ReTuneIn

Today at ReTuneIn, we welcome Prof. Andrea Kühn and Prof. Jens Volkmann, who share their perspectives on the future of adaptive deep brain stimulation and the evolving landscape of neuromodulation.Andrea Kühn, Professor of Neurology at Charité Berlin, offers insights into state-dependent stimulation, emerging biomarkers such as gamma activity, and the clinical experience with adaptive DBS in Parkinson’s disease.Jens Volkmann, Professor of Neurology at the University Hospital Würzburg, reflects on the challenges of translating technological innovation into meaningful patient outcomes, highlighting the role of large-scale data, AI, and personalized stimulation strategies.Together, they discuss the need to move beyond single-signal approaches, explore dynamic brain states, and rethink how stimulation can better mimic physiological processes—pointing toward the next generation of intelligent, patient-centered neuromodulation therapies.

In today’s episode, we welcome Prof. Petra Ritter and Prof. Philipp Böhm-Sturm — two researchers who share a passion for building the digital infrastructure that powers modern brain science.Petra Ritter brings a human-focused perspective through her work in computational brain modeling, while Philipp Böhm-Sturm contributes deep expertise in experimental MRI with animal models. Together, they explore how combining human and animal data can lead to better, faster, and more ethical neuromodulation research.Stay tuned for an inspiring conversation about collaboration, simulation, and the shared vision behind the ReTune research community.

Today at ReTuneIn, we welcome Lucia Feldmann and Hagai Bergman, who will provide fascinating insights into their research on adaptive deep brain stimulation. Lucia Feldmann, a Neurology Resident and Clinical Scientist at Charité Berlin, explores the application of electrophysiological recordings in Parkinson’s disease, focusing on beta oscillations and their modulation during sleep. Hagai Bergman, an expert in neurophysiology, brings his extensive experience working with non-human primates to the discussion, offering a unique perspective on movement disorders and brain stimulation. Together, they dive into the challenges of distinguishing physiological signals from artifacts, the role of oscillatory changes in sleep, and the future of closed-loop stimulation systems. Tune in for an engaging conversation on how these insights are shaping the next generation of neuromodulation therapies.

Welcome to another episode of ReTuneIn! Today, we’re joined by Dr. Jil Meier and Prof. Julian Neumann, who will share insights into their research on motor control and neural circuit adaptation.Jil Meier explores how whole-brain dynamical simulations —using the open-source platform The Virtual Brain — can improve our understanding of deep brain stimulation. Her work looks at how stimulation affects distributed brain networks and how we might use these insights to develop more personalized neuromodulation therapies.Julian Neumann focuses on the plasticity of basal ganglia circuits—how these networks adapt and reorganize, and what that means for movement execution. Together, they’ll dive into the challenges of studying these complex systems and what their findings could mean for the future of neuromodulation.

In the first episode, we welcome Lisa Harder and Yangfan Peng, who will give exciting insights into their research projects. Lisa Harder investigates cortico-striatal plasticity underlying phenotype manifestation in dystonia and discusses the potential applications of her findings, while Yangfan Peng will tell us about retuning pathway-specific neuronal population dynamics for movement initiation. Both will share their challenges, insights and the relevance of their work to the treatment of movement disorders in real life.