Gladstone Audio News

Thirty years after discovering a gene, Shinya Yamanaka and his team show that it’s essential for keeping intestinal stem cells stable, offering insight into how tissues repair themselves.Read this story on our website. 

A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases.Read this story on gladstone.org.

Scientists at Gladstone expanded their retron-based genome editing technology beyond E. coli, showing it works in 15 diverse bacterial species.Read this article on gladstone.org. Read the scientific publication. 

A team of scientists at Gladstone and UCSF created a new genetic roadmap that reveals hundreds of hidden players in HIV infection, including two proteins that stop HIV in its tracks.Read this story on gladstone.org.Read the scientific publication. 

New findings on the APOE4 gene variant point to a potential therapeutic target for Alzheimer’s disease. Read this story on gladstone.org.Read the scientific publication. 

Trained on data spanning the human lifespan, the tool developed at Gladstone can predict genes associated with aging and age-related diseases. Details appear in new study led by Christina Theodoris, MD, PhD, whose team developed the model.Read this story on gladstone.org.Read the preprint. 

A team of Gladstone scientists, led by Nadia Roan, uncovered a new path toward life without daily HIV pills, suggesting that a common diabetes pill could help achieve long-term remission.Read this story on gladstone.org.Read the scientific publication. 

A team of scientists, led by Gladstone Investigator Nadia Roan, developed a novel tool, named HIV-seq, that could uncover new opportunities for treating HIV.Read the scientific publicationRead this story on gladstone.org.

A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.Read this story on gladstone.orgRead the scientific publication

A team of scientists discovered that red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments.Read this article on gladstone.org.Read the scientific publication. 

In a new study featured in Nature Cardiovascular Research, Gladstone scientists identified a cellular boundary that guides heart development and revealed how disrupting it can lead to holes in the heart’s wall.Read the scientific publicationRead the article on Gladstone.org

A team of scientists at Gladstone developed a new gene editing method and showed that only a few variations of the therapy could treat the majority of patients with Charcot-Marie-Tooth disease.Read this article on gladstone.orgRead the scientific publication. 

Gladstone Institutes researcher Alex Marson and his collaborators at Stanford University developed a genomic mapping technique that helps close the gap in understanding why certain genetic variants are tied to disease.Read this story on gladstone.org.Read the scientific publication. 

A new study by scientists from Gladstone, the Innovative Genomics Institute, and UC Berkeley could influence how gene therapies are designed for many genetic diseases.Read the scientific publicationRead this article on gladstone.org

Gladstone Investigator Ken Nakamura led a study that strengthens the links between energy breakdown in cells and the onset of Parkinson’s, potentially illuminating new paths for treatment.Read the scientific publicationRead this article on Gladstone.org

Scientists at Gladstone Institutes and UC San Francisco learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.Read the scientific publicationRead the article on Gladstone.org

A powerful scientific platform opens new possibilities for treating cancer, autoimmune diseases, and other conditions in which reprogrammed T cells could provide a benefit to patients.Read this article on gladstone.org.Read the scientific publication. 

After decades of mystery, Gladstone researchers identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice.This is an audio version of the article, "Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome," published on Gladstone.org.  Read the article on our website.Read the scientific publication.

A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing Parkinson’s disease.This is an audio version of the article, "Overworked Brain Cells May Burn Out in Parkinson’s Disease." Read the article on our websiteRead the scientific publication

Listen to this in-depth explainer about different types of vaccines and what happens in the body after vaccination.Read the story on our website.

Gladstone scientists, led by Andrew Yang, PhD, show that known genetic risk factors for neurological diseases act in the brain’s blood vessels and immune cells, revealing new targets for therapies.This is an audio version of the article, "Blood Vessels and Immune Cells Drive Risk for Alzheimer’s and Stroke," published on gladstone.org on July 28, 2025. This episode is narrated by an AI-voice. Read this article on our website.Read the scientific publication.

A new study from the Roan lab found strong immune defenses in pregnant and lactating women, with key benefits that could guide future vaccine design.Read more about the study on our website.Read the scientific publication.This is an audio version of the article "Pregnancy, Lactation Shape Immune Response to COVID-19 Vaccine and Infection." This article was read by an AI-voice for accessibility and convenience. 

From discovering therapies that can repair the brain after stroke to using machine learning to detect early signs of cognitive decline, our researchers are at the forefront of neurological research. In honor of World Brain Day, discover some of Gladstone’s latest breakthroughs.Read this article on our website.Learn more about each of these topics:Stem Cell Therapy Jumpstarts Brain Recovery After Stroke. Read more about this study.Brain Immune Cells Amplify Damage Caused by Alzheimer’s Risk Gene. Read more about this study.Preventing Brain Damage in Preterm Babies. Read more about this study.Machine Learning Reveals Behaviors Linked with Early Alzheimer’s and Points to New Treatments. Read more about this study.Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy. Read more about this study.Powerful New Tool Can Identify Cells Promoting Health or Disease. Read more about this study.A New Therapeutic Target for Traumatic Brain Injury. Read more about this study.Cellular Clean Energy: Can Mitochondria Make More Energy Without Collateral Damage? Read more about this study. Combination of Two Cancer Drugs May Work Against Alzheimer’s. Read more about this study.

A new study has identified FDA-approved cancer drugs that reverse the gene expression signatures associated with Alzheimer’s.This is an audio version of the article, "Combination of Two Cancer Drugs May Work Against Alzheimer’s," published on gladstone.org on July 21, 2025. This episode is narrated by an AI-voice. MoreRead this article on our website.Read the scientific publication.

Gladstone scientists, led by Katie Pollard, unveiled a powerful computation tool that integrates different forms of biological data to reveal how cell types are related across tissues, experiments, and species—information that’s crucial for understanding disease.More Read this article on gladstone.org.Read the scientific publication in Cell Genomics. 

Sukrit Silas and his colleagues discovered that a well-known defense system in some bacteria can kill the cell as a last resort if viruses try to thwart it.Read this article on our website.Read the scientific publication in Molecular Cell.

In this audio article, discover how Gladstone scientists are utilizing the power of DNA to deepen our understanding of disease.Read this article on our website. Learn more about each of the topics covered in this episode:Creating a New Guide to Compare DNA Maps Advancing Single-Molecule DNA Sequencing TechnologiesPioneering Gene Editing Techniques with RetronsUsing Next-Gen CRISPR Tool to Create a Map of Immune ResponsesDetermining Genetic Risk in Global Populations

Gladstone President Deepak Srivastava explains how discoveries from NIH-funded labs spawn innovative new medicines that benefit society and the economy.Read the article on our website.Read more from Srivastava on this topic at the Voice of San Francisco. 

Gladstone scientists have developed a computational approach that accurately distinguishes cells of different identities or characteristics in complex biological samples used in diverse areas of biomedical and discovery research.This is an audio version of the article "Powerful New Tool Can Identify Cells Promoting Health or Disease," published on gladstone.org on April 7, 2025. This article is narrated by an AI voice. Read the article on gladstone.org.Read the scientific publication on Nature Genetics.