The Lupus Forum

Professor Eric Morand and Doctor Kathryn Connelly discuss two recent studies advancing the treatment landscape in SLE and lupus nephritis. This episode discusses antimalarial use and extra-renal damage accrual in lupus nephritis, as well as autologous CD19 CAR T-cell therapy for paediatric and adult SLE. Through expert-led discussion, this podcast offers practical perspectives for clinicians looking to stay at the forefront of lupus care. To explore the full papers and download accompanying slide decks, visit the Lupus Forum. Stay up to date with the latest research and monthly podcast episodes through this free independent resource: https://lupus-forum.com/

Tune into this episode of our 'Guiding lupus clinical management' podcast series and hear from Professors Ed Vital, Liz Lightstone and Brad Rovin as they discuss ACR and EULAR guidance on renal manifestations of lupus and lupus nephritis, along with what that means in practice.

Professor Ed Vital and Professor Chris Edwards discuss two recent studies advancing the treatment landscape in SLE. This episode discusses S1PR1-mediated modulation of immune cell trafficking as a potential upstream therapeutic strategy in SLE, and the efficacy and safety of obinutuzumab when added to standard therapy in adults with active SLE. Through expert-led discussion, this podcast offers practical perspectives for clinicians looking to stay at the forefront of lupus care.

Professor Victoria Werth and Professor Chi-Chiu Mok discuss two recent studies advancing the treatment landscape in SLE and lupus nephritis. This episode reviews findings from the Phase 2 TULIP-LN trial, highlighting how anifrolumab treatment leads to rapid reductions in urinary biomarkers of intrarenal inflammation in lupus nephritis, and discusses a single-arm Phase 2 trial evaluating daratumumab in SLE. Through expert-led discussion, this podcast offers practical perspectives for clinicians looking to stay at the forefront of lupus care. To explore the full papers and download accompanying slide decks, visit the Lupus Forum. Stay up to date with the latest research and monthly podcast episodes through this free independent resource: https://lupus-forum.com/

Professor Victoria Werth and Doctor Guillermo J. Pons-Estel highlights the new treatment safety and efficacy and impact of mental health outcomes in SLE. This podcast discusses efficacy and safety of SC anifrolumab in SLE, and the associations between discrimination and PROs and the role of mental health in these associations among a multiracial, multiethnic cohort with SLE. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Professor Ed Vital discusses two key publications covered on the Lupus Forum in December. his podcast reviews data from a randomised, double-blind, placebo-controlled Phase Ib/IIa trial of the anti-CD38 monoclonal antibody CM313 in adults with systemic lupus erythematosus (SLE), focusing on safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy. The episode also examines predictors of damage accrual by organ domain in SLE, highlighting factors associated with long-term disease outcomes. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Professor Richard Furie and Doctor Guillermo J. Pons-Estel review two key publications covered on the Lupus Forum in November. This podcast reports data from a multicentre, randomised, double-blind, placebo-controlled trial evaluating low-dose belimumab in patients with systemic lupus erythematosus (SLE), with a focus on disease flare prevention. The episode also reports findings on the efficacy and safety of allogeneic CD19 CAR NK-cell therapy in SLE, based on a case series conducted in China in patients with mild disease activity. If you are interested in the papers discussed, head on over to the Lupus Forum today!

Professor Vibeke Strand highlights the emerging treatments in SLE and LN. This podcast reports the efficacy and safety results of a Phase 3 trial of telitacicept at a dose of 160mg weekly as compared with PBO in Chinese persons with active SLE. The efficacy and safety of SC secukinumab 300mg compared with PBO, in combination with the SoC, in patients with active LN is also reported. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professor Ed Vital, Dr Guillermo J. Pons-Estel, Professor Richard Furie and Professor Chris Edwards on the Lupus Forum for their discussion of the recent webinar “Early use of advanced therapies in lupus”. Watch them discuss key highlights from the webinar, including limitations of SoC, insights from clinical trials and strategies for early intervention with advanced therapies. Visit www.lupusforum.com to access the full webinar content, including detailed slide materials from Dr Guillermo J. Pons-Estel, Professor Richard Furie and Professor Chris Edwards.

Join Professors Ed Vital and Maria Dall'Era as they review their highlights of the recent ACR 2025 congress, watch them discuss their abstracts and highlight key information.

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 4 of ACR 2025 (Wednesday, October 29th).

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 3 of ACR 2025 (Tuesday, October 28th).

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 2 of ACR 2025 (Monday, October 27th).

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 1 of ACR 2025 (Sunday, October 26th).

Join Professor Chris Edwards and Doctor Alice Mason as they discuss EULAR recommendations for a core dataset in SLE and efficacy and safety of upadacitinib as a monotherapy or combination with elsubrutinib for SLE. This podcast provides a valuable framework for guiding therapeutic decisions in SLE, and also supporting clinical care, translational/observation research. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professors Ed Vital and Maria Dall'Era as they preview what they are most looking forward to this ACR, introducing some of the top abstracts and posters we’ve chosen so that you can better plan your time at what will be a busy and exciting congress.

Professor Eric Morand and Professor Rangi Kandane-Rathnayake discuss the therapeutic strategies and emerging treatments in SLE and LN. This podcast provides a valuable framework for guiding therapeutic decisions for rare SLE manifestations where the available recommendations might be insufficient or inapplicable. The efficacy, PK and safety of iscalimab versus placebo as add-on to SoC therapy in patients with biopsy-proven active proliferative LN is also reported. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professor Brad Rovin for an expert-led discussion focused on emerging therapies and renal outcomes in LN. This podcast will provide an overview of the effect of long-term voclosporin treatment on renal histology in patients with active LN with repeat renal biopsies, and explore how BCMA-targeted CAR T-cell therapy can effectively induce disease remission in refractory LN. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professors Ed Vital and Maria Dall’Era, and Doctor Guillermo J. Pons-Estel for an expert-led discussion focusing on the latest ACR 2025 SLE Guidelines. This podcast provides an overview of the latest treatment recommendations, as well as ungraded, consensus-based good practice statements that are applicable to children and adults with SLE. If you are interested in the paper discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professors Ed Vital and Michelle Kahlenberg as they delve into the role of the cGAS pathway in systemic lupus erythematosus (SLE). This engaging discussion covers the pathway’s relevance in disease, recent clinical trial updates on cGAS inhibitors, and their potential role in the future treatment of SLE.

Join Professor Ed Vital, and Doctors Reuben Benjamin, Chris Wincup, and Marc Scherlinger on the Lupus Forum in their discussion on the recent webinar “CAR-T and CAR-NK therapies: Are they the future of lupus treatment?”. Watch them discuss key highlights from the webinar including the potential of CAR-T and CAR-NK therapies as transformative treatments for lupus. Highlighting the mechanisms, applications, and the challenges of this treatment. Visit www.lupusforum.com to access the full webinar content, including detailed slide materials from Doctors Reuben Benjamin, Chris Wincup, and Marc Scherlinger.

Join Professors Ed Vital and Chris Edwards as they review their highlights of the recent EULAR 2025 congress, watch them discuss their abstracts and highlight key information.

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 4 of EULAR 2025 (Saturday, June 14).

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 3 of EULAR 2025 (Friday, June 13).

Our Steering Committee Member Professor Maria Dall’Era is joined by Professor Vibeke Strand in the latest Lupus Forum podcast. Together they discuss the efficacy of belimumab treatment in patients with SLE. They will also discuss the impact of long-term anifrolumab treatment on patients’ perceived health status and health-related quality of life. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professor Ed Vital as he summarises his top abstracts, posters, and presentations from Day 2 of EULAR 2025 (Thursday, June 12).

EULAR 2025 Highlights: Day 1 by The Lupus Forum

Join Professors Ed Vital and Chris Edwards as they preview what they are most looking forward to this EULAR, introducing some of the top abstracts and posters we’ve chosen so that you can better plan your time at what will be a busy and exciting congress.

Join Professors Ed Vital, Cynthia Aranow, Richard Furie, and Chris Edwards as they discuss the role of the JAK-STAT pathway, the emerging evidence of using JAK Inhibitors in clinical trials (SLEek trial), and the need for long-term data and the challenges faced.

Join Professors Liz Lightstone and Maria Dall’Era for an expert-led discussion focused on lupus nephritis, exploring its current standard of care, practical implementation in clinical settings, and evolving treatment landscape. This podcast will delve into the latest advances in the management of lupus nephritis, including emerging therapies such as obinutuzumab, and examine the future treatment pipeline.

Join Professors Ed Vital, Brad Rovin, Liz Lightstone, and Maria Dall'Era as they review the current standard of care, the recommended guidelines, and emerging therapies in lupus nephritis. With discussions outlining strategies to improve real-world challenges in the management and overall quality of life for these patients.

Discussing Lupus: Insights into belimumab and telitacicept in SLE by The Lupus Forum

Our Steering Committee experts Professor Victoria Werth and Chris Edwards join the latest Lupus Forum podcast to discuss the effect of belimumab vs placebo on mucocutaneous manifestations of SLE, and the long-term impact of anifrolumab vs placebo on LLDAS and DORIS attainment in patients with SLE. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Advances in SLE: Highlights Podcast by The Lupus Forum

Discussing Lupus: Belimumab vs telitacicept post-rituximab, efficacy & safety of obinutuzumab in LN by The Lupus Forum

Challenges in Lupus Nephritis Highlights Podcast by The Lupus Forum

Professor Vibeke Stand (Stanford University) and Professor Eric Morand (Monash University) join the latest Lupus Forum podcast to discuss LLDAS and remission in SLE patients with HDAS, as well as the latest APLAR treatment consensus for LN.. If you are interested in the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Steering Committee member Professor Maria Dall’Era, Professor of Medicine and Chief of the Division of Rheumatology at the of University of California, San Francisco, USA, is joined by fellow member Professor Brad Rovin, who is Lee A. Hebert Professor of Nephrology and Medical Director at Ohio State University Clinical Research Management Institute, Columbus, Ohio, on the latest Lupus Forum podcast. Together, they discuss the efficacy and safety of a voclosporin-based triple immunosuppressive regimen and summarise the latest ACR guidance to screen, treat, and manage lupus nephritis. If you are interested in the paper discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Steering Committee member Professor Victoria Werth, who is Chief of the Division of Dermatology at the Philadelphia Veterans Administration Hospital, Pennsylvania, USA, is joined by fellow member Professor Chi-Chiu Mok, who is Chief of the Division of Rheumatology, Department of Medicine, Tuen Mun Hospital, Hong Kong, on the latest Lupus Forum podcast. Together, they discuss the efficacy and safety of iberdomide in CLE, as well as the efficacy and safety of SGLT2i vs. DPP4i for the primary prevention of cardiovascular disease and renal events in SLE and comorbid type 2 diabetes. If you are interested in any of the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Lupus at ACR 2024: Review Podcast by The Lupus Forum

Lupus at ACR 2024: Preview Podcast by The Lupus Forum

ACR 2024 Highlights: Day 3 by The Lupus Forum

ACR 2024 Highlights: Day 2 by The Lupus Forum

ACR 2024 Highlights: Day 1 by The Lupus Forum

Steering Committee members Professor Ed Vital, who is a Professor in Autoimmune Connective Tissue Diseases and Honorary Consultant Rheumatologist, at Leeds Teaching Hospitals NHS Trust, UK, is joined by Professor Richard Furie, who is Chief of the Division of Rheumatology at the Department of Medicine, Northwell Health, New York, and Professor of Medicine at the Zucker School of Medicine at Hofstra/Northwell, and Professor Liz Lightstone, from the Imperial College Healthcare NHS Trust Renal and Transplant Centre, Hammersmith, London, on the latest Lupus Forum podcast. Together, they discuss defining ANA-associated arthritis and proposing new basket trial groupings, as well as evaluating the achievement of EULAR/ERA-EDTA treatment targets in lupus nephritis and the need for therapy adjustments. If you are interested in any of the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Steering Committee members Professor Chris Edwards from the University Hospital Southampton NHS Foundation Trust is joined by Professor Victoria Werth, from the Philadelphia Veterans Administration Hospital, Pennsylvania, USA on the latest Lupus Forum podcast. Together, they discuss the efficacy and safety of sequential therapy with subcutaneous belimumab and one cycle of rituximab in patients with SLE, as well as CD19-CAR T-cell therapy inducing B cell deep tissue depletion! If you are interested in any of the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Join Professors Ed Vital, Vibeke Strand, Laurent Arnaud, and Guillermo Pons-Estel as they unpack the key challenges of inequities of outcomes in lupus treatment. Providing an overview of social determinants of health in SLE, the impact of race and ancestry, and controlling disease in low and middle income country populations. You can view this video on our website here: https://lupus-forum.com/expert-live/4/rising-to-the-challenge-of-inequity-of-outcomes-in-lupus-treatment

Lupus Forum Chair Ed Vital, from the University of Leeds, is joined by Doctor Antony Psarras, an NIHR Academic Clinical Lecturer in Rheumatology at the University of Oxford and at the Kennedy Institute of Rheumatology. Together, they discuss the use of CD163 as a marker for diagnosis and flare in lupus nephritis. They also discuss the impact of discontinuing immunosuppression on the disease, in particular looking at novel research surrounding the predictors of flares, time to withdrawal and long-term outcomes. If you are interested in any of the papers discussed, head on over to the Lupus Forum today! Download our latest slide decks and stay up to date with our monthly podcasts, all through this free independent resource: https://lupus-forum.com/

Lupus Forum Chair Ed Vital, from the University of Leeds, is joined by Professor Vibeke Strand, Adjunct Clinical Professor at the Division of Immunology and Rheumatology at Stanford University School of Medicine in California. Together, they discuss the efficacy and safety of upadacitinib and elsubrutinib combination and monotherapy, as well as the association of LLDAS with improved outcomes in SLE.

Lupus Forum Chair Ed Vital, from the University of Leeds, is joined by Professor Vibeke Strand, Adjunct Clinical Professor at the Division of Immunology and Rheumatology at Stanford University School of Medicine in California. Together, they discuss predictors of belimumab renal response in lupus nephritis, and the efficacy and safety of telitacicept in SLE with haematological involvement.