Kicking Gout in the Acid

Welcome to the second season finale Kicking Gout in the Acid. This season dove into additional topics of importance to not only those with gout, but for those treating the disease as well. Whether you’ve been recently diagnosed, care for someone suffering, or are a medical professional treating the disease, the Kicking Gout in the Acid podcast can help you learn more. The season finale of Kicking Gout in the Acid features a conversation between Dr. Larry Edwards and Dr. Brian Mandell, rheumatologist from the Cleveland Clinic, and member of the Gout Education Society’s Board of Directors. In this episode, Dr. Edwards and Dr. Mandell will look back at the history of gout treatment, discuss the current state of affairs for medications in development, and look towards the future of disease management.  Key Takeaways: Early treatments focused on symptom relief rather than the underlying disease, delaying recognition of gout as a condition driven by urate deposition that requires targeted, long‑term management. Medications like probenecid and later allopurinol reframed gout as a chronic condition that can be controlled by consistently lowering and maintaining serum urate to a defined target. This strategy opened the door to new options like febuxostat, uricosurics, and uricase-based therapies that allow for more individualized care. The future of gout treatment is bright with options as many are in the clinical pipeline. To Dr. Edwards and Dr. Mandell, an option that not only lowers urate more effectively but also directly targets inflammation pathways could be an interesting area of future research. Gout is treatable and curable when managed correctly. Successful outcomes depend on a team-based approach involving informed patients, appropriate medication use, adherence to treat‑to‑target principles, and consistent follow‑up. Start your journey with gout today via the Gout Education Society website and sign up for the monthly newsletter. Follow the Gout Education Society on X and Facebook Looking for nearby gout specialists? Find rheumatologists, nephrologists and more via the Gout Specialists Network. Educational Materials: Gout Patient Brochure Medical Professional Guide Crystal Clear Checklist Kicking Gout in the Acid is sponsored by Sobi.