The Noble journey part I with Randy Schekman

This is first part of the conversation with Randy Schekman. He is an  investigator of the Howard Hughes Medical Institute and a Professor of  Cell and Developmental Biology in the Department of Molecular and Cell  Biology at the University of California at Berkeley. He was awarded the Nobel Prize in Physiology or Medicine in 2013 for his  role in revealing the machinery that regulates the transport and  secretion of proteins in our cells. He shares the prize with James E.  Rothman of Yale University and Thomas C. Südhof of Stanford University.  In this conversation we talk about his early career, membranes,  exosomes, scientific publishing and Elife journal.  Listen to part II: https://youtu.be/MNjfkoutAhQ  Find more about Randy's work: http://mcb.berkeley.edu/labs/schekman/  Randy's biography: https://www.nobelprize.org/prizes/medicine/2013/schekman/facts/  Episode links: Website: https://www.reasonwithscience.com/home/the-noble-journey-with-randy-schekman-i Youtube: https://youtu.be/bl1uG4PbTOE  Spotify:  Apple podcast:   Google podcast:   Follow Reason with Science:   Website: https://www.reasonwithscience.com/   Youtube: https://www.youtube.com/channel/reasonwithscience   Spotify: https://open.spotify.com/show/5qFLGsPWjL4GAGidmF2nKh   Apple podcast: https://podcasts.apple.com/us/podcast/reason-with-science/id1641776894   Google podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9iMjMyNDZlOC9wb2RjYXN0L3Jzcw Timestamps:  00:00:00 Introduction  00:01:08 Interest in microbes  00:05:27 Yeasts have feelings too!  00:06:24 What was already known about vesicular trafficking?  00:08:42 How do you envision a cell?   00:09:51 Your work to understand 'what is life'?  00:12:48 Formation of membranes for the origin of life  00:14:39 Why membranes are ideal for life!  00:15:48 Differences of membranes   00:17:07 The evolution of membranes  00:19:02 Starting the work on vesicular trafficking  00:23:09 Discovery of COPII complex  00:25:24 The specialty of COPII complex   00:26:30 Importance of vesicular trafficking for animal physiology  00:27:39 Understanding of gut feeling!  00:28:56 What has changed after Nobel prize?  00:30:30 Different cellular trafficking system  00:32:11 Exosomes and miR223   00:34:29 Problems with exosomes as therapeutics  00:35:08 Peer-review and scientific publishing  00:39:44 Genesis of Elife   00:44:05 Impact factor of Elife  00:46:35 Thank you!   More Talks from Randy:  TEDx on scientific publishing: https://youtu.be/-N4Mb8tsyT8  iBiology: https://youtu.be/xvjUgTKlKyU  Nobel prize inspiration initiative lecture: https://youtu.be/Udg6bYkBtX8   #reasonwithscience #nobelprize #cellbiology