PODCAST · science
Science TLDR
by Raymond Ruff
Is that stack of scientific papers growing ever higher? Don't you wish you could fill that void in your life when you're off work and actually living your life with more work? Well then Science TLDR is the podcast for you! At some regular interval, a science paper (of my choosing for the time being) is summarized and broken down into a quick 15 minute-ish podcast. My budget is exactly $0 at the moment so the summaries and scripts are written using a variety of LLMs (mostly Gemini and notebookLM, but occasionally ChatGPT 4 and Claud) and read aloud sometimes with a zesty AI voice from 11labs. If I ever have enough money to convert this into something, I am committed to hire real human talent for these jobs. If you have any feedback or suggestions please send them to [email protected]
Episodes
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Episode 90: Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition Molecular Systems Biology, 2026 DOI: 10.1038/s44320-026-00246-1 Question: Do AI-designed minibinders function as CAR-T...
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Episode 89: Reddit Trending — Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse PS: Political Science & Politics, 2025 DOI: 10.1017/S1049096525101704 Question: Why has Congress barely...
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Episode 88: GPCR antagonism via rewiring of receptor trafficking and degradation
Monday Immune Engager — our weekly pick from the latest immune-engager digest. GPCR antagonism via rewiring of receptor trafficking and degradation Nature, 2026 DOI: 10.1038/s41586-026-11088-0 Question: Can bispecific antibodies that hijack transferrin receptor 1 trafficking degrade GPCRs that…
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Episode 87: Reddit Trending — Did Donald Trump Receive a Mandate for Sweeping Change in 2024?
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Did Donald Trump Receive a Mandate for Sweeping Change in 2024? PS: Political Science & Politics, 2025 DOI: 10.1017/S1049096525101868 Question: Did Trump's 2024 victory and subsequent polling give him a…
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Episode 86: Specific targeting of MR1-antigen complexes using nanobodies
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Specific targeting of MR1-antigen complexes using nanobodies Science Immunology, 2025 DOI: 10.1126/sciimmunol.aeb8726 Question: Can nanobodies be raised to selectively recognize MR1 only when it presents a spec
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Episode 85: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits Cell, 2026 DOI: 10.1016/j.cell.2026.08.002 Question: Can genome-scale CRISPRi…
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Episode 84: Reddit Trending — Predictors and prevalence of support for white nationalism in the United States
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Predictors and prevalence of support for white nationalism in the United States Nature, 2026 DOI: 10.1038/s41586-026-11018-0 Question: How common is explicit, informed support for white nationalism among white...
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Episode 83: Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex mAbs, 2026 DOI: 10.1080/19420862.2026.2731282 Question: Can building proteome-wide off-target counter-screening into TCR-mimic...
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Episode 82: Reddit Trending — Substantial under-detection of human rabies cases in the United States
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Substantial under-detection of human rabies cases in the United States Communications Health, 2026 DOI: 10.1038/s44528-026-00031-4 Question: Using rare transplant-transmitted rabies events as a proxy sample of...
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Episode 81: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability Authors: M. Frank Erasmus, Daniel Bedinger, Elizabeth Hopkins, Ginger Ferguson, et al.…
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Episode 80: Reddit Trending — Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata Authors: Bernt Bratsberg, Anders M. Fjell, Ole J. Rogeberg, Kristine B. Walhovd Journal:...
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Episode 79: Reddit Trending — Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study Authors: Bethany Stanley, Clare S. Allely, Jenna Charlton, Christopher Gillberg,...
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Episode 78: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation Authors: Fengzhen Zhang, Yuhan Dong, Kailu Liu, Hui Hu, et al. Journal: Angewandte...
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Episode 77: Reddit Trending — People prefer to negotiate with women, even when outcomes are identical and gender is unknown
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: People prefer to negotiate with women, even when outcomes are identical and gender is unknown Authors: Charlotte H. Townsend, Laura J. Kray, Solène Delecourt Journal: Proceedings of the National Academy...
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Episode 76: Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors Authors: Welbeck Danquah, Mélanie Pichery, Thomas Eden,...
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Episode 75: Reddit Trending — A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone Authors: Xiaotong Peng, Peng Zhou, Xikun Song, Giovanni Bianucci, et al. Journal: Nature, 2026 Why it matters: The discovery of a...
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Episode 74: Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow Authors: SangPhil Ahn, Tae-Sung Oh, Seonghyuk Suh, Joon-Young Jeon, et al. Journal: Molecular Therapy, 2026 Why it...
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Episode 73: Reddit Trending — Work from Home and Disability Employment
Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Work from Home and Disability Employment Authors: Nicholas Bloom, Gordon B. Dahl, Dan-Olof Rooth Journal: American Economic Review: Insights, 2025 Why it matters: The post-pandemic rise in remote work...
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Episode 72: From free speech advocates to critics: The Trump administration’s new rhetoric promotes support for censorship among Trump voters
Paper: From free speech advocates to critics: The Trump administration's new rhetoric promotes support for censorship among Trump voters Authors: Matthew E. K. Hall, B. Tyler Leigh, Brittany C. Solomon Journal: Proceedings of the National Academy of Sciences, 2026 Why it matters: The study offers...
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Episode 71: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial Authors: Martin Wermke, Sebastian Ochsenreither, Dirk Jaeger, Heiko Becker, et al.…
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Episode 70: Language Modeling Materializes a World Model of Protein Biology
Paper: Language Modeling Materializes a World Model of Protein Biology Authors: Salvatore Candido, Alexander Rives, et al. Journal: White paper — Biohub / Evolutionary Scale Why it matters: Training a protein language model on billions of diverse metagenomic sequences appears to produce not just...
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Episode 69: Novel bispecific T-cell engagers overcoming acquired EGFR resistance
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Novel bispecific T-cell engagers overcoming acquired EGFR resistance Authors: Lennart Kühl, Ann-Kathrin Löffler, Oliver Seifert, Dennis Michler, et al. Journal: mAbs, 2026 Why it matters: Acquired resistance to...
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Episode 68: The lived experience of rejection sensitivity in ADHD - A qualitative exploration
Paper: The lived experience of rejection sensitivity in ADHD — A qualitative exploration Authors: Annabel Rowney-Smith, Beth Sutton, Lisa Quadt, Jessica A. Eccles Journal: PLOS One, 2024 Why it matters: Emotional dysregulation — and rejection sensitivity in particular — affects the majority of...
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Episode 67: Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery Authors: Nan Wang, Hugh Yeh, Ben Lai, Jason Perera, Kevin M. Jude, et al. Journal: Nature…
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Episode 66: The political polarization of health outcomes in the USA
Paper: The political polarization of health outcomes in the USA Authors: Elizabeth Elder, Neil A. O'Brian Journal: Nature Human Behaviour, 2026 Why it matters: Political ideology has emerged as a measurable social determinant of health in the United States, with conservative Americans showing...
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Episode 65: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager
Paper: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager Authors: Moon Jung Choi, Eui Young So, Bedia Akosman, Young Eun Lee, et al. Journal: Molecular Therapy Oncology, 2026 Why it matters: Glioblastoma…
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Episode 64: Climate-driven depopulation and adaptation realities in America’s coastal ground zero
Paper: Climate-driven depopulation and adaptation realities in America's coastal ground zero Authors: Torbjörn E. Törnqvist, Brianna Castro, Jesse M. Keenan, Jayur M. Mehta, Zhixiong Shen Journal: Nature Sustainability, 2026 Why it matters: The central U.S. Gulf Coast — identified by the IPCC as...
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Episode 63: Engineering of acidic pH-responsive anti-CD3 binding antibodies
Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Engineering of acidic pH-responsive anti-CD3 binding antibodies Authors: Grégory La Sala, Katharina B. Kroell, Mudita Pincha, Christian Gassner, et al. Journal: mAbs, 2026 Why it matters: Tumor-selective T-cell...
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Episode 62: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study
Paper: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study Authors: Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, et al. Journal: BMC Medicine, 2023 Why it matters: Even when...
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Episode 61: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology
Paper: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology Authors: Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, et al. Journal: Clinical and Translational Medicine, 2021 Why it...
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Episode 60: A trophoblast glycoprotein specific 5 T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies
Paper: A trophoblast glycoprotein specific 5T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies Authors: Milon de Jong, Rok Žiberna, Myrthe Veth, Elisabetta Michielon, et al. Journal: Clinical Immunology, 2026 Why it matters: Solid...
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A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity
https://doi.org/10.1038/s41551-025-01569-4
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Language models cannot reliably distinguish belief from knowledge and fact
https://doi.org/10.1038/s42256-025-01113-8
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Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment
https://doi.org/10.1101/2025.06.06.657162
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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
https://doi.org/10.1038/s41586-025-09655-y
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Guidelines for Early Food Introduction and Patterns of Food Allergy
https://doi.org/10.1542/peds.2024-070516
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Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design
https://doi.org/10.1080/19420862.2025.2570748
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A genetic common factor underlying self-reported math ability and highest math class taken
https://doi.org/10.1038/s41380-025-03237-0
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Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition
https://doi.org/10.1021/acs.biochem.5c00274
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The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple?
DOI: 10.1080/17460441.2025.2522088
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Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
https://doi.org/10.1016/j.cell.2025.07.046
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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
https://doi.org/10.1038/s41586-025-09370-8
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Single-Chain Fab Chain-Exchange (scFab-PACE) converts targeted prodrugs into functional T cell engagers on tumor cells
https://doi.org/10.1016/j.jbc.2025.110490
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Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement
https://doi.org/10.1016/j.celrep.2025.115965
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Navigating protein landscapes with a machine-learned transferable coarse-grained model
https://doi.org/10.1038/s41557-025-01874-0
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Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions
https://doi.org/10.1038/s41592-025-02723-1
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Predicting human decisions with behavioural theories and machine learning
https://doi.org/10.1038/s41562-025-02267-6
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Tuning antibody stability and function by rational designs of framework mutations
https://doi.org/10.1080/19420862.2025.2532117
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Lying increases trust in science
https://doi.org/10.1007/s11186-025-09635-1
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ABOUT THIS SHOW
Is that stack of scientific papers growing ever higher? Don't you wish you could fill that void in your life when you're off work and actually living your life with more work? Well then Science TLDR is the podcast for you!
At some regular interval, a science paper (of my choosing for the time being) is summarized and broken down into a quick 15 minute-ish podcast. My budget is exactly $0 at the moment so the summaries and scripts are written using a variety of LLMs (mostly Gemini and notebookLM, but occasionally ChatGPT 4 and Claud) and read aloud sometimes with a zesty AI voice from 11labs. If I ever have enough money to convert this into something, I am committed to hire real human talent for these jobs.
If you have any feedback or suggestions please send them to [email protected]
HOSTED BY
Raymond Ruff
CATEGORIES
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Frequently Asked Questions
How many episodes does Science TLDR have?
Science TLDR currently has 61 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Science TLDR about?
Is that stack of scientific papers growing ever higher? Don't you wish you could fill that void in your life when you're off work and actually living your life with more work? Well then Science TLDR is the podcast for you! At some regular interval, a science paper (of my choosing for the time...
How often does Science TLDR release new episodes?
Science TLDR has 61 episodes. Check the episode list to see recent publication dates and frequency.
Where can I listen to Science TLDR?
You can listen to Science TLDR on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Science TLDR?
Science TLDR is created and hosted by Raymond Ruff.
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