NEJM February 5,2026 Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction.

This meta-analysis investigated whether prescribing beta-blockersprovides any clinical benefit to heart attack survivors who maintain a normal ejection fraction, a measure of healthy heart pumping function. By aggregating individual data from over 17,000 patients across five major trials, researchers compared those receiving the medication against those who did not over several years. The results clearly demonstrated that beta-blocker therapy offered no significant reduction in the risks of death, subsequent heart attacks, or heart failure for this specific group. Ultimately, the study suggests that the routine use of these drugs may be unnecessary for post-infarction patients whose hearts still pump blood effectively and who lack other medical reasons for the prescription.