How eCLIP revolutionized RNA-based therapeutic research with Dr. Gene Yeo   

Welcome to RNA Insights, an RNA therapeutics podcast hosted by Eclipsebio. Each month, we interview a different expert in the field of RNA and RNA-based medicine about their career and thoughts on the ever-evolving RNA therapeutic space. On this inaugural episode, we talk with Dr. Gene Yeo, co-developer of the eCLIP protocol and co-founder of Eclipsebio, about his journey identifying the need for and developing a more efficient method of crosslinking immunoprecipitation that changed the ways scientists perform RNA research. Resources referenced in the episode: Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals: https://pubmed.ncbi.nlm.nih.gov/15285897/ Identification and analysis of alternative splicing events conserved in human and mouse: https://pubmed.ncbi.nlm.nih.gov/15708978/ Yeo Lab Publications: https://yeolab.com/publications  ENCODE Overview: https://www.encodeproject.org/help/project-overview/  Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP): https://www.nature.com/articles/nmeth.3810 Circio enters in vivo cell therapy evaluation agreement with Acuitas Therapeutics: https://www.circio.com/en/circio-enters-in-vivo-cell-therapy-evaluation-agreement-with-acuitas-therapeutics/ Afrigen Biologics Announces RSV mRNA Vaccine Collaboration: https://www.afrigen.co.za/news-press-release-events/ Immorna Announces First Evidence of Tissue B Cell Depletion with In Vivo CAR T JCXH 213 in Systemic Sclerosis Patient, Underscoring Platform’s Potential to Address Autoimmune Diseases: https://www.immornabio.com/News-details/41.html Music by Ievgen Poltavskyi from Pixabay Sound Effect by Ribhav Agrawal from Pixabay Hosted by Grace Finnell-Gudwien