Age of Aging

The history of dementia research is a story of scientific progress stalled and derailed for nearly a century. 120 years ago, psychiatrist Alois Alzheimer made a groundbreaking discovery in the brain of a 55-year-old woman named Auguste Deter. Unfortunately, social and political turmoil would mean that his findings would not be widely understood until the end of the 20th century.   On this episode of The Age of Aging, Terrence Casey and Dr. Jason Karlawish reflect on Alzheimer’s discovery as well as the work of his colleague Oskar Fischer — a scientist on par with if not more consequential than Alzheimer in understanding the neuropathology of dementia — whose work was cut short by antisemitism and Nazi persecution. Together, they uncover how that finding was almost swallowed by the ideologies, politics, and global conflicts of the early 20th century — and the uncomfortable parallels between that time and our current moment.  Inside this episode:   0:48 – The First Case: Terrence Casey introduces the story of Auguste Deter, whose 1901 admission to a Frankfurt asylum would become the foundation of modern Alzheimer’s research.  4:34 – A Disease Without a Name: Why Deter’s symptoms didn’t fit existing diagnoses and how Alzheimer’s early observations challenged assumptions about aging and “senility.”  13:27 – A Revolutionary Idea: In 1911, Alzheimer proposed that “senile” and “presenile” dementia might be the same disease.  17:31 – Science Interrupted: How World War I, economic collapse, and political upheaval derailed progress in dementia research across Europe.  19:10 – The Forgotten Pioneer: How the contributions of Oskar Fischer to dementia research were nearly erased by antisemitism and Nazi persecution.  23:01 – The “Dark Ages” of Dementia: Why much of the 20th century viewed dementia as inevitable aging rather than disease.  30:48 – Lessons for Today: Why scientific progress depends on social, political, and economic stability — and what current global trends could mean for the future of dementia research.  32:41 – Rediscovery and Progress: The late 20th-century revival of Alzheimer’s research, including advances in diagnosis, biomarkers, and treatment.    Resources available on the episode webpage linked below  Learn more about the life and work of Alois Alzheimer   More information on the story of Alzheimer and Auguste Deter (PBS)  Read The Problem of Alzheimer's: How Science, Culture, and Politics Turned a Rare Disease into a Crisis and What We Can Do About It by Dr. Jason Karlawish  “Oskar Fischer and the study of dementia,” by Michel Goedert (National Library of Medicine)     Special thanks this episode to Jason Karlawish, MD.  The Age of Aging is a Penn Memory Center production, hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The show is made possible by generous support from the Michael Naidoff Communications Hub Fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, families across New Jersey and Pennsylvania receive guidance through every stage of the aging journey. Their team o...

What does it mean to age well? For soprano Lucy Shelton, the answer may lie in music itself. At 82, Shelton recently made her debut at the Metropolitan Opera — performing in the world premiere of Innocence, a Finnish opera about a school shooting, sung in nine languages. On this episode of The Age of Aging, Dr. Jason Karlawish sits down with Shelton to explore her remarkable career, the relationship between music and the aging mind, and what it means to keep creating — and performing — well into the eighth decade of life.   Inside this episode:  0:00 – Shepherd on the Rock: Dr. Karlawish introduces Lucy Shelton with her recording of "Shepherd on the Rock" by Franz Schubert and shares why he wanted to interview her.  4:17 – Met Opera Debut at 82: Shelton and Dr. Karlawish discuss her debut at the Metropolitan Opera in Innocence, a Finnish opera performed in nine languages.  9:08 – A Musical Life: Shelton reflects on growing up in a musical family, discovering her voice, and building a career as a singer — not an opera singer.  15:23 – Singer vs. Opera Singer: Shelton explains what sets her apart from traditional opera singers, including the vocal techniques that have allowed her to keep performing into her eighties.  20:56 – Art Meets Life in Lucidity: Shelton describes performing Lucidity, a chamber opera written for her about a singer living with dementia — and what it meant to hold her score on stage, not just as a prop, but out of personal necessity.  26:34 – Bringing Lucidity to Philadelphia: Dr. Karlawish and Shelton discuss the possibility of bringing the opera to Philadelphia.  27:26– Music, Memory, and the Mind: Dr. Karlawish and Terrence Casey explore the connection between music and the aging brain, including PMC's partnership in the Community Voices Choir — a collaboration welcoming adults of all levels of cognition through music.  Resources available on the episode webpage linked below  Review of “Innocence,” in The Wall Street Journal   The New York Times Review of “Innocence.”  More information on “Innocence.” (The New York Times)  Visit Lucy Shelton’s website  Learn more about Shelton’s previous opera, “Lucidity.” (NPR)  Learn more about sprechstimme (Britannica)  More information on the Community Voices Choir  What Is the Association Between Music-Related Leisure Activities and Dementia Risk? A Cohort Study (International Journal of Geriatric Psychiatry)  Longitudinal effects of choir singing on aging cognition and wellbeing: a two-year follow-up study (Frontiers in Human Neuroscience)  Special thanks this episode to Jason Karlawish, MD, and Lucy Shelton.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terr...

Exercise is one of the greatest things we can do for longevity and, according to Dr. Art Kramer, it’s never too late to start. On this episode of The Age of Aging, we look at one of the most accessible forms of exercise: running. We hear from competitive older runners about how they started, what keeps them going, and what running has given them over time.    Inside this episode:  4:13 – “Make Way for the Masters”: Masters athlete and Penn Relays coordinator Anthony Pugliese shares what makes the masters events at the Penn Relays so meaningful.  8:28 – Healthier Minds: Dr. Art Kramer explores how exercise benefits brain structure and function.  13:16 – A Half Hour Vacation: Masters runners reflect on how running helps them manage stress and clear their minds.  18:39 – Take it Slow: Bill McKenna and Anthony Pugliese offer advice for getting started with running and finding local track and field clubs.  Resources available on the episode webpage linked below  More information on Emily Largent   Visit the Penn Relays website  About the masters events at the Penn Relays  More information on Dr. Art Kramer  Study on Olga Kotelko’s brain  Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study (Sage Journals)  Aerobic Exercise Training Increases Brain Volume in Aging Humans (The Journals of Gerontology)  Mental Health Benefits of Running (WebMD)  Visit Greater Philadelphia Track Club website  Learn more about track clubs and meets at usatf.org  Special thanks this episode to Emily Largent, PhD, JD, RN, Anthony Pugliese, Guy DeLillio, Art Kramer, PhD, Tom Jennings, Lauren Siegel, Claudia Simpson, Delvin Dinkins, and Bill McKenna.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.    

How do you grieve someone who is still standing in front of you? In this episode, we go beyond the medical diagnosis to explore Ambiguous Loss, the “long goodbye” that defines the dementia experience. It is a journey of grieving every day while the person you love is still living.    Inside this episode:  2:59 – "I Want to Go Home": Dr. Jason Karlawish uses poetry to dissect a fading mind.  12:01 – From Partner to Solo Parent: Eileen Ware’s journey with her husband Steve’s early-onset Alzheimer’s.  20:15 – Finding the Words: Dr. Cindy Weinstein on reclaiming her relationship with her father while grieving for 15 years.  31:30 – The Dual Process Model: Alison Lynn on why mourning in dementia is never linear.  Resources available on the episode webpage linked below  Learn more about Pauline Boss and ambiguous loss (Cleveland Clinic)  Read Dr. Karlawish’s poem, “Ambiguous Loss” in JAMA.  Learn more about Dr. Cindy Weinstein and her memoir, Finding the Right Words: A Story of Literature, Grief and the Brain  More information on Alison Lynn  More information on PMC’s support groups  Special thanks this episode to Jason Karlawish, MD, Eileen Ware, Cindy Weinstein, PhD, and Alison Lynn, MSW, LCSW.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.    

 Nearly a year and a half ago, we released the Season 2 episode “In Sickness and in Health,” which explored new anti-amyloid therapies for Alzheimer’s disease, lecanemab and donanemab, known commercially as Leqembi and Kisunla.  After more than three years of lecanemab and nearly two years of donanemab in clinical use, how do patients, caregivers, and clinicians view these treatments today?  In this episode of The Age of Aging, we revisit the therapies reshaping Alzheimer’s care and hear from those experiencing them firsthand.  Inside this episode  Patients receiving anti amyloid therapy share reflections on treatment, uncertainty, and hope.  Dr. Justin Clapp discusses research on how patients, caregivers, and clinicians understand these therapies.  Dr. Kyra O’Brien reflects on prescribing the treatments and changes within clinical practice.  Dr. Jason Karlawish shares perspectives from patient conversations and clinical care.  Resources available on the episode webpage linked below  Listen to “In Sickness and in Health”  Learn more about Justin Clapp  Learn more about Kyra O’Brien  More information on anti-amyloid therapies  Special thanks this episode to Dave and Evelyn, Justin Clapp, PhD, MPH, Kyra O’Brien, MD, Joanne and Bruce Thomas, Sandy Shulan, and Jason Karlawish, MD.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.  Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.      

We often think of dementia as an interior condition, one that happens within a person’s mind, independent of the outside world. However, as dementia and design experts note, we are in constant contact with our environments, and people with dementia are profoundly impacted by the spaces they occupy. How do we design a world for people with cognitive change? And what do the environments traditionally designed for older adults say about their current role in society? In this episode of The Age of Aging, we look at how architecture and design can both benefit those with dementia or become a detriment to their longevity.   Inside this episode:  The Miracle Kitchen: Dr. Jason Karlawish discusses the Greenhouse Project and alternative approaches to dementia care design.   The History of Concealment: Architectural historian Annmarie Adams explains how concealment has historically defined spaces for the sick and the elderly.   Inclusive Design: Dementia Design Specialists Greg and Fiona Walsh share how they implement inclusive designs to reduce stress and promote independence.  Resources available on the episode webpage linked below  Learn more about the Greenhouse Project  Read “Concealment and Compassion” by Shannon Mattern  Listen to Sally Chivers’ podcast, “Wrinkle Radio”   Read “Deception and Design: The Rise of the Dementia Village”   Explore the Alzheimer’s Foundation of America’s “The Apartment”  Learn more about Shannon Mattern  Learn more about Annmarie Adams  Visit Fiona Kenney’s website  Visit the Dementia Design Specialist Architects website  Special thanks this episode to Jason Karlawish, MD, Shannon Mattern, PhD, Annmarie Adams, PhD, Sally Chivers, PhD, Fiona Kenney, Greg Walsh, and Fiona Walsh.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson. Contributors include Dalia ElSaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.    Today’s episode is sponsored by The TIAA Institute, a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.     

Being intentional about our diet is one of the best things we can do for the health and longevity of our brain. But what exactly is a healthy brain diet—and how do we make it realistic?    In the season 5 premiere of the Age of Aging, we break down the science and strategy behind the MIND diet and what it looks like to shop and eat for cognitive longevity.    Inside this episode:  Terrence sits down with Dr. Jason Karlawish to discuss the results and implications of the U.S. POINTER study for healthy brain aging.  Dr. Karlawish explains the science behind the MIND diet and how he implements it in his daily life.   Registered dietitian nutritionist (and Terrence’s sister) Trish St. Ledger shares how to create nutritious meals that are both simple and affordable. St. Ledger provides an overview of a what typical day of breakfast, lunch, and dinner might look like following the MIND diet.   Resources available on the episode webpage linked below  More information on the MIND Diet (Cleveland Clinic)  More information on healthy eating and longevity (National Institute on Aging)  Learn more about Trish St. Ledger  Special thanks this episode to Jason Karlawish, MD and Trish St. Ledger, MS, RD, LDN.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund.   

In season 4 of the Age of Aging, we decided to end every interview with the same question: what do you wish people understood more about aging?     In this special bonus episode of the podcast, we share some of their answers. They remind us of the prevalence of ageism, the many benefits of old age, and that we always have the ability to grow and change at any age.      Special thanks this episode to Lucy Davenport, Andrew Borba, Amanda Lee Williams, James Bonas, Tracey Leigh, Leo Marks, Jennifer Craft Morgan, PhD, Bruce Miller, MD, Leah Lawler, Candace Kemp, PhD, and Jake Broder.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Dalia Elsaid, Jason Karlawish, Emily Largent, and Alison Lynn. The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.     

The year 2025 was full of breakthroughs, debates, and big questions in Alzheimer’s research. One event that shaped many of these conversations? The Clinical Trials on Alzheimer’s Disease (CTAD) Conference. It may not have been on everyone’s radar, but its impact was undeniable.    In this special episode, Penn Memory Center Co-Directors Dr. Jason Karlawish and Dr. David Wolk share what stood out at CTAD, what’s changing in the field, and what to watch next.    Inside this episode:  Anti-amyloid therapies update: Where things stand with lecanemab and donanemab, and what the next generation of these drugs could look like   GLP-1 disappointment: Why Novo Nordisk’s semaglutide trials for Alzheimer’s disease came up short   Lifestyle interventions: The latest findings from the POINTER Study and what they mean for brain health  Resources available on the episode webpage linked below  Visit CTAD’s website  More information on anti-amyloid therapies  Novo Nordisk’s announcement of negative results “EVOKE” and “EVOKE+” trials  More information on the POINTER Study     Special thanks this episode to Jason Karlawish, MD and David Wolk, MD.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com. 

Art that tries to teach you things “stinks,” says playwright and actor Jake Broder.  “And yet there is a profound need for education, for awareness, for reducing stigma, for supporting the community and for medical education,” he said. A few years ago, while writing his latest play about the two individuals with frontotemporal dementia, he wrestled with how he could do both.  In the season 4 finale of the Age of Aging, we tell the story of UnRavelled, a play about perseverance through neurodegeneration, burgeoning creativity late in life and an artistic relationship across time. Producer Jake Johnson shares his first-hand experience of the play’s premiere and how it combined theater with community outreach and education.  What’s inside:   A historical perspective on composer Maurice Ravel’s brain condition and his work, “Bolero.”  An explanation from Dr. Bruce Miller on the relationship between frontotemporal degeneration and creativity.   Jake Broder’s insight into the inspiration and creation of the play as well as the associated Brain Health Festival.  The perspective of the show’s director and cast on creating the play and its core themes.  Resources available on the episode webpage linked below   Listen to Maurice Ravell’s Bolero  Learn more about Dr. Bruce Miller  Listen to Unraveling Bolero (Radiolab)  Learn more about Jake Broder  More information on For Their Thoughts Foundation  Visit the official website of UnRavelled   Subscribe to the Age of Aging Newsletter    Special thanks this episode to Dr. Bruce Miller, Jake Broder, Betsy Hall, Lucy Davenport, James Bonas, Leo Marks, Tracy Leigh, and the entire UnRavelled team.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.         

If you asked most caregivers, they would probably say there’s nothing funny about caring for someone with dementia. The stress, grief, and frustration can feel overwhelming. But what if the principles of improv comedy — being present, saying “yes,” and working together — could make caregiving easier and more joyful?  In this episode of the Age of Aging, we explore the surprising connection between improv and dementia care. You’ll hear how techniques from the stage are helping caregivers reduce stress, improve communication, and find moments of joy.  What’s inside:   A peek inside the Penn Memory Center’s Cognitive Comedy class, where caregivers and people living with dementia learn improv basics.   Dr. Anne Basting on why asking questions and staying present matters in tough caregiving moments.   Improv teacher and elder care educator Karen Stobbe shares her personal story of using improv to care for her mother with Alzheimer’s.   Researchers Dr. Candace Kemp, Dr. Jennifer Craft Morgan, and Amanda Lee Williams discuss the science behind improv’s benefits for caregivers.   Leah Lawler, creator of Cognitive Comedy, explains why teaching improv to older adults is her passion.   Whether you’re a caregiver, a healthcare professional, or simply curious about creative approaches to aging, this episode offers practical insights and inspiring stories that will change the way you think about care.  Resources available on the episode webpage linked below   Check out the Penn Memory Center’s Cognitive Comedy class  Learn more about improv (UChicago News)  Explore Timeslips’ website   Learn more about Anne Basting   Check out Karen Stobbe’s “In the Moment”  Listen to Karen and Mondy’s story in This American Life   Read Dr. Kemp and Dr. Morgan’s study on improv and dementia care (The Gerontologist)  Watch more of Leah Lawler talking about Cognitive Comedy  A list of improv games/exercises (improvencylcopedia.org)    Special thanks this episode to Jean Haskell and her Cognitive Comedy participants, Barry and Ray, as well as Anne Basting, PhD, Karen Stobbe, Candace Kemp, PhD, Jennifer Craft Morgan, PhD, and Amanda Lee Williams.  T Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    C...

Artificial intelligence is everywhere in 2025, and elder care is no exception. As the older adult population continues to grow, AI has the potential to provide desperately needed support. Both at home and in the hospital, AI systems are being developed that can summarize data, predict patient outcomes, and offer preventative interventions. These systems could help clinicians be more efficient as well as shoulder some of caregivers’ many responsibilities. Yet for as many problems as AI seems to solve in healthcare, many more questions arise as to how these innovative tools can be implemented ethically.  On this episode of the Age of Aging, we take a deep dive into the developing role of AI in the care of older adults.   We first hear from expert researchers in this space about the potential ways AI could be used to assist in the lives of older adults. Then, the co-founder of New Days AI, Dr. Babak Parviz, discusses how his company utilizes AI to help older adults protect against dementia. Finally, we look into the potential challenges and ethical questions that come with implementing AI in dementia care.   Resources available on the episode webpage linked below   NASA’s definition of artificial intelligence  Learn more about Dr. Alex Mihailidis  More on Dr. George Demiris  More information on Penn AI Tech   Visit New Days AI’s website  Learn more about Dr. Mai Lee Chang  More information on Oonjee Oh  “AI Photos” (Saturday Night Live)    Special thanks this episode to Alex Mihailidis PhD, PEng, George Demiris PhD, FACMI, Babak Parviz, PhD, Mai Lee Chang, PhD, and Oonjee Oh, MSN, RN    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric care coordinators, and public benefits specialists advocate for your loved one’s well-being and your peace of mind. Rothkoff Law Group — your partner in advocacy and senior care planning, every step of the way. Visit RothkoffLaw.com.     

Innovation in dementia care is revolutionizing the way we diagnose and treat older adults with neurodegenerative diseases. New tests have allowed doctors to diagnose patients with diseases like Alzheimer’s more accurately than ever before. The anti-amyloid therapies Lecanemab and Donanemab provide a real treatment for those living with Alzheimer’s. While these innovations are incredible for those experiencing dementia, they are also beginning to change our culture around dementia generally.  On this episode of the Age of Aging, Terrence Casey sits down with Dr. Jason Karlawish to talk about major steps forward in dementia care and how they’re changing the way we speak about dementia.   The topics in this conversation are pulled directly from the Dr. Karlawish’s new column, Neurotransmissions, in STAT News. Dr. Karlawish discusses the stigma-based way we talk about dementia in popular culture and the damage it does to older adults. He explains how new diagnostic tests and treatments are reshaping this culture by providing patients and caregivers with greater knowledge of their condition as well as hope for improvement. Dr. Karlawish said these changes will ultimately reduce the stigma associated with dementia and allow for further progress in the care of older adults.   Resources available on the episode webpage linked below   Read Dr. Karlawish’s column, Neurotransmissions, on STAT News  Read Illness as a Metaphor and AIDS and Its Metaphors by Susan Sontag  Learn more about LATE   Read Joshua Grill’s piece in the Philadelphia Inquirer    Special thanks to Dr. Jason Karlawish, MD, for being a part of this episode.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsors, the TIAA Institute and Rothkoff Law Group. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging.    Caring for an aging loved one isn’t easy — but you don’t have to do it alone. At Rothkoff Law Group, we guide families across New Jersey and Pennsylvania through every stage of your aging journey. Our team of elder care attorneys, geriatric ca...

Although the Age of Aging often focuses on science, art has been a recurring theme. In Season 2, Episode 2, “Diet, Exercise, and... Doodling?”, we explored how creativity can support longevity. However, beyond art’s apparent health benefits, making and consuming art can also help us better understand the experience of aging. In many ways, the change and loss associated with aging are best understood through art.  Today’s episode of the Age of Aging looks once again at art creation in aging through the stories and work of three artists living with brain disease.   Joe Vanek, a stage designer for more than 40 years, experienced a stroke that changed how he viewed time and creativity.  Scott LaMascus left graduate school in poetry to care for his father with ALS, finding meaning through writing and reflection.  Neesa Becker-Procaccino, a professional illustrator, stopped working after an Alzheimer’s diagnosis but returned to art as a way to heal and connect.  Each artist faced disruption. Yet through art, each found a way to continue creating and redefining identity in the face of illness.   Resources available on the episode webpage linked below  Watch the full video featuring Neesa Becker-Procaccino   Learn more about Joe Vanek  Read more of Joe Vanek’s story  Read “Dispatches from the Dark Side of the Moon” and “Hesitant Light”  Check out more of Joe Vanek’s illustrations  Saint Patrick  The Queen of Hearts  Our Lady Guadalupe   The Child of Prague  Nutcracker  The Snow Queen  Follow Joe Vanek on Instagram  Learn more about Scott LaMascus ...

Over the past year, the Age of Aging has spoken with expert clinicians who study the brain, as well as individuals living with neurodegenerative diseases like Alzheimer’s. We believe that these two perspectives are essential for fully understanding dementia in 2025.  In today’s episode, we hear from someone who can speak to both perspectives.  Dr. Daniel Gibbs is a retired neurologist and author currently living with Alzheimer’s disease. Joined by his wife and caregiver, Lois Seed, he sat down with Age of Aging Executive Producer Dr. Jason Karlawish to discuss Dan’s experience. While the two physicians have had repeated conversations over the years concerning Dan’s diagnosis, Lois’ presence highlights how the disease has progressed and how their relationship has taken on new caregiving dynamics.  What you will hear is an authentic depiction of living with Alzheimer’s disease, along with insights on how a partner begins to care for that person’s changing mind.  Resources available on the episode webpage linked below  Read A Tattoo on My Brain: A Neurologists Personal Battle with Alzheimer’s Disease. Watch the documentary, A Tattoo on My Brain  Learn more about Dan and Lois’ story  (American Heart Association)  Read Dr. Daniel Gibbs’ blog   Special thanks to Daniel Gibbs, MD, PhD, and Lois Seed for being a part of this episode.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharpe.  The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsor, the TIAA Institute. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insights that help individuals and employers navigate the complex journey of aging. 

At the Penn Memory Center, we often recommend exercise, social engagement, and a solid support system to help people age well. Owning a dog is not on that list, but maybe it should be. For many older adults, dogs are more than companions. They’re motivators to stay active, reasons to connect with neighbors, and steady sources of comfort through life’s challenges. Emerging research suggests that that this age-old bond between humans and dogs may be one of our healthiest friendships. On this episode of The Age of Aging, we celebrate dogs, and how they might help us live long, healthy lives.   First, we hear from caregivers and dog owners about how their dogs help them care for their loved ones with dementia. Then, Professor Philip Tedeschi explains how humans’ co-evolution with dogs has made us perfect support system for one another. Lynn Cronomiz recounts how a powerful moment between a therapy dog and her mother with Alzheimer’s helped her process her mother’s passing. Finally, we explore humans’ inseparable connection with nature through the biophilia hypothesis.  Resources available on the episode webpage linked below Dog ownership in the U.S. statistics – American Veterinary Medical Association  “2025 Alzheimer’s Facts and Figures” –  Alzheimer’s Association  Listen to Season 1 Episode 4, “Diagnosing Dementia,” featuring Lynn Cronomiz  Learn more about the Insitute for Human-Animal Connection  Visit KPETS, which Lynn Cronomiz does her therapy dog work with  Learn more about the “biophilia hypothesis”  Petfinder to adopt a pet near you  Visit the American Kennel Club website for more information on dog breeds    Special thanks to Tom Casey, Miguel Centeno, Kathy Oldfield, Philip Tedeschi LCSW, MSSW, Lynn Cronomiz, and Carlo Siracusa DVM, PhD, DACVB, DECAWBM    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and Penn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.    The Age of Aging is made possible by generous support from the Michael Naidoff Communications Hub fund and our sponsor, the TIAA Institute. The TIAA Institute is a think tank committed to building knowledge that advances lifelong financial security and well-being while considering the intersections of health and wealth. Their cutting-edge research provides actionable financial and longevity insig...

When we think about justice, older adults aren’t always top of mind. Yet in the United States, seniors often face stigma, exploitation, and insufficient social support, all while navigating cognitive and physical decline. As lifespans continue to grow globally, aging is a future we all hope to reach. So how do we ensure that future is just? And what does justice for older adults truly look like?    Welcome to Season 4 of The Age of Aging! We’re kicking off with a vital and multifaceted topic: elder justice. Joining us are three leading voices who help unpack the legal, cultural, and systemic challenges facing older adults — and what can be done to address them.  MT Connolly, author and elder justice advocate, explores the deep-rooted cultural and structural issues that shape aging in America, and offers ideas for meaningful reform.  Charlie Sabatino, former director of the American Bar Association’s Commission on Law and Aging, explains how working with an elder law attorney can help preserve autonomy and dignity throughout the aging process.  Judge Lois Murphy shares insights from the courtroom, including a real-life guardianship case that illustrates the complexities and consequences of our legal system’s approach to elder care.  If you enjoy the episode, please leave us a review and share it with a friend. Got a story idea for Season 4 or beyond? Reach out to us at [email protected].    Resources  Listen to Season 1 Episode 2, “Living Well with Purpose,” about supported decision-making.  Read The Measure of Our Age: Navigating Care, Safety, Money, and Meaning Later in Life by MT Connolly.  Learn more about MT Connolly.  More information on the RISE model  CDC Mortality Trend Graph  2023 CDC Life Expectancy  Learn more about Charlie Sabatino  More information on guardianship in Pennsylvania   Learn more about Judge Murphy     Special thanks to Charlie Sabatino JD, MT Connolly JD, and Judge Lois Murphy.  The Age of Aging is a Penn Memory Center production hoste...

Welcome to a mid-year bonus episode of The Age of Aging! While the podcast takes a short break between seasons, we wanted to bring you a special update on the state of Alzheimer’s today. Penn Memory Center Co-Directors Dr. Jason Karlawish and Dr. David Wolk sat down with Terrence Casey to share their reflections from this year’s Alzheimer’s Association International Conference (AAIC), which they attended earlier this summer. They discuss their biggest takeaways, including the impact of NIH funding cuts, the rapid innovations that continue to shape the field, and what they’re keeping their eye on for next year’s conference in London.   We hope you enjoy and stay tuned for season 4 of The Age of Aging this fall! If you enjoy the show, leave us a review and share this episode with a friend. If you have any story suggestions for Season 4 and beyond, contact us at [email protected].   Resources  Learn more about the Alzheimer’s Association and AAIC  Special thanks to Jason Karlawish, MD and David Wolk, MD.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp. 

When we talk about dementia on this podcast, we are often talking about its most common cause: Alzheimer's disease. However, dementia has many causes, and among the most prevalent after Alzheimer’s is Lewy Body Disease. Though it can share similarities with Alzheimer’s, Lewy Body Dementia (LBD) has distinct symptoms and challenges that can complicate diagnosis, treatment, and caregiving.   On the season 3 finale of the Age of Aging, we explore Lewy Body Disease and its impact on caregivers and families.   We begin with a clip from the documentary Facing the Wind, which follows two caregivers as they navigate caring for their husbands with Lewy Body Disease. Then, Co-Host Terrence Casey shares his reflections on a live Q&A following a screening of the film in Philadelphia. Finally, Dr. Jason Karlawish provides a deeper insight into Lewy Body Disease, its significance in the world of aging research, and what it reveals about caregiving today.  Resources  Find an upcoming screening of Facing the Wind  Learn more about Lewy Body Dementia  National Institute of Health booklet on Lewy Body Dementia  More resources on Lewy Body Dementia Association website  Special thanks to Tony Heriza, Deirdra Fishel, and Linda Szypula for sharing their film with us and being a part of this episode. Special thanks as well to ARTZ Philidelphia for presenting the screening and Q&A. The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp. 

Sex and intimacy can be difficult topics to navigate, especially for caregivers and their partners facing the challenges of a dementia diagnosis. These conversations are often avoided, yet the emotional toll of intimacy-related struggles can be profound, bringing feelings of grief, confusion, and isolation. The stigma surrounding sex and dementia only deepens this silence, making open dialogue all the more essential.   On this episode of The Age of Aging, we explore one caregiver’s deeply personal journey through love, loss, and change. Alison Lynn, Director of Social Work at the Penn Memory Center, speaks with author and advocate Lisa Marshall about her book Oh, Hello Alzheimer’s: A Caregiver’s Journey of Love.   Lisa shares the story of her husband Peter’s Alzheimer’s diagnosis and the emotional complexities that followed — including her decision to end their sexual relationship. With honesty and vulnerability, she reflects on the grief, guilt, and growth that came with that choice, offering insight and solidarity to others navigating similar paths.  Resources  This week’s Beautiful Question: What is a place with special meaning to you? Leave us a message at (571) 449-6474.  Read Lisa Marshall’s book, Oh, Hello Alzheimer's: A Caregiver's Journey of Love  Visit Lisa’s website   Special thanks to Lisa Marshall and Alison Lynn, MSW, LCSW for being a part of this episode.    The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.   

The U.S. healthcare system is changing—especially when it comes to caring for older adults. The COVID-19 pandemic revealed how vulnerable our aging population is, and how unprepared many parts of the system remain. Overstressed nursing homes, overworked primary care physicians, and a lack of accessible resources for dementia care remain persistent challenges.   But there’s hope. New technologies, treatments, and care models are reshaping what aging and diagnosis can look like. The question now is: How do we deliver these advances to the people that need them most?   In this episode of the Age of Aging, we explore the evolving landscape of elder care in the U.S.  We start with Dr. PJ Brennan, the Chief Medical Officer of Penn Medicine who discusses the challenges the U.S. healthcare system is currently facing with its elder population. Then Dr. Kyra O’brien explains why the new anti-amyloid therapies, lecanemab and donanemab, might help more people get diagnosed and allow clinics like the Penn Memory Center to expand their resources. Finally, Dr. O’Brien dives into the new federal program “GUIDE,” which aims to reshape dementia care across the country.    Resources  This week’s Beautiful Question: What is something that you could teach someone? Leave us a message at (571) 449-6474.  Listen to our episode on anti-amyloid therapies, “In Sickness and in Health”  Read more about anti-amyloid therapies  More information about GUIDE at Penn Medicine  Penn GUIDE interest form  General information on GUIDE (cms.gov)  Special thanks to PJ Brennan, MD, and Kyra O’Brien, MD, for being a part of this episode.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.   

We often think of dementia as something that affects the oldest among us, and that’s often true; at the Penn Memory Center, the average age of diagnosis is between 70 and 75. In most of those cases, caregiving falls to a spouse, partner, or adult child. But what happens when dementia is diagnosed before the age of 65?  In this episode of the Age of Aging, we explore early onset dementia and the young caregivers who step up when their lives are just beginning. The stories of teens and young adults reveal the unique challenges of caregiving and what they can teach us about care across all ages.  We begin with a segment from a recent episode of Science Friday, where Executive Producer Dr. Jason Karlawish discussed the FDA’s recent approval of new diagnostic blood tests for Alzheimer’s disease. Then, Paige Censale shares the life-changing decision she faced: accept a full scholarship to college or stay home as the sole caregiver for her mother. We then learn about Lorenzo’s House, an organization dedicated to supporting young caregivers and families impacted by early onset dementia. Finally, we hear from Sierra, a 16-year-old from South Pasadena California who began caring for her father with early onset dementia when she was just 8 years old.    Resources  This week’s Beautiful Question: What is something in your home that you treasure? Leave us a message at (571) 449-6474.  Thank you to Science Friday for letting us play part of their episode with Dr. Karlawish. You can listen to the full episode here.   Check out Paige Censale’s website  Learn more about early onset dementia (WebMD)  Learn more about Lorenzo’s House  Join Lorenzo’s House’s “Youth Summit” (June 20 – 21)   Special thanks to the Science Friday team, Jason Karlawish, MD, Paige Censale, Diana Cose M. ED, Patti LaFleur M. ED, CPD, Sierra Mercer, and Alison Lynn, MSW, LCSW, for being a part of this episode.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp. 

The world is getting older—and that reality is what inspired this podcast. Thanks to advances in medicine, healthier lifestyles, and improved living conditions, people are living longer than ever. That’s a good thing. However, longer lives will also require a lot of change from both individuals and society. We will have to prepare now for something earlier generations never considered possible: the second 50 years of our lives.  In this episode of the Age of Aging, Executive Producer Jason Karlawish speaks with Debra Whitman, Chief Public Policy Officer at AARP, about her new book, The Second Fifty: Answers to the 7 Big Questions of Midlife and Beyond. Together, they explore what it means to plan not just for retirement, but for an entire second half of life—dispelling myths about aging and offering practical insights for the years ahead.   Resources  This week’s Beautiful Question: What is something that makes you laugh? Leave us a message at (571) 449-6474.  Get your copy of The Second Fifty: Answers to the 7 Big Questions of Midlife and Beyond  Special thanks to Debra Whitman and Jason Karlawish, MD, for being a part of this episode.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Jason Karlawish, Emily Largent, and Meaghan Sharp.  The Age of Aging is made possible by generous donors like you. To learn more visit www.pennmemorycenter.org/ageofaging

No one wants to think about their death, let alone talk about it. But having a meaningful conversation with your loved ones about your final days is one of the most important things you can do for them and yourself. End of life is a logistically and emotionally challenging time, so making critical decisions before the process of dying can save you and those around you from further stress and turmoil. Luckily, some experts can help you navigate this time's many legal and emotional complexities.   On this episode of the Age of Aging, we are talking about death and what it means to plan for your final days.   First, we speak to death doula Chelsea Duckers about what exactly a death doula does and how one can guide you through the process of end of life. Then, elder law attorney Jerry Rothkoff goes through the legal documents you will want to get in order to prepare for end of life. Finally, we hear from someone who worked with a death doula while preparing for the death of her spouse.   Resources  This week’s Beautiful Question: What is something you are proud of in your life? Leave us a message at (571) 449-6474.  Learn more about death doulas  End of life planning resources from Rothkoff Law Group  Death Doula Workbook Request Form  Special thanks to Chelsea Duckers, BSW, CSW, CECC, Jerry Rothkoff, Esq., and Diane Cordell.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp.  The Age of Aging is made possible by generous donors like you. To learn more visit www.pennmemorycenter.org/ageofaging

At the Penn Memory Center, one of the most common questions we hear is: What can I do to keep my brain healthy as I age?   We often reference diet and exercise as essential tools when it comes to maintaining a healthy brain. There’s another, often-overlooked way to boost brain health, fight depression, and support cognitive resilience. It’s not a pill. It’s not a trend. It’s something far more human: our hands.   On this episode of the Age of Aging, we explore the power of our hands and why using them intentionally can be an incredible medicine for the mind.  We begin with Dr. Kelly Lambert, a behavioral neuroscientist at the University of Richmond. She explains the link between our hands, human evolution, and depression. Then, Drs. Vasiliki Meletaki and Gyulten Hyusein from the Penn Center for Neuroaesthetics discuss the benefits of hand movement as we age. Finally, artist Judith Schaechter shares her creative process in crafting stained glass pieces and how working with her hands has shaped her memory, mood, and creativity.      Resources  This week’s Beautiful Question: What is something you would like to learn? Leave us a message at (571) 449-6474.  Read the New York Times article featuring Dr. Lambert   Watch Dr. Lambert’s TED Talk  Learn more about Dr. Lambert’s lab  Learn more about the Penn Center for Neuroaesthetics  Explore more of Dr. Meletaki and Dr. Hyusein’s research  Video displaying Judith Schaechter’s biophilic dome  Visit Judith’s website  Read Judith’s blog about her work  Special thanks to Kelly Lambert, PhD, Vasiliki Meletaki, PhD, Gyulten Hyusein, PhD, and Judith Schaechter for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp.  The Age of Aging is made possible by generous donors like you. To learn more visit www.pennmemorycenter.org/ageofaging

In dementia care and research, it’s widely accepted that people living with advanced dementia often lose the ability to connect and communicate as they once did. However, one phenomenon has been the exception to the rule. “Paradoxical lucidity” is a term used to describe brief moments in which individuals with severe dementia suddenly regain clarity, communicate, and reconnect in ways thought to be long lost. While care partners witness and commonly share experiences with clinicians like Dr. Jason Karlawish, paradoxical lucidity remains understudied. In a recent study, Dr. Karlawish partnered with anthropologist Dr. Justin Clapp to explore the meaning and implications of these moments, both for our understanding of dementia and for the people living with it.  On this Season 3 premiere of the Age of Aging, we explore paradoxical lucidity—what it is, what it reveals, and how it reshapes the experiences of care and connection in the final stages of life.   We begin with an essay by writer Anne Basting, reflecting on a powerful lucid moment her mother experienced during a holiday meal. Then, we hear from Dr. Karlawish and Dr. Clapp, who explain how their research sheds new light on this phenomenon.  Finally, Elizabeth Donnarumma, a caregiver interviewed for their study, shares what her mother’s lucid moment meant for her.     Resources  This week’s “Beautiful Question”: What kind of food makes you happy? Leave us a message at (571) 449-6474  Read Anne Basting’s essay, “Christmas Crackers,” and subscribe to her Substack   Learn more about paradoxical lucidity  Listen to GeriPal's podcast on lucidity Special thanks to Anne Basting, Jason Karlawish, MD, Justin Clapp PhD, MPH, and Elizabeth Donnarumma for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp.  The Age of Aging is made possible by generous donors like you. To learn more visit www.pennmemorycenter.org/ageofaging

What does spring smell like?   What do you think is a beautiful sound?   If those questions made you pause for a second and reflect, that’s exactly the point. These are examples of “beautiful questions,” open-ended prompts designed to push you beyond your everyday thinking and invite you to look at the world a little differently. Writer and artist Anne Basting developed beautiful questions as a way to creatively engage people, particularly older adults with impaired cognition. These questions are part of what Dr. Basting calls “creative care,” a method that fosters meaning, conversation, and storytelling for those who otherwise have difficulty communicating. But anyone can ask and answer a beautiful question.   In this special bonus episode ahead of season 3 of the Age of Aging, Dr. Basting joins Jake to discuss the power of beautiful questions and shares a couple of her favorites.   We want to hear from you!  We’re inviting you, our listeners, to respond to the question: What do you think is a beautiful sound? Your answer could be featured in Episode 1 of Season 3. Call ‪(571) 449-6474 and leave a voicemail with your name, where you’re calling from, and your response.  Each episode this season will feature a new beautiful question, along with responses from our listeners. There are no right or wrong answers; we want to hear your unique perspectives!    Resources  Please call ‪(571) 449-6474 to leave your response.  Anne Basting’s website  Learn more about Anne Basting’s non-profit Time Slips  Read Creative Care: A Revolutionary Approach to Elder Care    Special thanks to Anne Basting for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp.  The Age of Aging is made possible by generous donors like you. To learn more visit www.pennmemorycenter.org/ageofaging

Welcome to a special bonus episode of the Age of Aging! As we bring in the New Year, we're taking a moment to reflect on the key milestones in dementia research and clinical care from 2024 and share our excitement for what's ahead in 2025. Today’s episode features a conversation between three distinguished leaders in dementia research and clinical care at Penn Medicine and beyond.     Dr. Jason Karlawish is a geriatrician and co-directs the Penn Memory Center. Dr. David Wolk co-directs the Penn Memory Center as well as the Institute on Aging, and is a cognitive neurologist. Finally, Dr. Eddie Lee co-directs the Institute on Aging and is a neuropathologist at UPenn.   Together, they'll share their highlights from 2024, discuss groundbreaking advancements in the field, and offer their perspectives on where dementia research and care are headed in 2025.    Don’t worry, regular episodes of the Age of Aging will return in 2025! Until then, we hope you enjoy this insightful conversation on aging to bring in the New Year.  

It’s the season 2 finale of the Age of Aging! To celebrate, we welcomed back guests from Seasons 1 and 2 and asked them to dream big to improve aging in America.   In this episode, you’ll hear a wide range of ideas: from integrated child and eldercare to ballet training for young adults to walkable communities and many more. This episode is an opportunity to think idealistically about the world, hear ideas from people in the Penn Memory Center community, and develop some ideas of your own.  Season 3 of the Age of Aging will begin early next year. Subscribe to our Age of Aging news magazine to be the first to know when new episodes drop.      Resources  More on intergeneration child and elder care   Check out Anne Basting’s work  Learn more about Memory Cafe’s at PMC  Timeline of Ballet Russes (Library of Congress)  Photo project on 72-year-olds around the world (NPR)  Benefits of walkable places (CNU)  60 Minutes segment on hologram for holocaust survivors (CBS)  More on Kneipp Therapy  Dementia care in Australia  TED Talk on Positive Deviance  Special thanks to Melissa Kelley, Anne Basting, Anthony Roth Castanzo, Jason Karalawish, MD, Emily Largent, JD, PhD, RN, Kate Lietz, Laynie Dratch, Lynn Cronomiz, Lauren Massismo, PhD, CRNP, FAAN, Meg Kalafsky, and Shana Stites PsyD, MA, MS for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawi...

The holidays are a time for celebration, joy, and being with loved ones. Unfortunately, it can also be a time that brings stress and anxiety. Between travel, shopping, and managing family dynamics, this season can feel overwhelming. For caregivers and individuals with dementia, these challenges are often magnified. Travel and social gatherings can pose unique difficulties, leaving many caregivers wondering: What will the holidays look like for my loved one and me this year?  To help you answer this question, we sat down with Director of Social Work at the Penn Memory Center, Alison Lynn, to explore strategies and tips for tackling the holidays.  First, Alison discusses the difficult but important task of adjusting your expectations for what is possible this year as a caregiver. Then, she lays out some tips for navigating holiday travel, whether by car or plane, with someone who has dementia. Finally, Alison gives advice for managing the actual holiday event, including how other family members can help and the importance of communication during this process.  Resources  “Please Be Patient” Cards  More on the holidays and Alzheimer’s   Programs and services at the Penn Memory Center  More on Alison Lynn at PMC  Special thanks to Alison Lynn MSW, LCSW for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp. 

Providing equitable aging research and care faces a major barrier: minorities that are disproportionately impacted by dementia are greatly underrepresented. Data shows that Black and African American individuals are twice as a likely to develop dementia. Hispanic and Latino populations are one and a half times as likely. At the core of this issue is what researchers call social and structural determinants of health (SSDOH). These are the ways our health is impacted by social factors in our environment, poverty, racism, and limited access to healthy food. Outreach is the central way research centers, such as those at the Penn Memory Center, attempt to address these disparities. Outreach coordinators attempt to establish ties with local communities, providing educational talks on aging as well encouraging members of the community to sign up for clinical trials. While important, much more is needed in order to overcome these disparities.   On this episode of the Age of Aging, we explore the disproportionality of dementia’s impact on underrepresented groups and how outreach efforts seek to address that.    We’ll first learn how PMC Outreach Coordinator, Morgann Adams works to establish ties with black and African American communities in Philadelphia. We will then hear from Dr. Eddie Lee about how social factors physically change a person’s brain as they age. Finally, Reverend Leroy Miles discusses the relationship between Enon Tabernacle Church and the Penn Memory Center and the aging needs of his community.    Resources  Learn more about aging disparities in underrepresented groups.   More on community outreach at PMC  More information on the Aging Brain Cohort Dedicated to Diversity (ABCD2) Study.  Read about the work of the Dr. Eddie Lee’s lab.  Visit Enon Tabernacle Baptist Church’s website  Special thanks to Morgann Adams, Eddie Lee, MD, PhD, and Reverend Leroy Miles for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp. 

This November, millions of Americans will head to the polls for the 2024 presidential election. But while the right to vote is essential to our democracy, unfortunately, the process of voting can present unique challenges for individuals with disabilities like dementia, often requiring outside assistance. If you’re a caregiver, how much can you help someone vote? What kind of assistance is available to those with dementia?   On episode 3 of the Age of Aging, we look at voting, and what the process means for individuals with dementia and their caregivers.   We begin by talking with Dr. Jason Karlawish who discusses the legal framework around voting capacity and shares his perspective on how to define a person’s capacity to vote. Then, voting advocate TJ DeLuca provides some important information on assisting the voting process for individuals with disabilities. Finally, we’ll hear from a voter who was falsely told he could not help his wife with dementia vote in 2020.   Resources  Pennsylvania Designated Agent Form  Check out the American Bar Association and Penn Memory Center’s guide to voting with cognitive impairment  More on Doe v. Rowe case  Read Dr. Karlawish’s study on voting in long-term care facilities  Visit disabilityrightspa.org or call 1-800-692-7443 to learn your rights  Special thanks to Jason Karlawish, MD, TJ DeLuca, and John Moore for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp.   

An Alzheimer's doctor goes to the opera...This isn't the start of a bad joke; it's the result of a collaboration between the Penn Memory Center and leaders of Philadelphia's arts community. The first of its kind at PMC, the Arts on the Mind Festival explored the intersection of the mind and art over a two-month event span. Music, literature, visual art, and film were all featured as mediums to better understand the importance of art in our lives and even how art can be used to help those with cognitive impairment.    On episode 2 of the Age of Aging’s second season, we take a look at the Arts on the Mind Festival to understand just how essential the arts and creativity are for us as aging humans.   We start at the first event of Arts on the Mind at the Franklin Institute for a discussion between Dr. Jason Karlawish and special guest Anne Basting on the mind and creativity. Then, we’ll hear from the festival’s creators on how their vision evolved over time and why it ultimately became what it did. Finally, we’ll examine the deeper connection between art and the brain, asking: Could creative expression be more than just a source of joy? Could it be a therapeutic tool for those with cognitive challenges?  Resources  Learn more about the Arts on the Mind Festival  Check out more programs at the Penn Memory Center  Visit Anne Basting’s website  Learn more about “A Song by Mahler”  Collaborators include: The Philadelphia Chamber Music Society, The Penn Memory Center, The Franklin Insitute, The Philadelphia Film Society, the Free Library, and ARTZ Philadelphia     Special thanks to Jayatri Das, PhD, Jason Karlawish, MD, Anne Basting, PhD, Miles Cohen, Judy Freedman, Allen Freedman, and Mark Neikrug for being a part of this episode.  The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, Meg McCarthy, and Meaghan Sharp. 

Over the past two years, the world has seen major developments in Alzheimer’s disease treatment with the release of two new medications: Lecanamab, marketed as Leqembi, and Donanemab, marketed as Kisunla. These two treatments are the first of their kind to reduce the physical signs of Alzheimer’s disease in the brain and potentially slow down the progression of cognitive decline. In the premiere episode of season 2 of the Age of Aging, we explore these new anti-amyloid therapies, what they are, and how they may change the lives of patients and caregivers. We begin with the personal story of a couple who have participated in the Donanemab clinical trials over the past three years, sharing their firsthand experiences with the medication. Project Manager of this trial at the Penn Memory Center, Melissa Kelley, provides insights into the journey of these participants.  Additionally, Dr. Sanjeev Vaishnavi offers an expert breakdown of anti-amyloid therapies, explaining what they are, how they work, and what they might mean for the future of Alzheimer’s disease treatment. Resources More resources on Lecanamab (Leqembi) Learn more about disease modifying therapies for Alzheimer’s disease Check out studies currently enrolling at the Penn Memory Center.   Special thanks to Dan and Susan Henderson, Melissa Kelley, and Sanjeev Vaishnavi MD, PhD, for contributing to this episode. The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Dalia Elsaid, Marie Ingegneri, Jason Karlawish, Emily Largent, and Meg McCarthy.

The first four episodes mark the end of the first season of the Age of Aging. But don’t worry! The second season of the Age of Aging will resume two weeks from now. With a slightly different format, the stories of Season 2 will feature old and new voices from researchers, clinicians, and patients.      In this episode, hosts Terrence and Jake reflect on their favorite stories from season one, share feedback from listeners, and talk about the lessons learned along the way. They’ll also give you a sneak peek into season two, highlighting some of the stories and topics to look forward to in the coming months.    Resources    Visit the Age of Aging page on the Penn Memory Center website  Listen to the Age of Aging on YouTube  Visit the Penn Memory Center, Penn FTD Center, and the Penn Institute on Aging websites     The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Marie Ingegneri, Jason Karlawish, Emily Largent, and Meg McCarthy. 

Diagnostic testing is at the heart of both the clinical care and research at the Penn Memory Center. Patients and research participants alike undergo various diagnostics such as PET scans, MRI scans, and cognitive tests. These tools help clinicians turn symptoms such as dementia into a diagnosis like Alzheimer’s disease. But what are these tests? And what can they actually tell us about aging?    On Episode 4 of the Age of Aging, we examine the full diagnostic experience.     Our first segment explores MRI and PET scans and what they tell us about the brain. Then, Dr. Lauren Massimo from the Penn Frontotemporal Degeneration Center introduces other dementia-causing diseases beyond Alzheimer’s. We then hear from one couple about their decisions to donate their brains after death to help further aging research. Finally, to end our first season, Dr. Massimo discusses the legacy of her late mentor, and a major figure in the world of aging research, Dr. Murray Grossman.    Resources     Learn more about the studies currently enrolling at the Penn Memory Center  Visit the Penn FTD Center website  Read more about the Kung’s decision to donate their brains  More information on brain donation at PMC  Watch the Dr. Murray Grossman’s full memorial symposium    Thank you to John Detre, MD, Lynn Cronomiz, Lauren Massimo, PhD, CRNP, FAAN, and Ed and Marcia Kung.      The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Marie Ingegneri, Jason Karlawish, Cait Kearney, Emily Largent, Meg McCarthy, and Olivia Vozzella. 

We often think of Alzheimer’s disease and other causes of dementia in terms of their impact on the individual living with the disease. Of course, this is with good reason: a person with an age-related neurological disease will experience difficulties in their day-to-day life incomprehensible to most others. However, for every patient, there is one person or many people caring for that person daily. Caregivers do the often unsung physical and emotional labor of dementia, making sure a person is safe, healthy, and living as comfortably as they can be.     In honor of this important role, today’s episode is dedicated to the caregivers.     In our first story, social worker Kate Lietz offers self-care tips for caregivers. Our second story comes from our friends at the podcast Bob’s Last Marathon, who spoke with the then-executive director of the Penn Memory Center Felicia Greenfield. Greenfield provides information on support groups and programs available to caregivers. Our final story in this episode will feature the voice and poems of Alexandra Martinez, whose collection of poems deals with her mother’s development of dementia due to Alzheimer’s.     Resources     Learn more about support services and programs at the Penn Memory Center  Listen to Bob’s Last Marathon  Stream, download, or buy Alexandra Martinez’s collection of poems HEARTBREAKER  Music credit: “Dawn Breaking,” and “Anywhere Else (alien’s re-bake)” by Moody Alien via Free Music Archive    Thank you to Kate Lietz, MSW, LSW, the folks at Bob’s Last Marathon, Felicia Greenfield MSW, LCSW, and Alexandra Martinez for contributing to this episode.     The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Marie Ingegneri, Jason Karlawish, Cait Kearney, Emily Largent, Meg McCarthy, and Olivia Vozzella.   

We all hope that we can age with as much independence, purpose, and well-being as possible in our later years. Unfortunately, aging is never so straightforward and we will all face our own unique challenges and complexities as we get older. So, with all this uncertainty, how do we get the most out of this later stage of life?    In our second episode of the Age of Aging, we explore stories about maintaining dignity, health, and a sense of meaning in our older years.      Our first story will look at a new model for care called “Supported Decision-Making,” which aims to give those with impairment greater autonomy for as long as possible. For our second, Dr. Claudia Kawas discusses her research on the oldest people in our population and what they can tell us about aging. Then, we will hear about the late Carl Duzen, who began creating art as his dementia from Alzheimer’s progressed. Our final story will cover Memory Cafés, a major program at Penn and beyond, which provides a safe space for art and community for those living with dementia.    Resources   Learn more about Supported Decision-Making  Check out the ACLU’s Supported Decision-Making Resource Library   Watch the extended interview with Dr. Claudia Kawas  Carl Duzen on “It’ll Make Sense When You’re Older” by This American Life  Moment to Moment by Mike Attie   Learn more about Carl Duzen  More information on Memory Cafés (AARP)  Learn more about Memory Cafés at the Penn Memory Center     Thank you to Emily Largent, PhD, RN, Claudia Kawas, MD, Carl Duzen, PhD, Susan Jewett, Louise Qualtrene, Marjorie Snelling, Meg Kalafsky, MHCI, Debbie Feldman, Joanne Beam for being a part of this episode. Thanks as well to the Quaker Notes for their wonderful singing.   The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Marie Ingegneri, Jason Karlawish, Cait Kearney, Emily Largent, Meg McCarthy, and Olivia Voz...

Clinical advancements have made it easier than ever to learn your personal risk of developing age-related diseases such as Alzheimer’s. Through genetic testing or biomarker measurement, you can learn if you’re more likely than your peers to develop dementia as you age. Do you want to know? In our first episode of the Age of Aging, we explore exactly that question. First, we’ll hear about the role of genetic counselors in guiding people through the process of genetic testing. In our second story, Dr. Emily Largent discusses how people react to learning their level of risk for Alzheimer’s. Then Dr. Shana Stites discusses the way stigma impacts those with cognitive impairment and those wanting to learn their risk. Finally, we’ll hear an update on how the Penn Memory Center is rolling out the new prescription Alzheimer’s disease treatment, Leqembi. Resources Find a genetic counselor through the National Society of Genetic Counselors (NSGC) More information on SOKRATES “Stigma causes underdiagnosis in dementia,” by Meghan McCarthy More information on Leqembi and other disease-modifying therapies for Alzheimer’s Thank you to Laynie Dratch, SCM, CGC, Elisabeth Wood, MS, LCGC, Deia Schlosberg, Emily Largent, PhD, RN, Shana Stites, PsyD, MA, MS, and Jason Karlawish, MD, for being a part of this episode. Special thanks to Melissa Flamporis, Melissa Kelley, Dan Papa, and Alex Prusky for lending their voices to the SOKRATES participants. The Age of Aging is a Penn Memory Center production hosted by Editorial Director Terrence Casey and Producer Jake Johnson, in partnership with the Penn FTD Center, the Penn Institute on Aging, and UPenn’s Alzheimer’s Disease Research Center. Contributors include Nicolette Calcavecchia, Marie Ingegneri, Jason Karlawish, Cait Kearney, Emily Largent, Meg McCarthy, and Olivia Vozzella.

A podcast about living well with an aging brain. Brought to you by the aging experts at the University of Pennsylvania.   Supported by the Penn Memory Center, Penn FTD Center, Penn Institute on Aging, and Penn Alzheimer’s Disease Research Center.   Episode 1 available Tuesday, 7/23