Physio 35: Gas Transport & pH

Ventilation brings oxygen into the lungs, but survival depends on how gases are carried, released, and buffered once they enter the blood. Oxygen delivery and carbon dioxide removal are inseparable from the regulation of pH—the chemical environment in which all cells function.In this episode, Medlock Holmes examines how gases are transported in blood and how acid–base balance is maintained. We explore haemoglobin binding, the oxygen–haemoglobin dissociation curve, carbon dioxide transport, buffering systems, and the interplay between lungs and kidneys in pH regulation.Rather than treating pH as a laboratory value, this episode frames it as a living constraint—one that shapes enzyme activity, cellular function, and physiological stability.Here, physiology teaches us that balance is not optional.It is chemically enforced.Key Takeaways* Oxygen transport depends on haemoglobin binding dynamics* The oxygen–haemoglobin dissociation curve enables adaptive delivery* Carbon dioxide is transported in multiple chemical forms* Buffer systems stabilise blood pH* Lungs and kidneys cooperate to maintain acid–base balance This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drmanaankarray.substack.com/subscribe