Ever Young Podcast

In this episode, I sit down with Dr. Bobby Dubois to unpack why so much health advice is driven by hype instead of evidence. We explore how to evaluate medical claims, when studies actually matter, how to run your own N-of-1 trials, and what AI will (and won’t) replace in medicine. This conversation will sharpen how you think about longevity, supplements, and modern healthcare.Dr. Bobby Dubois is a physician, scientist, Ironman triathlete, and host of Live Long and Well With Dr. Bobby. He trained at Harvard, earned his medical degree from Johns Hopkins, completed his Internal Medicine residency at Harbor-UCLA, and holds a PhD in Health Policy from the RAND Corporation. He has published more than 180 peer-reviewed scientific articles.As a physician-scientist, Dr. Dubois has dedicated his career to understanding what truly works in healthcare—and what does not—using rigorous scientific evidence to guide patients toward better health decisions.In recent years, he has focused his work on helping others live longer with renewed energy as they age, applying an evidence-based lens to longevity and wellness. Equal parts educator and myth-buster, he is also the owner of Madrone Springs Ranch, an exotic animal ranch and bed and breakfast in Texas, where principles of wellness and longevity are woven into the guest experience.Connect with Dr. Bobby DuboisWebsite: https://drbobbylivelongandwell.com/ Instagram: https://www.instagram.com/drbobbylivelongandwell/ LinkedIn: https://www.linkedin.com/in/drbobbydubois/ Connect with Dr. Rich HandleyYouTube: ⁠⁠https://www.youtube.com/@Richard.Handley⁠⁠ LinkedIn: ⁠⁠https://www.linkedin.com/in/drhandley/⁠⁠PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠⁠⁠⁠⁠⁠Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Dr. Blane Mire explores longevity escape velocity, healthspan, sleep, purpose, and why America’s aging crisis isn’t a technology problem.In this episode, I continue my conversation with Dr. Blane Mire as we explore longevity escape velocity, healthspan versus lifespan, and why Americans age more poorly despite higher healthcare spending. We dive into sleep, nutrition, stress, movement, and the overlooked role of purpose and meaning in aging well. This conversation connects science, lifestyle, and humanity—focusing on living better, not just longer.Dr. Blane Mire began his medical education journey attending Louisiana State University School of Medicine in Shreveport, La. He completed his Internal Medicine residency program through LSUMC in Baton Rouge, LA, in 1998. He has spent his career in private practice in Natchez, Mississippi, just a short drive up the Mississippi River from Baton Rouge. In recent years, he has focused on expanding his knowledge and completed a fellowship in anti-aging, functional, and regenerative medicine through A4M. Dr. Mire has continued to pursue education and specialized training to stay at the forefront of this exciting area of medicine. He also holds certifications in Longevity Medicine and Peptides.Connect with Dr. Blane MireWebsite: ⁠https://blanemiremd.com/⁠ Facebook: ⁠https://www.facebook.com/profile.php?id=61560820844113⁠ LinkedIn: ⁠https://www.instagram.com/dr.blanemireConnect with Dr. Rich HandleyYouTube: ⁠https://www.youtube.com/@Richard.Handley⁠ LinkedIn: ⁠https://www.linkedin.com/in/drhandley/⁠ PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠⁠⁠⁠⁠Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Integrative internist Dr. Blane Mire reveals how root-cause medicine, advanced diagnostics, and prevention strategies redefine true longevity.----In this episode, I sit down with Dr. Blane Mire to explore how he shifted from conventional internal medicine into a root-cause, longevity-driven approach to care. We talk about advanced cardiac markers, inflammation, LP(a), ApoB, omega ratios, nitric oxide, peptides, fasting, creatine, protein, and why muscle is the ultimate longevity tool. Dr. Mire breaks down the science, the gaps in traditional care, and what truly drives long-term health.----Dr. Blane Mire, MD began his medical education journey attending Louisiana State University School of Medicine in Shreveport, La. He completed his Internal Medicine residency program through LSUMC in Baton Rouge, LA, in 1998. He has spent his career in private practice in Natchez, Mississippi, just a short drive up the Mississippi River from Baton Rouge. In recent years, he has focused on expanding his knowledge and completed a fellowship in anti-aging, functional, and regenerative medicine through A4M. Dr. Mire has continued to pursue education and specialized training to stay at the forefront of this exciting area of medicine. He also holds certifications in Longevity Medicine and Peptides.----Connect with Dr. Blane MireWebsite: https://blanemiremd.com/ Facebook: https://www.facebook.com/profile.php?id=61560820844113 LinkedIn: https://www.instagram.com/dr.blanemire----Connect with Dr. Rich HandleyYouTube: https://www.youtube.com/@Richard.Handley LinkedIn: https://www.linkedin.com/in/drhandley/ ----PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠⁠⁠⁠----Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

A deep dive into Sinclair and Diamandis’ predictions on AI, longevity escape velocity, digital superintelligence, and the future of age reversal.----In this episode, I break down the bold predictions from David Sinclair and Peter Diamandis on aging, AI, and the future of human longevity. We explore whether age-reversal pills, digital superintelligence, and even doubling the human lifespan are realistic possibilities within the next decade. I share what excites me, what concerns me, and how these breakthroughs could reshape how we think about health, purpose, and the years ahead.----Dr. David Sinclair is a Harvard Medical School professor of genetics and a pioneer in longevity science, known for his work on the Information Theory of Aging and the use of Yamanaka factors to reverse age-related decline. Dr. Peter Diamandis is a Harvard-trained physician, futurist, and founder of XPRIZE and Fountain Life, leading global efforts to use exponential technology to extend human lifespan. Their work represents the forefront of a new era in medicine, where aging itself is being reimagined as a treatable condition.----Dr. Rich HandleyYouTube: ⁠https://www.youtube.com/@Richard.Handley⁠ LinkedIn: ⁠https://www.linkedin.com/in/drhandley/⁠ ----PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠⁠⁠----Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Dr. Rich Handley explores Dr. David Sinclair’s latest breakthroughs in gene therapy, epigenetic resets, and the future of reversing biological aging.----In this episode, I break down Dr. David Sinclair’s groundbreaking work on reversing aging through gene therapy and cellular reprogramming. We explore what it means to turn back the biological clock, what “longevity escape velocity” could look like, and how we might one day reset our bodies to a younger state. I also share my reflections on what such a future means for health, purpose, and the human experience.----Dr. David Sinclair is a Harvard Medical School professor and one of the world’s leading researchers on aging and longevity. His pioneering work on sirtuins, epigenetic reprogramming, and Yamanaka factors has reshaped how we understand biological aging. As co-founder of Life Biosciences and author of Lifespan: Why We Age—and Why We Don’t Have To, Dr. Sinclair continues to advance the science of reversing age-related decline through cutting-edge genetics and biotechnology.----Dr. David SinclairYouTube: https://www.youtube.com/@Richard.Handley LinkedIn: https://www.linkedin.com/in/drhandley/ ----PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠⁠⁠https://drtalks.com/podcast-service/⁠⁠⁠----Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Dr. Rich Handley unpacks David Sinclair and Peter Diamandis’s vision for reversing aging through AI, gene therapy, and the information theory of aging.----In this solo episode, Dr. Rich Handley dives into the groundbreaking longevity research of Dr. David Sinclair and Dr. Peter Diamandis. He explores how artificial intelligence, gene therapy, and Sinclair’s “Information Theory of Aging” are transforming what we know about reversing the biological clock. Dr. Handley unpacks the science, the ethics, and the real-world potential of a future where we can reset our cells—and maybe even redefine what it means to age.----Dr. David Sinclair is a Harvard Medical School professor of genetics and a pioneer in longevity science, known for his work on the Information Theory of Aging and the use of Yamanaka factors to reverse age-related decline. Dr. Peter Diamandis is a Harvard-trained physician, futurist, and founder of XPRIZE and Fountain Life, leading global efforts to use exponential technology to extend human lifespan. Their work represents the forefront of a new era in medicine, where aging itself is being reimagined as a treatable condition.----PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠⁠https://drtalks.com/podcast-service/⁠⁠----Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Entrepreneur David Guttman shares how a misdiagnosed terminal illness reshaped his views on leadership, legacy, and building deeply human companies.-----In this episode, I speak with David Guttman about the moment he was told he had six months to live—and how that shocking diagnosis reshaped his view of purpose, leadership, and life itself. We explore the power of humility, building meaningful relationships, and how emotional intelligence creates better teams and companies. This conversation is packed with raw wisdom, practical takeaways, and stories you won’t forget.-----David Guttman is a serial entrepreneur, 3X Inc. 500 honoree, and author of Lead Like You Give A Shit. With over 30 years of experience building, scaling, and exiting multiple companies, David brings deep insight into what it truly takes to lead. His work bridges rigorous business strategy with personal growth, emotional intelligence, and real-world experience, including surviving a shocking misdiagnosis that changed everything.----PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com ⁠https://drtalks.com/podcast-service/⁠----Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.

Ryan Smith shares how TruDiagnostic is using AI and DNA methylation to measure biological age, predict chronic disease, and transform longevity medicine. ----In this episode, I talk with Ryan Smith about how TruDiagnostic is leading a revolution in longevity. We dive into the power of epigenetic clocks, AI modeling, and personalized diagnostics to predict chronic disease, assess biological age, and identify what really works—from hyperbaric oxygen to Vitamin D. Ryan explains how epigenetic reprogramming and new CRISPR-style therapies may finally unlock true longevity escape velocity. ----Ryan Smith is the founder of TruDiagnostic and a pioneer in the field of epigenetics and longevity medicine. From his early breakthroughs in peptide science to launching one of the most advanced biological age testing platforms in the world, Ryan has been at the forefront of personalized health innovation. His work is transforming how we diagnose, track, and treat aging itself, making the science of living younger, longer, and more accessible to patients and clinicians alike.----PODCASTThank you for listening.Please subscribe and share.This podcast is produced by DrTalks.com https://drtalks.com/podcast-service/----Disclaimer*Richard Handley earned his MD degree (summa cum laude) and is licensed and board-certified as a PA-C in California, with active NPI and DEA registration. He does not practice as a physician. All content is for educational purposes only and is not a substitute for professional medical advice. Always consult your personal healthcare provider before making healthcare decisions.