Interleukin-1 Beta Connects Obesity to Aggressive Breast Cancer | IGF1s Role in Triple-Negative Breast Cancer Progression

In this episode of SciBud, we take a fascinating journey into the complex biology of triple-negative breast cancer (TNBC) and its relationship with obesity, centering on the pivotal role of interleukin-1 beta (IL-1β). Join Rowan as we unpack groundbreaking research that reveals how insulin-like growth factor 1 (IGF1)—often elevated in obese individuals—fuels the aggressiveness of TNBC by promoting cell proliferation and motility. Discover how IL-1β acts not only as a growth factor for tumors but also reprograms normal fibroblasts into cancer-associated fibroblasts (CAFs), creating a supportive environment for cancer progression. With a keen exploration of experimental methods and a critical evaluation of their strengths and weaknesses, this episode sheds light on potential therapeutic strategies that target these biological pathways. Tune in for an enlightening discussion on how understanding these interactions can pave the way for innovative treatments for patients battling these aggressive forms of cancer. Don't forget to subscribe to stay updated on the latest scientific breakthroughs! Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/36