Hope & Histamine: The Paediatric Allergy Podcast

Is it time to rethink the traditional blue reliever inhaler for children with mild asthma?In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we examine the landmark 2025 CARE trial published in The Lancet. This 52-week randomised controlled trial compared budesonide–formoterol with salbutamol as reliever therapy in children with mild asthma.We explore whether an anti-inflammatory reliever inhaler can provide better protection than salbutamol alone, examining the trial’s findings on asthma attacks, symptom control, safety and treatment burden. We also consider what the results could mean for paediatric asthma guidelines, clinical practice and conversations with children and their families.Whether you are a paediatrician, GP, nurse, pharmacist, trainee or parent, this episode offers a clear and clinically relevant discussion of a study that could reshape how mild childhood asthma is managed.Listen now to discover whether budesonide–formoterol could represent the future of reliever therapy for children with mild asthma.Source:Hatter, L., Holliday, M., Oldfield, K., Kearns, C., Barry, T., Black, M., Bruce, P., Colman, A., Dickinson, E., Eathorne, A., Harwood, M., Hills, T., Lamb, R., Kerse, K., Krishnamoorthy, S., Martindale, J., Semprini, A., Shortt, N., McNamara, D., Byrnes, C.A., Dalziel, S.R., Bush, A., Weatherall, M. and Beasley, R., 2025.Budesonide–formoterol versus salbutamol as reliever therapy in children with mild asthma (CARE): a 52-week, open-label, multicentre, superiority, randomised controlled trial. The Lancet, 406, pp. 1473–1483. Available at: https://doi.org/10.1016/S0140-6736(25)00861-X.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsHope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice.🎧 Listen and subscribe:https://hopeandhistaminepodcasts.buzzsprout.comIf you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions.Send us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Could a simple skin patch transform the treatment of peanut allergy in young children?In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence on epicutaneous immunotherapy (EPIT)—also known as the peanut patch—for toddlers and children with peanut allergy.Drawing on findings from the EPITOPE and EPOPEX studies, we examine how peanut patch therapy works, its long-term effectiveness and safety, and whether it can increase the amount of peanut a child can tolerate. We also discuss its potential to reduce the risk of allergic reactions from accidental exposure to packaged foods and consider how well EPIT works in children who also have atopic conditions such as eczema, asthma and allergic rhinitis.Can epicutaneous immunotherapy offer families meaningful protection while avoiding some of the challenges associated with oral immunotherapy? Could the peanut patch become part of routine childhood peanut allergy treatment?Join us as we translate the emerging research into clear, practical information for parents, clinicians and everyone interested in the future of paediatric food allergy care.Sources:Burks, A., Sindher, S., Wang, J., O'Sullivan, M., Du Toit, G., Kim, E., Bois, T. and Greenhawt, M., 2022. EPITOPE study results: Phase 3, randomized, double-blind, placebo-controlled study of epicutaneous immunotherapy in peanut-allergic toddlers [Abstract]. Annals of Allergy, Asthma & Immunology, 129(5 Supplement), p. S12.Greenhawt, M., Wang, J., DuToit, G., O’Sullivan, M., Brown-Whitehorn, T., Bois, T., Bee, K., Green, T., Sampson, H. and Burks, A., 2025. Long-term efficacy and safety of epicutaneous immunotherapy in peanut-allergic toddlers: EPOPEX end of study results [Abstract]. Annals of Allergy, Asthma & Immunology, 135(5 Supplement), p. S10. Remington, B.C., Krone, T., Kim, E.H., Bird, J.A., Green, T.D., Lack, G., Fleischer, D.M. and Koppelman, S.J., 2019. Estimated risk reduction to packaged food reactions by epicutaneous immunotherapy (EPIT) for peanut allergy. Annals of Allergy, Asthma & Immunology, 123(5), pp. 488-493. Scurlock, A.M., Fleischer, D.M., Du Toit, G., Arends, N.J.T., Pongracic, J.A., Trujillo, J., Turner, P., Vogelberg, C., Bee, K.J., Green, T.D., Meney, J., Bois, T., Campbell, D.E., Sampson, H.A. and Burks, A.W., 2025. Efficacy and safety of epicutaneous immunotherapy in children with peanut allergy with atopic comorbidities. Annals of Allergy, Asthma & Immunology, 135(2), pp. 203-210.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Dupilumab has transformed the treatment of several type 2 inflammatory conditions—but how does it work, which children may benefit, and what should clinicians and families know before starting treatment?In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the expanding role of dupilumab in paediatrics, including its use in atopic dermatitis (eczema), severe asthma and eosinophilic oesophagitis. We discuss how blocking interleukin-4 and interleukin-13 signalling helps control allergic inflammation, along with patient selection, administration, monitoring, potential adverse effects, and the practical considerations of biologic treatment.Whether you are a paediatrician, allergy specialist, healthcare professional, or parent, this episode provides a clear, clinically relevant introduction to how dupilumab is reshaping the management of childhood atopic disease.Sources:Foti Randazzese, S., Calamita, A., D’Angelo, D., Marseglia, A., Mesa Lombardero, E., Pedersoli, S., Tedeschi, M., De Amici, M., Manti, S., Brazzelli, V., Licari, A. and Marseglia, G.L. (2026) 'Emerging Paediatric Uses of Dupilumab Beyond Approvals', Clinical & Experimental Allergy. Available at: https://doi.org/10.1111/cea.70381.Gutsche, A., Grabowska, W., Altrichter, S., Grekowitz, E., Roll, S., Heine, G., Staubach, P., Pfützner, W., Brehler, R., Bauer, A., Wagner, N., Wurpts, G., Salameh, P., Salehzadeh-Yazdi, A., Jahandideh, S.S. and Metz, M. (2026) 'Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator-Initiated Study', Allergy. Available at: https://doi.org/10.1111/all.70454.Lasek, A., Bellon, N., Mallet, S., Aubert, H., Vera, C., Achour, L., Thénié, C., Prescilla, R., Abasq-Thomas, C. and Barbarot, S. (2026) 'Dupilumab treatment in children aged 6 months to 5 years with severe atopic dermatitis', Journal of the European Academy of Dermatology and Venereology, 40, pp. 1208–1217. Available at: https://doi.org/10.1111/jdv.70268.Wechsler, M.E., Wenzel, S.E., Groshong, S.D., Castro, M., Pavord, I.D., Rabe, K.F., Laws, E., Jagerschmidt, A., Gayvert, K., Harel, S., Hamilton, J.D., Amin, N., Zhang, L., Xing, H., Elfakir, A., Coulibaly, B., Naimi, S., Hamon, S., Rowe, P.J., Nestle, F., Cunoosamy, D.M., de Rinaldis, E. and Mannent, L.P. (2026) 'Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma', Allergy. Available at: https://doi.org/10.1111/all.70391.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Hereditary angioedema (HAE) is a rare but potentially life-threatening genetic disorder that often presents during childhood, yet diagnosis is frequently delayed for many years. Early recognition and timely treatment can dramatically improve quality of life and reduce the risk of serious complications, including airway obstruction.In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence and practical approaches to diagnosing and managing paediatric hereditary angioedema (HAE). Whether you’re a paediatrician, allergy specialist, emergency clinician, trainee, nurse, or allied healthcare professional, this episode provides a comprehensive overview of this important condition.In this episode, we discuss:Understanding the genetics and pathophysiology of hereditary angioedemaClinical features that distinguish HAE from allergic angioedemaCommon triggers and patterns of attacks in childrenDiagnostic investigations, including complement testing and genetic confirmationRecognising red flags for life-threatening laryngeal oedemaAcute management of HAE attacksShort-term and long-term prophylactic treatment optionsThe role of C1 esterase inhibitor replacement therapy, bradykinin-targeted treatments and emerging therapiesFamily screening, genetic counselling and transition to adult servicesPractical tips for emergency action plans and improving patient outcomesJoin us as we review current guidelines, discuss real-world clinical challenges, and share practical insights to help clinicians recognise hereditary angioedema earlier and deliver evidence-based care for children and young people living with HAE.Source:Farkas, H. et al. (2026) 'International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema', Allergy. Available at: https://onlinelibrary.wiley.com/doi/10.1111/all.70207. DOI: 10.1111/all.70207.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsHope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice.🎧 Listen and subscribe:https://hopeandhistaminepodcasts.buzzsprout.comIf you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions.Send us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Why do your ears feel blocked during allergy season? Can hay fever really affect your hearing? What causes that frustrating sensation of ear fullness, popping, crackling or pressure that just won’t go away?In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the important relationship between allergic disease and Eustachian Tube Dysfunction (ETD)—a common but often misunderstood condition affecting both children and adults.Join us as we discuss:What the Eustachian tube is and why it is essential for normal ear function.How allergic rhinitis, environmental allergies and nasal inflammation contribute to Eustachian Tube Dysfunction.The common symptoms of ETD, including ear fullness, pressure, popping, crackling, muffled hearing, tinnitus and discomfort during flying or altitude changes.How ETD differs from ear infections, glue ear and other causes of hearing problems.The role of allergy testing and ENT assessment in making an accurate diagnosis.Evidence-based treatments, including allergen avoidance, intranasal corticosteroids, antihistamines, saline nasal irrigation and when specialist ENT interventions may be appropriate.Practical self-care strategies for managing symptoms at home.When persistent ear symptoms require urgent medical assessment.Whether you’re a parent, patient, allergy sufferer, healthcare professional or simply curious about the connection between allergies and ear health, this episode provides clear, evidence-based guidance to help you better understand and manage Eustachian Tube Dysfunction.Source: Klimek, L. et al. (2025) 'Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An EAACI Position Paper', Allergy. doi: 10.1111/all.16554.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSubscribe to Hope & Histamine for expert discussions on paediatric allergy, immunology and related conditions, featuring the latest research and practical advice from specialists.🎧 Listen on your favourite podcast platform or visit:https://hopeandhistaminepodcasts.buzzsprout.comIf you enjoy the podcast, please subscribe, leave a review and share this episode to help others learn more about allergy-related conditions.Send us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Orofacial Granulomatosis (OFG) is a rare but often overlooked inflammatory condition that can present with persistent lip swelling, oral ulcers, gum changes, and facial swelling. Because its symptoms overlap with many other conditions, diagnosis is frequently delayed, leaving patients and families searching for answers.In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we take a deep dive into the science and clinical management of Orofacial Granulomatosis. We discuss what OFG is, why it develops, and its important associations with Crohn’s disease, allergy, and other inflammatory disorders. You’ll learn how clinicians approach the diagnosis, the role of biopsies and investigations, and the latest evidence-based treatment options available for both children and adults.Whether you’re a healthcare professional, medical student, patient, or parent, this episode provides a clear, practical, and evidence-based overview of this fascinating condition.In this episode, we cover:What is Orofacial Granulomatosis (OFG)?Common signs and symptoms, including persistent lip swellingCauses and current theories behind OFGThe relationship between OFG and Crohn’s diseaseIs allergy involved?How OFG is diagnosed and the role of biopsyImportant differential diagnoses clinicians should considerMedical and dietary treatment optionsLong-term outlook and follow-upKey take-home messages for patients, families, and healthcare professionalsJoin us as we separate fact from fiction and explore the latest understanding of Orofacial Granulomatosis, helping listeners recognise the condition earlier and understand the best approaches to diagnosis and management.Sources:Courtney, A., Holmes, Z., Sharma, S. and Brand, R., 2023. Orofacial granulomatosis: Challenges in diagnosis and treatment. Journal of Paediatrics and Child Health, 59, pp. 159-161.Galdiero, M.R., Maio, F., Arcoleo, F., Boni, E., Bonzano, L., Brussino, L., Cancian, M., Cremonte, L., Del Giacco, S.R., De Paulis, A., Detoraki, A., Firinu, D., Lamacchia, D., Loffredo, S., Nettis, E., Parente, R., Parronchi, P., Pellacani, G., Petraroli, A., Rolla, G., Senter, R., Triggiani, M., Vitiello, G., Spadaro, G. and Bova, M., 2021. Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature. Allergy, 76(7), pp. 2189-2200.Haaramo, A., Alapulli, H., Aine, L., Saarnisto, U., Tuokkola, J., Ruuska, T., Sipponen, T., Pitkäranta, A. and Kolho, K.L., 2017. Detailed Follow-up Study of Pediatric Orofacial Granulomatosis Patients. Journal of Pediatric Gastroenterology and Nutrition, 65(4), pp. 388-393.Marttala, A., Sihvonen, E., Kantola, S., Ylöstalo, P. and Tervonen, T., 2018. Diagnosis and Treatment of Orofacial Granulomatosis. Journal of Dentistry for Children, 85(2), pp. 83-87.Pathania, Y.S., 2022. Current treatment modalities in granulomatous cheilitis. International Journal of Dermatology, 61, pp. 755-759.Sahni, V.N., Yim, R., Amanullah, A., Sahni, D., Powell, D., deShazo, R., Rhoads, J.L.W., Clarke, J.T., Hansen, C.B., Zone, J.J., Hull, C.M. and Hopkins, Z.H., 2026. An Allergy-Based Approach to Orofacial Granulomatosis: A Narrative Review. Dermatitis, 37(1), pp. 13-19.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreations🎧 Subscribe to Hope & Histamine: The Paediatric Allergy Podcast for expert discussions on paediatric allergy, immunology, and related conditions. New episodes feature practical, evidence-based insights from leading specialists, designed for clinicians, patients, and families alike.🌐 Podcast website: https://hopeandhistaminepodcasts.buzzsprout.comSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

What happens when someone experiences anaphylaxis, but no trigger can be identified? In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore idiopathic anaphylaxis—a diagnosis that can be both frightening for patients and challenging for clinicians.Join us as we discuss the latest understanding of idiopathic anaphylaxis, including how it is diagnosed, important conditions that can mimic anaphylaxis, and the investigations needed to exclude identifiable causes such as food allergy, medication allergy, insect venom allergy, mast cell disorders, hereditary alpha-tryptasemia, and alpha-gal syndrome.We also cover:What idiopathic anaphylaxis is and why it occursCommon symptoms and clinical presentationDifferential diagnoses and conditions that mimic anaphylaxisThe role of serum tryptase, allergy testing, and other investigationsMast cell activation syndrome and systemic mastocytosisAcute emergency management of anaphylaxisLong-term treatment strategies and preventionAdrenaline (epinephrine) auto-injectors and personalised emergency action plansPatient education, follow-up, and improving quality of lifeThe latest evidence and future directions in researchWhether you’re a healthcare professional, paediatrician, allergist, trainee, medical student, or someone living with recurrent unexplained allergic reactions, this episode provides practical, evidence-based insights to help you better understand and manage idiopathic anaphylaxis.If you enjoy this episode, please follow, rate, and share the podcast to help us bring high-quality paediatric allergy education to a wider audience.Hope & Histamine: The Paediatric Allergy Podcast—making paediatric allergy evidence practical, accessible, and easy to understand.Sources:Applewhite, T.L. (2025) 'The Lived Experience of Patients With Idiopathic Anaphylaxis', The Journal for Nurse Practitioners, 21(1), p. 105329.Ben-Shoshan, M., Akin, C., Cook, V.E. and Khalaf, R. (2025) 'Idiopathic anaphylaxis', The Journal of Allergy and Clinical Immunology: In Practice, 13(12), pp. 3169-3175.Calvani, M. (2022) 'Update on idiopathic anaphylaxis', Pediatric Allergy and Immunology, 33(Suppl. 27), pp. 52-53.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Peanut allergy has become one of the most important and widely discussed topics in paediatric allergy. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the prevention and treatment of peanut allergy in children, from the landmark evidence supporting early peanut introduction to the evolving role of oral immunotherapy.We discuss why peanut allergy develops, which children are at higher risk, and how early dietary exposure may help reduce the chance of allergy in infancy. The episode also covers practical approaches to diagnosis, avoidance, emergency management, and treatment, including oral peanut immunotherapy and its potential benefits and limitations.Designed for parents, healthcare professionals, and anyone interested in childhood allergy, this episode brings together evidence-based guidance and practical clinical insights to help make sense of modern peanut allergy care.Source:Du Toit, G. and Lack, G. (2026) 'Prevention and Treatment of Peanut Allergy', New England Journal of Medicine, 394(24), pp. 2449–2458. Available at: https://doi.org/10.1056/NEJMcp2314424.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Eosinophilic Oesophagitis, or EoE— an increasingly recognised allergic inflammatory condition of the oesophagus that can affect feeding, swallowing, growth, and quality of life in children and young people.We break down the pathophysiology of EoE, including the role of food allergens, type 2 inflammation, eosinophils, epithelial barrier dysfunction, and immune signalling pathways. The episode also covers how EoE presents in different age groups, from feeding difficulties and reflux-like symptoms in younger children to dysphagia, food impaction, and avoidance behaviours in older children and adolescents.We discuss the key steps in diagnosing Eosinophilic Oesophagitis, including clinical suspicion, endoscopy, oesophageal biopsies, histological criteria, and the importance of excluding other causes of oesophageal eosinophilia. The episode then moves into practical treatment strategies, including proton pump inhibitors, swallowed topical steroids, dietary elimination approaches, multidisciplinary care, monitoring response, and emerging therapies such as biologics.This episode is ideal for paediatricians, allergy clinicians, gastroenterologists, nurses, dietitians, trainees, and parents who want a clear, practical, and evidence-informed overview of EoE in children.Sources:Dhar, A., Haboubi, H.N., Attwood, S.E. et al. (2022) 'British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults', Gut, 71, pp. 1459–1487.Mahon, M., Muir, A.B. and Lynch, K. (2026) 'Eosinophilic oesophagitis: pathophysiology, diagnosis, and treatment', BMJ Medicine, 5, p. e001459.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the diagnosis and management of Hymenoptera venom allergy in children, including allergic reactions to bee, wasp and other insect stings.We discuss how to distinguish between normal local reactions, large local reactions and systemic allergic reactions, and when a child should be referred for specialist allergy assessment. The episode covers key aspects of diagnosis, including clinical history, venom-specific IgE testing, skin testing and risk assessment.We also look at the acute management of sting-related allergic reactions, including the role of adrenaline auto-injectors, emergency action plans and education for families and schools. Finally, we explore long-term management, including venom immunotherapy, who may benefit from it, and how it can reduce the risk of future severe reactions.This episode is designed for parents, healthcare professionals and anyone supporting children with insect sting allergy, offering practical, evidence-informed guidance on recognising risk, improving safety and supporting confident long-term care.Sources:Biló, B.M., Rueff, F., Mosbech, H., Bonifazi, F., Oude-Elberink, J.N.G. and the EAACI Interest Group on Insect Venom Hypersensitivity (2005) 'Diagnosis of Hymenoptera venom allergy', Allergy, 60, pp. 1339–1349.Bonifazi, F., Jutel, M., Biló, B.M., Birnbaum, J., Muller, U. and the EAACI Interest Group on Insect Venom Hypersensitivity (2005) 'Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice', Allergy, 60, pp. 1459–1470.Dhami, S., Zaman, H., Varga, E.M., Sturm, G.J., Muraro, A., Akdis, C.A., Antolín-Amérigo, D., Biló, M.B., Bokanovic, D., Calderon, M.A., Cichocka-Jarosz, E., Oude Elberink, J.N.G., Gawlik, R., Jakob, T., Kosnik, M., Lange, J., Mingomataj, E., Mitsias, D.I., Mosbech, H., Ollert, M., Pfaar, O., Pitsios, C., Pravettoni, V., Roberts, G., Ruëff, F., Sin, B.A., Asaria, M., Netuveli, G. and Sheikh, A. (2017) 'Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis', Allergy, 72, pp. 342–365.Krishna, M.T., Ewan, P.W., Diwakar, L., Durham, S.R., Frew, A.J., Leech, S.C. and Nasser, S.M. (2011) 'Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines', Clinical & Experimental Allergy, 41, pp. 1201–1220.Sturm, G.J., Varga, E.M., Roberts, G., Mosbech, H., Biló, M.B., Akdis, C.A., Antolín-Amérigo, D., Cichocka-Jarosz, E., Gawlik, R., Jakob, T., Kosnik, M., Lange, J., Mingomataj, E., Mitsias, D.I., Ollert, M., Oude Elberink, J.N.G., Pfaar, O., Pitsios, C., Pravettoni, V., Ruëff, F., Sin, B.A., Agache, I., Angier, E., Arasi, S., Calderón, M.A., Fernandez-Rivas, M., Halken, S., Jutel, M., Lau, S., Pajno, G.B., van Ree, R., Ryan, D., Spranger, O., van Wijk, R.G., Dhami, S., Zaman, H., Sheikh, A. and Muraro, A. (2018) 'EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy', Allergy, 73, pp. 744–764.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Food allergies are often seen as a medical condition centred around avoidance, emergency plans and adrenaline auto-injectors — but the impact goes far beyond the plate. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore how food allergies affect children’s emotional wellbeing, family life, school experiences, social confidence and overall quality of life.We discuss the anxiety, fear and daily uncertainty that many children and parents live with, from checking food labels and managing birthday parties to navigating school meals, travel, eating out and the risk of accidental reactions. This episode also looks at the emotional burden on parents and carers, including hypervigilance, guilt, sleep disruption, family stress and the challenge of helping children feel safe without feeling restricted.Whether you are a parent, clinician, teacher, or someone living with a food allergy, this episode highlights why food allergy care must include psychological support, practical coping strategies, and compassionate conversations about quality of life.Sources:Knibb, R.C. and Semper, 2013. Impact of suspected food allergy on emotional distress and family life. Pediatric Allergy and Immunology, 24, pp. 798–803. Available at: https://doi.org/10.1111/pai.12176. (Note: The initial for the co-author Semper is not listed in the provided text).Knibb, R.C., Jones, C.J., Herbert, L.J. and Screti, C., 2024. Psychological support needs for children with food allergy and their families: A systematic review. Pediatric Allergy and Immunology, 35, p. e14108. Available at: https://doi.org/10.1111/pai.14108.Knibb, R.C., Howell, C., Whitehouse, A. and Peterson, C.C., 2025. The role of food allergy‐related worry and self‐efficacy in explaining quality of life in caregivers of children. Pediatric Allergy and Immunology, 36, p. e70248. Available at: https://doi.org/10.1111/pai.70248.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

NSAID hypersensitivity in children can be challenging to recognise, diagnose, and manage safely. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore paediatric NSAID hypersensitivity, including reactions to commonly used medicines such as ibuprofen and other non-steroidal anti-inflammatory drugs.We discuss the different types of NSAID reactions, how to distinguish true hypersensitivity from other adverse effects, and the importance of a careful clinical history. The episode also covers diagnostic approaches, the role of drug provocation testing, cross-reactive versus selective NSAID reactions, and practical management strategies for children who need safe pain relief or fever treatment.This episode is aimed at clinicians, trainees, healthcare professionals, and interested parents who want a clearer understanding of NSAID allergy and hypersensitivity in children.Listen to learn about:How NSAID hypersensitivity presents in childrenThe difference between NSAID allergy, intolerance, and adverse drug reactionsIbuprofen-related reactions and when to suspect hypersensitivityCross-reactive and selective NSAID hypersensitivityDiagnostic pathways and the role of supervised drug challengesSafe alternatives and practical management adviceA practical, evidence-informed discussion to help improve confidence in recognising and managing NSAID hypersensitivity in paediatric practice.Sources: Cousin, M., Chiriac, A., Molinari, N., Demoly, P. and Caimmi, D. (2016) 'Phenotypical characterization of children with hypersensitivity reactions to NSAIDs', Pediatric Allergy and Immunology, 27, pp. 743-748.Guvenir, H., Misirlioglu, E.D., Capanoglu, M., Buyuktiryaki, B., Onay, Z.R., Ginis, T., Toyran, M., Civelek, E. and Kocabas, C.N. (2018) 'The Frequency of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Children with Asthma', International Archives of Allergy and Immunology, 176(1), pp. 26-32.Kidon, M., Blanca-Lopez, N., Gomes, E., Terreehorst, I., Tanno, L., Ponvert, C., Chin, C.W., Caubet, J.C., Soyer, O., Mori, F., Blanca, M. and Atanaskovic-Markovic, M. (2018) 'EAACI/ENDA Position Paper: Diagnosis and management of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in children and adolescents', Pediatric Allergy and Immunology, 29, pp. 469-480.Mori, F., Atanaskovic-Markovic, M., Blanca-Lopez, N., Gomes, E., Gaeta, F., Sarti, L., Bergmann, M.M., Tmusic, V., Valluzzi, R.L. and Caubet, J.C. (2020) 'A Multicenter Retrospective Study on Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Children: A Report from the European Network on Drug Allergy (ENDA) Group', The Journal of Allergy and Clinical Immunology: In Practice, 8(3), pp. 1022-1031.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Penicillin allergy is one of the most commonly reported drug allergies in children — but many children labelled as “penicillin allergic” are not truly allergic. In this episode, we explore why penicillin allergy labels matter, how they can affect antibiotic choices, and why accurate assessment is so important for safer, better care.We discuss the difference between true allergic reactions and common childhood rashes, the key features clinicians look for in the history, and when referral or allergy testing may be needed. The episode also looks at penicillin allergy “delabelling” — the process of safely removing an inaccurate allergy label — and how this can help children access first-line antibiotics, reduce unnecessary use of broad-spectrum alternatives, and support antimicrobial stewardship.This episode is ideal for parents, healthcare professionals, medical trainees, nurses, pharmacists, and anyone interested in paediatric allergy and safe antibiotic prescribing.Listen now to understand penicillin allergy in children, how it is diagnosed, and why many allergy labels deserve a second look.Sources:Barbaud, A., Garvey, L.H., Torres, M., Laguna, J.J., Arcolaci, A., Bonadonna, P., Hofmeier, K.S., Chiriac, A.M., Cernadas, J., Caubet, J.C. and Brockow, K. (2024) 'EAACI/ENDA position paper on drug provocation testing', Allergy, 79, pp. 565-579. Available at: https://doi.org/10.1111/all.15996.Romano, A., Atanaskovic-Markovic, M., Barbaud, A., Bircher, A.J., Brockow, K., Caubet, J.C., Celik, G., Cernadas, J., Chiriac, A.M., Demoly, P., Garvey, L.H., Mayorga, C., Nakonechna, A., Whitaker, P. and Torres, M.J. (2020) 'Towards a more precise diagnosis of hypersensitivity to beta-lactams – an EAACI position paper', Allergy, 75, pp. 1300-1315. Available at: https://doi.org/10.1111/all.14122.Zambonino, M.A., Corzo, J.L., Muñoz, C., Requena, G., Ariza, A., Mayorga, C., Urda, A., Blanca, M. and Torres, M.J. (2014) 'Diagnostic evaluation of hypersensitivity reactions to beta-lactam antibiotics in a large population of children', Pediatric Allergy and Immunology, 25, pp. 80-87. Available at: https://doi.org/10.1111/pai.12155.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode of Hope & Histamine, we explore Alpha-Gal Syndrome (AGS) — a fascinating and increasingly recognised form of tick-bite-related allergy that can cause delayed allergic reactions to red meat and other mammalian-derived products.We break down what Alpha-Gal Syndrome is, how tick bites can trigger sensitisation to the alpha-gal molecule, and why symptoms often appear several hours after eating foods such as beef, lamb, pork or venison. The episode also covers the key clinical features of AGS, including urticaria, angioedema, gastrointestinal symptoms, respiratory symptoms and anaphylaxis.Designed for clinicians, families and anyone interested in allergy medicine, this episode discusses how Alpha-Gal Syndrome is diagnosed, the role of allergy testing, common hidden sources of mammalian products, and practical approaches to management, avoidance and emergency planning.Tune in for a clear, practical and evidence-informed guide to Alpha-Gal Syndrome, tick-bite meat allergy, delayed anaphylaxis and red meat allergy.Sources:Carson, A.S., Gardner, A. and Iweala, O.I. (2022) 'Where's the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome', The Journal of Immunology, 208(2), pp. 267-277.Kersh, G.J., Salzer, J., Jones, E.S., Binder, A.M., Armstrong, P.A., Choudhary, S.K., Commins, G.K., Amelio, C.L., Kato, C.Y., Singleton, J., Biggerstaff, B.J., Beard, C.B., Petersen, L.R. and Commins, S.P. (2023) 'Tick bite as a risk factor for alpha-gal-specific immunoglobulin E antibodies and development of alpha-gal syndrome', Annals of Allergy, Asthma & Immunology, 130, pp. 472-478.Mehlich, J., Fischer, J., Hilger, C., Swiontek, K., Morisset, M., Codreanu-Morel, F., Schiener, M., Blank, S., Ollert, M., Darsow, U., Biedermann, T. and Eberlein, B. (2019) 'The basophil activation test differentiates between patients with alpha-gal syndrome and asymptomatic alpha-gal sensitization', Journal of Allergy and Clinical Immunology, 143, pp. 182-189.Platts-Mills, T.A.E., Gangwar, R.S., Workman, L. and Wilson, J.M. (2025) 'The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat', Immunological Reviews.Wilson, J.M., Erickson, L., Levin, M., Ailsworth, S.M., Commins, S.P. and Platts-Mills, T.A.E. (2024) 'Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome', Allergy, 79, pp. 1440-1454. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Chronic urticaria can be frustrating, unpredictable and deeply disruptive — but modern treatment has moved far beyond “just take an antihistamine.” In this episode of Hope & Histamine, we explore the pharmacological treatment of chronic urticaria, from regular non-sedating antihistamines and dose escalation to specialist therapies such as omalizumab and emerging treatment options.We discuss how chronic spontaneous urticaria is managed using a stepwise approach, when to consider treatment escalation, why sedating antihistamines and repeated steroid courses are usually avoided, and how newer biologic therapies are changing outcomes for patients with persistent hives and angioedema.Designed for clinicians, trainees, parents and curious listeners, this episode breaks down chronic urticaria treatment in a clear, practical and evidence-informed way — helping turn itch, wheals and uncertainty into better understanding and control.Sources:Agache, I., Akdis, C.A., Akdis, M., Brockow, K., Chivato, T., del Giacco, S., Eiwegger, T., Eyerich, K., Giménez-Arnau, A., Gutermuth, J., Guttman-Yassky, E., Maurer, M., Ogg, G., Ong, P.Y., O’Mahony, L., Schwarze, J., Warner, A., Werfel, T., Palomares, O. and Jutel, M. (2022) 'EAACI Biologicals Guidelines—Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12–17 years old', Allergy, 77(1), pp. 17-38.Antia, C., Baquerizo, K., Korman, A., Alikhan, A. and Bernstein, J.A. (2018) 'Urticaria: A comprehensive review: Treatment of chronic urticaria, special populations, and disease outcomes', Journal of the American Academy of Dermatology, 79(4), pp. 617-633.Kolkhir, P., Fok, J.S., Kocatürk, E., Li, P.H., Okas, T.-L., Marcelino, J. and Metz, M. (2025) 'Update on the Treatment of Chronic Spontaneous Urticaria', Drugs, 85, pp. 475-486.Maurer, M., Church, M.K., Gonçalo, M., Sussman, G. and Sánchez-Borges, M. (2015) 'Management and treatment of chronic urticaria (CU)', Journal of the European Academy of Dermatology and Venereology, 29(Suppl. 3), pp. 16-32.Nochaiwong, S., Chuamanochan, M., Ruengorn, C., Awiphan, R., Tovanabutra, N. and Chiewchanvit, S. (2021) 'Evaluation of Pharmacologic Treatments for H1 Antihistamine–Refractory Chronic Spontaneous Urticaria: A Systematic Review and Network Meta-analysis', JAMA Dermatology, 157(11), pp. 1316-1327. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore chronic urticaria in children, including its key clinical features, underlying pathogenesis, and practical approach to diagnostic evaluation.Chronic urticaria can be distressing for children and families, often causing recurrent itchy wheals, angioedema, sleep disruption and anxiety about possible triggers. This episode breaks down how chronic urticaria presents, why it happens, and how clinicians can distinguish chronic spontaneous urticaria from inducible forms and other important differential diagnoses.We discuss the role of mast cells, histamine and immune dysregulation, while also addressing common misconceptions around food allergy, infection and extensive allergy testing. The episode highlights a structured, evidence-informed approach to history taking, examination and investigations, with a focus on avoiding unnecessary tests and supporting families with clear explanations.Whether you are a paediatrician, allergy clinician, trainee, GP, nurse, dietitian, pharmacist, parent or caregiver, this episode offers a practical overview of chronic urticaria diagnosis and assessment in children.Sources:Fricke, J., Ávila, G., Keller, T., Weller, K., Lau, S., Maurer, M., Zuberbier, T. and Keil, T. (2020) 'Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta-analysis', Allergy, 75, pp. 423–432. Available at: https://doi.org/10.1111/all.14037.Kolkhir, P., Bonnekoh, H., Metz, M. and Maurer, M. (2024) 'Chronic Spontaneous Urticaria: A Review', JAMA, 332(17), pp. 1464–1477. Available at: https://doi.org/10.1001/jama.2024.15568.Lang, D.M. (2022) 'Chronic Urticaria', New England Journal of Medicine, 387(9), pp. 824–831. Available at: https://doi.org/10.1056/NEJMra2120166. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode of Hope & Histamine, we explore the fascinating and often debated role of vitamin D in allergic disease. From eczema, asthma, and allergic rhinitis to food allergy, vitamin D has been linked to immune regulation and allergic inflammation in ways that continue to generate interest among clinicians, researchers, and families alike.We discuss what vitamin D actually does in the body, why it matters for the immune system, and what current evidence suggests about its relationship with allergic conditions in children. Does low vitamin D increase allergy risk? Can vitamin D supplementation help prevent or improve allergic disease? And where does the science remain uncertain?This episode breaks down the evidence in a clear, practical way, helping listeners understand the potential links between vitamin D deficiency and allergy, while separating scientific fact from hype.Perfect for parents, healthcare professionals, paediatric trainees, and anyone interested in child health and allergy.Sources:Reinholz, M., Ruzicka, T. and Schauber, J. (2012) 'Vitamin D and its role in allergic disease', Clinical & Experimental Allergy, 42, pp. 817–826. doi: 10.1111/j.1365-2222.2011.03923.x.Szydziak, J.M., Hrapkowicz, A., Janowska, K., Dąbkowska, D., Szeidl, O., Rehan, D., Wołoszczak, J. and Mioskowska, A. (2024) 'The Role of Vitamin D in Allergic Diseases', Quality in Sport, 31, p. 55762. Available at: https://dx.doi.org/10.12775/QS.2024.31.55762.Zhang, P., Xu, Q. and Zhu, R. (2024) 'Vitamin D and allergic diseases', Frontiers in Immunology, 15, p. 1420883. doi: 10.3389/fimmu.2024.1420883. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Severe asthma in children can be challenging to recognise, investigate and manage effectively. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the evaluation and management of severe asthma in children, including how to distinguish it from difficult-to-treat asthma, key clinical assessments, common mimics, adherence issues, comorbidities, and the latest treatment approaches.We discuss the importance of a structured paediatric severe asthma assessment, the role of inhaler technique, environmental triggers, multidisciplinary input, and when to consider advanced therapies such as biologics. Whether you are a paediatrician, trainee, allergy specialist, respiratory clinician, or healthcare professional with an interest in children’s asthma care, this episode offers practical, evidence-informed insights to support better outcomes for children with severe asthma.Listen now to learn more about severe asthma in children, paediatric asthma assessment, difficult asthma, and modern management strategies.Sources:Khurana, S. and Holguin, F. (eds.) (2020) Difficult To Treat Asthma: Clinical Essentials. Cham: Springer Nature Switzerland AG.Bush, A., Fleming, L. and Saglani, S. (2017) 'Severe asthma in children', Respirology, pp. 886-897. 🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode, we explore the growing role of biomarkers in asthma and allergic diseases and why they are becoming essential in modern diagnosis, phenotyping, monitoring, and personalised treatment. We discuss key asthma biomarkers and allergy biomarkers, including blood eosinophils, FeNO (fractional exhaled nitric oxide), total and specific IgE, and their relevance in identifying type 2 inflammation, allergic asthma, severe asthma, and other allergic conditions.This episode looks at how biomarkers in asthma can help support accurate diagnosis, guide targeted biologic therapy, improve asthma management, and advance precision medicine in allergy and respiratory care. We also consider the wider application of biomarkers in allergic rhinitis, eczema, food allergy, and eosinophilic disease, highlighting their importance in shaping more individualised and effective treatment strategies.Whether you are a paediatrician, allergist, respiratory clinician, trainee, healthcare professional, researcher, or someone interested in the latest advances in asthma care and allergic disease management, this episode provides a practical and accessible overview of how biomarkers are transforming clinical decision-making in asthma and allergy medicine.Sources:Agrawal, N. and Kraft, M. (2025) 'Novel biomarkers in asthma', Current Opinion in Pulmonary Medicine, 31(3), pp. 243-250.Alving, K., Diamant, Z., Lucas, S., Magnussen, H., Pavord, I.D., Piacentini, G., Price, D., Roche, N., Sastre, J., Thomas, M., Usmani, O. and Bjermer, L. (2019) 'Point‐of‐care biomarkers in asthma management: Time to move forward', Allergy, DOI: 10.1111/all.14045.Custovic, A., Siddiqui, S. and Saglani, S. (2022) 'Considering biomarkers in asthma disease severity', Journal of Allergy and Clinical Immunology, 149, pp. 480-487.Karaulov, A.V., Garib, V., Garib, F. and Valenta, R. (2018) 'Protein Biomarkers in Asthma', International Archives of Allergy and Immunology, 175(4), pp. 189-208.Leru, P.M. (2021) 'Biomarkers in Asthma - Interpretation, and Utility in Current Asthma Management', Current Respiratory Medicine Reviews, 17(2), pp. 62-68.Shamji, M.H. and Boyle, R.J. (2021) 'Biomarkers in asthma and allergic diseases', Clinical and Experimental Allergy, DOI: 10.1111/cea.13988.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

How does cigarette smoke affect asthma? In this episode, we discuss the relationship between asthma and cigarette smoke exposure, including secondhand smoke, passive smoking, and the impact of tobacco smoke on airway inflammation, wheeze, cough, breathlessness, asthma attacks, and long-term asthma control. Learn why smoke exposure is a major asthma trigger, how it affects children and adults, and what families and healthcare professionals can do to minimise exposure and protect lung health. A clear, practical episode for anyone interested in asthma prevention, asthma triggers, respiratory health, and smoke-free living.Sources:Bråbäck, L., Lodge, C.J., Lowe, A.J., Dharmage, S.C., Olsson, D. and Forsberg, B. (2018) 'Childhood asthma and smoking exposures before conception—A three-generational cohort study', Pediatric Allergy and Immunology, 29, pp. 361–368. Available at: https://doi.org/10.1111/pai.12883.Kamga, A., Rochefort-Morel, C., Le Guen, Y., Ouksel, H., Pipet, A. and Leroyer, C. (2022) 'Asthma and smoking: A review', Respiratory Medicine and Research, 82, p. 100916. Available at: https://doi.org/10.1016/j.resmer.2022.100916.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Asthma care is changing. In this episode, we explore the concept of treatable traits in asthma and why a personalised, precision-medicine approach is transforming the way we assess and manage patients. Rather than viewing asthma as a single disease, the treatable traits model helps clinicians identify specific biological, clinical, and behavioural factors that drive symptoms, poor control, and exacerbations.We discuss how traits such as eosinophilic inflammation, poor inhaler technique, allergen exposure, obesity, smoking, dysfunctional breathing, anxiety and comorbid rhinitis can all influence asthma outcomes—and how targeting these individually can lead to better control, fewer attacks and improved quality of life.Whether you are a healthcare professional, trainee, or simply interested in modern respiratory medicine, this episode offers a practical overview of how asthma care is moving beyond labels toward truly personalised management.Tune in to discover why identifying and addressing treatable traits may be one of the most important advances in asthma care today.Sources:Gibson, P.G. and McDonald, V.M. (2024) 'Integrating hot topics and implementation of treatable traits in asthma', European Respiratory Journal, 64, 2400861. Available at: https://doi.org/10.1183/13993003.00861-2024.Melhorn, J., Howell, I. and Pavord, I.D. (2022) 'Should we apply a treatable traits approach to asthma care?', Annals of Allergy, Asthma & Immunology, 128, pp. 390–397.Shi, H. and Huang, K. (2025) 'Asthma treatable traits: How far do we have to go?', Chinese Medical Journal, 138(7), pp. 757–762. Available at: https://doi.org/10.1097/CM9.0000000000003507.Tay, T.R. and Hew, M. (2018) 'Comorbid “treatable traits” in difficult asthma: Current evidence and clinical evaluation', Allergy, 73, pp. 1369–1382. Available at: https://doi.org/10.1111/all.13370.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Frey’s syndrome can look exactly like a food allergy: facial flushing, warmth, sweating (sometimes even a “rash-like” redness) that appears within minutes of eating. Parents panic, clinicians worry about IgE-mediated reactions, and children can end up labelled with a food allergy they don’t actually have.In this episode, we unpack Frey’s syndrome (gustatory sweating)—why it happens, who gets it (including infants and children), and the classic pattern: unilateral or patchy facial redness/sweating triggered by eating, with no systemic symptoms like wheeze, vomiting, hypotension, or widespread urticaria. We’ll contrast it with true food allergy and anaphylaxis, highlight the history clues that make the diagnosis, and talk through practical management—reassurance, avoiding unnecessary dietary restriction, and when (rarely) referral or treatment is needed.If you’ve ever seen a child “react” to strawberries, citrus, or spicy foods with facial redness but otherwise looks completely well—this one’s for you.Sources:Blanc, S., Bourrier, T., Boralevi, F., Sabouraud-Leclerc, D., Pham-Thi, N., Couderc, L., Deschildre, A., Dutau, G., Albertini, M., Tran, A. and Giovannini-Chami, L. (2016) 'Frey Syndrome', J Pediatr, 174, pp. 211-217.Smith, A. and Jonas, N. (2020) 'Frey’s Syndrome', N Engl J Med, 382(15), p. 1456.Tillman, B. N., Lesperance, M. M. and Brinkmeier, J. V. (2015) 'Infantile Frey’s syndrome', International Journal of Pediatric Otorhinolaryngology, 79, pp. 929-931.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode, we unpack The Foetal Origins of Allergy and the idea that the foundations of allergic disease may be laid before birth. Using the lens of early nutritional programming (often discussed within the DOHaD – Developmental Origins of Health and Disease framework), we explore how the in-utero environment can influence immune development, tolerance, and later risk of conditions like eczema, food allergy, allergic rhinitis, and asthma.We’ll break down what the science actually suggests about key influences such as maternal diet quality, vitamin D and fatty acids, metabolic health and inflammation, microbiome signals, and the wider exposome (stress, pollution, and lifestyle factors). Most importantly, we’ll translate this into practical, evidence-informed takeaways: what clinicians should consider in antenatal counselling, what parents can focus on without anxiety, and where the research is still evolving.If you’ve ever wondered whether allergy risk can be “programmed” early—and what that means for prevention—this episode is for you.Sources:Jenmalm, M.C. and Duchén, K. (2013) 'Timing of allergy-preventive and immunomodulatory dietary interventions – are prenatal, perinatal or postnatal strategies optimal?', Clinical & Experimental Allergy, 43, pp. 273–278.Goldring, S.T., Griffiths, C.J., Martineau, A.R., Robinson, S., Yu, C., Poulton, S., Kirkby, J.C., Stocks, J., Hooper, R., Shaheen, S.O., Warner, J.O. and Boyle, R.J. (2013) 'Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial', PLoS ONE, 8(6), p. e66627.Warner, J.O. and Warner, J.A. (2022) 'The Foetal Origins of Allergy and Potential Nutritional Interventions to Prevent Disease', Nutrients, 14(8), p. 1590.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Ever had a patient (or child) react to fish even when it’s been properly cooked—and the story just doesn’t fit a classic “fish allergy”? This episode dives into Anisakis: the tiny parasitic worm found in marine fish and squid that can trigger allergic reactions ranging from hives and swelling to anaphylaxis—sometimes even without active infection.We break down:What Anisakis is and which fish are most commonly implicatedHow reactions can mimic (or coexist with) true fish/seafood allergyTypical symptoms: urticaria, angioedema, wheeze, GI pain, and severe reactionsThe key clinical clues in the history (including reactions after “fresh” or home-prepared fish)How testing works (including the role and limitations of specific IgE)Practical prevention and safety advice: freezing, cooking, sourcing, and when to avoid fishWhat to tell families—and when to prescribe an adrenaline auto-injectorWhether you’re a clinician, a parent navigating seafood reactions, or simply curious about hidden causes of “fish allergy,” this episode will help you recognise Anisakis-triggered reactions and manage them confidently.Sources:AAITO-IFIACI Anisakis Consortium (2011) 'Anisakis hypersensitivity in Italy: prevalence and clinical features: a multicenter study', Allergy, 66, pp. 1563–1569. Available at: https://doi.org/10.1111/j.1398-9995.2011.02691.x.Nieuwenhuizen, N.E. and Lopata, A.L. (2014) 'Allergic Reactions to Anisakis Found in Fish', Current Allergy and Asthma Reports, 14(455). Available at: https://doi.org/10.1007/s11882-014-0455-3.Rama, T.A. and Silva, D. (2022) 'Anisakis Allergy: Raising Awareness', Acta Médica Portuguesa, 35(7-8), pp. 578–583. Available at: https://doi.org/10.20344/amp.15908.Uña-Gorospe, M., Herrera-Mozo, I., Canals, M.L., Martí-Amengual, G. and Sanz-Gallen, P. (2018) 'Occupational disease due to Anisakis simplex in fish handlers', International Maritime Health, 69(4), pp. 264–269. Available at: https://doi.org/10.5603/IMH.2018.0042.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Ever seen someone develop flushing, hives, a pounding headache, or even wheeze soon after eating fish—and everyone assumes it’s a “fish allergy”? In this episode, we unpack Histamine (Scombroid) Fish Poisoning, a common and often mislabelled cause of allergy-like reactions after eating fish such as tuna, mackerel, mahi-mahi, sardines, anchovies, and bonito.You’ll learn why it happens (histamine build-up from improper chilling/handling), how fast symptoms start, and the key clinical clues that help you tell scombroid vs true IgE-mediated fish allergy. We cover typical features like flushing, urticaria, burning/peppery taste, nausea/diarrhoea, palpitations, dizziness, and when to worry about more severe symptoms. We’ll also walk through first-aid at home, when to seek urgent care, and the evidence-based treatment—including why antihistamines usually help quickly and why adrenaline isn’t always necessary (but may be used if there’s genuine anaphylaxis or uncertainty).Finally, we zoom out to prevention: what safe storage looks like, what to do with leftovers, why multiple people getting ill after the same meal is a big clue, and how to avoid unnecessary lifelong “fish allergy” labels.Perfect for parents, clinicians, and anyone who loves fish and wants the facts—fast, practical, and myth-busting.Source:Feng, C., Teuber, S. and Gershwin, M.E. (2016) ‘Histamine (Scombroid) Fish Poisoning: a Comprehensive Review’, Clinical Reviews in Allergy & Immunology, 50, pp. 64–69. doi:10.1007/s12016-015-8467-x.  🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Shellfish allergy can feel scary—especially when reactions can be sudden and severe. In this episode, we break down shellfish allergy in a clear, practical way: common symptoms (from hives to breathing problems), when to suspect anaphylaxis, and what to do in the moment. We also cover diagnosis and testing (skin prick tests, blood IgE, and when an oral food challenge might be considered), plus the tricky stuff like cross-contact in restaurants, takeaway risks, and food labels.Whether you’re a parent, teenager, or clinician, you’ll leave with a confident plan—how to avoid shellfish safely, when to carry and use an adrenaline auto-injector, and how to manage school, travel, and eating out without living in fear.Sources:Gerez, I.F.A., Llanora, G., Yap, G.C., Cheng, Y.K., Thong, B.Y., Tang, C.Y., Van Bever, H.P.S., Shek, L.P.C., Curotto de Lafaille, M.A. and Lee, B.W. (2012) ‘Clinical Characteristics of Prawn Allergy in an Asian Population’,Journal of Allergy and Clinical Immunology [Abstract 643], February.Giovannini, M., Beken, B., Buyuktiryaki, B., Barni, S., Liccioli, G., Sarti, L., Lodi, L., Pontone, M., Bartha, I., Mori, F., Sackesen, C., du Toit, G., Lopata, A.L. and Muraro, A. (2023) ‘IgE-Mediated Shellfish Allergy in Children’, Nutrients, 15(12), p. 2714. doi: 10.3390/nu15122714.Khora, S.S. (2016) ‘Seafood-Associated Shellfish Allergy: A Comprehensive Review’, Immunological Investigations, 45(6), pp. 504–530. doi: 10.1080/08820139.2016.1180301.Lopata, A.L., Kleine-Tebbe, J. and Kamath, S.D. (2016) ‘Allergens and molecular diagnostics of shellfish allergy’, Allergo Journal International, 25, pp. 210–218. doi: 10.1007/s40629-016-0124-2.Lopata, A.L. and Lehrer, S.B. (2009) ‘New insights into seafood allergy’, Current Opinion in Allergy and Clinical Immunology, 9, pp. 270–277.Nguyen, N.N.Q., Nguyen, T.H., Le, M.K., Duong, T.B., Pham, D.L., Tran, T.T. and Trinh, T.H.K. (2025) ‘Integrated Diagnostic Approach Using Basophil Activation Test and IgE Assays for Shrimp and Prawn Allergy’, Medicina, 61, p. 1040. doi: 10.3390/medicina61061040.Shi, J., Ren, F., Zhang, X., Yuan, X., Zhong, Q. and Zhang, J. (2025) ‘A comprehensive review on biological properties of fish and shellfish allergens’, European Food Research and Technology, 251, pp. 3417–3444. doi: 10.1007/s00217-025-04848-1.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode, we explore a fascinating question in early-life allergy prevention: could colostrum act as a protective factor against peanut allergy? Using evidence from a birth cohort study, we break down what the research actually found, how strong the association is, and what it might mean for parents and clinicians.We’ll cover:What colostrum is and why it matters for immune developmentHow a birth cohort study is designed (and what it can and can’t prove)Possible biological mechanisms: immune tolerance, gut barrier function, and early microbial influencesKey limitations and confounders (because correlation ≠ causation)Practical takeaways for infant feeding conversations and allergy-risk counsellingWhether you’re a parent navigating feeding decisions or a clinician trying to stay up to date with prevention science, this episode gives you a clear, balanced, evidence-based overview—without the hype.Source:Bhasin, M., Cooper, M., Macchiaverni, P., Joys, R.S., O'Sullivan, T.A., Keelan, J.A., Venter, C., Palmer, D.J., Lowe, A.J., Prescott, S.L., Silva, D. and Verhasselt, V. (2025) ‘Colostrum as a Protective Factor Against Peanut Allergy: Evidence From a Birth Cohort’, Allergy. doi: 10.1111/all.70043.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Coeliac disease isn’t always a “gut problem.” In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we unpack the extraintestinal manifestations of coeliac disease—the symptoms that show up beyond the digestive tract and can be easy to miss.We explore the most common non-GI presentations, including iron-deficiency anaemia, fatigue, poor growth or delayed puberty, mouth ulcers, dental enamel defects, bone pain/low bone density, headaches, low mood/brain fog, and the classic skin condition dermatitis herpetiformis. You’ll learn why these symptoms happen, which red flags should prompt testing, and the practical steps to diagnose coeliac disease (including the role of coeliac serology and when to consider referral).Whether you’re a parent, patient, or clinician, this episode will help you recognise coeliac disease when the gut symptoms are mild—or not there at all—and understand how a strict gluten-free diet can improve whole-body health.Sources:Durazzo, M., Ferro, A., Brascugli, I., Mattivi, S., Fagoonee, S. and Pellicano, R., 2022. Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?. Journal of Clinical Medicine, 11, p.258.Jericho, H., Sansotta, N. and Guandalini, S., 2017. Extraintestinal Manifestations of Celiac Disease: Effectiveness of the Gluten-Free Diet. Journal of Pediatric Gastroenterology and Nutrition, 65(1), pp.75–79.Nardecchia, S., Auricchio, R., Discepolo, V. and Troncone, R., 2019. Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms. Frontiers in Pediatrics, 7, p.56.Salarian, L., Khavaran, M., Dehghani, S.M., Mashhadiagha, A., Moosavi, S.A. and Rezaeianzadeh, S., 2023. Extra-intestinal manifestations of Celiac disease in children: their prevalence and association with human leukocyte antigens and pathological and laboratory evaluations. BMC Pediatrics, 23(1), p.8.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Coeliac disease can be easy to miss — and the symptoms aren’t always “classic” tummy pain or diarrhoea. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we break down what coeliac disease is, why it happens, and how to recognise it early, especially in children.We cover:The common and hidden symptoms (from abdominal pain and bloating to fatigue, anaemia, mouth ulcers, headaches, and poor growth)Who should be tested — including children with family history, type 1 diabetes, thyroid disease, or persistent unexplained symptomsThe diagnostic pathway: blood tests (tTG-IgA, total IgA), what to do with IgA deficiency, and when an endoscopy/biopsy is consideredWhy you shouldn’t start a gluten-free diet before testingPractical, real-life guidance for living gluten-free: labels, cross-contamination, school meals, eating out, and staying nutritionally balancedFollow-up care: dietetic support, monitoring, and when to re-check symptoms and bloodsWhether you’re a parent trying to make sense of symptoms, or a clinician wanting a clear refresher, this is a calm, practical guide to coeliac disease diagnosis and gluten-free living.Sources:Amil-Dias, J. and Polanco, I. (eds.) (2022) Advances in Celiac Disease: Improving Paediatric and Adult Care. Cham: Springer Nature Switzerland AG.Catassi, C., Verdu, E. F., Bai, J. C. and Lionetti, E. (2022) ‘Coeliac disease’, The Lancet, 399, pp. 2413–2426. Available at: https://doi.org/10.1016/S0140-6736(22)00794-2.Lin, J. C. (no date) ‘Diagnosing paediatric coeliac disease’, Journal Club.Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E. A., Makharia, G. K., Mearin, M. L., Murray, J. A., Verdu, E. F. and Kaukinen, K. (2019) ‘Coeliac disease’, Nature Reviews Disease Primers, 5, Article number: 3. Available at: https://doi.org/10.1038/s41572-018-0054-z.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Wheat allergy can be confusing — especially when “gluten-free” gets mixed up with coeliac disease, wheat intolerance, or everyday tummy troubles. In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we break down wheat allergy in babies and children in a clear, practical way.You’ll learn the common symptoms (from hives and vomiting to wheeze and anaphylaxis), when to suspect an IgE-mediated reaction vs a delayed reaction, and how clinicians diagnose wheat allergy using a focused history, skin prick testing, specific IgE, and (when appropriate) supervised oral food challenges. We also cover hidden sources of wheat, smart label-reading tips, cross-contamination risks, and how to build a safe plan for nursery, school, parties, and travel.Whether you’re a parent looking for reassurance or a clinician needing a quick refresher, this episode gives you a confident framework for recognising reactions, managing risk, and supporting healthy nutrition while staying safe.Sources:Cianferoni, A. (2016) ‘Wheat allergy: diagnosis and management’, Journal of Asthma and Allergy.Ebisawa, M., Shibata, R., Sato, S., Borres, M.P. and Ito, K. (2012) ‘Clinical Utility of IgE Antibodies to ω-5 Gliadin in the Diagnosis of Wheat Allergy: A Pediatric Multicenter Challenge Study’, International Archives of Allergy and Immunology, 158, pp. 71–76.Inomata, N. (2009) ‘Wheat allergy’, Current Opinion in Allergy and Clinical Immunology, 9, pp. 238–243.Mäkelä, M.J., Eriksson, C., Kotaniemi-Syrjänen, A., Palosuo, K., Marsh, J., Borres, M., Kuitunen, M. and Pelkonen, A.S. (2014) ‘Wheat allergy in children – new tools for diagnostics’, Clinical & Experimental Allergy, 44, pp. 1420–1430.Pi, X., Ren, S., Ye, H., Cao, J., Chu, J., Cao, L., Li, B. and Zhang, B. (2025) ‘A review of wheat allergy: allergens characteristic, the impact of processing on allergenicity and future perspective’, Trends in Food Science & Technology, 164, p. 105244.Pourpak, Z., Mesdaghi, M., Mansouri, M., Kazemnejad, A., Toosi, S.B. and Farhoudi, A. (2005) ‘Which cereal is a suitable substitute for wheat in children with wheat allergy?’, Pediatric Allergy and Immunology, 16, pp. 262–266.Venter, C., Maslin, K., Arshad, S.H., Patil, V., Grundy, J., Glasbey, G., Twiselton, R. and Dean, T. (2016) ‘Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort’, Clinical and Translational Allergy, 6(22).Yanagida, N., Takei, M., Saito, A., Sato, S. and Ebisawa, M. (2022) ‘Clinical cross-reactivity of wheat and barley in children with wheat allergy’, Pediatric Allergy and Immunology, 33, p. e13878.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

🥞 Can pancakes really cause anaphylaxis?In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore Pancake Syndrome — a rare but potentially severe allergic reaction caused by dust mite-contaminated flour rather than the pancake ingredients themselves.You’ll learn how improper storage of flour can lead to mite proliferation, why cooking does not eliminate the allergen risk, and which children are most at risk — particularly those with house dust mite allergy, eczema, or allergic rhinitis. We discuss the typical symptoms, including sudden vomiting, urticaria, wheeze, and anaphylaxis, and how Pancake Syndrome can be easily misdiagnosed as food allergy or food poisoning.This episode also covers:✔️ The science behind Pancake Syndrome✔️ How to recognise red-flag symptoms early✔️ Practical flour storage and prevention advice for families✔️ When to prescribe adrenaline and refer to allergy servicesWhether you’re a parent, healthcare professional, or educator, this episode provides clear, evidence-based guidance to help keep children safe and informed.Sources: Kano, Y. and Murata, K. (2025) ‘What Did the Patient Really Eat? Pancake Syndrome’, The American Journal of Medicine, p. e149.Sanchez-Borges, M. and Fernandez-Caldas, E. (2015) ‘Hidden allergens and oral mite anaphylaxis: the pancake syndrome revisited’, Current Opinion in Allergy and Clinical Immunology, 15, pp. 337–343.Sánchez-Borges, M., Capriles-Hulett, A. and Caballero-Fonseca, F. (2006) ‘Oral mite anaphylaxis (pancake syndrome) also observed in children’, Annals of Allergy, Asthma & Immunology, 96(May), pp. 755–756.Sánchez-Borges, M., Suárez-Chacon, R., Capriles-Hulett, A., Caballero-Fonseca, F., Iraola, V. and Fernández-Caldas, E. (2009) ‘Pancake Syndrome (Oral Mite Anaphylaxis)’, World Allergy Organization Journal, 2(May), pp. 91–96.🎧 Listen now on Apple Podcasts, Spotify, YouTube and Amazon MusicDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Is house dust mite allergy the hidden cause of year-round sneezing, blocked nose, wheeze, or eczema in children?In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore house dust mite allergy—one of the most common triggers of persistent allergic symptoms in children and adults. This episode explains what house dust mites are, why they cause allergy, and how exposure inside the home can drive ongoing symptoms such as allergic rhinitis, asthma, cough, and eczema.We cover:What house dust mites are and where they liveCommon symptoms of house dust mite allergy in childrenHow house dust mite allergy is diagnosedEvidence-based strategies to reduce exposure at homeWhen to consider medications and allergy specialist referralWith clear, practical advice and up-to-date evidence, this episode helps families and clinicians understand how to manage symptoms effectively—without unnecessary measures or anxiety.Sources:Miller, J.D. (2019) ‘The Role of Dust Mites in Allergy’, Clinical Reviews in Allergy & Immunology, 57, pp. 312–329.Sánchez-Borges, M. et al. (2017) ‘International consensus (ICON) on: clinical consequences of mite hypersensitivity, a global problem’, World Allergy Organization Journal, 10(14). 🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Grass pollen allergy, commonly known as hay fever or seasonal allergic rhinitis, affects millions of children and adults—especially during the spring and summer months. In this episode, we break down what a grass pollen allergy is, why it happens, and how it can be effectively diagnosed and managed.You’ll learn how grass pollen triggers allergic inflammation, the common symptoms to watch out for (sneezing, itchy eyes, nasal congestion, cough, and fatigue), and how to distinguish hay fever from viral infections. We also explore evidence-based treatments, including antihistamines, steroid nasal sprays, avoidance strategies, and when allergen immunotherapy may be considered.With a clear focus on child and family health, this episode offers practical, reassuring guidance for parents, patients, and clinicians alike. Whether you’re navigating pollen season for the first time or looking to optimise allergy control, this conversation provides clear, trustworthy answers grounded in current allergy science.Sources:Bryson, R. (2012) ‘Sublingual Immunotherapy for Grass Pollen Allergy in Children: A Systematic Review and Meta-Analysis’, World Allergy Organization Journal, February, p. S75,.Darsow, U., Brockow, K., Pfab, F., Jakob, T., Petersson, C.J., Borres, M.P., Ring, J., Behrendt, H. and Huss-Marp, J. (2014) ‘Heterogeneity of molecular sensitization profiles in grass pollen allergy – implications for immunotherapy?’, Clinical & Experimental Allergy, 44, pp. 778–786,.Douladiris, N., Garib, V., Focke‐Tejkl, M., Valenta, R., Papadopoulos, N.G. and Linhart, B. (2019) ‘Detection of genuine grass pollen sensitization in children by skin testing with a recombinant grass pollen hybrid’, Pediatric Allergy and Immunology, 30, pp. 59–65,,.Fuertes, E., Jarvis, D., Lam, H., Davies, B., Fecht, D., Candeias, J., Schmidt-Weber, C.B., Douiri, A., Slovick, A., Scala, E., Smith, T.E.L., Shamji, M., Buters, J.T.M., Cecchi, L. and Till, S.J. (2024) ‘Phl p 5 levels more strongly associated than grass pollen counts with allergic respiratory health’, Journal of Allergy and Clinical Immunology, 153, pp. 844–851,,.Kiotseridis, H., Cilio, C.M., Bjermer, L., Tunsäter, A., Jacobsson, H. and Dahl, Å. (2013) ‘Grass pollen allergy in children and adolescents-symptoms, health related quality of life and the value of pollen prognosis’, Clinical and Translational Allergy, 3(19),.Senna, G.E., Calderon, M. and Milani, M. (2011) ‘Allergy immunotherapy tablet: Grazax® for the treatment of grass pollen allergy’, Expert Review of Clinical Immunology, 7(1), pp. 21–27.🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Pollen Food Syndrome (also known as Oral Allergy Syndrome) is one of the most common — yet frequently misunderstood — food-related allergic conditions.In this episode of Hope & Histamine, we unpack why people with hay fever or pollen allergy can experience itching, tingling, or swelling of the lips, mouth, and throat after eating certain fresh fruits, vegetables, and nuts.We explain:What Pollen Food Syndrome is and how it differs from true IgE-mediated food allergyThe role of pollen–food cross-reactivity (birch, grass, and weed pollens)Common trigger foods and why symptoms often occur with raw but not cooked foodsTypical symptoms, red flags, and when to seek specialist advicePractical, evidence-based tips for everyday management and reassurance for familiesThis episode is designed for patients, parents, and healthcare professionals, using clear language, real-world examples, and clinically accurate guidance to reduce anxiety and support informed decision-making.Sources:Al-Shaikhly, T. et al. (2024) ‘An International Delphi Consensus on the Management of Pollen-Food Allergy Syndrome: A Work Group Report of the AAAAI Adverse Reactions to Foods Committee’, The Journal of Allergy and Clinical Immunology: In Practice, 12(12), pp. 3242–3249.Edwards, S.E. and Halton, F.F. (n.d.) ‘Pollen food syndrome’, pp. 1–6.Eigenmann, P. and Ebisawa, M. (2022) ‘Editorial comments on: “Food allergy in early childhood increases the risk of pollen food allergy syndrome”’, Pediatric Allergy and Immunology, [e-journal]. Available at: 10.1111/pai.13788.Haidar, L. et al. (2025) ‘Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges’, Applied Sciences, 15(1), 66.Hamada, M. et al. (2025) ‘Evaluation of the incidence of systemic symptoms in PR-10-related pollen-food allergy syndrome in Western Japan’, Pediatric Allergy and Immunology, 36, e70104.Kim, M. et al. (2019) ‘Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen–Food Allergy Syndrome’, Yonsei Medical Journal, 60(10), pp. 960–968.Mastrorilli, C. et al. (2016) ‘Endotypes of pollen-food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification’, Allergy, 71, pp. 1181–1191.Skypala, I.J. et al. (2022) ‘BSACI guideline for the diagnosis and management of pollen food syndrome in the UK’, Clinical and Experimental Allergy, 52(9), pp. 1018–1034.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Can babies eat blueberries as one of their first solid foods? When should blueberries be introduced during weaning and complementary feeding? Are blueberries safe, nutritious, and allergy-friendly for infants?In this episode, we explore the role of blueberries as an early complementary food for babies starting solids. Drawing on evidence-based infant nutrition guidance, this episode breaks down when and how to introduce blueberries, their nutritional benefits (including fibre, antioxidants, and vitamins), and practical preparation tips to reduce the risk of choking.We also discuss food allergy considerations, including why blueberries are considered a low-allergen food, how they fit into early dietary diversity, and what parents should watch for when introducing new foods.Whether you’re starting solids at around 6 months, navigating first tastes, or supporting a child with eczema or food allergy risk, this episode offers calm, trustworthy, and practical advice to help families introduce foods with confidence.🎙️ Listen now and learn how blueberries can be a simple, nutritious, and baby-friendly first food.Sources:Glime, G.N.E., Matzeller, K.L., Frank, D.N., Kotter, C., Kofonow, J.M., Robertson, C.E., Venter, C., Campbell, W.W., Krebs, N.F. and Tang, M. (2025) ‘Introducing blueberry powder as one of the first complementary foods changes the gut microbiota composition and diversity in U.S. human milk-fed infants: a double-blind, randomized controlled trial’, Frontiers in Nutrition, 12, p. 1623521. Available at: https://doi.org/10.3389/fnut.2025.1623521.Venter, C., Boden, S., Pickett-Nairne, K., O’Mahony, L., Glime, G.N.E., Matzeller, K.L., Frank, D.N., Kotter, C., Kofonow, J.M., Robertson, C.E., Campbell, W.W., Krebs, N.F. and Tang, M. (2025) ‘Blueberry Consumption in Early Life and Its Effects on Allergy, Immune Biomarkers, and Their Association with the Gut Microbiome’, Nutrients, 17(17), p. 2795. Available at: https://doi.org/10.3390/nu17172795.🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Precautionary Allergen Labelling (PAL) — those familiar phrases like “may contain nuts” or “made in a factory that handles milk” — is meant to keep people with food allergies safe. But does it always help? Or can it create confusion and unnecessary fear?In this episode, we unpack the world of precautionary allergen labels and what they really mean for families living with food allergies. We explore how PAL is regulated, why companies use it, and the challenges it brings for parents trying to make safe food choices for their children.We also discuss:Why do different products use PAL inconsistentlyThe real risk behind cross-contaminationHow parents and clinicians can interpret PAL more confidentlyThe future of food allergen labelling and more transparent communicationWhether you’re a parent, healthcare professional, or someone living with allergies, this episode provides trusted, practical insights to help you make more informed decisions about the food on your plate.Sources:Dubois, A.E.J., Turner, P.J., Hourihane, J., Ballmer-Weber, B., Beyer, K., Chan, C.-H., Gowland, M.H., O’Hagan, S., Regent, L., Remington, B., Schnadt, S., Stroheker, T. and Crevel, R.W.R. (2018) ‘How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods? Report from an ILSI Europe Food Allergy Task Force Expert Group and Workshop’, Allergy, 00, pp. 1–10,.DunnGalvin, et al. (2019) ‘Evidence‐based approaches to the application of precautionary allergen labelling: Report from two iFAAM workshops’, Clinical & Experimental Allergy, 49, pp. 1191–1200,.Graham, F., Benhamou, A.H., Liu, Y.J., Caubet, J.-C. and Eigenmann, P.A. (2023) ‘Real‐life evaluation of tolerance to foods with precautionary allergen labeling in children with IgE- mediated food allergy’, Allergy,,. Available at: https://doi.org/10.1111/all.15821.🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Severe allergic reactions can happen anywhere, anytime — and every second counts. In this episode, we explore the exciting new development of adrenaline nasal spray (Neffy) as a potential needle-free treatment for anaphylaxis. Could this innovation improve how quickly lifesaving medication is delivered? Could it reduce hesitation, fear of injections, and treatment delays?Join us as we break down:How adrenaline nasal spray works in the bodySafety, ease of use, and real-world benefitsDifferences vs. traditional adrenaline auto-injectors (e.g., EpiPen)What this could mean for patients, carers, schools, and emergency respondersThe future of anaphylaxis management and allergy careWhether you’re a clinician, parent, educator, or someone living with severe allergies, this episode helps you stay ahead of the latest advances in food allergy and anaphylaxis treatment — all in clear, accessible language.You can listen now to discover how a simple nasal spray could become a lifesaving revolution in allergy emergencies.Sources:Chen, J., Chilampalli, et al. (2019). A Phase 1, Single-Dose, Open-Label, 5-Treatment, Crossover, Pharmacokinetic Study of Comparative Bioavailability of Epinephrine Nasal Spray and EpiPen® in Healthy Adults With Seasonal Allergies. J Allergy Clin Immunol, February 2019, AB144 Abstracts.Crescioli, G., et al. (2025). Epinephrine nasal spray for the treatment of anaphylaxis: perspectives in pediatrics. Curr Opin Allergy Clin Immunol, 25(6), pp. 511–517. doi: 10.1097/ACI.0000000000001109.Dribin, T.E., et al. (2025). Intranasal epinephrine: The need to have confidence in efficacy. Journal of Allergy and Clinical Immunology, doi: 10.1016/j.jaci.2025.07.023.Ellis, A.K., Casale, et al. (2024). Development of neffy, an Epinephrine Nasal Spray, for Severe Allergic Reactions. Pharmaceutics, 16(811). doi: 10.3390/pharmaceutics16060811.FDA Approves First Epinephrine Nasal Spray (2024). AJN, 124(12), p. 16.Fleischer, D.M., et al. (2025). Pharmacokinetics and Pharmacodynamics of neffy, Epinephrine Nasal Spray, in Pediatric Allergy Patients. J Allergy Clin Immunol Pract, 13(6), pp. 1335–1341. doi: 10.1016/j.jaip.2025.03.019.Golden, D.B.K., Greenhawt, M. & Shaker, M.S. (2025). Prescribing nasal epinephrine spray: Confidence limits with novel treatments. J Allergy Clin Immunol, 156(614-5), pp. 614–615. doi: 10.1016/j.jaci.2025.06.008.Greenhawt, M., et al. (2024). Pharmacokinetic and Pharmacodynamic Profile of Epinephrine Nasal Spray Versus Intramuscular Epinephrine Autoinjector in Healthy Adults. J Allergy Clin Immunol Pract, 12(12), pp. 3274–3282. doi: 10.1016/j.jaip.2024.10.006.Treudler, R., et al. (2025). Adrenaline nasal spray in emergency management: An initial expert opinion. Allergologie select, 9, pp. 80–85. doi: 10.5414/ALX02590E.🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Ultra-processed foods (UPFs) are now a major part of children’s diets — colourful packaging, cartoon characters, and convenience make them hard to resist. But what are these foods really doing to young bodies and developing brains?In this episode, we uncover the science behind UPFs and children’s health, including:• How ultra-processed foods affect growth, metabolism, and immune health• Links with obesity, diabetes, fatty liver disease & heart disease risk• The impact on gut bacteria, behaviour, mood, and sleep• Why kids become “hooked” on high-sugar, high-additive foods• Practical tips for families to reduce UPFs without stress or guilt• Realistic swaps for school lunches, snacks & busy eveningsBacked by evidence and expert insight, this episode empowers parents, carers, and healthcare professionals to make informed, child-focused nutrition choices — even in a world where UPFs are everywhere.Sources:Barbaresko, J., Bröder, J., Conrad, J., Szczerba, E., Lang, A. and Schlesinger, S. (2025) Ultra-processed food consumption and human health: an umbrella review of systematic reviews with meta-analyses. Critical Reviews in Food Science and Nutrition, 65(11), pp. 1999–2007. doi:10.1080/10408398.2024.2317877.Gibney, M.J., Forde, C.G., Mullally, D. and Gibney, E.R. (2017) Ultra-processed foods in human health: a critical appraisal. The American Journal of Clinical Nutrition, 106(—), pp. 717–24. doi:10.3945/ajcn.117.160440.Levy, R.B., Barata, M.F., Leite, M.A. and Andrade, G.C. (2024) How and why ultra-processed foods harm human health. Proceedings of the Nutrition Society, 83(—), pp. 1–8. doi:10.1017/S0029665123003567.Monteiro, C.A., Louzada, M.L.C., Steele-Martinez, E., Cannon, G., Andrade, G.C., Baker, P., Bes-Rastrollo, M., Bonaccio, M., Gearhardt, A.N., Khandpur, N., Kolby, M., Levy, R.B., Machado, P.P., Moubarac, J-C., Rezende, L.F.M., Rivera, J.A., Scrinis, G., Srour, B., Swinburn, B. and Touvier, M. (2025) Ultra-processed foods and human health: the main thesis and the evidence. The Lancet. doi:10.1016/S0140-6736(25)01565-X.🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Discover how ImmunoCAP ISAC multiplex allergen testing is reshaping the future of allergy diagnosis.In this episode, we break down the science behind ISAC technology, how it identifies over 100 molecular allergen components in a single test, and why it’s transforming clinical decision-making for food allergy, respiratory allergy, venom allergy, and complex polysensitisation.We explore:How ImmunoCAP ISAC works and what makes it uniqueWhen clinicians should consider multiplex molecular diagnosticsThe difference between whole-extract tests vs component-resolved approachesReal-world advantages: precision, phenotyping, cross-reactivity patterns & risk stratificationLimitations, costs, and interpretive challenges every clinician should knowWhere ISAC fits within modern precision allergy medicineWhether you’re a clinician, scientist, trainee, or someone curious about advanced allergy diagnostics, this episode explains the evidence, the applications, and the future direction of molecular allergy testing — all in clear, practical language.Sources:Diem et al. (2022) Real-life evaluation of molecular multiplex IgE test methods in the diagnosis of pollen-associated food allergy. Allergy, 77, pp. 3028–3040. DOI: 10.1111/all.15329.Erskine et al. (2021) A Retrospective Clinical Audit of the ImmunoCAP ISAC 112 for Multiplex Allergen Testing. International Archives of Allergy and Immunology, 182, pp. 14–20. DOI: 10.1159/000509776.Jensen-Jarolim et al. (2017) Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future. Debate Open Access [Online]. Available at: DOI: 10.1186/s40413-017-0162-3.Maesa et al. (2021) ImmunoCAP ISAC in food allergy diagnosis: a systematic review of diagnostic test accuracy. Clinical and Experimental Allergy, 51, pp. 778–789. DOI: 10.1111/cea.13871.Seyfarth et al. (2014) Diagnostic value of the ISAC allergy chip in detecting latex sensitizations. International Archives of Occupational and Environmental Health, 87, pp. 775–781. DOI: 10.1007/s00420-013-0921-6.🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode, we dive deep into the Basophil Activation Test (BAT) — one of the most advanced tools in modern allergy diagnostics. Join us as we break down how BAT works, when to use it, and what the evidence really says about its accuracy in diagnosing IgE-mediated food allergy, drug allergy, and complex sensitisation patterns.You’ll learn:• How BAT compares with skin prick testing and specific IgE• The clinical value of basophil activation markers such as CD63 and CD203c• When BAT improves diagnostic confidence and reduces the need for oral food challenges• Limitations, pitfalls, and real-world barriers to using BAT in paediatric and adult allergy practice• Future trends and innovations in functional allergy testingWhether you’re a clinician, researcher, or allergy enthusiast, this episode offers a clear, evidence-based look at a test that’s increasingly shaping the future of precision allergy diagnosis.Sources:Dreborg, S. (2017) Methodological cutoff of basophil activation test and basophil activation test diagnostic value. [Journal of publication not explicitly contained within the source]. (Correspondence) [382, 388].Duan L., et al. (2021) Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study. Allergy, 76, 1800–1812. doi:10.1111/all.14695. [47, 123].Kim, S.Y., Kim, J.H., Jang, Y.S., Choi, J.H., Park, S., Hwang, Y.I., Jang, S.H. and Jung, K.S. (2016) The Basophil Activation Test Is Safe and Useful for Confirming Drug-Induced Anaphylaxis. Allergy Asthma Immunol Res, 8(6), 541–544. doi:10.4168/aair.2016.8.6.541. [399, 402].Mayorga C., Çelik G.E., Pascal M., Hoffmann H.J., Eberlein B., Torres M.J., Brockow K., Garvey L.H., Barbaud A., Madrigal-Burgaleta R., Caubet J.C. and Ebo D.G. (2024) Flow- based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper. Allergy, 79, 580–600. doi:10.1111/all.15957. [226, 380].Mayorga C., Ariza A., Barrionuevo E. and Salas M. (2017) Reply [to Dreborg]. [Journal of publication not explicitly contained within the source]. (Correspondence) [391].Santos A.F., Alpan O. and Hoffmann H.J. (2021) Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice. Allergy, 76, 2420–2432. doi:10.1111/all.14747. [127, 224].Sturm G.J., Kranzelbinder B., Sturm E.M., Heinemann A., Groselj-Strele A. and Aberer W. (2009) The basophil activation test in the diagnosis of allergy: technical issues and critical factors. Allergy, 64, 1319–1326. doi:10.1111/j.1398-9995.2009.02004.x. [5, 6].🎧 Listen on Apple, Spotify, Amazon, and YouTube Podcasts.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

How accurate are the tests we rely on to diagnose IgE-mediated food allergy? In this episode, we explore the science behind skin prick testing, serum-specific IgE, and oral food challenges, examining their sensitivity, specificity, predictive values, and real-world limitations.Join us as we separate evidence from assumption, discussing false positives, cross-reactivity, and component-resolved diagnostics—and how to interpret results in the context of clinical history.Whether you’re a clinician, allergy trainee, or researcher, this episode will help you navigate the complex landscape of allergy diagnostics with clarity and confidence.Source:Riggioni, C., Ricci, C., Moya, B., Wong, D., van Goor, E., Bartha, I., Buyuktiryaki, B., Giovannini, M., Jayasinghe, S., Jaumdally, H., Marques-Mejias, A., Piletta-Zanin, A., Berbenyuk, A., Andreeva, M., Levina, D., Iakovleva, E., Roberts, G., Chu, D., Peters, R., du Toit, G., Skypala, I. and Santos, A.F. (2024) 'Systematic review and meta- analyses on the accuracy of diagnostic tests for IgE- mediated food allergy', Allergy, 79, pp. 324-352. DOI: 10.1111/all.15939.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Component-Resolved Diagnostics (CRD) is transforming the way we diagnose and manage food and aeroallergy. In this episode, we break down what CRD really is, how molecular allergy testing works, and how it improves clinical decision-making beyond traditional IgE and skin prick testing.We explore:✅ What CRD is and when to use it✅ Benefits of molecular allergen testing over extract-based testing✅ Clinical interpretation of key allergen components (Ara h 2, Cor a 9, Fel d 1 and more)✅ Risk stratification for anaphylaxis using CRD✅ Practical pros, limitations, and cost considerations✅ When CRD really changes patient outcomesWhether you are a paediatrician, allergist, GP with a specialist interest, immunology trainee, dietitian, nurse specialist, medical student, or healthcare professional, this episode offers practical, evidence-based insights you can apply in clinical practice tomorrow.🔬 Precision medicine starts with precision allergy testing — let’s decode CRD together.Sources:Blank, S., Bil o, M. B. & Ollert, M. (2018) Component-resolved diagnostics to direct in venom immunotherapy: Important steps towards precision medicine. Clinical and Experimental Allergy, 48(4), pp. 354–364. doi:10.1111/cea.13090.Eller, E. & Bindslev-Jensen, C. (2013) Clinical value of component-resolved diagnostics in peanut-allergic patients. Allergy, 68(2), pp. 190–194. doi:10.1111/all.12075.Flores Kim, J., McCleary, N., Nwaru, B. I., Stoddart, A. & Sheikh, A. (2018) Diagnostic accuracy, risk assessment, and cost-effectiveness of component-resolved diagnostics for food allergy: A systematic review. Allergy, 73(8), pp. 1609–1621. doi:10.1111/all.13399.Petersen, T. H., Mortz, C. G., Bindslev-Jensen, C. & Eller, E. (2018) Cow’s milk allergic children—Can component-resolved diagnostics predict duration and severity?. Pediatric Allergy and Immunology, 29(2), pp. 194–199. doi:10.1111/pai.12854.Schoos, A. M. M., Nwaru, B. I. & Borres, M. P. (2021) Component-resolved diagnostics in pet allergy: Current perspectives and future directions. Journal of Allergy and Clinical Immunology, 147(3), pp. 1164–1173. doi:10.1016/j.jaci.2020.12.640.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Peach allergy is more common than most people realise—especially in Europe and among people with seasonal hay fever or birch pollen allergy. In this episode, we unpack everything you need to know about peach allergy, including oral allergy syndrome (OAS) and lipid transfer protein (LTP) allergy, two very different immune responses linked to peach sensitivity.We explore:✅ Why some people get an itchy mouth from peaches✅ When a peach allergy can cause anaphylaxis✅ Practical advice for diagnosis, allergy testing and management✅ Who is at higher risk and why some populations see more severe reactions✅ Daily living tips — from food labels to safe alternative fruitsWhether you’re a parent, clinician, allergy sufferer or curious learner, this episode brings clear, evidence-based guidance for living safely with peach allergy.🎧 Listen now and take control of fruit allergies with confidence.Sources:Barni, S., Caimmi, D., Chiera, F., Comberiati, P., Mastrorilli, C., Pelosi, U., Paravati, F., Marseglia, G.L. & Arasi, S. (2022). Phenotypes and Endotypes of Peach Allergy: What Is New? Nutrients, 14(5), 998. doi:10.3390/nu14050998.Gao, Z.S., Yang, Z.W., Wu, S.D., Wang, H.Y., Liu, M.L., Mao, W.L., Wang, J., Gadermaier, G., et al. (2013). Peach allergy in China: A dominant role for mugwort pollen lipid transfer protein as a primary sensitizer. Journal of Allergy and Clinical Immunology, 131(1), 224–226.e3. doi:10.1016/j.jaci.2012.07.015.Kallen, E.J.J., Revers, A., Fernández-Rivas, M., Asero, R., Ballmer-Weber, B., Barreales, L., Belohlavkova, S., de Blay, F., et al. (2023). A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity. Allergy, 78, 2497–2509. doi:10.1111/all.15783.Katoh, Y., Natsume, O., Takayanagi, F., Sakai, A. & Fukuie, T. (2022). A case of oral immunotherapy for peach allergy sensitized to Pru p 7. Pediatrics International, 64(1), e14860. doi:10.1111/ped.14860.Klingebiel, C., Chantran, Y., Arif-Lusson, R., Ehrenberg, A.E., Östling, J., Poisson, A., Liabeuf, V., Agabriel, C., et al. (2019). Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy. Clinical & Experimental Allergy, 49, 526–536. doi:10.1111/cea.13345.Pastorello, E.A., Farioli, L., Stafylaraki, C., Scibilia, J., Giuffrida, M.G., Mascheri, A., Piantanida, M., Baro, C., et al. (2013). Fennel Allergy Is a Lipid-Transfer Protein (LTP)-Related Food Hypersensitivity Associated with Peach Allergy. Journal of Agricultural and Food Chemistry, 61(3), 740–746. doi:10.1021/jf303291k.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the complex world of Lipid Transfer Protein (LTP) allergy — a powerful plant food allergen that can cause severe and unexpected allergic reactions.Join us as we unpack how LTP allergy differs from pollen-related food syndromes, why it’s often seen in Mediterranean populations, and what clinicians, families, and patients need to know about cross-reactivity, diagnosis, and management.You’ll learn about:🌿 What LTPs are and how they trigger allergy🍑 Common culprit foods — from peach to peanut⚕️ The role of component-resolved diagnostics in identifying LTP sensitisation🧠 Practical tips on prevention, patient education, and emergency planningWhether you’re a paediatrician, allergy trainee, dietitian, or an interested parent, this episode offers a clear, evidence-based overview of one of the most under-recognised causes of severe food allergy.Sources:Marinho, S., Frleta-Gilchrist, M., Hunter, H., Murgasova, D., Patel, N., Till, S. and Skypala, I. J. (2025) Diagnosis and Management of Lipid Transfer Protein Allergy—A BSACI Clinical Practice Statement. Clinical and Experimental Allergy, 55(4), pp. 307–318. doi: 10.1111/cea.70022.Olivieri, B. and Skypala, I. J. (2024) The Diagnosis of Allergy to Lipid Transfer Proteins. Current Allergy and Asthma Reports, 24, pp. 509–518. doi: 10.1007/s11882-024-01164-8.Olivieri, B., Scadding, G. and Skypala, I. J. (2025) The diagnosis of lipid transfer protein allergy—Discriminating between sensitisation and allergy. Clinical and Translational Allergy, e70065. doi: 10.1002/clt2.70065.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Have you ever wondered why some people get an itchy mouth or tingling lips after eating fresh fruit, vegetables, or nuts—especially during pollen season? In this episode of Hope & Histamine, we uncover the fascinating connection between pollen and food allergies, known as Pollen Food Allergy Syndrome (PFAS) or Oral Allergy Syndrome.Join us as we explore how pollen proteins “cross-react” with certain plant foods, why birch and grass pollens are the usual culprits, and what symptoms parents and clinicians should watch for. We’ll also discuss practical tips on diagnosis, dietary management, and when to refer for specialist allergy testing.Whether you’re a healthcare professional, a parent, or simply curious about the science behind seasonal allergies, this episode offers evidence-based insights and simple explanations that bring clarity to a common—but often misunderstood—allergic condition.Sources: Al-Shaikhly, T., Cox, A., Nowak-Wegrzyn, A. et al. (2024) 'An International Delphi Consensus on the Management of Pollen-Food Allergy Syndrome: A Work Group Report of the AAAAI Adverse Reactions to Foods Committee', J Allergy Clin Immunol Pract, 12(12), pp. 3242–3249.Eigenmann, P. and Ebisawa, M. (2022) 'Editorial comments on: “Food allergy in early childhood increases the risk of pollen food allergy syndrome”', Pediatric Allergy Immunology, 35(5), doi: 10.1111/pai.13788.Haidar, L., Bănărescu, C.F., Ut,a, C. et al. (2025) 'Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges', Appl. Sci., 15(1), p. 66.Kelso, J.M. (2000) 'Pollen±food allergy syndrome' (Editorial), Clinical and Experimental Allergy, 30(7), pp. 905–907.Kim, M., Ahn, Y., Yoo, Y. et al. (2019) 'Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen–Food Allergy Syndrome', Yonsei Med J, 60(10), pp. 960–968.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Did you know that allergies to beans, peas, lentils and chickpeas are becoming more common? In this episode, we explain what a legume allergy really means, why some people with peanut allergy react to other legumes, and how to read food labels safely. We explore the science and clinical nuances of legume allergy, from immunological cross-reactivity and diagnostic challenges to practical dietary management and allergen labelling under UK and EU regulations.We also provide practical tips for parents, schools, and young people living with food allergies — from meal planning to navigating eating out with confidence.Sources:Lisiecka, M.Z. 2024, Characteristic features of food allergy to legumes: From epidemiology to prevention, Human Immunology, vol. 85, no. 111179. doi:10.1016/j.humimm.2024.111179.Mastrorilli, C., Chiera, F., Arasi, S., Giannetti, A., Caimmi, D., Dinardo, G., Gracci, S., Pecoraro, L., Del Giudice, M.M. and Bernardini, R. 2024, IgE-Mediated Legume Allergy: A Pediatric Perspective, Journal of Personalized Medicine, vol. 14, no. 9, p. 898. doi:10.3390/jpm14090898.Mittag, D., Vieths, S., Vogel, L., Wagner-Loew, D., Starke, A., Hunziker, P., Becker, W.-M. and Ballmer-Weber, B.K. 2005, Birch pollen-related food allergy to legumes: identification and characterization of the Bet v 1 homologue in mungbean (Vigna radiata), Vig r 1, Clinical and Experimental Allergy, vol. 35, pp. 1049–1055. doi:10.1111/j.1365-2222.2005.02309.x.Soyak Aytekin, E., Unsal, H., Sahiner, U.M., Soyer, O. and Sekerel, B.E. 2022, IgE mediated legume allergy in east Mediterranean children: A reflection of multiple food allergies, Pediatric Allergy and Immunology, vol. 33, p. e13775. doi:10.1111/pai.13775.Verma, A.K., Kumar, S., Das, M. and Dwivedi, P.D. 2013, A Comprehensive Review of Legume Allergy, Clinical Reviews in Allergy & Immunology, vol. 45, pp. 30–46. doi:10.1007/s12016-012-8310-6.Allergy UK 2022, Reactions to Legumes, Allergy UK National Charity. Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Soya is one of the 14 major allergens, but it often hides in unexpected places. In this episode, we explore the world of soya allergy, uncovering the role of soya lecithin in foods, and what allergen labelling laws really mean for patients, families, and healthcare professionals. We’ll discuss the difference between soya protein and soya derivatives, why some people react to trace amounts, and how manufacturers handle precautionary allergen labelling.Whether you’re living with a soya allergy, supporting a child with food allergies, or working in allergy care, this episode offers practical insights, expert tips, and up-to-date knowledge to help navigate everyday food choices safely.Sources:Patel, N., Vazquez-Ortiz, M., Lindsley, S., Campbell, D. E., & Turner, P. J. (2018). Low frequency of soya allergy in peanut-allergic children: Relevance to allergen labelling on medicines. Allergy, 6.Maruyama, N., Sato, S., Cabanos, C., Tanaka, A., Ito, K., & Ebisawa, M. (2018). Gly m 5/Gly m 8 fusion component as a potential novel candidate molecule for diagnosing soya bean allergy in Japanese children. Clinical & Experimental Allergy, 48, 1726–1734.Gholmie, Y., Lozinsky, A. C., Godwin, H., Reeve, K., Dzubiak, R., Shah, N., & Meyer, R. (2020). Tolerance of soya lecithin in children with non-immunoglobulin E-mediated soya allergy: a randomised, double-blind, cross-over trial. Journal of Human Nutrition and Dietetics, 33, 232–240.ECARF (European Centre for Allergy Research Foundation). (2016, July). Soya allergy. ECARF Magazine.North West Allergy Network. Soya bean Allergy. Allergy Leaflets.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Beyond the Usual: Exploring Atypical FPIES takes you inside the complex world of Food Protein-Induced Enterocolitis Syndrome (FPIES)—a rare but increasingly recognised form of food allergy. This podcast unpacks the science, clinical challenges, and lived experiences surrounding atypical FPIES, where allergic mechanisms blur the line between classic FPIES and IgE-mediated food allergy.Whether you’re a healthcare professional, researcher, or parent navigating FPIES, this podcast offers clear, compassionate, and practical knowledge to help make sense of a challenging condition.Join us as we shed light on this hidden food allergy, one story at a time.Sources:Nowak-Węgrzyn, A., et al. (2017) 'International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology', Journal of Allergy and Clinical Immunology, 139(4), pp. 1111-1126.Bartnikas, L.M., Nowak-Wegrzyn, A., Schultz, F., Phipatanakul, W. and Bingemann, T.A. (2021) 'The Evolution of FPIES: From a Diagnosis That Did Not Exist to a Condition in Need of Answers', Annals of Allergy, Asthma & Immunology, 126(5), pp. 489-497.Bhagwath, A., et al. (2024) 'Prevalence of Atypical Food Protein Induced Enterocolitis Syndrome (FPIES) in a Regional, Multicenter FPIES Registry', Annals of Allergy, Asthma & Immunology, 133, p. S74.Harrison, D., Battaglia, J. and Jarvinen-Seppo, K. (2024) 'A RETROSPECTIVE CASE SERIES OF NOVEL ATYPIC-AL PHENOTYPES OF FOOD PROTEIN-INDUCED ENTEROCOLITIS', Annals of Allergy, Asthma & Immunology, 133, p. S74.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Food Protein-Induced Enterocolitis Syndrome (FPIES) can be overwhelming for parents and healthcare professionals alike. In this episode, we break down everything you need to know about FPIES — from understanding the symptoms and triggers to exploring the latest research, diagnosis strategies, and treatment options. Featuring expert insights and practical tips, this podcast is your go-to resource for navigating FPIES with confidence. Whether you’re a parent, paediatrician, allergist, or dietitian, you’ll gain valuable knowledge to support children and families living with FPIES.Sources:Brown-Whitehorn, T.F. and Cianferoni, A. (eds.) (2019) Food Protein Induced Enterocolitis (FPIES): Diagnosis and Management. Cham: Springer Nature Switzerland AG. doi:10.1007/978-3-030-21229-2.The FPIES Foundation. (2017) What is FPIES?. Available at: https://www.thefpiesfoundation.orgDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay. 

Anaphylaxis remains one of the most critical emergencies in allergy care, yet myths, misconceptions, and inconsistent guidelines often leave both clinicians and patients confused. In this episode, we cut through the noise to explore the truth behind anaphylaxis management, debunk common myths about epinephrine use, and highlight key differences across major guidelines from organisations like BSACI, EAACI, AAAAI, and NICE.Join us as we bring in expert insights, real-world case studies, and evidence-based recommendations to help healthcare professionals, educators, and allergy advocates improve patient safety and confidence in managing severe allergic reactions. Whether you’re a doctor, nurse, paramedic, or someone living with allergies, this episode delivers practical takeaways for navigating the complexities of anaphylaxis care.Sources:Dodd, A., Hughes, A. and Turner, P. J. (2021) ‘Anaphylaxis management — Why are guidelines inconsistent? A rapid review of advanced life support guidelines for cardiac arrest associated with anaphylaxis’, Resuscitation. Available at: http://dx.doi.org/10.1016/j.resuscitation.2020.12.026.Anagnostou, K. and Turner, P.J. (2019) ‘Myths, facts and controversies in the diagnosis and management of anaphylaxis’, Archives of Disease in Childhood, 104(1), pp. 83–90. doi: 10.1136/archdischild-2018-314867.Disclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsSend us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay.