Audiommunity

A retrospective on audiommunity, and some solid rants about the importance of science,science communication, and government funding. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Matt and Kevin stick with the brain,this time looking at the immunological implications ofa variant of a gene called Apolipoprotein Ethat has been linked to Alzheimer's and other neurodegenerative diseases.It's a long one, and we get snarky in this one folks!Buckle up! Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Matt and Kevin are joined by [Nicole Ackermans](https://nicoleackermans.com)to discuss her recent review paper tracing human thoughts about headbuttingfrom 10,000 BCE to the present day.How are animals like bighorn sheep and woodpeckers protectedfrom brain injury?Actually, wait... **are** they protected from brain injury? Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode Matt and Kevin welcome special guest Zach Hiltfrom the University of Toledo -we're talking neonatal Tregs! Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Matt and Kevin talk about glycoRNAs and inflammation,but Matt insists that it's really about Lupus Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Matt and Kevin take a humbling look back a classic 1989 immunology paperfrom the lab of David Baltimore (RIP)in which the gene encoding RAG-1,one of two genes that is responsible forthe VDJ recombination -a mechanism for the generation of diversityin the adaptive immune system. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Someone made an AI-based "virtual lab" to engineer nanobodies -is this a paradigm shift in how we do science,or a transpararent and cynical effort to slurp up all of the citations for being first?Por que no los dos? Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Bacteria have immune systems? Even adaptive immune systems? And autoimmunity?Well... sort of Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Matt and Kevin discuss a new paper about the "subfornical organ"which (once again) undermines the idea of immune privilage,and also points to an interesting evolutionary question:why would T-cells migrating from fat to the brain affect hunger response? Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Think vaccines aren't important?Kate, Kevin, and Matt discuss a paper modeling just how wrong you are - that is, unless you don't mind children dying. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Matt and Kevin speak with Abbie Smith,an assistant professor at Emory's Hope Clinic,about the current state of American biomedical science. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Matt and Kevin discuss an excellent paper showing how skin-regulatory Tregs have a distinct role in protecting hair follicles from autoreactive CD8 T-cells; it’s a really clear illustration of why animal research is critical to advancing our understanding.Also, for future reference, apparently riverside.fm’s bot transcription cannot distinguish Tregs from T-rex.Links* The paper* Yes she will, Precious, she will get the hose Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

I'm certain that what you've really been missing in these dark timesis two guys mansplaining menstruation...but also cool immunology! Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking about a strange phenomenon where the immune systemseems to intentionally shuttle certain microbes from the gut to lymph nodes and the spleen. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking about the OAS-RNaseL virus-sensing pathway,and the passage of its product, 2,5-oligoadenylate, through gap junctions. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

How does "rewilding" mice change their immune system? Also, an interview with an organizer of the Atlanta Stand Up for Science march! Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking itch, and the sweet sweet relief you get when degranulating your mast cells. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Are you bleak, disenchanted, stressed out, and unhappy? No, we're not talking (only) about US politics,we're talking about Postdocs! And about a new paper showing how academic successis linked to publications. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Audiommunity is back! Again! Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

I swear, we know how to count; this episode was originally recorded back in January, but Camilla's audio file was weirdly corrupted. And in this attempt, Chadene's computer exploded, but we soldiered on without her. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Chadene, Kate and Kevin discuss Kate's recently published paper about how STING, once thought to be involved only in defense against DNA viruses, actually slows RNA virus replication as well. Also, Chadene throws herself under the bus, and Kevin manages to only talk for about 20% of the time. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking about *Salmonella*, and the peculiar way in which it tries to keep you eating to keep you alive. Who knew pathogens could be so kind? Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Kevin and Camilla discuss *Salmonella* virulence,* and how different strains alter the immunogenicity of pathogens. Oh, and Kate's here too... KATE'S BACK!! WOO!! Dr. Franz has a new job, but is just as snarky and ill-prepared as ever. Plus she refuses to drink on the job. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Today (well, three weeks ago), Matt and Kevin talked about epitope spreading in Lupus, and a ton of crazy mouse models that allowed researchers to dissect the way a single auto-reactive B-cell clone can spread the disease party to its neighbors. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking cure for the common cold... or at least, a vaccine for it. Also, Kevin and Matt read the wrong paper, Chadene corrects Kevin's pronunciation of her name (again!) and we give a big round of applause for Dr. Kate Franz (though she's still too busy for us). Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking cancer, checkpoint blockade and poop - what's not to love? Also, Camilla is the only one drinking, Matt thinks the study needs more mice, and it took Kevin an extra 2 hours to edit this episode to remove all (he hopes) of his sniffles. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

We've got a couple of new hosts - Please give a warm welcome to Chadene Tremaglio and Camilla Engblom! Kate is still holed up in a cave (lab) trying to wrap up her PhD. But she'll soon return... we hope... Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Audiommunity loves Tasmanian devils, so we bite the s**t out of them... In this episode, we're talking about a contagious tumor that couldn't happen to a nicer species. No seriously, it really couldn't. Tasmanian devils bite each other on the face to say hello. WTF devils? Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

This week - Evidence that viruses drive the evolution of their hosts - who would have guessed? Matt struggles to remember how evolution works, and Kate and Kevin yell past each other about open peer review. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Matt and Kevin give in to aesthetics. This paper's just really pretty. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

This week, a guy gets a kiwi allergy from a bone marrow transplant from his sister, Matt envisions a magic mouse, and Kate peaces out after 20 min. Meanwhile, Kevin continues to be the only one drinking... that schtick may not last much longer. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Something a bit different this episiode. Last month, we joined Jesse Noar, host of the excellent Bacteriophiles podcast to record an episode about oncolytic viruses (viruses that blow up cancer cells). Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, how parasitic worms alter in immunomodulatory effects of the gut microbiome. Also, Kate expresses her distaste for large datasets and animal experiments, and Matt proposes a weight loss company that will only market to identical twins. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we talk about the innate immune system's Trojan cow strategy - using a cyclic dinucleotide as a signaling molecule means that viruses can package the seeds of their own destruction. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode we talk about lymphatics in the brain and why that's both obvious and not obvious. Meanwhile, Kate drinks disgusting smoothies and Kevin triggers Matt with a trigger warning. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Matt and Kevin discuss checkpoint blockade cancer immunotherapy (wow, that's a mouthful). When cancer stamps down the breaks of the immune system, cutting the break line can allow T-cells to do their job. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

This week, we're discussing DRACOs - not the Harry Potter character, a "new" class of antiviral therapeutics that links up the double-stranded RNA-binding part of one protein to the cell-death (apoPtosis)-activating part of a different protein. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking about the placental microbiome - that is, the bacteria that hang around a developing fetus in the womb. Wait, there are bacteria hanging around a developing fetus? Apparently! Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we discuss the moral implications of doing experiments on babies without brains, and editing the genomes of unborn humans. I reveal my nature as a moral monster, and Kate can't resist bringing up Kim Kardashian's artificial selection of her own offspring. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

To celebrate the return of the warm(ish) weather, we discuss a paper looking at immune responses to bee venom, and the underlying causes of environmental allergy. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

A discussion about sCD38, a molecule that's secreted in mouse and human sperm,and may play a role in suppressing a mother's immune response to a new fetus. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Turns out *Staphylococcus aureus* can evade the immune system by activating it.Also, Matt's bad hair day and a link between tacos and tampons. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're joined by Abbie Smith, a postdoctoral fellow studying HIV at Emory University, and author of the popular (and always wonderful) ERV blog. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Kate and Kevin talk influenza and gain of function research. Should we be making flu more deadly? Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

After a hard day's work, sometimes you want to just kick your feet back and relax. Unfortunately, sometimes your CD8 T-cells want the same thing, even though they don't have feet. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, Kevin talks with Pamela Ronald, professor of plant pathology at the University of California, Davis. Almost 20 years ago, Ronald discovered Xa21, a plant pattern recognition receptor that guards against bacterial infection. This receptor shares many features with Toll-like receptors, and the role of Xa21 was shown a year before TLRs were implicated in immunity. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In Episode 5, we're talking about neutrophils, and the special way they die. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

After a long absence, we're back! With an episode about the autoimmune disease multiple sclerosis and how immune cells navigate the around the body. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

Today, we're talking the *other* immunity (that both Kate and Kevin happen to study). Neglected for nearly one hundred years, the innate immune system is required for getting inflammation going, and without it, adaptive immunity wouldn't function. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe

In this episode, we're talking antibodies - what they are  and what they have to do with Vaccines. Also, we discuss efforts to use engineered antibodies to treat HIV. Get full access to Audiommunity Org at audiommunity.substack.com/subscribe