The Cracking Cancer Podcast

Smashing the Stigma: New Hope and Breakthroughs in Small Cell Lung Cancer In this powerful episode, host Dr. Kyle Concannon is joined by Matthew Baker, a never-smoker living with limited-stage small cell lung cancer (SCLC), and Dr. Misty Shields, a physician-scientist at Indiana University and founder of the "Small Cell Smashers." Together, they strip away the "Google-induced" terror of an SCLC diagnosis to reveal a rapidly changing clinical landscape. The conversation covers the grueling reality of standard "classic" chemotherapies, the emotional weight of radiation, and the traumatic side effects like ototoxicity (hearing loss) that Matt has navigated. Dr. Shields explains why small cell is uniquely "addicted to growth," making it highly sensitive to treatment but also prone to rapid resistance. However, the focus is on the future: the trio discusses the "transformative" rise of T-cell engagers (BiTEs), Antibody-Drug Conjugates (ADCs), and the controversial shift away from prophylactic cranial irradiation (PCI). It’s an episode about finding your "tribe," advocating for second opinions, and reclaiming hope in a field that is finally seeing its first major breakthroughs in decades.   Key Takeaways: The "Neuroendocrine" Factor The Platinum Standard The "Silent" Side Effect—Ototoxicity The PCI Controversy The New Era of BiTEs and ADCs   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Meet the Guests (04:32) What Small Cell Is (06:03) Staging Confusion Explained (08:03) Chemo and Radiation Reality (14:00) Radiation Process and Support (18:48) Side Effects and Safety Tips (21:56) Hair Loss and Hearing Loss (25:05) Caregivers and Not Burdening (32:22) Extensive Stage Treatment Basics (37:57) Second Opinions Self Advocacy (39:55) PCI Controversy Explained (50:15) Transformative Trials New Drugs (52:03) Biomarkers Personalized Therapy   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Demystifying Radiation: From "Adult Coloring" to Molecular Smart Drugs In this enlightening episode of Cracking Cancer, host Dr. Kyle Concannon is joined by academic radiation oncologist Dr. Tim Waxweiler and stage IV neuroendocrine patient Bill Thach. They strip away the "sci-fi" mystery surrounding radiation therapy, addressing common patient fears—such as "Am I radioactive?"—and explaining the meticulous physics behind modern treatment. The trio discusses the evolution of radiation from broad-beam "front-to-back" treatments to modern dose painting, where specialists use complex algorithms to steer energy toward tumors while sparing healthy organs. Bill shares his raw experience navigating 25 rounds of external radiation and the cutting-edge world of Radiopharmaceuticals (PRRT). Dr. Waxweiler breaks down the "Goldilocks" quest for the perfect dose, the nuances of Proton Therapy, and why staying physically active is the most powerful tool a patient has to combat radiation-induced fatigue. This episode is an essential guide for anyone facing a radiation referral, offering clarity on everything from simulation casts to the cumulative risks of diagnostic scans.   Key Takeaways: Radiation is "Targeted Energy" External Beam vs. Brachytherapy The Rise of Radiopharmaceuticals (PRRT) The Proton Therapy Debate The Cumulative "Radiation Bucket"   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Radiation Basics Explained (07:47) Planning and Beam Shaping (17:59) Why Not Radiate Everything (29:10) Risks of Repeat Radiation (33:18) Lutathera Side Effects (41:39) How Targeted Particles Work (52:05) Choosing Treatment Together (58:35) Advice for New Patients     To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Young, Sick, and Isolated: Navigating the AYA Cancer Crisis with Stupid Cancer In this vital episode of Cracking Cancer, host Dr. Kyle Concannon is joined by JJ Singleton, a colorectal cancer survivor diagnosed at age 27, and Alison Silberman, CEO of Stupid Cancer. They dive into the world of Adolescent and Young Adult (AYA) cancer—defined as patients diagnosed between the ages of 15 and 39. While cancer rates in younger adults are rising, the medical system remains largely tailored to older populations, leaving AYAs in a "clinical gap" between pediatrics and geriatrics. The trio discusses the profound isolation felt by young patients who don't see themselves reflected in oncology waiting rooms and the specific milestones—fertility, career building, and financial independence—that cancer abruptly derails. Alison highlights the work of Stupid Cancer in providing "hub and spoke" resources for this community, while JJ shares his journey from "stunted growth" and mental health struggles to finding a life-changing community. This episode is a call to action for providers to integrate psychosocial checklists into clinical care and a roadmap for young survivors to stop isolating and "say yes" to community.   Key Takeaways: The AYA "Clinical Gap" The rising Incidence is Real The "Burden" of the Stoic Male Psychosocial Checklists are Needed Stop the Isolation   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer  Chapters: (00:00) Why AYA Cancer Matters (02:41) Allison’s Advocacy Origin (03:35) JJ’s Diagnosis Story (13:43) Unique AYA Life Challenges (17:32) Fixing Care Communication Gaps (25:49) Family Planning After Cancer (27:53) Stupid Cancer Programs (37:21) AYA Biology and Trials (41:58) Defining AYA Care Standards (46:55) Finding Resources and Community   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this crucial episode of Cracking Cancer, host Dr. Kyle Concannon is joined by patient advocate Samantha Murrell and world-renowned expert Dr. Laura Alder, a thoracic oncologist at Duke University. Together, they demystify Leptomeningeal Disease (LMD)—a condition where cancer cells spread to the thin layers of tissue (meninges) surrounding the brain and spinal cord. LMD is often considered "the scariest" diagnosis by patients because of its historic poor prognosis and the diagnostic difficulty it presents. The team explores why an MRI alone isn't always enough for a diagnosis, the "50/50" reality of lumbar punctures, and the revolutionary shift toward CSF genomic profiling. Dr. Alder highlights the "multi-disciplinary tumor board" approach to treatment, discussing everything from intrathecal chemotherapy via Ommaya reservoirs to the latest CNS-penetrant targeted therapies. This conversation moves past the fear to focus on the emerging tools and clinical trials that are offering new hope and extended quality of life for those facing LMD.   Key Takeaways: LMD vs. Brain Metastases The Diagnostic Challenge Know the Neurological Red Flags The "Blood-Brain Barrier" Hurdle Advocating for Inclusion   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) What Is LMD (06:51) Patient Fears And Misconceptions (14:08) Diagnosing LMD MRI And Spinal Tap (23:57) Timing Risk And Why It Happens (31:47) Targeted Drugs for CNS (37:43) CNS Patients Excluded (48:06) Prognosis and Urgency (53:05) CNS vs Spine Confusion   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

In this poignant episode of Cracking Cancer, co-host Ashley Holt steps into a different role to interview Lauren Case, whose sister, Lexi, is living with Stage IV EGFR Exon 20 lung cancer. While the spotlight often remains on the patient, this conversation illuminates the emotional and logistical weight carried by sisters who become researchers, advocates, and "truth-tellers" in the face of terminal illness. Lauren shares the raw reality of the "work zone" she entered following Lexi’s diagnosis—balancing her own family life while managing the complex logistics of her sister’s care, from coordinating cross-country flights for clinical trials to picking her up from chemotherapy infusions. The duo discusses the unique challenges of the sibling dynamic, the "delayed grief" that comes with staying strong for others, and the vital role a caregiver plays in ensuring oncologists hear the unvarnished truth about treatment side effects. This episode is a tribute to the "village" that supports a cancer patient and a roadmap for siblings navigating the ebbing and flowing stages of grief.   Key Takeaways: The "Logistics Zone" as a Coping Mechanism The Caregiver as "Truth-Teller" Grief is a Family Diagnosis The Power of the Village Authenticity and Risk   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Meet Lauren the Caregiver (08:09) Hearing Lexi’s Diagnosis (13:52) Busy Now Grieve Later (22:06) Burden vs Love in Support (29:31) Quality of Life vs Longevity (37:03) How Support Networks Show Up (44:14) Can You Ever Forget Cancer (52:05) It Takes a Village   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode of Cracking Cancer, host Dr. Kyle Concannon sits down with patient advocate and caregiver Max Doppelt to pull back the curtain on national cancer conferences. As we navigate the complex oncology landscape of 2026, this conversation explores whether these high-level medical meetings—like ASCO, AACR, and IASLC—are truly the best use of a patient’s most precious resource: time. From the intimidating halls of Chicago’s McCormick Place to niche-targeted therapy meetings in California, Max shares his journey from "cornering trial coordinators" to finding a therapeutic community of peers. This episode is a must-listen for anyone wondering if they should attend a major medical meeting or if their time is better spent elsewhere.   Key Takeaways The Knowledge Gap is Smaller Than You Think Networking Over Data The "Standing Ovation" Paradox Pharma: Partner or Profit? Patient Advocacy Groups as the "Bridge"   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Max Conference Origin Story (04:22) Expectations Versus Reality (12:25) Small Versus Huge Meetings (16:13) Asking Experts Respectfully (20:36) Advocacy Groups As Filters (32:31) Patient View On Pharma Limits (45:16) Advocating at Posters (55:18) Emotional Weight of Data   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

In this highly personal follow-up episode of "Cracking Cancer," host Dr. Kyle Concannon and patient advocate Ashley Holt navigate the "mental hell" that can arise when advanced medical technology outpaces clinical certainty. Ashley, a Stage I lung cancer survivor, shares the harrowing story of her Signatera blood test (a tumor-informed ctDNA test) turning positive on her one-year diagnosis anniversary. The episode pulls back the curtain on the months of uncertainty that followed: a clean PET scan and brain MRI, two follow-up blood redraws, and the agonizing wait for results during the holiday season. Dr. Kyle and Ashley dive deep into the catch-22 of "over-testing"—where the tools meant to provide peace of mind actually trigger profound scanxiety and unnecessary medical procedures. They challenge the misconception that "more is always better" and provide a rare look into the friction between medical science liaisons, oncologists, and the patients who must live with the fallout of a 1% false positive.   Key Takeaways: The False Positive is Not Benign The "Standard of Care" is Not "Sub-Par" ctDNA Sensitivity vs. Actionability Question the MSL and the Sale The Right to a "Test Vacation"   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) The Positive Test Scare (05:39) Redraws and Second Opinions (10:57) Does Earlier Detection Help (19:35) How Tumor DNA Blood Tests Work (29:26) Standard Care Reality (38:00) Uncharted Follow Up (49:35) Malpractice Pressure (51:39) Shared Decisions Balance (56:48) Surveillance Moving Forward   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

In this moving episode of "Cracking Cancer," host Dr. Kyle Concannon is joined by JJ Singleton and Bill Thach to discuss the "hidden" struggle of the cancer experience: social isolation, specifically among men. Both JJ and Bill share a striking commonality—it took each of them five years post-diagnosis to find a social support group that actually resonated with their needs. The conversation dives deep into why traditional support groups often fail men, particularly Adolescent and Young Adult (AYA) patients. Bill and JJ candidly discuss the "stoic male" stereotype, the fear of having vulnerability weaponized, and the frustration of groups that focus solely on medical jargon rather than real-life struggles. They highlight the transformative power of Man Up to Cancer, a community that prioritizes social-emotional support and "campfire-style" vulnerability over clinical agendas. From navigating terminal diagnoses to the "superpower" of asking for help, this episode is a roadmap for any man—or loved one of a man—looking to break the silence and find a community that truly understands the weight of the fight.   Key Takeaways The "Five-Year Gap" Vulnerability as a Superpower The Problem with "Medical-Only" Groups Unique Struggles of AYAs (Age 15–39) The "Gathering of Wolves"   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Why Social Support Matters in Cancer (05:08) Finding the Right Fit: Facebook Groups, AYA Meetups, and Time Barriers (13:48) Safe Vulnerability: Trust, Brotherhood, and Men Supporting Men (22:18) When Support Groups Hurt (33:35) The real cost of “miracle cures.” (42:00) Beyond disease type: building support around shared social struggle (53:55) Bill’s postcard moment: joining, lurking, then going to Gathering of Wolves (57:40) Taking the leap to an in-person retreat   To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this high-stakes episode of "Cracking Cancer," Dr. Kyle Concannon and Samantha Murrell are joined by Max Doppelt, an engineer-turned-caregiver who transformed his mother’s terminal diagnosis into a mission for systemic change. Max shares the harrowing reality of navigating the "ivory tower" of oncology, where regulatory burdens and institutional silos often prevent patients from accessing the very drugs that could save them. From the heartbreak of failing trial screenings due to rigid exclusion criteria to the bold, life-saving decision to source a next-generation TKI from China during a trade war, this conversation pulls back the curtain on the logistical "nightmare" of the current trial system. The trio discusses why the burden of research often falls on the terminally ill and how Max is using his "special nerd powers" to bridge the gap. He introduces Patient Data Vault, a privacy-first AI platform designed to automate the clinical trial search, turning a list of thousands of irrelevant options into a curated handful of actionable leads. It’s an episode about patient empowerment, the "action layer" of AI, and the lengths a family will go to when the standard of care is no longer enough.   Key Takeaways: The Regulatory Gap The Problem with "Ivory Towers" Inclusion/Exclusion Paradox AI as the Great Equalizer Proactive "Second Opinion" Strategy   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Understanding Clinical Trials (01:56) Max's Experience with Clinical Trials (05:40) Samantha's Clinical Trial Journey (08:37) Challenges in Finding the Right Trial (12:41) Max's Search for a Clinical Trial (25:16) The China Solution (31:07) Navigating Treatment Options: A Personal Journey (41:02) The Burden on Patients to Find Trials (48:50) Innovative Solutions: Patient Data Vault (58:48) The Future of AI in Healthcare   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

In this dedicated episode of "Cracking Cancer," host Dr. Kyle Concannon and co-host Samantha Murrell explore a challenging phenomenon in oncology: histologic transformation. This occurs when a cancer fundamentally changes its "wiring" to evade treatment, essentially transforming from one type of cell (like adenocarcinoma) into another, often more aggressive type (like small cell lung cancer). The episode is dedicated to the memory of Caroline, a member of the lung cancer community who recently passed away after her EGFR-mutated cancer transformed into small-cell cancer. Dr. Concannon explains the biological "bucket" of resistance, distinguishing between new mutations in the same protein and this more radical cellular reprogramming. They discuss the necessity of repeat biopsies upon disease progression, as imaging alone cannot detect these shifts. While the topic is sobering, Dr. Concannon emphasizes that even after transformation, there are emerging therapies—including new antibody-drug conjugates and radiation—that offer hope and meaningful survival for patients facing this complex evolutionary hurdle.   Key Takeaways The "Wolf to Chihuahua" Shift Biopsy is Mandatory for Detection Driven by Evolutionary Pressure Treatment Shifts to Chemotherapy Hope Amid Aggression   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Understanding Histologic Transformation (10:12) Biopsy and Diagnostic Techniques (21:32) Research and Future Directions (30:15) Understanding Small Cell Transformation (39:38) The Role of Biopsies and Oncologist Advice (45:46) Balancing Aggressiveness in Treatment (49:54) Patient Community Insights (54:56) Hope and Realism in Cancer Care   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this high-impact episode of "Cracking Cancer," host Dr. Kyle Concannon is joined by patient advocate Samantha Murrell and Dr. James DeGregori, interim director of the University of Colorado Cancer Center. They discuss Dr. DeGregori’s groundbreaking study published in Nature, which explores how respiratory viruses—specifically SARS-CoV-2 and influenza—can act as a catalyst to "awaken" dormant cancer cells in the lungs.   Dr. DeGregori explains that while many cancer survivors may be ostensibly "cured," microscopic cancer cells can lie dormant for decades. His research reveals that acute inflammation caused by a new viral infection can trigger the rapid expansion of these cells, potentially leading to disease progression. The team discusses the science behind IL-6 (Interleukin-6) as a primary signaling molecule in this reawakening and explores why vaccination and early infection management are critical tools for cancer survivors. Balancing rigorous science with the reality of "scanxiety," this conversation brings much-needed clarity to the intersection of viral immunology and oncology.   Key Takeaways: Viral Triggers and Dormancy The Role of IL-6 Vaccination as a Defense Acute vs. Chronic Inflammation Knowledge Over Fear   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Understanding the Link Between Respiratory Viruses and Cancer (09:23) Exploring Broader Implications and Future Research (24:59) Practical Advice for Cancer Survivors (34:40) The Role of Viral Infections in Awakening Cancer Cells (38:43) Dormant Cancer Cells: A Hidden Threat (47:39) Balancing Health and Enjoyment in Life (49:57) Challenges in Cancer Research and Epidemiology     The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this uniquely powerful episode of "Cracking Cancer," host Dr. Kyle Concannon interviews his own mentor and boss, Dr. Ross Camidge, Director of the Lung Cancer Program at the University of Colorado. Dr. Camidge, a world-renowned lung cancer expert, shares the "ironic elephant in the room": his own 2022 diagnosis with Stage IV metastatic lung cancer. Dr. Camidge provides a rare, dual-perspective look at the oncology system. He recounts the four-day whirlwind from his first chest X-ray to starting targeted therapy for an EGFR mutation, acknowledging the professional stoicism that initially masked a deep personal terror regarding his daughters' futures. The conversation dives into the "black box" of academic research, where both doctors critique the current incentive structures that often prioritize low-risk, incremental papers over high-stakes breakthroughs. From the frustrations of "billing-driven" hospital logistics to the hidden anxieties of scan results, Dr. Camidge’s story serves as a call for radical transparency and a more human-centered approach to both clinical care and scientific discovery.   Key Takeaways The Dual Reality of a Physician-Patient The Problem with Research Incentives Breaking the "Knowledge Gap" The "One-Tier" System of Care Institutional Barriers to Efficiency   Want to get more involved with cancer research and support the podcast? Visit the link below: ⬇️ (All proceeds go strictly towards furthering cancer research and supporting this podcast) Giving.CU.EDU/CrackingCancer    Chapters: (00:00) Ross Camidge's Personal Cancer Journey (01:13) The Diagnosis and Initial Reactions (04:50) Navigating Treatment and Professional Insights (10:20) Balancing Professionalism and Personal Struggles (17:08) Impact on Patient Care and Practice (24:59) Challenges in the Healthcare System (31:57) Empowering Patients Through Knowledge (41:31) Incentives in Academic Medicine (54:44) Frustrations with Clinical Trials (58:48) Conclusion and Final Thoughts   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this revealing episode of "Cracking Cancer," host Dr. Kyle Concannon pulls back the curtain on his role as a physician-scientist at the University of Colorado. Joined by patient advocate Samantha Murrell, Dr. Kyle demystifies the "black box" of oncology research, discussing the intense process of setting up a new laboratory and the personal pivot that reshaped his career.   Dr. Kyle shares the logistical and emotional challenges of running an independent lab—from the high cost of reagents and the competitive nature of grant funding to the personal urgency that arose when his own boss was diagnosed with lung cancer. The conversation dives deep into the specific preclinical models used to fight disease, including cell lines and mouse models, explaining how they serve as the first line of defense before human trials. Dr. Kyle also highlights his lab's most exciting work: developing enhanced CAR T-cell therapies designed to not just manage, but potentially cure metastatic cancer. This episode is a raw look at the grit required to move science forward and the powerful partnership between researchers and the patients who drive their mission.   Key Takeaways: The Reality of Setting Up a Lab Cell Lines vs. Mouse Models The High Cost of "Reagents" Pivoting for Impact The Promise of Next-Gen CAR T-Cell Therapy   Want to get more involved with cancer research and support the podcast, visit the link below: ⬇️ https://www.crackingcancer.org/get-involved   Chapters: (00:00) Dr. Kyle's Secret Lab Revealed (05:59) Understanding Reagents and Research Costs (14:35) Building the Right Team (27:17) Mouse Models in Cancer Research (34:17) Challenges in Preclinical Research (45:41) Funding and Collaborations (56:48) The Future of Cancer Research (01:05:46) Concluding Thoughts and Call to Action   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this essential episode, host Dr. Kyle Concannon and co-host Samantha Murrell break down the science, promise, and limitations of Tyrosine Kinase Inhibitors (TKIs)—a class of highly effective, usually pill-form, targeted therapy. Dr. Concannon explains that TKIs are molecular snipers, designed to attack the root cause of cancer by blocking the signaling from a mutated protein (kinase) that causes cells to divide uncontrollably. They clarify the process from DNA blueprint to protein addiction, explaining why these targeted therapies are often more elegant and have fewer side effects than traditional chemotherapy.   The discussion also tackles the billion-dollar question of resistance. Dr. Concannon outlines three primary ways tumors evade TKIs: on-target resistance (a new mutation in the same protein), upregulation of other kinases (the tumor activates a second signaling pathway), and lineage change (the tumor stops relying on the oncogene altogether). Samantha shares her experience, confirming that while TKIs are not without side effects (like fatigue and potential for diarrhea), they represent a massive leap forward in treatment, offering hope for longer, higher-quality survival.   Key Takeaways: TKIs Are Molecular Snipers Cancer Cells Become "Addicted" to the Signal Understanding Resistance is Key Side Effects are Different, Not Absent The TKI Landscape is Evolving   Chapters: (00:00) Understanding Tyrosine Kinase Inhibitors (TKIs) (07:11) The Role of Kinases in Cancer (13:47) The Evolution of Cancer Treatments (22:16) Resistance to Tyrosine Kinase Inhibitors (32:09) Understanding EGFR and Its Role in Cancer (41:20) The Role of Protein Analysis in Cancer Treatment (50:31) Managing TKI Toxicity and Side Effects (59:25) Combining Therapeutic Modalities for Better Outcomes (01:00:26) Conclusion and Final Thoughts   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this essential episode of "Cracking Cancer," host Dr. Kyle Concannon, a medical oncologist, is joined by patient advocate Ashley Holt and Dr. Erin Baurle, a Clinical Health Psychologist specializing in oncology. They tackle the emotionally charged question: Does stress or trauma cause cancer?   Ashley, who was diagnosed with lung cancer shortly after a difficult divorce, shares her personal spiral of guilt and the psychological need to find a reason—even a self-blaming one—for her diagnosis. Dr. Baurle firmly states the scientific consensus: Stress and trauma, in and of themselves, do not cause cancer. However, they do stress the necessity of managing the distress that inevitably accompanies a diagnosis, as well-managed stress leads to better treatment outcomes and quality of life.   The discussion also provides practical coping tools, including the benefits of anti-anxiety medication, the Stoplight Meditation technique, and the power of "sitting in the discomfort" of fear to diminish its long-term power. Finally, they advocate for making mental health resources, like an oncology psychiatrist, an automatic part of the patient's care pathway, rather than an added burden for the patient to seek out.   Key Takeaways Stress Does NOT Cause Cancer Manage Distress for Better Outcomes Anxiety is Normal, Medication is a Tool Practice "Sitting in the Discomfort" Advocate for Automatic Mental Health Care   Chapters: (00:00) The Impact of Stress on Cancer (07:52) Debunking Myths: Stress and Cancer (18:09) The Role of Social Support (23:00) Coping Strategies and Personal Insights (30:43) Living with Cancer: The Emotional Toll (41:19) The Role of Mental Health in Cancer Treatment (51:12) The Reality of Cancer Diagnosis and Treatment (56:08) The Importance of Mental Health Support (58:15) Final Thoughts and Takeaways   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In the conclusion of this vital two-part series, host Dr. Kyle Concannon, Dr. Allie Mungo (Thoracic Surgeon), and post-operative patient advocate Samantha Murrell delve into the risks, recovery, and long-term rationale for surgical resections in Stage IV cancer patients. Dr. Mungo details the different lung surgeries (wedge, segmentectomy, lobectomy, pneumonectomy) and the critical surgical complexities, including the "stickiness" caused by pre-surgical systemic therapies and the danger of operating close to major heart vessels. Samantha shares her candid, non-trivial recovery experience, highlighting the challenge of managing post-operative nerve pain and the emotional "slap in the face" of being reminded of her Stage IV diagnosis. The discussion reinforces that for highly selected, medically fit patients with tumors responsive to modern targeted therapies, the goal of surgery is not a cure, but rather a powerful step in transforming cancer into a chronic, manageable disease. This episode provides indispensable guidance on patient selection, recovery expectations, and the importance of multidisciplinary care at high-volume centers. Key Takeaways Size of Surgery Matters for Quality of Life The Surgical Risks are Real Recovery Requires Pushing and Patience Targeted Therapy is the Game Changer Go to the Experts   Chapters: (00:00) Surgical Procedures for Stage Four Cancer (06:12) Travel Considerations for Surgery (13:35) Second Opinions and Surgery Decisions (20:42) Air Leak Incident (27:16) Surgical Complications (36:19) Future of Cancer Treatment (38:32) Conclusion and Resources   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this riveting first part of a two-episode series, host Dr. Kyle Concannon, a medical oncologist, is joined in person by Dr. Allie Mungo, a thoracic surgeon, and patient advocate Samantha Murrell, who is just two weeks post-surgery for her Stage IV HER2-mutated lung cancer. They dive into the controversial topic of consolidative surgery—surgically removing residual tumor in patients with metastatic (Stage IV) cancer. Samantha shares her personal journey, explaining how a remarkable response to targeted therapy—which rendered her PET scan active only at the primary tumor site—compelled her to "hunt down" a surgeon willing to take her case. Dr. Mungo outlines the factors that have rapidly changed the medical community's opinion on these once-taboo procedures. The discussion centers on the critical criteria for candidacy: having limited, actionable residual disease; the ability to safely remove the tumor without compromising quality of life (e.g., avoiding a full pneumonectomy); and the necessity of being in optimal physical condition to survive the recovery. This episode offers profound insight into the evolving, highly individualized decisions being made at the cutting edge of cancer care.   Key Takeaways: The Goal of Consolidative Surgery is Changing The Procedure is Not Considered Curative Candidacy is Highly Individualized Surgeries are Easier with Targeted Pills The Emotional Drive to Remove the "Mothership"   Chapters: (00:00) Samantha's Cancer Journey (06:08) Surgical Considerations and Challenges (15:24) Evolving Surgical Practices (22:50) Surgical Outcomes and Reflections (26:02) Targeted Therapy and Its Impact (31:26) Post-Surgery Recovery and Challenges (38:31) Criteria for Surgical Candidates (43:57) Conclusion and Final Thoughts   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this powerful episode of "Cracking Cancer," host Dr. Kyle Concannon sits down with co-host JJ Singleton, a colorectal cancer patient who has been undergoing continuous treatment for almost 10 years. JJ provides a raw, unfiltered look at the reality of treating cancer as a chronic disease, sharing his journey from a localized Stage II diagnosis to the devastating discovery of metastatic disease that required a decade of ongoing systemic therapy. JJ recounts the most challenging chapters of his life, including the initial despair of endless chemotherapy, the 14 months he spent confined to bed and reliant on TPN (total parenteral nutrition), and the internal struggle to find hope when all his treatment options were failing. He discusses the emotional hurdles of survivor's guilt, the challenges of invisible side effects (like neuropathy and skin pain), and the difficulty of maintaining a sense of self-worth when life deviates dramatically from expectations. JJ's story is a testament to human resilience and the transformative power of advocacy, revealing how he leveraged his suffering to create a meaningful life and become a vital voice for others. Key Takeaways Chronic Cancer is a Long Battle Chronic Disease is Not Always Stable The Emotional Burden of the "Hidden Curriculum" Advocacy as a Source of Purpose Don't Give Up Quality of Life   Chapters: (00:00) JJ Singleton's Cancer Journey Begins (04:51) Facing the Challenges of Chemotherapy (16:06) The Turning Point: Clinical Trials and Surgery (25:13) Rediscovering Life After Treatment (33:04) The Impact of Immunotherapy (42:48) Advocacy and Personal Growth (57:40) The Future of Cancer Treatment   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this revealing episode of "Cracking Cancer," host Dr. Kyle Concannon and co-host Samantha Murrell are joined by Kerry Wentworth, Chief Regulatory Officer at Nuvation Bio, to pull back the curtain on the pharmaceutical and biotech industry. Kerry, a veteran in the field, addresses the common perception that pharmaceutical companies are driven purely by financial metrics, stating that the primary mission is, in fact, patient-centered—to bring healthier, longer living to people. The conversation dives deep into the high-risk reality of drug development. Kerry explains why drugs cost billions: the price must account for the staggering 90% failure rate of investigational new drugs, extensive animal and human trials, and complex manufacturing. They demystify the clinical trial process, clarifying the phases, the rigorous site selection process, and dispelling the myth that physicians receive financial kickbacks for enrolling patients. This episode is a must-listen for anyone who wants an honest, science-driven understanding of the dedication, cost, and high-stakes nature of the work required to bring a new cancer therapy to market. Key Takeaways Mission is Patient-Driven, Not Just Financial Why Drugs Cost Billions The Clinical Trial Timeline Dispelling the Kickback Myth The Future is Chronic Care   Chapters (00:00) Understanding the Pharmaceutical Industry (08:08) The Role of a Chief Regulatory Officer (11:55) The Drug Development Process (17:19) Clinical Trials: Design and Execution (26:10) Phase One Trials and FDA Approval (35:15) Understanding Investigator Payments (42:16) Challenges in Cancer Vaccine Development (49:41) Mistrust in Pharmaceutical Companies (59:08) New Developments at Nueva Bio   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

Testicular cancer is the most common form of cancer in men aged 15-35, but nobody is talking about it! Until today that is. In this crucial episode of "Cracking Cancer," host Dr. Kyle Concannon is joined by Dr. Andrew Johns, a GU Cancer specialist from MD Anderson Cancer Center, and Jon Fox, a testicular cancer survivor. They tackle the vital topic of testicular cancer, shedding light on its biology, treatment, and remarkably high survival rates. Dr. Johns explains that the majority of cases are germ cell tumors and breaks down the staging and risk stratification (favorable, intermediate, and unfavorable), emphasizing that even with metastatic disease, long-term survival can be over 90% for favorable-risk cases. Guest Jon provides a raw, first-hand account of his fast-paced diagnosis—from noticing subtle pain to dealing with the ambiguity of his aggressive tumor subtype (Embryonal Carcinoma) and the resulting discrepancy in treatment recommendations (3 vs. 4 cycles of BEP chemotherapy). They discuss the standard workup, the significance of tumor markers, and the rigorous recovery required after major surgeries like the RPLND. This is essential listening for young men, their families, and anyone seeking clarity on a highly treatable yet highly aggressive disease. Key Takeaways Testicular Cancer is a Young Man's Disease Early Symptoms & Workup High Cure Rates, Even When Metastatic Complex Treatment Decisions Screening and Long-Term Monitoring   Chapters (00:00) Understanding Testicular Cancer (02:30) Signs and Symptoms of Testicular Cancer (04:07) John's Personal Experience with Testicular Cancer (07:22) Diagnosis and Initial Reactions (17:49) The Role of Tumor Markers (35:20) Understanding Testicular Cancer Survival Rates (43:31) The Importance of Accurate Staging (49:14) Chemotherapy Experience and Side Effects (53:43) Post-Chemotherapy Treatments and Surgery (01:10:50) Advice for Testicular Cancer Patients   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

In this crucial episode of "Cracking Cancer," host Dr. Kyle Concannon and patient advocate Samantha Murrell delve into Antibody Drug Conjugates (ADCs), a revolutionary class of targeted therapy. Samantha, who was treated with an ADC for her HER2 non-small cell lung cancer, shares her real-time experience with the drug's potent effects and cumulative side effects. Dr. Concannon explains the sophisticated engineering behind ADCs: an antibody (the "key") is chemically linked to a highly toxic chemotherapy payload (the "bomb"). The goal is to specifically target cancer cells, providing the power of chemotherapy with fewer systemic side effects. The discussion covers the mechanism of action, the risks of "on-target, off-tumor" effects (hitting healthy cells with the same target), and drug "leakage" into the bloodstream, which is responsible for common side effects like nausea, fatigue, and hair loss.  This episode is a must-listen for anyone starting an ADC regimen, offering candid advice on managing side effects, the importance of open communication with your care team, and the power of patient support groups.   Key Takeaways: What is an ADC? Antibodies are the key to specificity. Side effects are still a reality. Cumulative toxicity may require a break. ADCs are pioneering new treatments.   Chapters: (00:00) Understanding Antibody Drug Conjugates (ADCs) (05:19) Antibodies and Their Specificity (12:21) Challenges and Side Effects of ADCs (17:06) Managing Side Effects and Treatment Breaks (31:16) Understanding Drug Half-Life (39:02) Managing Side Effects and Toxicities (48:35) Future of ADCs in Cancer Treatment (55:55) Advice for Patients Starting ADCs   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos  

In this essential episode of "Cracking Cancer," host Dr. Kyle Concannon, a physician scientist and medical oncologist, sits down with patient advocate Samantha Murrell to demystify the role of the medical oncologist and how they fit into a patient's care journey. They clarify the distinct but collaborative roles of medical, surgical, and radiation oncologists. Dr. Concannon provides an honest, behind-the-scenes look at the high-stakes world of oncology, from the personal preparation required for a first patient meeting to the emotional toll of difficult end-of-treatment conversations. He discusses the inner workings of the Tumor Board, the realities of clinical trials (including the inherent biases), and the challenges providers face when patients pursue alternative therapies. This episode is crucial for any patient seeking clarity on who their providers are, what they do, and how to best advocate for their personalized care plan.   Key Takeaways: The Three Primary Oncology Roles The Medical Oncologist is not a Gatekeeper The Purpose of a Tumor Board Second Opinions are Encouraged The Ethical Challenge of Alternative Therapies   Chapters: (00:00) Introduction to Cracking Cancer (03:43) Training Pathways for Oncology Specialists (08:09) Patient Care and Oncologist Collaboration (19:31) The Importance of Second Opinions (27:31) Alternative Therapies and Supplements (33:38) Understanding Tumor Boards (39:26) The Role of Clinical Trials in Oncology (53:23) Emotional Impact on Oncologists   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode, Dr. Lauren Groner, a Cardiothoracic Radiologist and Health Services Researcher, demystifies the field of radiology and its critical, often unseen, role in oncology. Dr. Groner breaks down the differences between Diagnostic and Interventional Radiologists, explaining how the former interprets complex images (CT, MRI, PET, X-rays) to diagnose and stage disease, while the latter performs minimally invasive, image-guided treatments. Dr. Groner offers a rare glimpse into the daily life of a diagnostic radiologist, detailing their extensive medical training and the highly specialized nature of their work. She explains how radiologists act as "little detectives," synthesizing imaging findings with a patient’s full clinical history to narrow down a diagnosis and guide treatment. The discussion also explores the future of the field, highlighting exciting advances in AI, rapid imaging technology, and opportunistic screening that are transforming patient care.    Key Takeaways: Diagnostic vs. Interventional Radiologists Radiologists are Physicians A Report is a Detective Story The Power of Opportunistic Screening Communicate with Your Radiologist   Chapters (00:00) Introduction to Radiology (04:40) Radiology Reports and Clinical Decision Making (11:26) Radiology in the Post-COVID Era (20:49) Interacting with Patients and Providers (44:26) Challenges and Responsibilities in Radiology (54:33) The Importance of Radiologists   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this timely episode of "Cracking Cancer," host Dr. Kyle Concannon, a physician scientist, speaks with patient advocate Ashley Holt about the challenges of navigating new, aggressive cancer surveillance technologies. Ashley, a survivor of Stage I non-small cell lung cancer with a ROS1 mutation, chose to go beyond the standard of care by incorporating the Signatera circulating tumor DNA (ctDNA) blood test into her post-lobectomy monitoring. Ashley shares her intense, real-time experience after her third ctDNA test came back positive despite all her conventional CT scans and a follow-up PET scan being normal. This outcome catapulted her into an "evidence-free zone," a state of profound anxiety and confusion where she must make critical treatment decisions—such as whether to start a lifelong targeted therapy—without clear medical consensus or established guidelines. The conversation explores the ethical and emotional trade-offs of aggressive surveillance: the benefit of detecting potential recurrence earlier versus the harm of provoking intense anxiety and forcing patients to choose a path with no definitive right answer. This is essential listening for any patient considering advanced monitoring or struggling to reconcile standard medical guidelines with the flood of new, but unvalidated, technologies.   Key Takeaways The Unintended Consequences of Aggressive Surveillance The ctDNA Challenge Shared Decision-Making is Imperfect "Standard of Care" is Often the Best Care Ask the Right Questions Upfront   Chapters: (00:00) Navigating Post-Surgery Surveillance (05:23) The Emotional Impact of Positive Test Results (13:08) The Role of Clinical Trials and Guidelines (20:41) Balancing Surveillance and Quality of Life (30:29) Navigating Mental Health Amidst Cancer Uncertainty (36:10) The Importance of Genetic Testing (47:30) Empowering Patients in Their Cancer Journey (59:25) Final Thoughts and Advocacy   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this deeply personal episode of "Cracking Cancer," host Dr. Kyle Concannon and guest Sara Sandoval, a stage four metastatic breast cancer patient, explore the rarely discussed intersection of faith and a cancer diagnosis. Sara shares her journey of turning to her Catholic faith after her diagnosis, finding solace, strength, and a sense of control in an otherwise chaotic and frightening reality. This conversation is not about religious doctrine but about the human experience of grappling with a life-altering illness. Sarah and Dr. Concannon discuss the difficult question of "why me?" and the emotional struggle of facing a disease that feels outside of one's control.  This episode is a raw, honest, and moving exploration of how spirituality and faith can provide a powerful source of comfort and purpose, helping people not just survive, but truly live during their cancer journey.   Key Takeaways: Faith as a Source of Control The Power of Prayer Spirituality Beyond the Church Mindset is a Choice Leveraging Suffering for Good   Chapters: (00:00) Meet Sara Sandoval: A Stage Four Cancer Patient (03:38) The Power of Prayer in Coping with Cancer (25:59) Signs and Symbols: Finding Comfort in Faith (30:23) Community Support in Religious Groups (36:33) Faith and Coping with Cancer (51:46) Belief in the Afterlife (01:05:14) Conclusion and Final Thoughts   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Navigating a cancer diagnosis often means a barrage of medical terms and images that can be confusing and frightening. In this powerful episode of "Cracking Cancer," host Dr. Kyle Concannon sits down with guests Heidi Onda, a lung cancer survivor and founder of the White Ribbon Project, and Dr. Lauren Groner, a cardiothoracic radiologist, to demystify the world of medical scans. Heidi shares her personal experience with "scanxiety"—the intense emotional toll of waiting for scan results—and offers practical coping mechanisms. Dr. Groner provides a rare, behind-the-scenes look into the radiologist's process, breaking down the different types of scans (CT, PET, MRI), explaining the terminology in a patient-friendly way, and revealing the human judgment behind every report. The discussion reveals why a patient's self-advocacy and a trusting relationship with their care team are crucial for navigating a healthcare system that, despite its best intentions, can be slow and overwhelming. This episode is a must-listen for anyone who wants to regain a sense of control and hope during their cancer journey by better understanding the tests that guide their care.   Key Takeaways Understanding "Scanxiety" Radiology is more than just a picture The terminology in a report has meaning Advocate for yourself You're on the same team   Chapters: (00:00) Introduction to Cracking Cancer (02:37) The Importance of Scans in Oncology (15:55) The Radiologist's Perspective (20:26) Reading and Understanding Your Scan Report (28:13) Common Terminology and Misconceptions (37:49) Heidi's Personal Experience with Scans (43:51) Understanding Radiology Reports (01:04:18) The White Ribbon Project (01:06:07) Lung Cancer Screening and Resources   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode of "Cracking Cancer,"  Sara Sandoval, a stage four triple-positive metastatic breast cancer patient, and Whitney Lewis, an oncology pharmacist, provide an intimate and transparent look at taxane chemotherapies, a class of drugs commonly used in many cancer treatments. Sarah shares her personal experience, offering a patient's perspective on the physical and emotional realities of treatment, from the initial shock of diagnosis to her unique experience of feeling better almost immediately after starting chemotherapy. Whitney provides her expert insight, explaining the science behind how taxanes work, why they're so widely used, and the differences between various formulations like paclitaxel and docetaxel. The conversation addresses common side effects like hair loss and neuropathy, and both guests offer invaluable advice on managing these challenges, from practical tips for finding wigs and using cold caps to the crucial importance of open communication with your care team. This episode is a powerful and empowering guide for anyone facing a cancer diagnosis, providing clarity and hope by revealing that with the right knowledge and mindset, you can live a full life, even during treatment.   Chapters: (00:00) Introduction to Cracking Cancer (04:33) Pharmacist's Perspective on Taxanes (14:14) Dosing Regimens and Side Effects (20:11) Sarah's Journey and Hair Loss (34:19) Navigating Wig Options (44:21) Medications to Manage Side Effects (01:00:40) Managing Neuropathy (01:08:56) Final Advice and Encouragement   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Lung Cancer Screening: Why You Should Get Checked and the Hope That Follows In this episode of "Cracking Cancer," Dr. Kyle Concannon, and guests, Dr. Lauren Groner, and seven-year lung cancer survivor Heidi Onda, tackle a critical public health issue: lung cancer screening. They explore the current guidelines for who should be screened, the science behind the low-dose lung CT, and the significant barriers—from patient anxiety to provider education—that prevent more people from getting this life-saving test. Dr. Groner, a cardiothoracic radiologist, demystifies the screening process, addressing common fears about radiation and false positives. Heidi Onda, founder of the White Ribbon Project, shares her powerful personal story as a non-smoker diagnosed with late-stage lung cancer, highlighting the urgent need to change public perception and eliminate the stigma associated with the disease. The discussion reveals the dramatic progress in lung cancer treatment and how early detection is the single greatest tool for improving outcomes and achieving cures. This episode is an essential listen for anyone who has ever wondered about lung cancer risk, the importance of screening, and the powerful role of patient advocacy in driving medical change.   Key Takeaways Who is eligible for lung cancer screening? The low-dose lung CT is safe and effective. Changing the narrative is critical. Screening rates are alarmingly low. Don't be afraid not to get screened.   Chapters (00:00) Introduction to Cracking Cancer (00:22) Meet the Guests (03:05) Understanding Low Dose Lung CT Screening (07:23) Eligibility Criteria for Lung Cancer Screening (14:33) Barriers to Screening Adoption (30:06) Understanding Screening Statistics and Impact (40:46) Insurance Coverage and Cost Considerations (48:23) Future of Lung Cancer Screening (57:54) Final Advice and Closing Thoughts      The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Welcome to a powerful new episode of "Cracking Cancer," where hosts Dr. Kyle Concannon and patient advocate Samantha Murrell pull back the curtain on the complex world of cancer research. In this candid discussion, they tackle the fundamental questions you've always wanted to ask: Who are the key players in cancer research? How is it funded, and why does it feel like progress is so slow? From the "bench" in the lab to the "bedside" in the clinic, this episode explores the often-misunderstood journey of a potential cancer treatment. They demystify everything from government and pharmaceutical funding to the difference between basic science and clinical trials.   👨‍⚕️Dr. Concannon provides a rare, inside look into the day-to-day realities of a physician-scientist's lab, revealing the immense costs, endless hours, and high-stakes decisions that shape the future of oncology. 🎗️Samantha offers her invaluable perspective as a patient, highlighting the emotional and systemic barriers that the community faces.   This episode is a must-listen for anyone seeking to understand the inner workings of the cancer industry, the real reason behind a drug's long development, and how patient advocacy is a critical driver of hope and progress.   Key Takeaways: Who funds cancer research? The biggest barrier to progress is cost. A "promising" idea is a big risk. The difference between mice and humans. Patient advocacy is crucial.   Chapters (00:00) Introduction to Cracking Cancer (02:16) Major Players in Cancer Research (08:23) The Role of Funding in Cancer Research (13:54) Challenges and Costs in Cancer Research (23:21) Evaluating Promising Cancer Therapies (30:00) The Complexity of Cancer Research Trials (40:30) Challenges in Clinical Trials (50:10) The Role of Mice in Cancer Research (58:38) Funding and Financial Risks in Cancer Research (01:10:27) Concluding Thoughts and Future Directions   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode, Dr. Kyle Concannon and patient advocate Samantha Murrell dive deep into lung cancer. They discuss the basics of lung cancer, how it forms, common misconceptions, and the differences between small cell and non-small cell lung cancers. They also cover the symptoms and signs of lung cancer, how it is diagnosed, the importance of molecular testing, and various treatment options, including chemotherapy, immunotherapy, targeted therapies, and more. This comprehensive discussion aims to bring clarity, hope, and practical information to anyone affected by lung cancer.   Chapters (00:00) Introduction to Cracking Cancer (01:42) How Lung Cancer Forms and Spreads (04:40) Lung Nodules: What They Mean and When to Worry (07:17) Primary Tumors in the Lungs: Size and Spread (11:33) Types of Lung Cancer: Small Cell vs. Non-Small Cell (23:04) Symptoms and Signs of Lung Cancer (34:40) Diagnosing Lung Cancer: Scans and Biopsies (58:13) Exploring Treatment Options (01:08:44) Conclusion and Next Steps   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode of Cracking Cancer, host Dr. Kyle Concannon is joined by Heidi Onda, a lung cancer survivor and founder of The White Ribbon Project. After going to the doctor with concerns of ovarian cancer, Heidi's world was rocked when they instead found Stage 3 Lung Cancer. Looking for support in the Lung Cancer community, Heidi was shocked to find the community lacked key representation, and a symbol to flock around within the medical community.   Today, they discuss Heidi's journey from diagnosis to advocacy, the creation and growth of The White Ribbon Project, and how it aims to provide support and raise awareness for lung cancer patients. Heidi shares her personal story, the challenges of battling lung cancer stigma, and the importance of community, collaboration, and advocacy in improving outcomes for all affected by the disease. Hear about the impact of grassroots movements and learn how to get involved in creating positive change in the cancer community.   Chapters (00:00) Introduction to Cracking Cancer (01:32) The Shocking Diagnosis and Initial Reactions (08:55) The Birth of the White Ribbon Project (12:43) Challenges and Triumphs in Advocacy (20:54) Building a Supportive Community (26:27) Personal Reflections and Future Hopes (34:02) Pharmaceutical Donations and Stigma (38:40) The Role of Celebrities and Media (42:02) Fundraising and 501(c)(3) Status (53:21) The White Ribbon Project's Mission (01:02:11) Conclusion and Final Thoughts   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Dr. Kyle Concannon, joined by co-host JJ Singleton, dives deep into the sensitive topic of male fertility affected by cancer treatments. Joined by Dr. Cathy Ang, a medical oncologist from Vanderbilt Ingram Cancer Center, and colorectal cancer survivor JJ Singleton, they discuss the often-overlooked issue of fertility planning for cancer patients. JJ shares his personal journey and the emotional and financial barriers he faced, while Dr. Ang provides insights into the clinical side of male fertility preservation. Tune in for an honest and informative discussion aimed at empowering cancer patients and breaking stigmas around male fertility.   Chapters (00:00) Introduction to Cracking Cancer (01:44) The Importance of Discussing Male Fertility (05:47) The Emotional Impact of Fertility Issues (09:48) Medical Perspectives on Fertility and Cancer Treatment (17:38) Challenges in Addressing Male Fertility (21:59) Mental Health and Coping Strategies (27:48) Challenges in Discussing Sperm Banking (38:19) Financial and Emotional Hurdles (43:22) Barriers and Solutions in Oncology Clinics (48:51) Final Thoughts and Advice   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

When you hear that someone is being treated for cancer, the immediate thought can often be about chemotherapy, and the horror story that you've heard so many times. Nausea, sores, suffering, all in hopes to live. In this episode, we dive into platinum-based chemotherapy with insights from clinical pharmacist Whitney Lewis and lung cancer patient advocate Samantha Murell. You'll learn about the function, history, and impact of platinum chemotherapy, including cisplatin, carboplatin, and oxaliplatin. Discover common side effects, coping strategies, and real-world experiences from someone who's been through the treatment. Join us as we demystify chemotherapy, discuss supplement interactions, and offer vital advice for those beginning their cancer treatment journey.   Chapters (00:00) Introduction to Cracking Cancer (01:17) Understanding Platinum Chemotherapy (04:51) Patient Experience and Common Questions (14:02) Types of Platinum Chemotherapy (19:09) Side Effects and Management (39:42) Understanding Chemotherapy's Impact on the Immune System (44:24) The Importance of Communication with Your Care Team (56:32) Addressing Misconceptions and Best Practices (01:19:19) Conclusion and Closing Remarks   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

With over 1.3 million U.S. citizens alone being in the military, it is without a doubt a number of them will inevitably be faced with a cancer diagnosis during their active status. Today, we speak with Commander Bill Phillips, a retired military aviator, and co-host Samantha, a military spouse, to disucss the unique challenges faced by cancer patients in the military.   The discussion focuses on how a military mindset can help in preparing and proceeding through cancer treatment. Learn about the emotional and logistical hurdles, the value of peer support, and practical advice for military personnel and their families dealing with cancer. Discover how to adapt, overcome, and find purpose even in the face of such a daunting diagnosis.   Chapters (00:00) Introduction to Cracking Cancer (02:04) Bill's Experience with Military Healthcare (04:55) Navigating Delays and Challenges (12:46) Samantha's Story and Military Support (20:46) Finding Purpose and Advocacy (29:32) Support Systems and Resources (36:11) Impact on Military Careers (41:37) The Importance of Adaptability and Resilience (54:03) The Role of Coaching in Cancer Care (01:04:18) Resources for Military Families Facing Cancer   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Joined by prostate cancer patient Tim Fitzgerald and medical oncologist Dr. Justin Lebenthal, Dr. Kyle Concannon discusses the complexities of prostate cancer and dives into the general community perception that prostate cancer is not a "big deal".   Dr. Lebenthal explains the basics of prostate cancer, the function of the prostate, and the importance of PSA screening. Tim Fitzgerald shares his personal journey, from diagnosis to treatment and ongoing management, including the impact on his daily life and mental health. They discuss the challenges of living with prostate cancer, the pros and cons of various treatments, and the importance of maintaining quality of life. The episode also touches on the advancements in prostate cancer treatment and the role of AI in improving diagnosis and management.   To hear more about Tim's journey with prostate cancer, check out his own podcast here.   Chapters (00:00) Introduction to Cracking Cancer (01:48) Understanding Prostate Cancer (04:48) Tim Fitzgerald's Prostate Cancer Journey (10:01) The Emotional and Psychological Impact of Cancer (21:13) The Importance of Early Detection and PSA Testing (29:41) Prostate Cancer Staging and Treatment Options (38:29) A Life-Changing Call (42:09) Challenges of Chemotherapy (50:18) Screening and Overdiagnosis (55:33) Living with Prostate Cancer (01:14:10) Final Thoughts and Support Networks   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Dr. Kyle Concannon engages in an insightful conversation with cancer patients JJ Singleton and Bill Phillips about how men uniquely experience cancer. Covering topics such as personal identity, coping mechanisms, and the impact on masculinity, this discussion delves into the emotional and psychological challenges faced by men during their cancer journey.   The episode also highlights the transformative work being done by the KFG Project, a nonprofit founded by Bill Phillips, aimed at providing professional support to patients and caregivers. Tune in to hear real stories, practical advice, and life-changing perspectives.   Want to learn more about Bill's KFG project? Home | KFG Project   Chapters (00:00) Introduction to Cracking Cancer (04:00) Bill's Story: Shock and Coping Mechanisms (07:17) The Male Experience: Resilience and Vulnerability (10:18) Compartmentalization: Coping Strategies (22:32) Finding Purpose: The KFG Project (42:40) The Mental and Physical Connection (49:19) Incontinence and Radiation Side Effects (01:14:11) The Importance of Open Dialogue (01:22:04) Introducing the KFG Project (01:28:12) Final Thoughts and Closing Remarks   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode, we delve into the complex topic of cancer remission. What does 'remission' really mean? How does it differ across different stages of cancer? Dr. Concannon and Samantha discuss their experiences and provide insights into the terminologies like complete response, partial response, stable disease, and no evidence of disease (NED).   We also tackle the emotional rollercoaster that comes with scans and tumor monitoring, while debunking common misconceptions around alternative therapies. Whether you're a patient, caregiver, or curious learner, this episode aims to bring clarity and hope in navigating the fight against cancer. For more information, visit crackingcancer.org.   Chapters (00:00) Introduction to Cracking Cancer (06:46) Complete Response vs. Partial Response (15:15) The Reality of Stable Disease (21:04) The Concept of Cancer 'Sleeping' (30:56) Understanding Treatment Timelines (35:59) The Role of the Immune System (42:04) Emotional Rollercoaster of Monitoring (47:50) Misconceptions About Remission (51:20) Caution with Alternative Therapies (59:09) Final Thoughts and Advice   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Dr. Kyle Concannon dives into the intricate world of pulmonary nodules with real patient Ashley Holt and pulmonologist Dr. Alex Dragnich. They talk about the essential questions to ask after a nodule is detected, the diagnostic processes involved, and the emotional journey of discovering and treating potential lung cancer.   Ashley shares her personal experience from an incidental finding to undergoing a lobectomy, while Dr. Dragnich explains what a pulmonary nodule is, the likelihood of it being cancerous, and the importance of monitoring and second opinions. This episode offers invaluable insights into empowering oneself with information and advocating for better care in the fight against cancer.   Chapters: (00:00) Introduction to Cracking Cancer (04:06) Understanding Pulmonary Nodules (09:11) Risk Factors and Monitoring Lung Nodules (28:42) Biopsy Procedures and Risks (37:00) Understanding Cancer Risk in Lung Nodules (41:47) Diagnosis and Initial Reactions (51:05) Surgical Interventions and Recovery (58:29) The Importance of Second Opinions (01:04:49) Final Thoughts and Advice for Patients   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

Today's episode features JJ Singleton, a resilient cancer survivor and member of the Cracking Cancer team, sharing his emotional journey from diagnosis to treatment and beyond. JJ discusses the mental and physical struggles he faced, the significance of milestones, the impact of community and mental health support, and his dedication to advocacy. Learn about the complexities of coping with a cancer diagnosis, the evolution of JJ's mindset, and the importance of finding purpose in the fight against cancer. Perhaps the most important lesson JJ has learned: needing support and community doesn't equal weakness.     Chapters:   (00:00) Introduction to Cracking Cancer (01:10) The Initial Diagnosis: A Life-Changing Moment (05:57) Surgery and Recovery: A Turning Point (16:18) Chemotherapy: The Mental and Physical Struggle (21:22) The Cancer Returns: A Darker Chapter (30:30) Hitting Rock Bottom (37:03) The Role of Family and Support (47:04) The Power of Advocacy and Community (50:00) Balancing Positivity and Negativity (57:56) Spirituality and Personal Growth (01:02:23) Conclusion and Final Thoughts   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License   X: (1) Cracking Cancer Podcast (@Cracking_Cancer) / X IG: Cracking Cancer (@crackingcancerpodcast) • Instagram photos and videos

In this episode of Cracking Cancer we are talking with Yvonne Diaz, a stage four ALK positive lung cancer patient and a dedicated advocate. She discusses the importance of patient advocacy in the cancer community, how patients can drive positive change, and the integration of patient perspectives into cancer research.   Yvonne shares her journey into advocacy, the challenges she faced, and how she contributes to advancing cancer research and patient empowerment through organizations like ALK Positive Inc. and Oncogene Cancer Research. Tune in to learn how patient involvement is crucial in shaping the future of cancer care.   To learn more about Yvonne's advocacy, visit Oncogene Cancer Research   Chapters: (00:00) Introduction to Cracking Cancer (01:46) Yvonne's Advocacy Journey: From Diagnosis to Action (04:09) Advancing Cancer Research Through Advocacy (12:36) Challenges and Barriers in Cancer Research (16:16) Empowering Patients to Participate in Research (28:06) Navigating Patient Advocacy and Research Organizations (32:12) Empowering Through Connection (36:07) Challenges and Rewards of Pharma Collaboration (43:18) Clinical Trials and Patient Involvement (50:43) Educating and Empowering Patients (58:01) Current Initiatives and Future Goals   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Dr. Kyle Concannon and Co-Host Samantha delve into the crucial topic of how best to support loved ones who have cancer. Supporting loved ones with cancer is an obvious thing to do, and yet subtly complicated. They discuss the subtle dynamics of offering meaningful support. From understanding the importance of asking 'How can I help you?' to practical suggestions like setting up a meal train, joining patients at appointments, and providing thoughtful care packages. They also explore the emotional challenges both patients and their supporters face, and emphasize the significance of continuous support beyond initial diagnosis. Tune in to learn how we can all bring clarity, hope, and action to those navigating their cancer journey.   Chapters: (00:00) Welcome to Cracking Cancer (02:43) Practical Ways to Offer Support (11:40) Navigating Appointments and Infusions (23:20) Effective Communication and Offering Help (30:49) Supporting Newly Diagnosed Patients (34:44) The Impact of Simple Gestures (40:54) The Importance of Practical Help (45:10) Thoughtful Care Packages (51:21) Long-Term Support for Cancer Patients (58:07) Concluding Thoughts and Gratitude   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Demystifying Immunotherapy: Hope and Reality in Cancer Treatment In this episode Dr. Kyle Concannon sits down with Dr. Natalie Vokes, a thoracic oncologist and immunotherapy expert, and JJ Singleton, a 10 year colorectal cancer patient. They dive deep into "What is Immunotherapy?", exploring its mechanisms, benefits, and challenges directly from patients and world experts. Learn how immunotherapy differs from traditional chemotherapy, what to expect from treatment, and why it offers unprecedented hope for many.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer (12:10) Patient Experience with Immunotherapy (20:51) Biomarkers and Personalized Treatment (30:03) Community Insights and Advocacy (36:39) Finding Support in the Cancer Community (43:28) Understanding Immunotherapy Resistance (01:03:31) Conclusion and Final Thoughts   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Dr. Concannon and co-host Samantha are diving into the often confusing and difficult world of cancer and oncology treatments within social media. They discuss the credibility of various cancer-related reels, the emotional toll of conflicting information, and the importance of evidence-based treatment. Samantha shares her personal experiences with social media recommendations and alternative therapies, stressing the need for reliable guidance. Dr. Concannon offers insights into interpreting medical studies and the challenges in distinguishing credible information from misleading claims. Join us as we explore the intersection of cancer treatment, patient advocacy, and social media.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer (01:35) Navigating Misinformation and Anecdotal Evidence (12:59) The Pressure of Alternative Therapies (17:27) Financial and Emotional Costs of Cancer Treatments (20:09) Debunking Cancer Cure Myths (28:54) Introduction to Mouse Models in Cancer Research (33:05) Interpreting Preclinical Studies (40:09) The Role of Integrative Oncology (47:12) The Guilt and Pressure of Cancer Treatment Choices (52:30) Monetary Gain and False Hope in Cancer Cures (58:01) Conclusion and Final Thoughts   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

What Is Colon Cancer? A Deep Dive with Experts & Patients Colon cancer is often misunderstood—but we're here to change that. In this episode of Cracking Cancer, Dr. Kyle Concannon is joined by Dr. Mark Lewis, an oncologist and cancer survivor, along with patient advocate JJ Singleton, who shares his powerful journey. Together, they break down what colon cancer is, how it forms, and the latest advancements in treatment. From personal insights to cutting-edge medical knowledge, this episode is packed with real talk, expert advice, and hope. Hit play to learn what you need to know, whether you're newly diagnosed, supporting a loved one, or simply seeking knowledge.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer (01:47) Understanding the Colon and Its Functions (03:49) Causes and Risk Factors of Colon Cancer (06:13) The Role of Diet and Polyps in Colon Cancer (09:37) The Importance of Colonoscopy (16:14) How Colon Cancer Develops at the Cellular Level (24:18) Understanding Colon Cancer Metastasis (27:32) Personal Diagnosis Journey: JJ's Story (35:57) Navigating Chemotherapy: Tips and Experiences (45:42) The Future of Cancer Treatment: Immunotherapy and Beyond (50:49) Final Thoughts and Closing Remarks   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

In this episode, Dr. Kyle Concannon and co-host Samantha Murrell are joined by oncologist Dr. Ben Fangman to discuss the differences between community and academic oncology, or in simpler terms, research hospitals vs. the traditional hospitals most people are accustomed to. Discover the unique challenges and benefits of each, and learn how to navigate your cancer care journey effectively. Whether you're a patient seeking clarity or a supporter wanting to understand more, this conversation is packed with valuable insights.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer (01:31) Community vs. Academic Oncology (06:50) Challenges in Community Oncology (12:57) Patient Experiences in Community and Academic Settings (18:46) Defining Community Oncology (28:31) Navigating Differing Oncologist Opinions (31:51) Clinical Trials: Options and Realities (38:34) Future of Community and Academic Oncology Collaboration (45:55) Patient Knowledge and Oncologist Interaction (59:23) Final Thoughts and Takeaways   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Today, the Cracking Cancer team is discussing the critical topic of what not to say to someone diagnosed with cancer. Obviously, a hard diagnosis for any patient, friends, families, and strangers alike can also find it hard to know what to say and when to say it for patients going through these troubling journeys. Dr. Concannon and Samantha explore common yet potentially harmful statements, why they can be hurtful, and how to navigate these delicate conversations. Whether you're a patient, a supporter, or simply here to learn, this episode aims to provide clarity, hope, and actionable guidance in the fight against cancer.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer (01:46) Samantha's Personal Experiences and Insights (05:24) The Impact of Positivity on Cancer (14:18) The Reality of Stage Four Cancer (26:13) Chemotherapy: Misconceptions and Realities (30:15) Facing the Reality of Indefinite Treatment (34:32) Navigating Social Media and Cancer (40:47) Misconceptions About Hair Loss and Cancer (45:07) The Pressure of Alternative Treatments (54:08) The Importance of Communication with Your Medical Team (58:45) Concluding Thoughts and Future Topics   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Your First Oncology Visit: What to Expect and How to Prepare   In this episode of Cracking Cancer, Dr. Concannon and Samantha Murrell, a patient advocate with stage four non-small cell lung cancer, discuss the essential aspects of the first oncology visit.   They tackle critical topics such as the emotional and logistical preparation, the importance of bringing medical records and support systems, understanding the diagnosis, and managing the waiting period before treatment begins.   Samantha shares her personal experiences and anxieties, while Dr. Concannon provides valuable insights into what patients can expect during this crucial first step in cancer care. Tune in to gain clarity, hope, and actionable advice for navigating the initial stages of cancer treatment.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer (03:39) Preparing for the First Oncology Appointment (12:59) Emotional Impact of the First Visit (18:49) Building a Strong Patient-Doctor Relationship (23:17) Essential Items to Bring to Your Oncology Visit (28:08) Understanding Different Types of Scans (31:04) Developing a Personalized Cancer Treatment Plan (34:35) Discussing Prognosis and Treatment Goals (38:19) The Waiting Period and Patient Advocacy (40:38) Balancing Urgency and Thoroughness in Cancer Care (46:12) Advocating for Timely Cancer Treatment (53:10) Final Thoughts and Takeaways   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

In this episode, Dr. Kyle Concannon, and Co-Host Samantha Murrell are taking a deeper dive into the complexities of metastasis, discussing what metastatic disease means, its implications for treatment, and how it varies across different types of cancer. Samantha shares her personal journey, shedding light on common misconceptions and the emotional toll of living with stage four cancer. Tune in to understand the biological processes behind metastasis, the importance of staging, and why stability in cancer treatment is worth celebrating!   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to Cracking Cancer Podcast (01:06) Understanding Metastasis: What Does It Mean? (04:30) Clarifying Misconceptions About Metastasis (11:48) The Biology of Cancer Spread (25:14) The Role of PET Scans in Cancer Diagnosis (30:38) Impact of Metastasis on Treatment Options (35:10) Understanding Cancer Symptoms and Treatments (38:12) Personal Experiences with Chemotherapy (47:55) The Significance of NED and Stability (56:32) The Future of Cancer Treatment (59:22) Conclusion and Final Thoughts   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Dr. Kyle Concannon and Co-Host Samantha Murrell talk all things chemotherapy in this episode of Cracking Cancer. They tackle common myths and misconceptions in the public sphere regarding chemo, and dive into Samantha's first-hand experiences battling Stage 4 Lung Cancer and receiving continuous chemotherapy infusions.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Welcome to Cracking Cancer (01:01) Diving into Chemotherapy (03:30) Common Misconceptions About Chemotherapy (07:17) Understanding How Chemotherapy Works (13:24) Preparing for the First Chemotherapy Infusion (18:39) Tips for a Better Chemotherapy Experience (24:08) Managing Side Effects of Chemotherapy (30:48) Understanding Chemotherapy Cycles (35:02) Individual Variations in Side Effects (40:57) Common Chemotherapy Side Effects (46:23) Addressing Immune System Concerns (55:48) Final Thoughts and Advice   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License

Understanding Cancer: From Diagnosis to Treatment and Support   In this very first episode of the Cracking Cancer podcast, Dr. Kyle Concannon, MD and patient advocate Samantha Murrell, focus on answering the fundamental question: 'What is cancer?' Dr. Concannon explains the basic biological ways that cancer works, including mutations and cell regulation, while Samantha shares her personal journey with stage four non-small cell lung cancer. The discussion covers the complexity and variability of cancer, the impact of lifestyle factors, the significance of molecular profiling, and the importance of early diagnosis and staging. Samantha emphasizes the emotional and social aspects of her cancer diagnosis and the invaluable support she has found within patient advocacy groups. The episode aims to empower listeners with crucial knowledge about cancer and provide a sense of community and support for those affected.   The Cracking Cancer Podcast's main focus is to further education about cancer and its effects on people and communities through continued discussion and to raise funds for the continued research of cancer treatments and positive outcomes. All raised proceeds go directly to the continued upkeep of this podcast and cancer research. To find out more about supporting the show and research endeavors, please go to the following website: www.crackingcancer.org   Chapters: (00:00) Introduction to the Cracking Cancer Podcast (01:28) Samantha's Personal Cancer Journey (04:29) The Complexity of Cancer Origins (17:18) Targetable Mutations and Treatment Options (29:30) The Affects of What We Eat on Cancer (45:42) The Emotional and Social Impact of Cancer (49:53) The Importance of Community and Support (57:02) Conclusion and Final Thoughts   Attributions The music track - Progression Pulse - is provided by Denys Brodovskyi through the Attribution 4.0 International License