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Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

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Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

Supported by a Wellcome Trust Public Engagement grant (2006-2008) in the History of Medicine to Professor Tilli Tansey (QMUL) and Professor Leslie Iversen (Oxford), the History of Modern Biomedicine Research Group at Queen Mary, University of London presents a series of podcasts on the history of neuroscience featuring eminent people in the field: From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ' endothelium-derived relaxing factor' (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulato

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  1. 24

    Growing up in Central America

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  2. 23

    Medical school and expulsion from El Salvador

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  3. 22

    Starting work in John Vanes laboratory, 1971

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  4. 21

    Prostaglandins and Aspirin the importance of bioassay

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  5. 20

    Group leader at Wellcome Research Laboratory

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  6. 19

    Blood platelet function - why aspirin causes bleeding

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  7. 18

    Discovering thromboxane synthase, and a new enzyme

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  8. 17

    The Prostacyclin Discovery

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  9. 16

    Homeostatic functioning of the blood vessel wall

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  10. 15

    Structure of prostacyclin, 1976: Nobel Prize, 1982

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  11. 14

    Discovery of EDRF (Endothelium Derived Relaxing Factor), 198

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  12. 13

    Discovering that EDRF is nitric oxide (NO), 1986

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  13. 12

    Measuring nitric oxide produced by endothelial cells

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  14. 11

    Determining how nitric oxide is made

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  15. 10

    The biochemical pathway of nitric oxide in the brain

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  16. 9

    Nobel Prize, 1998

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  17. 8

    Nitric oxide as regulator of blood pressure and blood flow

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  18. 7

    Nitric Oxide in pregnancy

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  19. 6

    Nitric oxide, erectile dysfunction and Viagra

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  20. 5

    Inflammation, rheumatoid arthritis and tissue damage

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  21. 4

    Septic shock

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  22. 3

    Mitochondria nitric oxide as modulator of oxygen consumption

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  23. 2

    Mitochondria new ideas about the way cells use energy sources

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

  24. 1

    Wellcome's important characteristics

    Today's Neuroscience, Tomorrow's History - Professor Salvador Moncada

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ABOUT THIS SHOW

Supported by a Wellcome Trust Public Engagement grant (2006-2008) in the History of Medicine to Professor Tilli Tansey (QMUL) and Professor Leslie Iversen (Oxford), the History of Modern Biomedicine Research Group at Queen Mary, University of London presents a series of podcasts on the history of neuroscience featuring eminent people in the field: From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ' endothelium-derived relaxing factor' (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulato

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Professor Salvador Moncada

Produced by Queen Mary, University of London

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