carpenters 40% of people treated with chemotherapy develop persistent, severe nerve pain References: D'Souza RS, et al. Reg Anesth Pain Med. 2025;doi:10.1136/rapm-2024-106229. Elfatih NM, et al. BMC Pulm Med. 2025;doi:10.1186/s12890-025-03535-x. Malozzi C. Implementation science (application of research into practice/policy). Presented at: American College of Cardiology's Advancing the Cardiovascular Care of the Oncology Patient course; Feb. 14-16, 2025; Washington, D.C. Rajaram R, et al. CHEST. 2023;doi:10.1016/j.chest.2023.11.042. Wang S, et al. J Thorac Dis. 2024;doi:10.21037/jtd-24-1052.

In this edition, robotic-assisted bronchoscopy a 'game changer', global mortality related to tobacco drops, particulate matter rises and more. Read the full coverage here: Robotic-assisted bronchoscopy a 'game changer' in early diagnosis of lung cancer Global lung cancer mortality related to tobacco drops, particulate matter rises in 2019 Osimertinib linked to more therapy-related cardiac events than other TKIs for NSCLC Survival better with lobectomy vs. wedge resection in early stage lung cancer Zenocutuzumab exhibits efficacy in NRG1 fusion-positive cancers References: Expert Submission Jani CT, et al. eClinicalMedicine. 2025;doi:10.1016/j.eclinm.2024.103033. Lin CY, et al. JAMA Netw Open. 2024;doi:10.1001/jamanetworkopen.2024.48364. Schram AM, et al. N Engl J Med. 2025;doi:10.1056/NEJMoa2405008. Seder C. Anatomic lung resection is associated with improved survival compared with wedge resection for stage IA non-small cell lung cancer. Presented at: 2025 Society of Thoracic Surgeons Annual Meeting; Jan. 24-26; Los Angeles.

In this edition, combination extends survival vs. standard first-line therapy, integrated care for smoking cessation during lung cancer screening and more. Read the full coverage here: Combination extends survival vs. standard first-line therapy for advanced lung cancer Integrated care 'best treatment option' for smoking cessation during lung cancer screening FDA proposes cap on nicotine levels in cigarettes Global lifetime risk for lung cancer in 2022 differs by human development index, sex FDA grants priority review to oral non-small cell lung cancer drug References: Cinciripini P, et al. JAMA Intern Med. 2024;doi:10.1001/jamainternmed.2024.7288. Li M, et al. Chin Med J (Engl). 2024;doi:10.1097/CM9.0000000000003368. Press Release Press Release Press Release

In this edition, we bring you Healio's top lung cancer headlines in 2024. Read the full coverage here: California doctor with lung cancer receives first-of-its-kind lung-liver transplant 'We were shocked': Vaping considerably increases lung cancer risk among people who smoke FDA places hold on trial of cell therapy for lung cancer after patient death Findings highlight 'desperate need' to improve end-of-life cancer treatment 'We have the technology': Telehealth increases access to palliative care for cancer References: Canavan ME, et al. JAMA Oncol. 2024;doi:10.1001/jamaoncol.2024.1129. Greer JA, et al. Abstract LBA3. Presented at: ASCO Annual Meeting; May 31-June 4, 2024: Chicago. Healio Interviews Press Release Press Release

In this edition, single-fraction SBRT outcomes for central lung tumors, adjuvant durvalumab extends survival in limited-stage small cell lung cancer and more. Read the full coverage here: Single-fraction SBRT confers 'surprisingly excellent' outcomes for central lung tumors Adjuvant durvalumab extends survival in limited-stage small cell lung cancer Depression among people with head and neck cancers likely underreported, undertreated FDA approves tumor treating fields as part of combination therapy for advanced lung cancer First-line maintenance regimen improves OS, PFS in extensive-stage small cell lung cancer References: Cheng Y, et al. Abstract LBA81. Presented at: European Society for Medical Oncology Congress; Sept. 13-17, 2024; Barcelona, Spain. Malik NK, et al. Abstract 285. Presented at: ASTRO Annual Meeting; Sept. 29-Oct. 2, 2024; Washington, D.C. Martinez MC, et al. JAMA Otolaryngol Head Neck Surg. 2024;doi:10.1001/jamaoto.2024.3233. Press Release Press Release

In this edition, FDA approves Rybrevant for advanced lung cancer, screening orders in eligible patients higher with digital health program and more. Read the full coverage here: FDA approves Rybrevant for advanced lung cancer Lung cancer screening orders in eligible patients higher with digital health program FDA approves Opdivo regimen for resectable NSCLC Study quantifies survival benefit of immunotherapy in metastatic NSCLC FDA expands osimertinib approval for advanced non-small cell lung cancer References: Miller DP, et al. A direct-to-patient digital health program increases lung cancer screening: A pragmatic randomized controlled trial of mPATH-Lung. Presented at: CHEST Annual Meeting; Oct. 6-9, 2024; Boston. Press Release Press Release Press Release Ward Y, et al. Cancer. 2024;doi:10.1002/cncr.35476.

In this edition, blue-collar workers more likely to miss work or quit due to psoriatic arthritis, infliximab biosimilar increase after release of a third option and more. Read the full coverage here: Blue-collar workers more likely to miss work, quit due to psoriatic arthritis Infliximab biosimilar uptake rapidly increased only after release of a third option National Psoriasis Foundation to honor leaders at 2025 Commit to Cure Gala Safety checklist compiles clinically important DMARD warnings in one place Guselkumab demonstrates long-term efficacy, safety in psoriasis References: Colla N, et al. Clin Rheumatol. 2024;doi:10.1007/s10067-024-07077-1. Gargiulo L, et al. J Drugs Dermatol. 2024;doi:10.36849/JDD.7486R1. Press Release Roberts ET, et al. Arthritis Rheumatol. 2024;doi:10.1002/art.42963. Skaarup L, et al. Drug Saf. 2024;doi:10.1007/s40264-024-01461-1.

In this edition, FDA approves first subcutaneous anti-PD-L1 cancer immunotherapy, ivonescimab 'may be a new standard' and more. Read the full coverage here: FDA approves first subcutaneous anti-PD-L1 cancer immunotherapy Ivonescimab extends PFS vs. pembrolizumab in advanced NSCLC, may be 'a new standard' Perioperative nivolumab improves outcomes in resectable NSCLC Despite progress, barriers to lung cancer biomarker testing persist Atezolizumab regimen 'merits further study' for unresectable NSCLC References: Forde PM, et al. Abstract 3589. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego. Press Release Ross HJ, et al. JAMA Oncol. 2024;doi:10.1001/jamaoncol.2024.1897. Smeltzer M, et al. Abstract 3000. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego. Zhou C, et al. Abstract 2700. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego.

In this edition, FDA approves first subcutaneous anti-PD-L1 cancer immunotherapy, Ivonescimab 'may be a new standard' and more. Read the full coverage here: FDA approves first subcutaneous anti-PD-L1 cancer immunotherapy Ivonescimab extends PFS vs. pembrolizumab in advanced NSCLC, may be 'a new standard' Perioperative nivolumab improves outcomes in resectable NSCLC Despite progress, barriers to lung cancer biomarker testing persist Atezolizumab regimen 'merits further study' for unresectable NSCLC References: Forde PM, et al. Abstract 3589. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego. Press Release Ross HJ, et al. JAMA Oncol. 2024;doi:10.1001/jamaoncol.2024.1897. Smeltzer M, et al. Abstract 3000. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego. Zhou C, et al. Abstract 2700. Presented at: IASLC World Conference on Lung Cancer; Sept. 7-10, 2024; San Diego.

In this edition, enrollment and dosing complete in phase 1 trial of AIV007, popular benchmarks in clinical practice guidelines and more. Read the full coverage here: Enrollment, dosing complete in phase 1 trial of AIV007 for AMD, diabetic macular edema OCT, visual acuity popular benchmarks in clinical practice guidelines for DME First patient dosed in phase 2 trial of EC-104 implant for diabetic macular edema OCS-01 eye drop for DME in second stage of phase 3 trial Q&A: Susvimo delivers immediate durability after implantation in wet AMD References: Crawford C. Update on OCS-01: A novel topical drop for DME in phase 3 trials. Presented at: Clinical Trials at the Summit; June 8, 2024; Park City, Utah. Healio Interviews McAllister M, et al. Assessing the strength of clinical practice guidelines for managing diabetic macular edema — A systematic literature review. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm. Press Release Press Release

In this edition, drug discounts through Medicare price negotiations, opioid use has fallen 15% annually since 2014 and more. Read the full coverage here: Enbrel, Stelara to be discounted nearly 70% through Medicare price negotiations Opioid use has fallen 15% annually since 2014 in autoimmune rheumatic disease Inhibitor class PsO treatments exhibit similar efficacy in mitigating PsA risk S100 protein levels predict abatacept response in juvenile idiopathic arthritis Izokibep shows early promise in hidradenitis suppurativa References: Brunner HI, et al. Arthritis Res Ther. 2024;doi:10.1186/s13075-024-03347-0. Falasinnu T, et al. Lancet Rheumatol. 2024;doi:10.1016/S2665-9913(24)00120-6. Press Release Press Release Tsai SHL, et al. J Am Acad Dermatol. 2024;doi:10.1016/j.jaad.2024.07.1473.

In this edition, low education level raises follow-up risk in screening program, screening judgement strongly influenced by clinicians and more. Read the full coverage here: Low education level raises risk for loss to follow-up in lung cancer screening program Lung cancer screening judgement strongly influenced by clinicians Occupational benzene exposure heightens lung cancer likelihood Chemotherapy plus nintedanib has 'promising' efficacy in small cell lung cancer with IPF Blood biomarker identifying benign lung nodules performs well across subgroups References: Ikeda S, et al. Ann Am Thorac Soc. 2024;doi:10.1513/AnnalsATS.202311-941OC. Long KJ, et al. CHEST. 2023;doi:10.1016/j.chest.2023.06.037. Mugutso E, et al. Ann Am Thorac Soc. 2023;doi:10.1513/AnnalsATS.202304-348RL. Núñez ER, et al. Am J Respir Crit Care Med. 2024;doi:10.1164/rccm.202301-0155OC. Wan W, et al. Am J Respir Crit Care Med. 2024;doi:10.1164/rccm.202306-0942OC.

In this edition, sozinibercept combination therapy shows durability, comparable improvements with aflibercept and more. Read the full coverage here: Sozinibercept combination therapy shows durability in patients with DME, neovascular AMD VIDEO: Comparable improvements seen with aflibercept 8 mg vs. 2 mg in DME DPP-IV, SGLT2 and GLP-1 drugs do not increase risk for diabetic macular edema Eluminex doses first patient in phase 1b trial of EB-105 for diabetic macular edema VIDEO: Port delivery system maintains visual, anatomic improvements in DME at 2 years References: Awh C. Port delivery system with ranibizumab for continuous treatment of diabetic macular edema: First readout of the phase 3 Pagoda trial year 2 results. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm. Do D. Outcomes of patients with DME and baseline BCVA of 20/50 or worse or 20/40 or better treated with aflibercept 8 mg and 2 mg in the phase 2/3 PHOTON trial. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm. Phu A, et al. J Diabetes Complications. 2024;doi:10.1016/j.jdiacomp.2024.108808. Press Release Steinle NC. Durability of combination therapy of sozinibercept (OPT-302), an anti-VEGF-C/-D 'trap' with ranibizumab in nAMD or aflibercept in DME. Presented at: American Society of Retina Specialists annual meeting; July 17-20, 2024; Stockholm.

In this edition, guselkumab brings 'stringent' control through 2 years, SARDs outpatient visits result in opioid prescriptions and more. Read the full coverage here: Guselkumab brings active psoriatic arthritis into 'stringent' control through 2 years Nearly one-quarter of all SARDs outpatient visits in US result in opioid prescription FDA approves biosimilar Pyzchiva for all approved Stelara indications Tofacitinib effective for juvenile idiopathic arthritis through 4 years Bimekizumab results in rapid, sustained improvements to PsA patient reported outcomes References: Brunner HI, et al. Ann Rheum Dis. 2024;doi:10.1136/ard-2023-225094. Gossec L, et al. Rheumatology. 2024;doi:10.1093/rheumatology/keae277. Huang Y, et al. Arthritis Care Res. 2024;doi:10.1002/acr.25378. Press Release Ritchlin CT, et al. Clin Rheumatol. 2024;doi:10.1007/s10067-024-06991-8.

In this edition, atezolizumab benefits PD-L1-selected patients with NSCLC, risks persist with e-cigarette use after quitting tobacco smoking and more. Read the full coverage here: Adjuvant atezolizumab benefits PD-L1-selected patients with NSCLC Lung cancer risks persist with e-cigarette use after quitting tobacco smoking COPD, IPF end of life health care use differs from lung cancer Tecentriq combination fails to improve survival in metastatic lung cancer Risk for lung cancer reoccurrence may be associated with OSA-related hypoxemia References: Figueroa Rodriguez F, et al. 0468: CRASH: Cancer reoccurrence is accelerated by episodic hypoxemia. Presented at: SLEEP; June 1-5, 2024; Houston. Kim Y, et al. Association of electronic cigarette use after conventional smoking cessation with lung cancer risk: A nationwide cohort study. Presented at: American Thoracic Society International Conference; May 18-22, 2024; San Diego. Press Release Suen AO, et al. Am J Respir Crit Care Med. 2024;doi:10.1154/ajrccm-conference.2024.209.1_MeetingAbstracts.A5040. Wakelee HA, et al. Abstract LBA8035. Presented at: ASCO Annual Meeting; May 31-June 4, 2024; Chicago.

In this edition, FDA approves Vabysmo prefilled syringe for retinal diseases, 4D Molecular Therapeutics updates on retinal disease candidates and more. Read the full coverage here: FDA approves Vabysmo prefilled syringe for retinal diseases VIDEO: 4D Molecular Therapeutics shares update on retinal disease candidates FDA approves Eylea biosimilar FYB203/Ahzantive VIDEO: Oral therapy improves central subfield thickness in DME in early-stage study ANI Pharmaceuticals to acquire Alimera Sciences References: Agrawal R. RZ402: Initial results from a phase 2 study of a novel, orally administered PKal inhibitor in patients with DME. Presented at: Clinical Trials at the Summit; June 8, 2024; Park City, Utah. Healio Interviews Press Release Press Release Press Release Editor's note: At the 1:35 mark, we mention that Vabysmo will be available later this year. This specifically applies to Vabysmo pre-filled syringe. There is a currently available formulation already on the market.

In this edition, extensive psoriasis and IBD history predict difficult-to-treat psoriatic arthritis, targeted therapies demonstrate low risk for serious infection and more. Read the full coverage here: Extensive psoriasis, IBD history predict difficult-to-treat psoriatic arthritis Targeted psoriatic arthritis therapies demonstrate low risk for serious infection VIDEO: Dermatologists, rheumatologists share care in psoriasis, psoriatic arthritis Patients with arthritis at higher risk for poor nutrition regardless of function FDA approves Rinvoq for JIA, psoriatic arthritis in children aged 2 years and older References: Bastard L, et al. RMD Open. 2024;doi:10.1136/rmdopen-2023-003865. Bennett R, et al. Sci Rep. 2024;doi:10.1038/s41598-024-58370-7. Husni ME. Update in the treatment of psoriatic arthritis. Presented at: Medical Dermatology Therapy Update III; May 29-31, 2024; Cleveland. Press Release Vassilakis KD, et al. Rheumatology. 2024;doi:10.1093/rheumatology/keae263.

In this edition, screening program identifies airways disease in previously undiagnosed COPD, positive results show benefits of subcutaneous bispecifics and more. Read the full coverage here: Lung cancer screening program identifies airways disease in previously undiagnosed COPD Positive results in lung cancer show benefits of subcutaneous bispecifics Adagrasib delays progression of pretreated KRAS-mutant lung cancer Durvalumab extends survival in limited-stage small-cell lung cancer Osimertinib delays progression 'way more' than hoped in EGFR-mutant lung cancer References: Bernstein E, et al. JCO Precis Oncol. 2024;doi:10.1200/po.23.00447. Leighl NB, et al. Abstract LBA8505. Presented at: ASCO Annual Meeting; May 30–June 3, 2024; Chicago. Ramalingam SS, et al. Abstract LBA4. Presented at: ASCO Annual Meeting; May 31-June 4, 2024: Chicago. Seigo MA, et al. Pulmonary comorbidities, respiratory symptoms, and spirometry in a real-world, urban lung cancer screening program. Presented at: American Thoracic Society International Conference; May 17-22, 2024; San Diego. Spigel DR, et al. Abstract LBA3. Presented at: ASCO Annual Meeting; May 31-June 4, 2024: Chicago.

In this edition, AI model helps predict anti-VEGF response in DME, Merck to acquire EyeBio and more. Read the full coverage here: VIDEO: AI model helps predict anti-VEGF response in diabetic macular edema Merck to acquire EyeBio VIDEO: IOP remains stable up to 48 weeks with aflibercept 8 mg for DME Phase 2 study of potential DME oral therapy meets primary endpoints FDA approves aflibercept biosimilars Yesafili, Opuviz References: Barakat MR. Intraocular pressure outcomes with intravitreal injection of aflibercept 8 mg and 2 mg in patients with diabetic macular edema through week 48 of the phase 2/3 PHOTON trial. Presented at: Association for Research in Vision and Ophthalmology meeting; May 5-9, 2024; Seattle. Luvisi J. Using a convolutional neural network to predict response of diabetic macular edema to intravitreal anti-vascular endothelial growth factor. Presented at: Kiawah Eye; May 30-June 1, 2024; Kiawah Island, South Carolina. Press Release Press Release Press Release