Medicine Weekly with Del Parrish

This week we cover a JAMA cohort study finding that sitting 10 or more hours a day during pregnancy more than doubles the risk of adverse pregnancy outcomes, and a landmark New England Journal of Medicine trial on surgically implanting lab-grown heart muscle patches onto a failing human heart.If you enjoy the show, consider supporting my fundraiser for Ronald McDonald House Charities of Western Washington and Alaska: https://gofund.me/5641ee7bbReferencesBarone Gibbs B, Kim J, Gallagher J, et al. Adverse pregnancy outcomes and sedentary behavior, light-intensity physical activity, and daily steps. JAMA. Published online May 27, 2026. doi:10.1001/jama.2026.6986Zimmermann WH, Ensminger S, Kutschka I, et al. Stem-cell–derived biologic ventricular assist tissue in heart failure. N Engl J Med. 2026;394:1991-2001. doi:10.1056/NEJMoa2513525Find Medicine Weekly with Del Parrish on Spotify and Apple Podcasts.

This week we cover a major trauma resuscitation trial on whether whole blood outperforms blood components in prehospital care, a study testing whether weight loss improves atrial fibrillation symptoms in older adults, and new research on what acute stress does to your brain's ability to learn and make inferences.Find Medicine Weekly with Del Parrish on Spotify and Apple Podcasts.ReferencesSperry JL, Guyette FX, Cotton BA, et al. Prehospital resuscitation with type O whole blood for trauma and hemorrhage. N Engl J Med. Published online May 18, 2026. doi:10.1056/NEJMoa2602167Sclafani M, Spartera M, Esmati Y, et al. Weight loss in older patients with persistent atrial fibrillation: the LOSE-AF randomized clinical trial. JAMA. Published online May 20, 2026. doi:10.1001/jama.2026.5787Schüren KA, et al. Stress impairs memory integration and dampens insight. Sci Adv. 2026;12:eaea5496. doi:10.1126/sciadv.aea5496

This week I cover a phase 3 trial out of the New England Journal of Medicine on a first in class oral treatment for dermatomyositis, a rare and difficult to treat autoimmune disease, and a JAMA Dermatology study on combining a psoriasis biologic with tirzepatide, the drug class behind Mounjaro, to simultaneously treat psoriasis and obesity.Find Medicine Weekly with Del Parrish on Spotify and Apple Podcasts.

This week on Medicine Weekly, I share what I learned about a new study researching how to activate the clotting cascade. I also break down a major stroke trial that came back negative and why that matters, and I cover a new Nature study showing that the unconscious brain continues to process language and learn while under general anesthesia.

This week I cover a NEJM study asking whether PFA should be the new standard treatment for AFib instead of a life of taking pills, a JAMA trial on whether video games can make emergency physicians better at triage, and some new research from Nature on synthetic blood clots that can stop bleeding in seconds using Nobel prize winning chemistry.

Welcome to Medicine Weekly with Del Parrish! In this brief introduction I tell you a little about myself, the show, and what you can expect every week. Next week we're looking at a JAMA study on whether video games can make physicians better at triage.