Lead: Methadone Dose and Patient-Directed Discharge in Hospitalized Patients with Opioid Use Disorder

Methadone Dose and Patient-Directed Discharge in Hospitalized Patients with Opioid Use Disorder JAMA Network This retrospective observational cohort study of 554 individuals examined rates of patient-directed discharge (PDD) among hospitalized patients with opioid use disorder who received methadone during the first 72 hours of hospitalization from July 2019 to June 2022. Higher doses of methadone were associated with a decreased rate of PDD. For each additional 10 mg of methadone received in the first 24 hours, there was a decrease in odds of PDD at 48 hours (adjusted OR 0.71). This study highlights the importance of adequate treatment of opioid withdrawal to reduce the risk of PDD.   Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM