Australian Prescriber Podcast

Therapeutic Guidelines expert group member Lee Fong returns to the podcast to talk to Justin Coleman about the brand-new Kidney and Urinary guidelines. Focusing on GP management, the conversation covers some of the new content, including screening and medication regimens for chronic kidney disease, lower urinary tract symptoms, wetting in children and much more.

Laura Beaton talks to hepatology research fellow Richard O'Halloran about his paper on metabolic dysfunction–associated fatty liver disease (MAFLD). Richard outlines risk factors and comorbidities to consider, and diagnostic tests for MAFLD. The conversation also covers management of MAFLD through risk stratification, addressing health risk behaviours, and surveillance. Read the full article in Australian Prescriber.

Dhineli Perera chats with maternal–fetal medicine specialist Lisa Hui about her paper on cytomegalovirus (CMV) in pregnancy. Lisa explains how the virus is acquired and outlines strategies for reducing risk of infection. The conversation also covers testing for CMV and the role of valaciclovir in reducing the risk of fetal transmission. Read the full article in Australian Prescriber.

Dhineli Perera speaks to infectious diseases physicians Aadith Ashok and Bradley Gardiner about their paper on preventing infections in immunosuppressed patients. They explain how to individualise risk assessments and screening investigations, and discuss antimicrobial prophylaxis and helpful safe living advice for patients. Read the full article in Australian Prescriber.

David Liew talks to rheumatologist Jessica Pisaniello about her paper on Intra-articular hyaluronic acid (viscosupplementation) for osteoarthritis. They discuss the limited benefits and the risks of using of hyaluronic acid in joints, what current guidelines recommend, and what the evidence says. Jessica also advises on how to approach conversations with patients who ask prescribers about using hyaluronic acid. Read the full article in Australian Prescriber.

Laura Beaton chats with David Brieger, head of cardiology at Concord Hospital, Sydney, about the 2025 Australian acute coronary syndromes [ACS] clinical guideline. David explains the importance of secondary prevention for ACS, including new approaches to tailoring the duration of dual antiplatelet therapies, new lipid targets, and the limited role of beta blockers and colchicine. Read the full article in Australian Prescriber.

In a follow-up to our episode on attention deficit hyperactivity disorder (ADHD) in children and adolescents, Justin Coleman talks to psychiatrist Shuichi Suetani about the pharmacological management of ADHD in adults. They discuss the different considerations for managing adults compared with children, as well as important adverse effects and monitoring of ADHD medications. Shuichi also outlines other factors to consider when assessing treatment response. Read the full article in Australian Prescriber.

Jo Cheah talks to Terri-Lynne South, Medical Director at Lifestyle Metabolic in Brisbane, about her paper on injectable drugs for weight management. Terri-Lynne outlines the available GLP-1 drugs and how they work in managing weight. The conversation also covers important considerations for prescribers, including off-label use, potential adverse effects and the need for behavioural and lifestyle modifications. Read the full article by Terri-Lynne and her co-author Natasha Yates in Australian Prescriber.

Justin Coleman chats with sexual health physician Louise Owen about her paper on HIV testing. The conversation covers who and when to test, including higher risk populations and indicator conditions, and the types of HIV tests available, such as rapid point-of-care testing. Read the full article in Australian Prescriber.

AP Podcast hosts David Liew and Dhineli Perera talk about Australia's top 10 drugs over the last year. They discuss the top drugs dispensed under the PBS, based on prescription count and cost to the government. They touch on changes to the use of certain drug classes such as oral anticoagulation, and the impact of the COVID pandemic on antiviral drug use. Read the full article for 2024-25 in Australian Prescriber.

Jo Cheah speaks to clinical pharmacologist Paul Chin about safe use of direct oral anticoagulants and warfarin for adults with atrial fibrillation or venous thromboembolism. They talk about dosing in renal impairment and extremes of body weight, drug interactions, anticoagulant assays, when to use anticoagulant antidotes and when to consult an anticoagulant service. Read the full article in Australian Prescriber.

Justin Coleman chats with paediatrician Daryl Efron about his paper on the pharmacological management of attention deficit hyperactivity disorder (ADHD) in children and adolescents. They discuss the role of stimulants and non-stimulants, starting and stopping treatment, and monitoring for adverse effects. Read the full paper in Australian Prescriber.

Laura Beaton talks to endocrinologist Chris Nolan about the new Australasian consensus recommendations on the screening and diagnosis of gestational diabetes. The conversation covers changes to diagnostic thresholds, indications for early testing, and pharmacological therapies. Read the full article in Australian Prescriber.

David Liew speaks with endocrinologists Faran Khalili and Morton Burt about their article on practical guidance for stopping glucocorticoids. The discussion includes common glucocorticoids used in Australia, when to stop abruptly versus when to taper, recognising adrenal insufficiency and sick day management. Read the full article in Australian Prescriber.

Justin Coleman chats to Lee Fong, member of the Oral and Dental Expert Group, about some of the updates in the latest version of Therapeutic Guidelines: Oral and Dental. With a focus on GP management of dental issues, the conversation includes discussion of preventative steps, oral risks during pregnancy, oral mucosal diseases, acute infections and much more.

Dhineli Perera talks to infectious diseases physician and clinical microbiologist Carly Hughes about the latest recommendations for aminoglycoside use in Australia. They discuss indications for parenteral aminoglycosides, drug selection, dosing and therapeutic drug monitoring. Read the full article by Carly and her co-authors in Australian Prescriber.

Laura Beaton speaks with Steph Hopkins (rheumatology registrar) and David Liew (rheumatologist and clinical pharmacologist) about choosing a nonsteroidal anti-inflammatory drug (NSAID) for pain. Steph and David discuss the importance of considering the adverse effect profile and selectivity of NSAIDs, and balancing the benefits and risks when selecting the ideal drug for a patient. Read the full article in Australian Prescriber.

Justin Coleman chats with geriatrician and clinical pharmacologist Alex Choo about potentially inappropriate medicines [PIMs] for older people. They discuss the challenges of prescribing for older people and how to use the new Australian PIMs list. The discussion covers some of the 15 drug classes on the list, including antidepressants, benzodiazepines, opioids and NSAIDs. Read the full article by Alex in Australian Prescriber.

Dhineli Perera talks to Laxmi Iyengar, dermatology research fellow and GP, and Jane Li, consultant dermatologist, about male and female pattern hair loss. Laxmi and Jane discuss presentations and available treatments, as well as important considerations for prescribing. Read the full article in Australian Prescriber.

Justin Coleman speaks with Hester Wilson, Chief Addiction Medicine Specialist for NSW, and pharmacist Jillian Kanck about the medicines used in the treatment of opioid dependence. They explain how opioid dependence is diagnosed and discuss the advantages of long-acting buprenorphine, as well as the place of sublingual buprenorphine and methadone in treatment. Read the full article by Hester and Jillian in Australian Prescriber.

David Liew chats with Sophie Stocker, co-chair of the Royal College of Pathologists of Australasia Pharmacogenomics Working Group, about using pharmacogenomics to personalise drug therapy. They discuss pre-emptive, concurrent and reactive testing, and the current landscape of pharmacogenomics in Australia. Read the full article by Sophie and her co-author, Thomas Polasek, in Australian Prescriber.

Justin Coleman talks to Kate McKenzie, General Practitioner and member of one of the Antibiotic Expert Groups, in part 2 of our series on the latest updates to Therapeutic Guidelines: Antibiotic. This episode focuses on changes to guidance for primary care, including new recommendations for UTIs, infectious diarrhoea, bronchiectasis, infections of diabetes-related foot ulcers and much more.

Laura Beaton speaks with Emma Mason, lecturer in sexual and reproductive health, about the latest changes in contraceptive products in Australia. They outline key practice points for selecting appropriate contraception and managing adverse effects, as well as some useful resources to support the prescribing of contraceptives. Read the full paper by Emma and her co-author, Kirsten Black, in Australian Prescriber.

Jo Cheah chats to dermatologist Jonathan Chan about the latest therapies for psoriasis. Jonathan outlines the different treatments for mild to moderate and moderate to severe psoriasis, and when to refer patients to a non-GP specialist. They discuss the benefits and risks associated with biologic medicines for psoriasis, and considerations for patients with comorbidities. Read the full article by Jonathan in Australian Prescriber.

Dhineli Perera talks to pharmacists Amy Legg and Tony Lai about their paper on the safe and effective use of vancomycin. They discuss the evolution of vancomycin therapeutic drug monitoring, including trough concentrations, and demystify AUC monitoring. They cover current recommendations, including targets for drug efficacy and safety, and priority patient groups. Read the full article by Amy, Tony, and their co-authors, in Australian Prescriber.

Justin Coleman speaks with Alice Poulton, genetic counsellor, about noninvasive prenatal testing (NIPT) to screen for aneuploidies such as trisomy 21 (Down syndrome). Alice explains how NIPT differs from serum screening and ultrasound options, and when each option may be used. The conversation also covers advice on interpreting the NIPT results and when invasive testing may be offered. Read the full paper in Australian Prescriber.

David Liew talks to Linny Phuong, paediatric infectious diseases physician, about changes to prevention and management of respiratory syncytial virus (RSV). They discuss how RSV infections affect communities in Australia, high-risk groups to watch out for, and when to test for RSV. Linny also outlines available RSV immunisations for different populations. Read the full article by Linny and her co-author, David Foley, in Australian Prescriber.

Dhineli Perera chats with Allen Cheng, director of Infectious Diseases at Monash Health and member of the Antibiotic Expert Group, about some of the updates in the latest version of Therapeutic Guidelines: Antibiotic. Allen talks about changes to severity assessment and treatment for community-acquired pneumonia, updated antimicrobial dosing advice, a new tiered approach for managing patients with sepsis and much more.

Jo Cheah talks to Bronwyn Jenkins, consultant neurologist, about the role of calcitonin gene-related peptide (CGRP)–targeted therapies in migraine treatment. Bronwyn explains the difference between tension-type headaches and migraines, and outlines current treatment options. The conversation also covers adverse effects, patient eligibility, and other important considerations for prescribers. Read the full article in Australian Prescriber.

Justin Coleman speaks with Kate Ziser, a pharmacist at the Princess Alexandra Hospital in Brisbane, about her paper on the role of triple antithrombotic therapy in patients with atrial fibrillation following coronary stent insertion. Kate explains when triple therapy is indicated, the duration of therapy, and the step-down approach to antithrombotic therapy. Read the full article by Kate and her co-authors in Australian Prescriber.

Laura Beaton chats with Nadia Mouchaileh, senior pharmacist, and Jillian Cameron, head of movement disorders and consultant neurologist at Austin Health, about device-assisted therapies for Parkinson disease. They discuss the benefits vs traditional therapies, when to refer patients to a specialised movement disorder centre and what to look for when caring for a patient using a device. Read the full article in Australian Prescriber.

Jo Cheah talks to Debra Kennedy, director of MotherSafe, about her paper on drug safety in pregnancy. Debra discusses the key considerations when stopping or starting a medicine during pregnancy, and the ways in which medicines can affect developing fetuses. Debra also explains the Australian categorisation system for prescribing medicines in pregnancy. Read the full article by Debra and her co-author, Ronald Batagol, in Australian Prescriber.

Dhineli Perera speaks with Lee Fong, a medical advisor for the Australian Commission on Safety and Quality in Health Care, about the need to establish a national clinical care standard for people with chronic obstructive pulmonary disease (COPD). Lee explains how the Standard can be used to identify gaps in care and optimise the management of patients with COPD. Read the full article by Lee and his co-authors in Australian Prescriber.

David Liew talks to Claire Larter, a medical officer at the pharmacovigilance branch of the TGA, about her paper on adverse event reporting. Claire explains why pharmacovigilance is important for clinicians, and outlines what type of adverse events should be reported. The conversation also covers the process of reporting adverse events and how the TGA handles reports. Read the full article by Claire and her co-authors in Australian Prescriber.

Laura Beaton chats with Paul Kubler, director of Rheumatology at Royal Brisbane and Women's hospital, about how to identify and manage antiphospholipid syndrome. They discuss the key presentations of APS, classification criteria and approaches to treatment. They also cover patients with catastrophic APS and asymptomatic people with persistent antiphospholipid antibodies. Read the full article by Paul and his co-authors in Australian Prescriber.

Jo Cheah talks with Eileen Cole, GP lead, and Jennifer Kyi, pharmacist advisor at Quit, about the use of therapeutic vapes for smoking cessation. They discuss the current evidence and new Australian guidelines. The conversation also covers choosing a vape and how to prescribe or supply vapes. Read the full article by Eileen, Jennifer, and their co-authors, in Australian Prescriber.

In this episode Dhineli Perera speaks to John Turnidge, who leads the national surveillance program for Antimicrobial Use and Resistance in Australia. They discuss the significant impact of the pandemic on reducing antibiotic use in the community, and how this benefit can be sustained and improved on. Read the full article by John and his co-authors, Carolyn Hullick and Kim Stewart, in Australian Prescriber.

Laura Beaton chats with Debbie Rigby, from the National Asthma Council, about her paper on inhaler device selection for people with asthma or chronic obstructive pulmonary disease. Debbie outlines the different types of inhalers available, and explains their benefits, limitations and environmental considerations. They also discuss ensuring patients are using their inhalers effectively. Read the full article by Debbie in Australian Prescriber.

Jo Cheah talks to Tom Simpson, President, and Jerry Yik, Head of Policy and Advocacy, at Advanced Pharmacy Australia. They discuss the ongoing challenge of medicine shortages in Australia, and advise on how to identify, communicate and manage shortages using available resources. Read the full article by Tom and Jerry in Australian Prescriber.

Laura Beaton chats with endocrinologist Jillian Tay about her article on the pharmacological management of polycystic ovary syndrome (PCOS). They discuss the 2023 international PCOS guideline, including updates to the diagnostic criteria, and different pharmacological treatments to manage symptoms of PCOS. Read the full article by Jillian and her co-author, Carolyn Ee, in Australian Prescriber.

Dhineli Perera talks to complex care coordinator Deirdre Criddle and senior pharmacist Rohan Elliott about their paper on safe medication management during transitions of care from hospital. They cover the potential hazards that arise during transitions of care, available services, and the need for a stewardship framework for managing hospital transitions. Read the full paper by Deirdre, Rohan, and their co-authors, in Australian Prescriber.

Laura Beaton sits down with infectious diseases physician Anna Pierce to discuss her article on the management of occupational exposure to blood and body fluids in primary care. Anna explains the importance of prevention measures, the steps to take after an exposure, as well as the principles of management for exposure to hepatitis B, hepatitis C and HIV. Read the full article in Australian Prescriber.

David Liew talks to rheumatologist Nicola Cook about the utility of common investigations for suspected inflammatory arthritis in adults. They discuss the notion of pretest probability and how this is used to determine the utility of testing, and the role of specific tests. Nicola also talks about the potential harm of overinvestigation. Read the full article by Nicola and her co-author, Rachelle Buchbinder, in Australian Prescriber.

Dhineli Perera chats with infectious diseases physician Emily Tucker about her article on controversies in the management of community-acquired pneumonia (CAP) in adults. Laura talks about severity scoring tools, organisms involved with CAP, and the antibiotics and other treatments used to manage CAP. Read the full article by Emily and her co-authors in Australian Prescriber.

Dhineli Perera talks to Jonathan Dartnell, managing director of QUM Connect, and Darlene Cox, Executive Director of Health Care Consumers' Association, about changes to the quality use of medicines landscape. They discuss the challenges and opportunities following the closure of NPS MedicineWise and speculate on the future of QUM in Australia. Read the full article by Jonathan, Darlene, and their co-authors, in Australian Prescriber. This interview was conducted on 3 July 2024.

Laura Beaton talks to pharmacist Aili Langford and geriatrician Sarah Hilmer about their article on deprescribing antihypertensive drugs in frail older adults. They discuss how the potential benefits and harms of lowering blood pressure may change with increasing age and frailty, the evidence for deprescribing, and how to deprescribe antihypertensive drugs. Read the full article by Aili, Sarah, and their co-authors, in Australian Prescriber.

David Liew speaks with geriatrician and dementia specialist Louise Waite about her article on new and emerging therapies for Alzheimer disease. Louise explains key biomarkers for Alzheimer disease, and the potentially disease-modifying monoclonal antibody therapies that have been approved by the FDA and are now being considered by the TGA in Australia. Read the full article by Louise in Australian Prescriber.

Justin Coleman talks to Darren Mansfield, Director of the Epworth Sleep Centre, about his article on the diagnosis and management of obstructive sleep apnoea (OSA) in adults. Darren outlines high-risk populations for OSA and the importance of screening. He also covers treatments, including CPAP therapy, positional and oral appliances, and surgical options. Read the full article by Darren and his co-author, Daniel Hynes, in Australian Prescriber.

Jo Cheah speaks to Peter Wark about his article on biologic therapies for severe asthma with persistent type 2 inflammation. Peter explains the difference between difficult and severe asthma and how to test for persistent type 2 inflammation. He also runs through the available biologics and when and how they are used. Read the full article by Peter and his co-author, Sahan Chandrasekara, in Australian Prescriber.

Justin Coleman talks to Garry Jennings, Chief Medical Advisor of the National Heart Foundation of Australia, about his article on the 2023 Australian Guideline for Assessing and Managing Cardiovascular Disease Risk. Garry discusses the updates to the guideline, including the age from which assessment should occur and new risk factors considered, and he gives some tips for communicating cardiovascular disease risk to patients. Read the full article by Garry and his co-authors in Australian Prescriber.