National Institute for Health Research

Professor of clinical oncology at the University of Oxford and Clinical Director of the Oxford Institute for Radiation Oncology - Stratified medicine studies: what we have learnt from the set-up and delivery of the adaptive FOCUS 4 trial. Transcript: https://docs.google.com/document/d/1kkNeISk15owBsojhUk68ypHnUueDDcGnD6kv3by_L4w/edit

Dr Emma Gray Assistant Director of Research at the MS Society Development of the multi-arm, multi-stage trial ‘Octopus’ for people with progressive MS www.mssociety.org.uk/stop-ms Transcript:https://docs.google.com/document/d/1kaoWeiRiZr7kZczP1omst2FvYWbwVun4VIN2MIzCHfU/edit?pli=1

Dr Hugh Davies chair of the Oxford research ethics committee and was formerly a research ethics advisor to the health research authority. Dr. Davies trained in medicine and was a consultant paediatrician for many years. Transcript: https://docs.google.com/document/d/1JJR0JF_1jPKOoxN45M-xZtD8obbEWd9S3ezHKR5f-K0/edit?usp=sharing

Matt Sydes Professor of Clinical Trials and Methodology at the MRC Clinical Trials Unit at University College London. The importance of communicating trial results to the study participants. Transcript:https://docs.google.com/document/d/1_tCdh1o9gWFsu5yXeTyXf8JDozGWF4qNrVTspeWNoFA/edit?usp=sharing

Professor Sir Munir Pirmohamed - The NHS, the UK’s not so secret weapon in delivering Covid-19 research. COVID-19 - the importance of embedding research and the clinical care interface as a whole, working seamlessly together, to improve future outcomes for patients. Transcript:https://docs.google.com/document/d/1tvGNL5rWd7t3NVbtWy1z8HJPzVPfZR9db-NgwmRCXf8/edit?usp=sharing

Professor Thomas Jaki - Professor of Statistics at Lancaster University and Programme Leader at the MRC Biostatistics Unit at the University of Cambridge The AGILE initiative and the advantages and challenges of Platform Trials. Transcript: https://docs.google.com/document/d/1ad6R8yTfRsdna7Wk442ybKHwPB4h5oZF3WzUqqEMubw/edit?usp=sharing

Professor Pam Kearns, Director of the Cancer Research UK Clinical Trials Unit, University of Birmingham The CATALYST trial: Accelerating drug development for COVID-19 Transcript: https://docs.google.com/document/d/1h5c5C15kiTqsPEJPoHXkbcDTD_hbhIBNzSQjQavteLk/edit?usp=sharing

Dr Camille Carroll Associate Professor and Honorary Consultant Neurologist Peninsula Medical School (Faculty of Health). NSL for Neurology NIHR CRN The role of digital technology, such as sensors and wearables, in clinical trials. Transcript https://docs.google.com/document/d/1OwnBt7efXXCn3-DpefjIukDHtrrXYzEg9XmzXfhZQoc/edit?usp=sharing

Dr Kirsty Wydenbach deputy unit manager and senior medical assessor at the clinical trials unit in the MHRA Challenges and advice for complex innovative design trials, and how COVID-19 has impacted on the MHRAs approach. Transcript:https://docs.google.com/document/d/1HS-c3mR-B4m3RCtRpWHb5kIS8Xv90XJ2IIReWOg4fpw/edit?usp=sharing

Yan Yiannakou Clinical Director of the NIHR Patient Recruitment Centre – Newcastle Running a wholly virtual trial during the COVID19 pandemic. Transcript: https://docs.google.com/document/d/1_HkW3ixWip1XtrqUAGeiinQX7J3divCC1tKo_X_HUWg/edit?usp=sharing

Emma Lowe - acting head of research policy for clinical research and growth at the UK department of health and social care (DHSC) - focus on the Innovation in delivery of research studies during the COVID pandemic. Transcript: https://docs.google.com/document/d/13XO3AK7ar2co34e0zT-jPWZ-iI88xavLaqzXo0O09DE/edit?usp=sharing

Following on from our first round of podcasts that evolved from the recommendations in the paper; Effective delivery of Complex Innovative Design (CID) cancer trials- a consensus statement focusing on complex innovative design trials the NIHR CRN coordinating center has again collaborated with the Health Research Authority and in this series, the NIHR Office for Clinical Research Infrastructure. This time, we will be discussing some of the key learning points from the COVID-19 pandemic, such as: - Has the recent success using innovative design and delivery of research studies during the COVID pandemic been part due to the advance of innovation in trials pre-COVID-19? Could Continuous Improvement mean innovation in COVID-19 research inform studies post the pandemic? And how can we evidence this? The general learnings and happenings throughout the COVID-19 pandemic, and we will be building on the further questions around the management and delivery of innovative design trials during the pandemic. From Weds 27th January we will roll out a weekly podcast here aimed at anyone with an interest in designing, delivering or reviewing Innovation in Trail Design and Study Delivery. They are presented by experienced research professionals from across the research environment. The research delivery infrastructure in the UK provided by the NIHR, working closely with the NHS, regulators and stakeholders, continues to deliver unparalleled clinical research activity to address the COVID-19 pandemic. Agility, coordination and innovation are core attributes that are driving this impact made by our clinical research. They are also attributes that will ensure the UK can regrow the comprehensive health and social care research portfolio as soon as the harm of the COVID-19 pandemic upon health and social care is overcome. Drawing upon proven research infrastructure and our culture of continuous improvement from recent experience (such as those shared in this podcast series) provides this platform for future success.

Kelly Fricker is the lead research nurse at The Boathouse Surgery in Pangbourne, Reading. Here she speaks about what her role involves, studies into conditions such as arthritis and chronic obstructive pulmonary disease (COPD) and how her team are able to carry out research in their GP practice with the support of the National Institute for Health Research (NIHR).

Emma Lowe Dept. of Health and Social Care and CID Trials as she discusses the definition of complex innovative trials and on the role of the Dept. of Health and Social Care.

Prof. Julie Lovegrove and Nutritional Research by NIHR