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In vivo cell therapies represent a new frontier in medicine, offering the potential to treat diseases like cancer by directly modifying immune cells within the body. Unlike traditional ex vivo therapies where cells are extracted, modified, and reintroduced, in vivo approaches aim for simpler, more efficient treatments. Imagine injecting a treatment that reprograms your own immune system to fight disease. This is the promise of in vivo cell therapies, a rapidly developing field with the potential to revolutionize medicine. This podcast will explore the science behind in vivo cell therapies, focusing on their potential to treat a variety of diseases, including cancer. We'll examine the key components needed for successful in vivo cell therapies, such as delivery vectors (like lentiviral vectors and nanoparticles) and the therapeutic payloads they carry. We'll also discuss the importance of shared biology across payloads, which can increase the likelihood of success in developing these therapies. A major focus of the podcast will be T-cell exhaustion, a phenomenon that often hinders the effectiveness of immunotherapies. When T-cells, the warriors of our immune system, become exhausted, they lose their ability to effectively fight off disease. We will discuss groundbreaking research, like that from the Wherry Lab, that is uncovering ways to reverse T-cell exhaustion and unlock the full potential of in vivo cell therapies. Axial Newsletter: https://axial.substack.com/ Build with Axial: https://build.axialvc.com/ https://linktr.ee/axialxyz