The Empowering Neurologist Podcast

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====Why is psychiatry the only medical specialty that doesn't look at the organ it treats? In this episode, Dr. Daniel Amen joins me to challenge how mental health is diagnosed and treated — and to make a compelling case that "depression" is as vague a diagnosis as "chest pain."Dr. Amen is a double-board-certified psychiatrist, 18-time New York Times bestselling author, and founder of Amen Clinics, where his team has performed nearly 300,000 SPECT brain scans — the largest functional brain imaging database in the world.We dig into what these scans actually reveal: hidden traumatic brain injuries patients never reported, the inflammatory aftermath of COVID, why SSRIs work for some and fail for others, and why the brain you have today is not the brain you're stuck with.====00:00 - Introduction01:42 - Psychiatry's Missing Link: The Organ of Treatment03:22 - The Divergence of Neurology and Psychiatry05:18 - Beyond Symptoms: Patterns of Brain Health08:34 - Machine Learning and Autism Insights10:45 - The Role of the Cerebellum in Thought Coordination12:46 - The Impact of Undiagnosed Traumatic Brain Injury14:58 - Reversing Damage: NFL Brain Study Results16:26 - What SPECT Imaging Reveals About Metabolic Activity17:38 - COVID-19 and Infectious Causes of Psychiatric Issues22:11 - Neuroplasticity: Growing a Healthier Brain at Any Age25:54 - New Technologies: 40 Hz Light and Sound Stimulation28:27 - Metabolic Health: How Weight Affects Brain Volume30:25 - Chronic Stress and the Overactive Limbic Brain31:38 - Predicting Suicide Risk Through Imaging33:41 - Volunteering and the Default Mode Network35:01 - Concerns Over Psilocybin and Marijuana Scans40:12 - Chronic Pain: Breaking the "Doom Loop"43:12 - Lightning Round: Daily Habits for a Better Brain====Daniel G. Amen, MD is a double board-certified psychiatrist, clinical neuroscientist, and brain imaging specialist whose pioneering clinical use of SPECT (single-photon emission computed tomography) has built the world's largest functional brain imaging database, with nearly 300,000 scans on patients from 155 countries. A graduate of Southern California College (now Vanguard University), Dr. Amen earned his medical degree from Oral Roberts University School of Medicine. His training includes a general psychiatric residency at Walter Reed Army Medical Center in Washington, D.C., and a child and adolescent psychiatry fellowship at Tripler Army Medical Center in Honolulu. Currently, Dr. Amen serves as founder and CEO of Amen Clinics, with eleven locations across the United States, and is the founder of BrainMD and Amen University. He is a Distinguished Fellow of the American Psychiatric Association, a multiple-time New York Times bestselling author whose books have been translated into 50 languages, and the lead researcher on the world's largest brain imaging and rehabilitation study on professional football players. His work has been published in Molecular Psychiatry, Translational Psychiatry, PLOS One, and the Journal of Neuropsychiatry and Clinical Neurosciences.___________________________Instagram: / davidperlmutter Website: https://www.drperlmutter.com/Subscribe to our channel: / @davidperlmuttermd

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====Loneliness is no longer a private struggle, it’s a public-health issue that we’ve discussed quite a bit in my recent books. Research increasingly links social isolation to cognitive decline, depression, cardiovascular disease, and shortened lifespan. Yet despite these findings, we rarely explore how to build and sustain meaningful connection in a modern world designed for distraction.That’s why I invited Barnet Bain to join me on The Empowering Neurologist podcast.Barnet is a filmmaker, author, and educator whose work bridges psychology, spirituality, and lived human experience. You may recognize his work from films such as What Dreams May Come or Milton’s Secret, but his newest contribution may be his most relevant yet.His book, How to Be a Friend (In an Unfriendly World), is not about social performance or personality traits. It’s about safety, presence, listening, and emotional responsibility, qualities that directly influence nervous-system regulation and mental health.What makes this work especially important is that it reframes friendship as a skill set rather than a personality trait. Bain shows how fear, shame, unresolved trauma, and cultural conditioning quietly erode our relationships, and how conscious awareness can restore them.From a neurological perspective, this matters deeply. The brain is a social organ. Connection shapes stress responses, inflammation, cognition, and emotional regulation. Friendship isn’t a luxury, it’s foundational.This conversation isn’t about having more friends. It’s about being a better one. To others. And to yourself. In a world that feels increasingly fast, cold, and fragmented, this is a conversation worth having.====00:00 Intro02:58 Why Friendship Matters for Health and Resilience06:24 From Columbia to the Practice of Presence10:41 Friendship as Non-Transactional Love14:20 The Childhood Stories That Shape the Self21:39 Ad: Optoceutics23:39 Projection, Parenting, and Conditional Love30:08 Friendship as a Crucible for Self-Awareness35:42 Why Connection Feels Harder in Modern Life39:03 Safety, Self-Knowledge, and the Ground of Friendship41:34 Ad: 3X4 Genetics44:34 Boundaries, Values, and the Meaning of Honor49:16 Friendship, Self-Forgiveness, and Inner Change56:25 Presence as the Greatest Gift58:34 Why Feeling Is Harder Than Doing====Barnet Bain is a Canadian filmmaker, author, and educator. His film credits include “Milton’s Secret” (director, writer), Oscar winner “What Dreams May Come” (producer), Emmy Award nominee for Outstanding TV Movie “Homeless to Harvard” (executive producer), “The Celestine Prophecy” (writer, producer), and “Jesus,” translated into more than 2,245 languages and often cited as the most widely seen film in history by The New York Times.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====On this episode of The Empowering Neurologist, I spend time with Dr. Trisha Pasricha, gastroenterologist and author of the provocative and important new book, You’ve Been Pooping All Wrong. Yes, the title makes you smile, but the science inside should make all of us pay attention.Dr. Pasricha is part of a new generation of neurogastroenterologists exploring one of the most fascinating frontiers in medicine: the deep, bidirectional communication between the brain and the gut. Raised as the daughter of renowned gastroenterologist Dr. Pankaj “Jay” Pasricha and trained at Johns Hopkins, she brings both personal insight and rigorous science to a topic that too often lives in the shadows.What makes this book so important is that it dismantles myths we’ve carried since childhood. For example, at one point in the book she describes how students taking an oral exam nearly doubled their intestinal permeability, simply from psychological stress. That single experiment powerfully illustrates how the brain can alter gut biology in real time.And in another unforgettable section, she shares her early research showing that when subjects lied, their stomach’s electrical rhythm shifted into chaos, an arrhythmic pattern detectable on electrogastrogram. The stomach as a lie detector! That’s not just fascinating, it underscores how emotionally and neurologically integrated our digestive system truly is.====00:00 Intro03:05 Why We Need to Talk About Pooping07:17 The Stigma Around Bowel Symptoms09:31 Why Early-Onset Colorectal Cancer Is Rising12:11 Should Screening Start Earlier?14:59 Colonoscopy vs. Stool and Blood Tests18:34 Ad: Optoceutics20:35 Why Colonoscopy Still Matters Most31:00 What “Leaky Gut” Really Means34:42 What Worsens Intestinal Permeability36:10 Ad: 3X4 Genetics38:09 Gut Permeability, Inflammation, and Brain Disease48:45 Could Fecal Transplants Help Parkinson’s?56:52 The Different Causes of Constipation1:02:23 The Myth of One Bowel Movement a Day1:05:42 Final Takeaways on Gut and Brain Health=====Trisha Pasricha, MD, MPH is an instructor of medicine at Harvard Medical School and the “Ask A Doctor” columnist for The Washington Post where she translates complex medical topics into must-read insights—with a touch of humor—for millions each week. A graduate of Harvard College, Dr. Pasricha earned her medical degree from Vanderbilt University School of Medicine and a Master of Public Health from the Harvard T.H. Chan School of Public Health. Her training includes an internal medicine residency at The Johns Hopkins Hospital and gastroenterology and motility fellowships at Massachusetts General Hospital. Currently, Dr. Pasricha serves as director of the Institute for Gut-Brain Research at Beth Israel Deaconess Medical Center, leading an NIH-funded research laboratory at the forefront of gut-brain science. Her work has been published in The New England Journal of Medicine, JAMA Network Open, and Nature Reviews.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).3x4 Genetics - https://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====00:00 Intro01:06 The Promise of Psychedelic-Assisted Therapy05:16 Why Psychedelics Faced Decades of Pushback09:40 Psychedelic Therapy Requires Guidance11:27 The Failure of the “Pill Fixes Everything” Model15:31 Risks of Unregulated Psychedelic Retreats24:20 Psychedelics Within Integrative Medicine25:30 Ad: Optoceutics27:31 What “Integration” Really Means30:08 Why Psychiatry Still Resists Psychedelics38:52 Why Lifestyle Still Matters After Therapy41:45 Psychedelics and Addiction Treatment50:50 Microdosing vs Full Therapeutic Doses53:52 Ad: 3X4 Genetics57:28 The Rise of Ketamine Clinics1:00:54 Ibogaine: Risks, Duration, and Safety1:04:50 Final Thoughts on Psychedelic Responsibility====Will Van Derveer, MD is a psychiatrist and author of Psychedelic Therapy: Restore Your Mental Health and Reclaim Your Life which will be published by ShambhalaPublications in the Spring of 2026. He is co-founder of Integrative Psychiatry Institute, which has provided comprehensive training for 2500 mental health professionals in psychedelic-assisted psychotherapy several thousand professionals in other continuing education programs. He is medical director of Integrative Psychiatry Center of Boulder, CO, providingintegrative psychiatry for a broad range of conditions and ketamine-assisted psychotherapy for treatment-resistant depression and PTSD. In addition to his clinical practice and teaching, he has staffed clinical trials sponsoredby MAPS, investigating MDMA-assisted psychotherapy for chronic, treatment-resistant PTSD. Dr. Van Derveer is co-host of the Higher Practice Podcast, where he explores what it takes to achieve optimal mental health.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.3x4 Genetics - http://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====00:00 Intro04:49 Andrew Koutnik’s Story Obesity Type 1 Diabetes and Metabolism09:44 Ketogenic Diets and Type 1 Diabetes20:15 Sponsor Break - Optoceutics21:28 Why This Goes Far Beyond Type 1 Diabetes26:59 Why Low Carb Diabetes Care Was Abandoned31:49 Ketosis vs Diabetic Ketoacidosis35:10 Sponsor Break - Fresh Pressed Olive Oil37:04 How to Measure Ketone Levels39:13 Are Breath Ketone Tests Reliable40:15 What Beta Hydroxybutyrate Actually Does42:39 Exogenous Ketones and High Altitude Performance45:49 Sponsor Break - 3X4 Genetics48:33 MCT Oil and Ketone Production52:52 The Carb Loading Myth in Sports Performance1:00:06 Metabolic Flexibility and Keto Adaptation1:03:17 Rethinking Hypoglycemia in Keto Adapted Athletes1:07:19 How Carbohydrates Shut Down Fat Burning1:09:58 Body Fat vs Glycogen as Fuel1:14:34 What This Means for Endurance Athletes1:16:17 Fat Metabolism as a Survival Mechanism1:18:09 The New USDA Dietary Guidelines1:20:46 Ultra Processed Food and Alzheimer’s Risk1:22:40 Final Thoughts on Metabolic Flexibility====Dr. Andrew Koutnik is a research scientist focused on how nutrition, metabolism, and lifestyle can optimize human health, performance, and resilience. Living with type 1 diabetes for over 17 years, his work bridges personal experience with cutting-edge science across chronic disease and extreme environments.He earned his PhD in Medical Sciences from the University of South Florida and has led research funded by organizations including NASA, the Department of Defense, and the NIH, contributing to over 100 scientific publications and presentations. His work spans exercise physiology, cardiometabolic health, and therapeutic nutrition.At Florida State University, Dr. Koutnik studies dietary strategies for diabetes, obesity, and performance under metabolic stress, collaborating with leading institutions worldwide. His mission is to advance evidence-based approaches that empower individuals to improve metabolic health and performance.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.3x4 Genetics - http://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====If you’ve followed my work for any length of time, you know that one of the central themes we return to on The Empowering Neurologist is this: your brain is far more adaptable, resilient, and improvable than conventional wisdom ever allowed us to believe.This week, I’m thrilled to share a conversation with someone who has spent more than three decades proving exactly that. Dr. Majid Fotuhi, neurologist, neuroscientist, Harvard- and Johns Hopkins-trained physician, and now author of the new book The Invincible Brain, has dedicated his career to helping people reclaim their cognitive potential. His message aligns powerfully with the philosophy behind my upcoming book, Brain Defenders: that the trajectory of your brain is not predetermined, and that meaningful change is possible at any age.In our interview, we explore the groundbreaking ideas that shaped The Invincible Brain. Dr. Fotuhi lays out why intelligence is not fixed, how memory can be strengthened through surprisingly simple practices, and why Alzheimer’s disease is not the single, linear condition we once imagined, but rather a complex “soup” of abnormalities with multiple entry points for intervention.====00:00 Intro01:44 Choices influencing brain trajectory and resilience04:25 Redefining intelligence beyond IQ08:20 Synergy of memory and habit change13:09 Challenging genetic determinism with epigenetics18:00 Ad Break: Optoceutics20:23 Alzheimer's as a metabolic and inflammatory soup29:45 Ad Break: Fresh Pressed Olive Oil38:04 Exercise and metabolism in brain health43:45 Ad Break: 3x4 Genetics49:38 Brain training and five pillars of brain health54:55 Mindset as key to becoming a superager====Dr. Majid Fotuhi earned his PhD in Neuroscience from Johns Hopkins University in 1992 and his Medical Degree from Harvard Medical School in 1997. Currently, he serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins University, while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in teaching, clinical practice, and neuroscience research, Dr. Fotuhi has pioneered a multidisciplinary approach to enhancing brain vitality and cognitive performance at any age. His groundbreaking “Brain Fitness Program” combines a comprehensive baseline “Brain Portfolio” assessment with 12 bi-weekly brain training sessions. This program targets lifestyle optimization and cognitive stimulation to improve memory, focus, and overall brain health. Dr. Fotuhi’s program has delivered measurable success for patients dealing with memory loss due to aging, concussions, and ADHD, as documented in several peer-reviewed journals. ___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.3x4 Genetics - http://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====On this episode of The Empowering Neurologist, I’m joined by Dr. Sarah Marzi, a neuroscientist at King’s College London and a principal investigator at the UK Dementia Research Institute, whose work is transforming how we understand neurodegenerative disease risk.Dr. Marzi’s research focuses on gene regulation in the human brain, particularly within microglia, the immune cells that orchestrate inflammation, synaptic pruning, and repair. Her studies show that genetic risk for diseases like Alzheimer’s is concentrated not in protein-coding genes, but in regulatory regions of the genome, epigenetic switches that control immune behavior in the brain.This conversation with Dr. Marzi is not just about disease. It’s about agency. Understanding epigenetics helps explain how lifestyle, environment, and immune balance can influence brain destiny. It’s science that empowers prevention, resilience, and hope.====00:00 Intro03:12 Epigenetics and Neurodegenerative Disease04:49 Why Alzheimer’s Is Not a Single Gene Disorder09:18 Protein Aggregation and Brain Cleanup Failure10:55 Microglia vs Neurons in Alzheimer’s19:04 Blood Brain Barrier and Inflammatory Signaling20:39 ApoE Genetics Explained23:37 Human Microglia Transplanted Into Mouse Brain30:02 Vitamin D Receptor and Protective Gene Programs38:18 Environmental Toxins and Parkinson’s44:59 C1q Activation and Synapse Loss49:33 Why Substantia Nigra Is Uniquely Vulnerable51:39 Paraquat, Mitochondria and Converging Toxic Pathways53:00 Epigenetic Memory of Toxic Exposure54:09 Histones and Gene Regulation in Alzheimer’s57:41 Oligodendrocytes as a Hidden Player59:32 Why Single Target Drugs May Fail01:02:10 Detecting Disease Through Blood and Machine Learning01:04:41 Can Lifestyle Modify Epigenetics====Dr Sarah Marzi is a Senior Lecturer in Neuroscience at King’s College London and a Group Leader at the UK Dementia Research Institute. Her work focuses on how our genes and environment change cellular processes in the brain and can predispose us to neurodegenerative diseases such as Alzheimer’s, Parkinson’s and motor neuron disease.An expert in epigenetics – the chemical switches that turn genes on and off – Dr Marzi uses cuttingedge genomic techniques on human brain tissue as well as cell and animal models. Her team combines these experiments with advanced statistics, bioinformatics and AI to map the earliest molecular changes that make brain cells vulnerable to disease, particularly in immune cells of the brain called microglia. This work aims to reveal how both genetic variants and environmental exposures, including pesticides, contribute to disease risk and to uncover new avenues for therapy.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.3x4 Genetics - http://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====On this episode of The Empowering Neurologist, I sit down with one of the most influential voices in modern nutrition and women’s health, Rachel Swanson, MS, RD, LDN. Her new book, Trying! A Science-Based Plan to Optimize Your Fertility, is poised to reshape how we think about fertility, moving it out of the narrow confines of hormone-focused conversations and into the broader landscape of systems biology, metabolism, environmental exposure, and cellular health.Swanson’s work begins with a powerful premise: fertility is not a mystery, and it’s certainly not something women should feel powerless about. Instead, she argues, fertility is a measurable, improvable expression of whole-body health. And her book provides the first integrated blueprint to understand and support that health.The conversation starts with the microbiome, which Swanson calls the “mission control headquarters” of fertility. Who knew that our gut bacteria were playing an important role in determining fertility? Drawing from her book, she describes how the gut, vaginal, and even oral microbiomes create the biochemical environment that influences hormone balance, inflammation, implantation, egg quality, and partner sperm health.What makes this book, and this podcast episode, so compelling and empowering is Rachel’s rare combination of scientific precision and heartfelt dedication to women’s autonomy. She refuses to oversimplify fertility into quick fixes or fad-driven advice. Instead, she offers deeply practical strategies rooted in peer-reviewed research and years of high-level clinical practice.====00:00 Intro - Rachel Swanson04:38 Fertility as Whole-Body Health11:37 Metabolic Health Comes Too Late18:48 Ad - EVY21:17 The Microbiome as a Foundation of Health27:28 PCOS Is a Metabolic Disease, Not Just Hormonal35:15 Ad - Fresh Pressed Olive Oil37:07 Menstrual Products and the Vaginal Microbiome40:41 Inflammation and Metabolism Drive Fertility49:06 Ad - 3x4 Genetics50:26 Personalized Fertility Over One-Size-Fits-All56:16 Closing Thoughts====Rachel Swanson, MS, RD, LDN, is a registered dietitian and one of America’s most sought-after nutritionists, known for optimizing human performance through science-backed, personalized care. Her clients include celebrities, professional athletes, and Fortune 500 executives who trust her expertise in concierge medicine and private practice. Rachel is a highly principled, intellectually rigorous, and passionately empowering expert, whose communication and sentiment are consistently driven by a profound conviction in her book's unique, holistic framework as the transformative solution to outdated and fragmented fertility advice, reflecting a deep commitment to women's health and autonomy. ___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off & free shipping (90 days risk-free).Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.3x4 Genetics - http://3x4genetics.com/DrPerlmutterfor a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====Gene therapy is no longer a distant promise, it is rapidly becoming one of the most disruptive technologies in medicine. And few figures embody the urgency, controversy, and pioneering spirit of this field more than Elizabeth Parrish, CEO of BioViva and widely recognized as the world's first self- engineered "GMO human." In this episode of The Empowering Neurologist, we dive deep into her bold vision to treat aging not as an inevitable decline, but as a disease that can be targeted, modified, and potentially reversed. Again, treating aging as a disease. Her journey into genetics began with a simple but profound realization: the diseases that kill most of us, including Alzheimer's, cardiovascular disease, cancer, and overall frailty, are rooted in the biology of aging itself. Instead of waiting for late-stage decline, she argues that medicine should intervene upstream, correcting the genomic and cellular faults that accumulate over time. This perspective led her to take an extraordinary step: undergoing experimental gene therapy on herself in 2015, outside traditional regulatory frameworks.====0:00 Intro3:16 Treating Aging as a Disease12:16 Launching a Radical Biotech Company15:49 Why Telomere Length Mattered Most18:51 Fear at the Edge of Experimentation24:19 Ad: Optoceutics26:08 Alpha-Klotho, The Longevity Gene30:02 Why Alzheimer’s Still Has No Cure32:21 Mitochondria at the Center of Brain Health36:04 Ad: Fresh Pressed Olive Oil Club39:04 Keeping PGC-1 Alpha Switched On42:43 Tracking Telomere Length Year After Year47:11 Ad: 3x4 Genetics48:37 Myokines and Whole-Body Health51:48 Glutathione Deficiency and Neurodegeneration1:00:20 Closing Thoughts====Elizabeth (Liz) Parrish, MBA, is the Founder and CEO of BioViva Sciences USA Inc., a pioneering biotechnology company committed to extending healthy human lifespan through advanced gene therapies. Under her leadership, BioViva is developing next-generation combinatorial gene treatments powered by its proprietary CMV delivery platform, positioning the company at the forefront of therapeutic innovation.An accomplished entrepreneur, author, and visionary thinker, Liz is one of the leading global voices behind the Best Choice Medicine (BCM) initiative—a regulatory framework aimed at accelerating access to genetic therapies worldwide. She is deeply involved in international scientific education and has delivered keynote talks at major conferences and institutions, including WIRED, TEDx, and numerous other high-profile venues.https://www.instagram.com/lizlparrish/?hl=enhttps://bioviva-science.com/___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Thank you to our sponsors:EVY - https://www.optoceutics.com Use code perlmutter26 to save $200 & get free shipping on EVY (90 days risk-free). Fresh Pressed Olive Oil - https://www.getfresh389.com For a complimentary bottle of one of the greatest olive oils I've ever discovered.====Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.====In this week’s episode of The Empowering Neurologist, I sit down with registered dietitian, personalized-nutrition pioneer, and longtime friend, Ashley Koff, RD, to explore what may be one of the most misunderstood areas in all of health: weight, metabolism, and the pursuit of sustainable well-being. As the founder of The Better Nutrition Program, Nutrition Course Director at UC Irvine’s Integrative Health Institute, and faculty member at IFNA, Ashley brings a depth of clinical and practical insight that few can match.Her new book, Your Best Shot,  tackles one of the most talked-about questions of our time: Is the GLP-1 shot your best shot—or not? But this is far from a book about medications. Instead, Ashley reframes the entire conversation around personalization, body-ecosystem thinking, and the liberating shift from perfectionism to her signature philosophy: better, not perfect.In our conversation, Ashley explains why most people aren’t struggling with a lack of knowledge, but rather an overwhelming flood of it, something she calls “INFObesity.” She discusses the Switch Framework she developed to help individuals identify the key metabolic levers that matter most for them, and she shares compelling patient stories that demonstrate how real transformation happens when we align nutrition and lifestyle choices with our unique biology.What emerges is a far more hopeful, empowering narrative about weight-health, one that acknowledges the complexity of modern life while giving us practical tools to navigate it.If you’ve ever felt frustrated or confused by the conflicting messages around diet, GLP-1 medications, metabolism, or weight-loss strategies, this episode is an essential listen. It offers clarity, compassion, and a science-based path toward truly optimal health.====0:00 Intro3:39 Misinformation in the world of weight loss8:28 Calories in vs calories out12:52 The importance of satiety related hormones18:10 The experiment of GLP-124:49 Ad: Optoceutics26:37 GLP-1 agonist drugs and the brain37:16 Ad: Fresh Pressed Olive Oil Club40:27 GLP-1 and mental health50:02 Disconnect between food policy and obesity solutions55:09 Conclusion====Ashley Koff, RD is the founder of The Better Nutrition Program (BNP), the Nutrition Course Director for UC Irvine’s Susan Samueli Integrative Health Institute's Integrative and Functional Medicine Fellowship, and a faculty member at the Integrative and Functional Nutrition Academy (IFNA), where she teaches “An Integrative and Functional Nutrition Approach to Obesity and Weight Management.” She is also the author of the upcoming book, Your Best Shot (Harper One, January 6, 2026). A practitioner for over 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real health outcomes. Through patient stories and personal experience, she shows that optimal health is not just possible—it’s essential to living your fullest life. Koff has been recognized as one of CNN’s Top 100 Health Makers, featured in InStyle as “Hollywood’s Leading Dietitian,” and has been selected as Westin’s Global Nutrition Ambassador.

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Today on The Empowering Neurologist podcast we are going to explore PTSD, post traumatic stress disorder, a pervasive issue that can be profoundly debilitating. PTSD is experienced by about 6% of the US population at some point in their lifetime and at any given time approximately 5% of American adults are living with this disorder. Certainly, we see high risk and veterans with PTSD affecting about 11 to 20% of veterans who served in operations Iraqi Freedom and Enduring Freedom. Vietnam veterans experience a lifetime prevalence somewhere in the neighborhood of 30%. PTSD symptoms usually begin within three months of a traumatic event, but can actually surface many years later making the diagnosis and the relationship to a traumatic event challenging. In about 1/3 of cases, PTSD becomes chronic and can last for years or even decades.We know that there are significant comorbidities associated with PTSD, including other mental health conditions like depression or anxiety disorder, substance use disorders, and even cognitive decline.While cognitive behavioral therapy, CBT, and pharmaceutical intervention are the “go to” treatments for this problem, hyperbaric oxygen therapy presents us with a new and emerging therapy now receiving global recognition. We will review research on this podcast demonstrating the profound effectiveness of hyperbaric oxygen in treating PTSD, research that makes it clear that this is one of the most powerful interventions ever developed for treating this challenging disorder.We will visit the Aviv Clinic in Central Florida, and spend time with Dr. Mohammad Elamir. ====0:00 Intro4:55 Why Hyperbaric Works for PTSD Patients8:44 Evaluating patients with PTSD12:30 How the Protocol Was Chosen & Implemented 16:40 Potential Side Effects 18:00 Youngest People Treated with This19:32 Combining Therapy Modalities for PTSD20:14 Other Conditions that Can Be Helped By This22:04 Amazing Results From These Studies24:06 Using this with Our Military 26:00 Getting to the Root Problems 26:48 Treating Traumatic Brain Injuries 28:54 Why This Isn’t More Widely Being Offered 29:49 The Right Formula for This32:55 Get Involved Today====Dr. Mohammed Elamir, or “Dr. Mo”to his patients, has been part of the Aviv Clinics team in The Villages since the clinic opened in 2020. As lead physician, he oversees the medical treatment for all clients in the Aviv Medical Program, collaborating with other members of Aviv’s clinical team to provide truly comprehensive care. As a presenter, his seminars often sell out, thanks in part to his ability to translate complex scientific concepts and data into easily-relatable language. Prior to joining Aviv Clinics, Dr. Elamir practiced internal medicine at the MM Jersey Breathing Center while also owning a medical spa in New Jersey. He completed his internal medicine internship and residency at RWJ-Barnabas: Jersey City Medical Center where he was chief resident and a member of the ethics committee. Dr. Mo has a passion for helping others who are pursuing a career in medicine and continues to mentor pre-med and medical school students. Dr. Elamir became involved with Aviv Clinics after his late father suffered a stroke, which sparked Dr. Mo’s interest in novel approaches to healing the brain. He is the father of two children, including a son with autism spectrum disorder (ASD). Dr. Elamir considers it his life’s mission to help progress his son’s development and better understand the causes and treatment of ASD.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱In this compelling episode of The Empowering Neurologist, I sit down with Dr. Ray Dorsey, a leading voice in the world of neurology and author of the important new book, The Parkinson’s Plan. Dr. Dorsey is a passionate advocate for changing how we view and address Parkinson’s disease. His message is bold—and urgently needed: Parkinson’s is not simply a disease of aging or bad luck. It is, in his words, “a man-made disease,” driven by preventable environmental exposures.Dr. Dorsey’s work shines a much-needed spotlight on the role of toxins in triggering Parkinson’s. In his new book, he lays out a comprehensive framework for understanding and reversing the rising tide of Parkinson’s cases, which have more than doubled in recent decades. He argues that this surge is no coincidence—it correlates with increased exposure to industrial chemicals, pesticides, and air pollutants that interfere with the brain’s delicate dopamine system.One of the most striking recent contributions from Dr. Dorsey’s research is a JAMA-published study linking Parkinson’s risk to proximity to golf courses—locations that are frequently treated with high volumes of chemical herbicides and pesticides. The study found a significantly increased risk of developing Parkinson’s disease in individuals living near these manicured greens. This adds to a growing body of evidence that toxic environmental exposures play a key role in the development of this neurodegenerative condition.In our conversation, Dr. Dorsey discusses how Parkinson’s (once a rare disease) has become the world’s fastest-growing brain disorder, and why its rise can’t be explained by aging populations alone. He shares practical strategies for individuals and families looking to reduce their toxic burden and offers hope for a new paradigm. One in which we actively prevent, treat, and ultimately aim to eliminate Parkinson’s.Try Lichen Air, an air filter carefully constructed to remove the maximum amount of PM 2.5 and smaller air pollutants possible:https://lichenair.com/====0:00 Intro2:40 Living Near to a Golf course Raises Parkinson’s Risk4:58 How Pollutants Lead to Parkinson’s7:12 Danger of Dry cleaning Chemicals11:45 Parkinson’s is not just about Genetics14:15 Why aren't these chemicals illegal?17:07 Toxicity of Weed Killer21:00 Chemicals that Damage Mitochondria 26:39 Why Diabetes Increases Parkinson’s Risk29:38Air Pollution & WildFires34:04 The Air Purifier We Recommend 34:49 Dealing with Indoor Air Pollution37:02 Wash All Produce (Even Organic)38:12 Best Diet for Parkinson’s Prevention41:26 Safe Practices for Farming & Dry Cleaning45:23 Benefits of Exercise48:01 Public Figures Who Faced Parkinson's Disease49:58 Why Men are More Likely to Get It51:21 An Empowering Message for Us54:27 Conclusion ====Dr. Ray Dorsey is the director of the Center for the Brain & the Environment at the Atria Health and Research Institute. The center’s mission is to identify the root causes of brain diseases from autism to Alzheimer’s so that we can prevent them. With his colleagues, he wrote Ending Parkinson’s Disease and the forthcoming The Parkinson’s Plan, which details a new path to preventing and treating this terrible disease.Ray previously directed the Center for Health + Technology at the University of Rochester, chaired the international Huntington Study Group, led the movement disorders division at Johns Hopkins, and consulted for McKinsey & Company.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱I’m thrilled to announce this exciting podcast episode featuring an inspiring and thought-provoking conversation with Dr. Mai Nguyen, CEO and Co-founder of OptoCeutics. Dr. Nguyen is a pioneering force in the field of neurotechnology, and in this episode, we unpack her revolutionary work using non-invasive light stimulation to enhance brain function and potentially prevent neurodegenerative disease.At the center of our conversation is the EVY, a 40 Hertz light stimulation device developed by OptoCeutics under Dr. Nguyen’s leadership. This device is designed to target and enhance gamma oscillations in the brain—a specific frequency range of neural activity (around 40 Hz) that is critically involved in memory, attention, and perception. In recent years, scientific studies have linked disruptions in gamma oscillations with the progression of Alzheimer’s disease. By restoring these rhythms, the EVY device aims to provide a non-pharmacological, non-invasive way to support brain health.During our podcast, Dr. Nguyen explains how EVY works: the device emits flickering light at a precise 40 Hz frequency, which is thought to entrain brain activity to resonate at that same frequency. This gentle stimulation may help reduce amyloid-beta accumulation, improve neural connectivity, and promote immune system engagement in the brain—mechanisms that could slow or even reverse aspects of cognitive decline.What sets Dr. Nguyen apart is not just her scientific brilliance, but her deep commitment to translating research into real-world solutions. She leads OptoCeutics with a clear mission: to bring accessible, evidence-based neurotechnology into homes and clinics, empowering people to take charge of their cognitive well-being. Her approach is both deeply human and rigorously scientific, blending innovation with empathy.As you’ll hear in the interview, Dr. Nguyen's work exemplifies the exciting convergence of biology, technology, and therapeutic application. This episode is essential listening for anyone interested in the future of brain health, the science of neuroplasticity, and the promise of light-based therapies. Whether you're a clinician, researcher, caregiver, or simply curious about how to support your brain as you age, Dr. Nguyen’s insights will leave you informed, inspired, and hopeful.====0:00 Intro2:46 How Dr. Mai Started Studying it5:16 How Light Enhances Gamma Oscillation 7:22 Promise of These Studies8:51 How the EVY Device Works11:20 Early Clinical Results + Potential Side Effects13:53 Application of this technology 16:36 Why Mainstream is Late to Adopt This22:04 Impact of Auditory Stimulation23:38 The Future of This Research25:25 Get Involved Today====Dr. Nguyen is a trailblazer in neurotechnology, pioneering advancements in non-invasive brain stimulation technology for the prevention and treatment of Alzheimer’s and dementia. As CEO and Co-founder of OptoCeutics, Dr. Nguyen leads the charge in bridging the gap between neuroscience and therapeutic innovation, offering new hope to millions affected by cognitive decline. Under Dr. Nguyen’s leadership, Optoceutics has become a frontrunner in brain stimulation technology and a recognized authority in non-invasive neuromodulation. Her unique approach combines rigorous scientific methodology with groundbreaking therapeutic solutions.This vision is shaped by her academic excellence, including a PhD in Integrative Biology at the University of California, Berkeley with a specialization in Neuroendocrinology, and her extensive training in management, technology innovation, and entrepreneurship.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱In our modern world, we are surrounded by a staggering number of invisible threats. These chemicals and pollutants can silently undermine our immune systems, increase our risk for chronic illness, and sabotage our health at the cellular level. That’s why I’m especially excited to welcome Dr. Aly Cohen to this episode of The Empowering Neurologist. This conversation is not only eye-opening, it’s empowering and filled with practical, actionable steps that each of us can take starting today.In our conversation Dr. Cohen takes us through the science and the soul of her mission. We explore what inspired her to write Detoxify, a journey that began at the intersection of clinical frustration and personal awakening. Over the years, she began noticing that many of her patients with autoimmune diseases, chronic fatigue, hormonal imbalances, and neurological complaints shared a common thread: consistent exposure to environmental toxins. This wasn't just about vague “bad stuff.”Dr. Cohen has zeroed in on a specific category of chemicals she terms “Immune-disrupting chemicals (IDCs).” These are substances that directly interfere with the immune system's ability to regulate and repair.Dr. Cohen doesn’t stop at theory… she gets specific - with personal care products to avoid, water purification tips every household should know, and simple DIY recipes for safer cleaning and skincare. Her “Detoxify Food Pyramid” reimagines what a clean, immune-supportive diet looks like in a world of processed foods and contaminated agriculture.We also touch on how environmental toxins can act as potent triggers for autoimmune conditions like lupus and rheumatoid arthritis - diseases Dr. Cohen treats in her clinical practice almost every day. If you’re feeling overwhelmed by the sheer scale of modern toxicity, this episode offers a clear and hopeful path forward. Dr. Cohen emphasizes that detoxifying your life doesn’t mean doing everything at once. It’s about starting small. Things like switching to a glass water bottle, choosing fragrance-free detergents, and reading ingredient labels can lead to profound health benefits.====TIMESTAMPS00:00 Introduction02:15 Welcoming Dr. Amy Cohen & Her Inspiration for Her Book05:45 Water & How Contamination Dysregulates Our Immune System10:44 Recommendations for Filtration and Purification13:13 Quality of Bottled Water Is Sub Par & Likely Tap Water18:03 Endocrine Disrupting Chemical Contaminants Found In Our Water21:47 Sparking Change with The Four A's: Assess, Avoid Or Swap, Add, Allow27:39 How Did These Chemicals Enter Our Food & Water Supply?34:10 How Do Genetics Determine Your Ability To Detoxify?37:50 Air Quality, Pollution, and The Impact On Our Bodies43:49 Navigating How To Improve The Air You Breath47:41 Detoxifying The Body From Air Pollution51:18 Hidden Threats In Your Personal Care Products & How To Avoid Them1:04:19 Conclusion====Dr. Aly Cohen is a board-certified physician practicing in rheumatology and integrative medicine, as well as an environmental health expert in Princeton, New Jersey. Her new book, DETOXIFY: The Everyday Toxins Harming Your Immune System and How to Defend Against Them, available now for preorder, connects the dots between everyday chemicals and the epidemic rise in immune disorders and autoimmune disease...and what we CAN all do about it! You can follow her health and wellness tips and recommendations on Facebook at The Smart Human, Twitter, and Instagram: @thesmarthuman, and TikTok. ___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱The ketogenic diet has become a household term, often associated with rapid weight loss and an effective means of shedding stubborn fat. However, as my guest on this episode of The Empowering Neurologist, Dr. Dominic D’Agostino, will explain, there is so much more to the ketogenic lifestyle than simply dropping a few pounds. We’re diving deep into the science of metabolism, insulin sensitivity, and how our lifestyle choices impact long-term health, particularly brain health.While many people adopt a ketogenic diet for its well-documented benefits in weight management, its effects on metabolism reach far beyond simple fat burning. Nutritional ketosis helps the body transition from relying primarily on carbohydrates for energy to efficiently burning fat and producing ketones, an alternative fuel source for the brain and muscles.As Dr. D’Agostino will discuss, one of the most crucial aspects of metabolic health is insulin sensitivity. When insulin function is compromised, the body struggles to regulate blood sugar levels, leading to increased risks of obesity, type 2 diabetes, and even cognitive decline. By keeping insulin sensitivity in check through dietary choices, fasting, and exercise, we can enhance our metabolic health and lower the risk of chronic disease.The brain is an energy-intensive organ, and its function is directly influenced by our metabolic state. Research has shown that ketones provide a more efficient and neuroprotective fuel source for the brain compared to glucose. This is particularly relevant for conditions such as Alzheimer’s disease, epilepsy, and even traumatic brain injury.By making intentional choices about what we eat, how we move, and how we recover, we can take control of our metabolic health and improve our longevity.====00:00  Introduction 02:21 How Dr. D’Agostino Went From Seizure Research To Nutrition Science03:31 From Drug Failures To The Medical Power Of Ketosis05:15 What Ketones Really Are And Why They’re A Metabolic Game-Changer09:37 Why Ketogenic Therapy Is Now In 400+ Clinical Trials Worldwide12:21 GLP-1 Drugs, Weight Loss, And Keto: What They Do To Your Metabolism15:10 Inside A Ketogenic Body: Fat Burning, Fuel Switching, And More17:25 How Lowering Insulin Turns On Fat Burning And Ketone Production20:03 Why Ketones Keep The Brain Stable And Cravings Under Control23:54 The Right Amount Of Protein For Muscle, Aging, And Staying In Ketosis27:03 Do You Actually Need Fiber? The Carnivore Diet And Gut Health30:00 How Ketosis Reduces Inflammation And Repairs The Gut Barrier34:31 Genomics of Ketonics: Beta-Hydroxybutyrate’s Epigenetic Power45:38 Allulose: The Sweetener That Lowers Blood Sugar And Boosts GLP-152:03 Why MCT Oil Might Be The Most Underrated Keto Hack Available54:30 Conclusion====Dominic D’Agostino, Ph.D., is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a Senior Visiting Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications.  ___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Cancer remains a formidable global challenge, with nearly one in six deaths worldwide attributed to the disease. Over 60% of patients undergoing conventional treatments experience severe side effects, highlighting the need for complementary therapies that enhance efficacy and reduce harm.Dr. Valter Longo, a leading figure in aging and nutritional science, has introduced a groundbreaking approach known as the fasting mimicking diet (FMD). Through years of research, Dr. Longo has shown that cycles of controlled fasting can trigger cellular regeneration, reduce inflammation, and improve metabolic health.His work has reshaped our understanding of nutrition’s role in health and disease, providing a scientific basis for fasting as a tool to support standard cancer therapies. The fasting mimicking diet offers a promising adjunct to traditional treatments. By strategically reducing calorie intake, FMD protects healthy cells and makes cancer cells more vulnerable to chemotherapy and radiation.This dual effect boosts the effectiveness of treatment while mitigating debilitating side effects. Dr. Longo’s new book, Fasting Cancer, the subject of our podcast, explores the science behind fasting and its potential to transform cancer care. He shares practical guidelines, compelling case studies, and robust research that illustrate how FMD can be integrated with standard therapies for better outcomes.Listeners of The Empowering Neurologist were captivated by Dr. Longo’s ability to translate complex science into actionable advice in his previous appearance, and this episode is no exception. His work continues to inspire both patients and healthcare professionals to explore innovative, science-driven approaches in the fight against cancer.As research unfolds, the fasting mimicking diet stands as a testament to the power of nutritional science in modern medicine. Embracing this strategy, patients and clinicians alike are witnessing a promising future in cancer care.====00:00 Introduction02:10 The Cancer Nutrition Scientist Changing Everything04:36 How Cancer Cells Hack Aging And Stay Immortal06:00 The Hidden Danger Of Cancer Cell Survival After Chemo07:30 Why Young People Are Getting More Cancer Than Ever10:48 Are We Eating Too Much Protein For Longevity13:22 A Diet That Weakens Cancer But Shields Healthy Cells17:55 What Is The Fasting Mimicking Diet And Why It Works21:40 The Critical Timing That Makes Chemo More Effective23:00 How Starving Cancer Creates A Predictable Weak Spot27:30 The Multi-Angle Attack That Slows Glioblastoma29:15 Could This Diet Delay Or Reverse Alzheimer’s32:50 Clinical Trials Show This Diet Reverses Diabetes36:30 How Fasting Triggers Organ Regeneration In Humans41:05 The Shocking Risks Behind Popular Weight Loss Drugs57:14 Conclusion====Valter Longo is the director of the Longevity Institute at the University of Southern California in Los Angeles. He studies basic and clinical research on nutrition, aging, and disease, with a focus on cancer, autoimmunity, Alzheimer’s, and cardiometabolic illness. Dr. Longo has received multiple awards including the 2010 Nathan Shock Lecture Award from the National Institute on Aging, the 2013 Vincent Cristofalo Rising Star Award, and the 2016 Glenn Award for Research in the Biological Mechanisms of Aging. In 2018, Time named him one of the 50 most influential people in health care, and in 2021 Science magazine called him a pioneer in nutrition and cancer. He is the author of Fasting Cancer and The Longevity Diet.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Welcome back to The Empowering Neurologist! In this episode we have a truly fascinating conversation lined up with none other than Dr. Steven Gundry, a world-renowned heart surgeon-turned-functional medicine expert, whose work has transformed the way we understand diet, disease, and longevity.Dr. Gundry is no stranger to challenging conventional medical wisdom. In his latest book, The Gut-Brain Paradox: Improve Your Mood, Clear Brain Fog, and Reverse Disease by Healing Your Microbiome (HarperCollins; April 15, 2025), he flips the script on the traditional gut-brain connection. His research reveals a startling truth: your microbiome is not just influencing your brain—it’s controlling it.For years, we’ve heard that the brain sends signals to the gut. But Dr. Gundry shows that it’s actually the other way around: the microbes in our gut are shaping our thoughts, emotions, and even personality. From food cravings to mental health struggles, from cognitive decline to addiction—these tiny gut-dwelling organisms are the real puppet masters. And when our gut falls out of balance, neurological dysfunction follows.In this episode, we’ll explore:✅ How gut bacteria influence cravings, mood, and even personality✅ The surprising link between gut inflammation and drug tolerance✅ Why a leaky gut can lead to brain fog, neurodegeneration, and mental health issues✅ How to reclaim control of your mind by healing your microbiomeDr. Gundry lays out a powerful, science-backed plan to restore gut health and optimize brain function, mental clarity, and emotional well-being. If you’ve ever struggled with brain fog, anxiety, depression, or unexplained neurological symptoms, this episode is a must-listen. Tune in to this eye-opening conversation and discover how fixing your gut provides an important step to unlocking your brain’s full potential.==== 00:00 Introduction03:00 Why a Heart Surgeon Wrote a Book on the Brain06:18 The Forgotten Hero Who Was Beaten to Death for Washing His Hands09:08 A Parkinson’s Case Reversed by Healing the Gut?13:28 Gluten Cross-Contamination and a Son’s Cutting Board: A Shocking Relapse19:16 Gut Leaks, Brain Barriers, and Immune Sabotage: The Mechanism Explained23:15 The Alzheimer’s Barrier Theory: Why Beta-Amyloid Might Be the Brain’s Defense System26:20 Can Depression Be Healed Through the Gut?30:27 Are Bacteria Controlling Your Addictions and Cravings?34:02 The Scariest Mind-Control Parasite You’ve Never Heard Of38:41 Eat This, Not That: How to Hack Your Gut for Better Brain Health41:23 Neu5Gc and How it Impacts Our Brains48:03 Are Polyphenols the Brain’s Secret Weapon?56:38 Dead Bacteria, Live Benefits: Why Your Probiotic Doesn’t Need to Survive01:05:05 Conclusion and Thank you====Steven R. Gundry, MD, is the director of the International Heart and Lung Institute in Palm Springs, California, and the founder and director of the Center for Restorative Medicine in Palm Springs and Santa Barbara. After a distinguished surgical career as a professor and chairman of cardiothoracic surgery at Loma Linda University, Dr. Gundry changed his focus to curing modern diseases via dietary changes. He has written more than three hundred articles published in peer-reviewed journals on using diet and supplements to eliminate heart disease, diabetes, autoimmune disease, and multiple other diseases. He is the host of the top ranked nutrition podcast The Dr. Gundry Podcast and founder of Gundry MD, a wellness brand. Dr. Gundry lives with his wife, Penny, and their dogs in Palm Springs and Montecito, California.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱We hear so much these days about various “biohacking” techniques that are purported to be helpful for us in terms of improving our health and even extending our lifespan. But I think it's really important that we unpack some of these ideas and get a good understanding as to what they involve and what we can expect if we were to engage them. We're going to explore a variety of hot topics like exosome therapy, peptide therapy, cryotherapy hyperbaric oxygen therapy, and other innovative techniques. But most importantly we will explore how our simple, day-to-day lifestyle choices impact our health in terms of preserving our resistance to disease, and possibly even extending our lives.Our guest is Dr. Darshan Shah, a powerful influencer in the area of health-span improvement. Let me tell you a little bit more about Dr. Shah.Darshan Shah, MD, is a health and wellness specialist, board-certified surgeon, published author, entrepreneur, and founder of Next Health, the world's first and largest Health Optimization and Longevity clinic. As a Longevity Medicine specialist, he has advised thousands of patients on how to optimize their well-being and extend their healthspan and lifespan. Dr. Shah began his career at an accelerated MD program and earned his medical degree at the age of 21, becoming one of the youngest doctors in the United States. He continued his training at the Mayo Clinic, one of the most prestigious medical institutes in the country. Dr. Shah’s belief in continual education and self-improvement has earned him alumni status at Harvard Business School, Singularity University, and other prestigious institutions. His passion is speaking on the topics of longevity and health, having done over 100+ speaking engagements and appearances.0:00 Intro2:52 How Dr. Darshan Shah Began Studying Longevity9:14 The Next Health Clinic: Cutting-Edge Longevity Science12:11 The Biggest Health Mistake People Don't Realize14:47 Evaluating Biomarkers & Their Clinical Importance20:52 Key Biomarkers to Monitor Inflammation & Uric Acid23:43 Why Uric Acid Matters25:32 Clarifying the Confusion Surrounding Cholesterol29:20 Hormone Levels as a Key Marker of Health (TRT)35:22 Cutting Edge Science: Peptide Therapy 41:54 The Success of These Treatments43:05 Science of Exosome Therapy 44:55 NAD & Stimulating the Mitochondria46:41 Effectiveness of Cryotherapy48:19 How Mainstream Physicians View this Approach50:37 Cognitive Decline52:09 His #1 Health Practice for Longevity53:40 Conclusion====Dr. Darshan Shah is a health optimization expert, board-certified surgeon, and founder of Next Health, the world’s first Health Optimization and Longevity clinic. A graduate of an accelerated MD program, he earned his medical degree at 21 and trained at the Mayo Clinic. With over 20,000 surgeries performed and multiple ventures in the wellness space, Dr. Shah now focuses on helping people extend their healthspan through cutting-edge science and personalized care. He’s also a sought-after speaker and lifelong learner with credentials from Harvard Business School and Singularity University.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.comThe idea that we can live however we want and then rely on a magic treatment for cognitive issues is unrealistic and dangerous. The reality is that our daily choices profoundly impact our brain’s future, and once cognitive decline begins, there is no clear-cut pharmaceutical solution.I had the pleasure of speaking with Dr. Dale Bredesen, whose book The Ageless Brain is an incredible resource for protecting brain health. He has pioneered a comprehensive approach to preventing and even reversing cognitive decline. This book offers a powerful blueprint not only for sharpening your mind but also for building resilience against neurodegenerative diseases.In The Ageless Brain, Dr. Bredesen distills decades of research into actionable steps. He explores key lifestyle factors—nutrition, sleep, exercise, stress management, and supplementation—that influence cognitive performance and long-term brain resilience. What’s exciting is his proactive, personalized approach. Rather than waiting for symptoms to appear, Dr. Bredesen shows us how to build a brain that resists aging from the start.Today, we’ll unpack some of the most impactful strategies from his book, discuss major breakthroughs in neuroscience, and explore how we can all take charge of our cognitive health. If you’ve ever wondered what it takes to maintain lifelong clarity and vitality, you won’t want to miss this conversation.Dale Bredesen, MD, is an internationally recognized neurologist specializing in neurodegenerative diseases. He is the Senior Director of Precision Brain Health at Pacific Neuroscience Institute® and the Chief Scientific Officer at Apollo Health.Guided by his belief that Alzheimer’s is not just preventable but reversible, Dr. Bredesen’s groundbreaking research has helped explain the biological mechanisms behind memory loss. His decades of study have led to new treatment approaches, including the ReCODE Protocol™—also known as the Bredesen Protocol—a strategy designed to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s, dementia, and mild cognitive impairment.Timestamps:0:00 Introduction to Guest2:48 Phase 3 Trial Upcoming10:11 Alzheimer’s: Different Triggers, Different Outcomes13:11 Could Brushing Your Teeth Save Your Brain? (Oral Microbiome & Alzheimer’s18:45 The 3 Major Players in Brain Health22:24 How to Make Sure You Never Get Dementia22:33 Blood Markers for Alzheimer’s: What Your Tests Reveal28:10 Diabetes and Alzheimer’s: The Hidden Connection34:18 The #1 Contributor to Cognitive Decline: Insulin Resistance39:54 How to Match Your Brainspan to Your Lifespan40:31 Top Supplements for Brain Health43:15 The Power of Nitric Oxide for Your Brain48:07 Leaky Gut & Cognitive Decline54:15 Metformin & Brain Longevity57:31 Why Do More Men Than Women Get Parkinson’s1:05:24 ADHD & Alzheimer’s: The Fruit Fly Discovery ("Alzflymers")___________________________Dale Bredesen, M.D., is an expert in neurodegenerative diseases such as Alzheimer’s. He is a graduate of Caltech and received his MD from Duke University Medical Center. His career includes serving as Chief Resident in Neurology at UCSF, working as an NIH Postdoctoral Fellow, and holding faculty positions at UCSF, UCLA, and UC San Diego. He was the director of the Program on Aging at the Burnham Institute and the founding President and CEO of the Buck Institute. His work has led to a new therapeutic approach for treating Alzheimer’s. He is the author of The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Yes, we need stress in our lives! Staying in our comfort zone may be doing us more harm than good. That’s probably surprising to hear from me having spoken about the importance of reducing stress over the years. But, nonetheless, a level of stress that is not overly damaging, and that may actually have positive benefits. Today we are going to learn much more about that will be looking at the book, The Stress Paradox with Dr. Sharon Horesh Bergquist. We're going to learn about the"Stress dilemma" that we face, how stress enhances, cellular resilience, how our life compares to the lives of our ancestors in terms of the physical stresses that we endure. We will explore how stressing ourselves in relation to the times that we eat, our physical exercise, and even explore how sleep or lack of sleep, may affect us in negative and even perhaps positive ways. All in all, we"re learning these days how we want to do our best to leverage the value of being out of our comfort zone but also recognizing ourboundaries. 00:00 Introduction02:00 Welcoming Sharon and Introducing The Stress Paradox06:33 Sleep is Critical07:12 Good Stress (HIIT) vs. Bad Stress (Financial Hardship)09:50 Hormetic Stress? Current Environment vs. Ancestors' Stress Levels13:20 Stress Responses Stored in Phytochemicals and our Evolutionary Relationship with Plants19:01 10,000 DNA Injuries Any Given Day, 7 Per Minute22:03 The Biggest Factor Related to Longevity26:01 Relationship with Decreased Risk of Alzheimer’s & The Role of Myokines30:17 Microglia Cells Can Share Mitochondria (Before & After)35:13 Heat Exposure Mimics the Benefits of Exercise38:01 Key Strategies for Longevity and Vitality45:32 Personalized Health Strategies for Optimal Performance50:25: The Cortisol Spike and Why It is Necessary 58:20 Why You Need Non-negotiables In Your Physiology50:20 Conclusion====Sharon Horesh Bergquist, MD, is an award-winning physician, innovative healthcare leader, and visionary researcher renowned for spearheading a science-based approach to applying lifestyle as medicine. She has helped lead numerous clinical trials, including the Emory Healthy Aging Study and the NIH funded Emory Healthy Brain Study. Dr. Bergquist is widely published in peer-reviewed journals and has contributed to over 200 news___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱We all want to live a stress-free life. But as it turns out, this may not necessarily be in our best interest having a low level of stress of various types turns out to be good for our physiology and can even help us recover from illness. When stress is implemented in this way, it is termed, other words, the upside of low-grade stress. That stress can be exercise, immersion ourselves in cold or hot temperatures, time restricted eating, or even various forms of light exposure all of which we will explore on my podcast today, which is an interview with my good friend, Jeff Krasno. His new book, Good Stress, that he wrote along with his wife Schuyler GrantHe is the CEO and founder of Commune Media, a masterclass platform for well-being that features renowned authors and teachers. He hosts the Commune podcast, which has over 520 episodes and generates more than 750,000 monthly downloads, featuring interviews with luminaries such as Deepak Chopra, Marianne Williamson, Matthew McConaughey, and Gabor Maté. Additionally, Jeff writes a weekly "Commusing" essay exploring well-being, spirituality, and culture, distributed to an email list of over one million subscribers.Prior to founding Commune Media, Jeff co-created Wanderlust, a global series of wellness events that have significantly contributed to popularizing yoga practices and principles in the U.S. and beyond. In 2016, Oprah Winfrey selected him as part of the SuperSoul100, recognizing him as one of the nation's leading entrepreneurs.Jeff's latest book, "Good Stress: The Health Benefits of Doing Hard Things," co-authored with his wife, Schuyler Grant, is set to be released on March 25, 2025. I've had the opportunity to read the galley and it's a terrific book that will open a lot of doors for each and every one of you in terms of regaining your health.TIMESTAMPS00:00 Introduction and Personal Connection with Jeff Regarding the Los Angeles Wildfires8:51 Introducing Jeff’s Book, Good Stress: The Health Benefits of Doing Hard Things13:42 The Personal and Societal Costs of Poor Health18:27 Jeff’s Background and Personal Approach to Wellness22:54 Homeostasis as the Foundation of Health25:42 Rethinking "Normal"—The Flaws of the Bell Curve Perspective29:24 Evolutionary Perspectives on Health and Adaptation34:55 Thermoregulation as a Pathway to Homeostatic Flexibility38:15 Hypoxia and Its Role in Physiological Adaptation47:04 The Therapeutic Potential of Thermal Shock49:51 The Concept of Good Stress and the Evolutionary Mismatch of Modern Lifestyles55:01 Optimal Timing and Approaches for Cold Plunging1:00:46 Jeff’s Personal Biohacking Journey1:07:08 Exploring the Benefits of Light Therapy and the Revival of Raw Milk Consumption====Jeff Krasno is the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being and co-creator of Wanderlust, a global series of wellness events. He hosts the Commune podcast, interviewing a wide variety of luminaries from Deepak Chopra and Marianne Williamson to Matthew McConaughey and Gabor Maté. His latest venture expands Jeff’s personal story and protocols into a book, Good Stress: The Benefits of Doing Hard Things (Hay House, March 2025). The book dives deeper into the concepts from the course, distilling insights from over 400 podcast conversations Jeff has conducted, along with his personal experiences applying these ideas to transform his own health. It explores deliberate, self-imposed behaviors that promote social, psychological, and physical well-being, offering both a philosophical exploration of true wellness and practical steps to achieve it.Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱We all know that exercise is good for the body and specifically, very good for the brain. In fact, exercise is the most important inroad to better brain health, better brain function, protecting the brain against decline, and even with respect to mood issues like depression.But it's reasonable to ask how in fact does this work? How is it that exercising muscles does good things for the brain?On today's episode of the Empowering Neurologist we spent time with Dr. Austin Perlmutter. He takes us on a deep dive exploring the exact connection between muscle and its endocrine function in terms of creating various chemicals that are so helpful for better brain health. It's a great discussion that looks at things like how much exercise is appropriate, what type of exercise is best, how much protein we should be consuming, and what other supplements will augment the benefits of exercise in terms of better brain health. I think you will really enjoy this episode. I know I sure did, after all, getting to spend time with my son is always special!=====00:00:00 Introduction & Welcoming Dr. Austin00:01:56 The Relationship of Muscle Health, Mental Health, and Brain Health00:09:15 The Power of Exercise to Improve Cognition vs Pharmaceuticals & The Muscle as an Endocrine Organ00:16:36 The Molecules Produced by Muscles: Myokines 00:20:10 Myokines, Inflammation, and Metabolic Health 00:26:43 Sarcopenia and The Risk of Dementia00:31:50 Brain Derived Neurotropic Factor, Neuroplasticity & Weight Training 00:39:40 Animal versus Plant Protein to Build Healthy Muscle00:46:26 Cycling Anabolic and Catabolic States00:51:31 Why Women Are 2x More Likely to Develop Alzheimer's and What Supplementation Is Necessary to Compliment Building Muscle01:05:40 Conclusion and Wrap Up=====Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster and entrepreneur. His mission is to help people get their brains unstuck for better mental and cognitive health. Dr. Perlmutter’s work on how environment and diet influences brain health has been featured on PBS, Rolling Stone, Newsweek, NPR, Fox, CBS and other top media outlets. He has co-produced and hosted some of the world’s largest online brain health events including Alzheimer’s, the Science of Prevention and the Better Brain Blueprint. He is the Managing Director of Big Bold Health, where he led a pioneering study exploring plant nutrient effects on human aging. He is the CEO of Lichen Air, which provides science-backed indoor air solutions for better brain health and longevity. He is also a research consultant to the Helfgott Research Institute, where he studies the epigenetic, metabolic, microbiome and immune effects of ayahuasca. Website: https://www.austinperlmutter.com/YouTube: https://www.youtube.com/@draustinperlmutterIG: https: https://www.instagram.com/draustinperlmutter/Lichen AIr: https://lichenair.com/Dr. Austin Perlmutter's Muscle-Brain eGuide: https://www.austinperlmutter.com/muscleguide___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Over the last several decades, it’s been interesting to watch the progression of ideas for treating Alzheimer’s change from focusing on brain chemistry to targeting the accumulation of proteins in the brain associated with the disease. Recently, there’s been exciting interest in studying how the brain’s electrical circuits and rhythms change in Alzheimer’s and other brain degenerative disorders.The human brain operates in rhythms, with gamma frequencies playing a critical role in cognitive functions such as memory, attention, and learning. In neurodegenerative diseases like Alzheimer’s, these gamma oscillations are disrupted, contributing to the accumulation of harmful proteins such as amyloid-beta and tau. Cognito Therapeutics has developed a pioneering approach using non-invasive light and sound stimulation to restore these rhythms and trigger natural mechanisms for clearing these toxic proteins.In preclinical and early clinical trials, this method has demonstrated remarkable potential. By stimulating gamma oscillations, the therapy has shown the ability to reduce inflammation, enhance synaptic function, and activate microglia—immune cells responsible for clearing debris and maintaining brain health. For families battling cognitive decline, these results offer hope for improving quality of life and potentially slowing disease progression. Cognito’s research focuses on safety, accessibility, and scalability. Unlike pharmaceutical interventions, this approach avoids invasive procedures or systemic side effects, making it an attractive alternative or complementary treatment for Alzheimer’s.As the company advances its clinical trials, the implications extend far beyond Alzheimer’s. Cognito’s technology could pave the way for treatments for neurological conditions like Parkinson’s, MS, and traumatic brain injury.On our podcast today, we are joined by Christian Howell, CEO of Cognito Therapeutics. Howell is committed to advancing the understanding of brain health and delivering groundbreaking therapeutic solutions to improve patient outcomes. Under his leadership, Cognito Therapeutics has made significant strides in the development of gamma-frequency neuromodulation technologies, leveraging light and sound stimulation to address the mechanisms of Alzheimer’s and other neurodegenerative disorders. Howell is a strong advocate for translating cutting-edge research into real-world applications and has spearheaded the company’s efforts to validate its therapies through rigorous scientific studies and clinical trials.Howell holds advanced degrees in neuroscience and bioengineering and has dedicated his career to bridging the gap between scientific discovery and patient care. His work reflects a commitment to improving the lives of individuals and families impacted by cognitive decline and to shaping the future of brain health through innovation and collaboration.====00:00 Introduction00:59 Optogenetic Light & SoundTherapy 11:28 Innovations in Light and Sound Therapy at 40Hz Interval; Generating Neuroplasticity17:48 Rethinking Alzheimer’s Treatment and Gamma Wave Stimulation’s Impact on Proteins20:43 Overview of Cognito Therapeutics at Home Device25:30 Usage for Therapeutic, Preventative, and Performance Enhancement. 28:37 Disease States: Dysregulation of Microglia; Long Covid, Chemo Brain, Sepsis 30:45: Breakthrough Designation from FDA For the Device38:07 FDA Approval, Distribution, and Insurance Approval; Economic Burdens of Alzheimer’s 44:30 Closing Insights on Revolutionary Therapies====Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 After decades of stagnation, the field of psychiatry is undergoing a transformative shift. For 75 years, mental health issues were largely viewed as “chemical imbalances” best treated with medications. While these medications have helped many, their efficacy is often limited, and they come with common side effects like fatigue, weight gain, and sexual dysfunction. Enter metabolic psychiatry—a groundbreaking new approach that reimagines mental health challenges as issues rooted in brain metabolism. This fresh perspective is revolutionizing how we perceive and address mental health conditions, offering powerful, practical, and safe solutions that are accessible to everyone. The most exciting discovery of our time? Robust mental health is deeply connected to robust metabolic health—and achieving metabolic health starts with a brain-friendly diet. For those struggling with mental health, understanding how dietary changes can provide benefits that no medication can is critical. However, the key lies in making the right changes—ones that go beyond conventional dietary advice. By integrating cutting-edge research on brain metabolism with evidence-based insights on brain-nourishing foods, we can unlock a powerful formula for optimal mental well-being. This exciting synergy is the focus of our podcast, and today, we’re thrilled to feature an expert in this field: Dr. Georgia Ede, MD, author of Change Your Diet, Change Your Mind. In this episode, Dr. Ede shares her insights on the revolutionary potential of metabolic psychiatry and the role of diet in mental health. Together, we’ll explore how rethinking the way we nourish our brains can lead to profound changes in how we think, feel, and live. Join us for a deep dive into the intersection of nutrition and psychiatry and discover how small, actionable dietary changes can unlock a brighter, healthier future for your mind. ==== 0:05 Introduction 4:15 Welcoming Dr. Ede 5:01 Dr. Ede's Backstory And Experimenting with Her Own Diet 10:46 Shifting Beliefs From Standard Psychiatric Medicine 15:22 SSRI's And Their Efficacy 20:13 Standard American Diet And Widespread Mental Health Crisis 26:21 Inflammation And Its Affect On Mental Health 30:18 Insulin Resistance, The Brain, and Impact on Mental Health 34:49 The Pushback Georgie Has Received W 39:28 Metabolism, Mitochondrial Function Relation To Mental Health Issues 44:36 Using A Ketogenic Diet To Manage Mental Health 52:55 Personalized Medicine Through A Diet That Works For Your Body 1:01:20 Thank you to Dr. Georgia and Conclusion ==== Dr. Georgia Ede is an internationally recognized expert in nutritional and metabolic psychiatry. Her twenty-five years of clinical experience include twelve years at Smith College and Harvard University, where she was the first psychiatrist to offer students nutrition-based approaches to mental health conditions. Dr. Ede co-authored the first inpatient study of the ketogenic diet for serious mental illness, developed the first medically accredited course in ketogenic diets for mental health, and is a recipient of the Baszucki Brain Research Fund’s Metabolic Mind Award. Her bestselling new book Change Your Diet, Change Your Mind was recommended by the New York Times Book Review as among the three best mental health books of 2024. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠  Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Tune in to The Empowering Neurologist Podcast for an Inspiring Conversation with Dr. Jill Carnahan, Author of Unexpected I’ve just finished recording a very moving interview with Dr. Jill Carnahan—Functional Medicine expert, speaker, and author. This was an unforgettable conversation about her new book, Unexpected. Dr. Carnahan’s story is one of resilience, empathy, and transformation, and her insights have changed countless lives through her compassionate approach to health. Dr. Carnahan’s journey to becoming a functional medicine leader is anything but conventional. Early in her career, she faced serious health challenges that nearly ended her life and forever transformed her approach to patient care. After being diagnosed with breast cancer at just 25, Dr. Carnahan was forced to confront the fear, uncertainty, and upheaval that accompany life-altering illness. During her treatment, she developed a deeper understanding of what her patients were experiencing, not only physically but also emotionally. Just as she was beginning to regain her health, she was diagnosed with Crohn’s disease, a severe autoimmune disorder that impacted her life for years. These back-to-back health crises became defining moments for Dr. Carnahan. They pushed her to pursue holistic healing modalities, ultimately shifting her career path toward Functional Medicine. Through her own journey of recovery, she developed a unique perspective on health that goes beyond treating symptoms, instead focusing on addressing the root causes of illness and the interconnectedness of mind, body, and spirit. In our time together Dr. Carnahan discusses: ☑️ The pivotal moments in her life that led her to Functional Medicine and reshaped her philosophy on health ☑️  How emotional resilience and compassion are critical components of healing ☑️  Practical strategies to detoxify, restore gut health, and promote holistic recovery ☑️  Insights into managing autoimmunity and chronic illness in a way that prioritizes the whole person ☑️  The role of mindset and self-compassion in transforming personal health challenges into opportunities for growth My hope is that you will find our conversation to be an inspiring and enlightening experience. Her warmth, empathy, and expertise make her a true pioneer in Functional Medicine and a source of hope for anyone on their own health journey. ==== 00:11  Intro 01:09  Introduction to Dr. Jill 04:30  Dr. Jill’s Cancer Diagnosis 09:16  How She Learned To Trust Herself: Blending Intuition with Logic 11:54  The Illusion of Certainty & Embracing Fear 14:53  Returning to Medical School Post Chemo 20:12  Where Jill’s Cancer May Have Originated 24:24  The Diet That Helped Dr. Jill’s Crohn’s, Colitis, SIBO and SIFO Flare Ups 34:51  Dr. Jill’s Journey Into Functional Medicine as a Doctor 39:45  Dr, Perlmutter Shares His Patient’s Gluten-Free Experience 41:11 Using The Human Genome in Functional & Integrative  Medicine 50:00 How Personal Agency Impacts The Healing Process 51:50 Upstream From The Microbiome Is The Soil & Outro ==== Dr. Jill Carnahan is Your Functional Medicine Expert® dually board certified in Family Medicine for 10 years and in Integrative Holistic Medicine. She is the founder and Medical Director of Flatiron Functional Medicine, a widely sought-after practice with a broad range of clinical services including functional medical consulting, chiropractic therapy, physical therapy, naturopathic medicine, acupuncture, and therapeutic massage. Be sure to follow her @drjillcarnahan on Instagram. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 What makes a good brain go bad? And if we can answer that question, how do we fix it? Of all the things that we consider that are important for brain cell function, the activity of the mitochondria is primary. And, what do mitochondria need to function at their best? The answer is not a supplement. It's not other forms of nutrients, it is oxygen. And as it turns out, enhancing, the oxygen availability for mitochondria is a powerful therapeutic tool across a wide variety of neurological issues. Mitochondrial dysfunction is central to things like dementia, autism, stroke, head injury, and even long COVID. Hyperbaric oxygen is a clearly the most leading edge therapy that targets mitochondrial function and improves blood supply to the brain. This is a technique in which individuals are placed in a chamber, the atmospheric pressure is increased, and they breathe oxygen in varying concentrations through a facemask. Today we are going to visit the Aviv Clinic in central Florida as I am joined by Amir Hadanny, MD, PhD, Aviv’s Chief Medical Officer and Head of Research. Dr. Hadanny has done and continues to do incredible research using hyperbaric oxygen therapy as an interventional tool to treat a variety of issues, including those mentioned above. The results, that are published in preview journals, are outstanding. Clearly hyperbaric oxygen therapy, when provided with a regimented protocol as we see at the Aviv Clinic, is giving people, a second chance. ==== 00:00 Intro 00:01:28 The Evolution of Hyperbaric Medicine Research 00:03:00 Clinical Applications: PTSD and Long COVID 00:05:30 Inside the Aviv Clinics Experience 00:09:22 Long COVID Study: Research Design and Findings 00:33:40 Cognitive and Physical Benefits in Healthy Aging 00:37:28 PTSD Breakthrough Study and Government Adoption 00:43:47 Future of Hyperbaric Medicine 00:45:50 Closing Remarks and Future Prospects ==== Amir Hadanny, MD, PhD is a neurosurgeon and researcher at Aviv Clinics, specializing in the use of hyperbaric medicine to optimize brain and body performance. He also serves as Chief Medical Officer and Head of Research at Aviv Scientific. Dr. Hadanny completed his MD at Tel Aviv University, his PhD in Bioinformatics and Computational Biology focused on machine learning from Bar Ilan University, and his neurosurgery training at Galilee Medical Center in Israel. He completed a Stereotactic and Functional Neurosurgery fellowship at Albany Medical Center and a Harvard Research Fellowship in the Brain Modulation Lab at Massachusetts General Hospital. Through his work at Aviv Clinics and Aviv Scientific, Dr. Hadanny has published more than 60 scientific studies on the use of a unique hyperbaric oxygen therapy protocol for neurorehabilitation and recovery in different brain pathologies and its effect on the biology of aging. https://www.nature.com/articles/s41598-022-15565-0 https://pubmed.ncbi.nlm.nih.gov/38360929/#:~:text=The%20results%20indicate%20HBOT%20can,after%20the%20last%20HBOT%20session. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 We are certainly all aware of the health consequences associated with consumption of ultra processed foods. And this discussion always moves to the role of the sugars and refined carbohydrates in these foods in terms of threatening our metabolic health - and rightfully so. But there’s another threat associated with these and other foods that is equally important. And that’s the type of oils they contain. In this episode of The Empowering Neurologist, I’m thrilled to welcome Dr. Cate Shanahan, a groundbreaking physician and the author of the eye-opening book Dark Calories. Dr. Shanahan dives deep into a topic that is often overlooked in conversations about nutrition: the dangers of seed oils and their pervasive presence in our diets. In Dark Calories, Dr. Shanahan reveals how seed oils—despite being marketed as healthy alternatives—can have detrimental effects on our brain and overall health. We explore the science behind these oils, explaining how they can lead to inflammation, oxidative stress, and toxicity, and how these mechanisms threaten our health. By bringing awareness to the hidden dangers of these ubiquitous ingredients, Dr. Shanahan encourages us to reconsider what we think we know about healthy eating. What makes this episode truly valuable is not just the scientific insights Dr. Shanahan shares but also the wealth of actionable material she provides. Throughout our conversation, we discuss practical steps listeners can take to reduce seed oil consumption and make healthier food choices. From understanding food labels to selecting healthier cooking fats, Dr. Shanahan equips us with the tools we need to nourish our bodies and brains effectively. She emphasizes the importance of whole, nutrient-dense foods, urging us to prioritize traditional fats over industrial seed oils that can contribute to chronic inflammation and cognitive decline. Whether you’re a health enthusiast or simply looking to improve your diet, this episode is packed with invaluable tips, like what to order when you go out to eat, that you can implement immediately. ==== 00:00 Introduction to Cate + the Dangers of Seed Oils 03:18 The 'Hateful Eight' Oils Explained 06:20 Origins of Vegetable Oils in the Food Supply 10:47 Toxicity of Refined Oils 15:03 Health Risks of Heated Oils 18:01 Medical Industry Conflicts 32:12 Strategies for Avoiding Harmful Oils 37:03 Comparison of Saturated vs. Unsaturated Fats 40:35 Impact of Toxic Oils on Chronic Diseases 53:00 Summary and Closing Out ==== Cate Shanahan, MD, has shaped the best parts of today’s food and health landscapes. Her books and other publications have taught a generation of health influencers what an ideal human diet looks like and the damaging effects of a collection of 8 common seed oils (“The Hateful 8”), informing the full spectrum of nutrition leaders, including keto, carnivore, functional medicine and more. Her science backed diet advice has inspired food entrepreneurs to make billions, including bone broth, live-culture ferments, and seed-oil-free business empires like the Primal Kitchen and Bulletproof brands. As a family physician, she has personally worked 1:1 with thousands of patients to improve energy metabolism and reduce fatigue, cellular inflammation, and organ dysfunction. Through her works and influence, she has helped millions escape the vicious cycle of sickness and drug dependence.  Dr. Cate’s Monthly Newsletter signup: https://drcate.com/newsletter-signup/  About Dr. Cate’s Books https://drcate.com/which-drcate-book-should-i-buy/ LinkedIn: @DrCateShanahan X: @DrCateShanahan Instagram: @DrCateShanahan  ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 What can we do to improve our brains? This is clearly a topic that is central to our messaging. And we have focused on a variety of levers to pull, including exercise, sleep, dietary changes, nature, connection, etc. But we've now learned about a powerful input that has proven incredibly effective in improving brain function, especially in a variety pathological situations like cognitive decline, anorexia, depression, and even autism. This innovative approach has been called olfactory enrichment. And basically, this involves stimulating the brain with various types of scents. Perhaps the top researcher on the planet exploring this subject and creating innovative ways for us to take advantage of olfactory enrichment is Dr. Michael Leon.He received his PhD from the University of Chicago and joined the professoriate at the young age of 24. He is currently Professor emeritus in the Department of Neurobiology and Behavior at the University of California Irvine. He has received the Research Scientist Development Award from the National Institute for Mental Health for his work on the neurobiology of early learning, the D.G. Marquis Award from the American Psychological Association for developing an effective treatment for children with autism, and the Healthcare Technology Acceleration Award from the California HealthCare Foundation for his work on body weight normalization. In a recent analysis from the Stanford University, he was ranked among the top 2% of scientists in the world. On the podcast we review this empowering science in detail and I am certain you will be you captivated by the therapeutic potential of this intervention.Also, we’ll explore the device Dr. Leon has created so that everyone can take advantage of these exciting developments.  ==== 0:00 Intro 2:48 Researching Olfactory Enrichment  7:25 Impact of Olfaction on Disease 13:47 Relationship Between Inflammation & Sense of Smell 16:27 Study of Olfactory & Memory Loss 19:41 Losing Sense of Smell In Covid 24:01 Relationship of Taste to Olfaction 26:04 Impact on Depression  27:26 Difference Between this and Aromatherapy  31:59 Treating Anorexia with This 33:11 How This Works on a Subconscious Level 34:50 Memory Air Device  36:25 Conclusion ==== Michael Leon received his PhD from the University of Chicago and joined the professoriate at the age of 24.  He is currently Professor emeritus (recalled) in the Department of Neurobiology and Behavior at the University of California Irvine. He also is a member of the Center for the Neurobiology of Learning and Memory, as well as the Institute for Memory Impairments and Neurological Disorders at UCI.  He has received multiple awards for teaching undergraduates, including the Professor of the Year Award as the best teacher on the UCI campus. He has received the Research Scientist Development Award from the National Institute for Mental Health for his work on the neurobiology of early learning, the D.G. Marquis Award from the American Psychological Association for developing an effective treatment for children with autism, and the Healthcare Technology Acceleration Award, from the California HealthCare Foundation, Booz Allen Hamilton, and the Robert Wood Johnson Foundation for his work on body weight control. In a recent analysis from the Stanford University School of Medicine, he was ranked among the top 2% of scientists in the world for the impact of his research. He is a partner in Science Lab 3 and the Mando Group. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Our lifestyle choices are fundamental as it relates to the health of our brains. Who knew? Well one person who knows this information and has done an amazing job getting this out to public awareness is Louisa Nicola, neurophysiologist, human performance coach and  founder of Neuro Athletics, a human performance coaching firm that supports the highest performing athletes and executives in the world. This organization bring science-based solutions to elite performers who want to perform at their highest level. Luisa graduated from the university of Sydney medical school and specializes in Neurophysiology. She is currently completing her PhD and has recently published fascinating report on the benefits of resistance exercises as it relates to Alzheimer's disease. The podcast that you were about to watch extremely empowering. What you will find in Louisa’s messaging is a heartfelt devotion to empowerment for all who will listen that truly, our brain’s destiny is something we can control. I'm very grateful that she joined us on the podcast today. ==== 0:00 Intro 2:37 How Louisa Got Started 5:00 Exercise’s Impact on Brain Health 11:37 Aerobics vs Strength Training  14:56 Wearable Devices to Track Exercise  19:53 What Happens in the Brain During Exercise  25:11 Importance of Restorative Sleep 30:42 Best Type of Diet for the Brain 33:09 Phd: Resistance Training & Alzheimer’s 36:28 Conclusion ==== Neurophysiologist and human performance coach, Louisa Nicola is the founder and head performance advisor of Neuro Athletics - a human performance coaching firm that boasts the highest performing athletes and executives in the world. Neuro Athletics brings science based solutions to elite performers who want to perform at their peak. Louisa graduated from the University of Sydney Medical School and specialises in neurophysiology.  https://www.instagram.com/louisanicola_/ https://apple.co/3H02jPa  https://neuroathletics.substack.com/subscribe  https://www.neuroathletics.com.au/ ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Around 60 million people around the world have dementia. 300 million have depression, and billions of people are experiencing brain problems due to chronic stress. These conditions are partially preventable, but most people don’t know the steps to take to decrease their risk and protect their brains. It turns out that the place where our brains are at the highest risk for being damaged is actually in our homes, and that we have an incredible amount of control over what happens here. But sadly, most of us are being unintentionally exposed to things in our houses that are poisoning our brain health. In this episode, we’re going deep into the science that examines those factors in our environments that are damaging our brains. We connect with an expert in environmental and lifestyle medicine, Dr. Austin Perlmutter. We’re going to explore exactly what we are exposing ourselves to, in our homes, cars and offices, that threaten to worsen our cognitive and mental health. And, importantly, Dr. Perlmutter will reveal simple steps we can employ, today, to reduce this threat.  ==== 0:00 Intro 3:06 How our environment threatens our brain 8:18 Health Begins in the Kitchen 12:10 Air Pollution in the Kitchen 18:13 Pollution in our World Today 23:23 Hidden Sources of Pollution: Vacuums & Incense 28:34 Effectiveness of N95 Masks 31:00 We Can’t Overlook This 35:00 Air Fresheners & Perfumes  39:13 Indoor Filtration & Ventilation  46:40 Other Pollutants to Watch Out For 49:25 Conclusion ==== Here's more about our guest, and yes, my son: Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher and international educator. His mission is to help people improve their health by targeting the biological basis of “stuckness” in our brains and bodies. His writings, presentations, podcasts, and online educational programs explore how environmental factors influence our cognitive and mental state and have reached millions. Dr. Perlmutter has been featured on PBS, Rolling Stone, MedPage today, Newsweek, Medical News Today, NPR and a wide range of other media outlets. He is a co-producer of the Alzheimer’s, the Science of Prevention series, and host of the Better Brain Blueprint series. Dr. Perlmutter currently serves as the managing director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he is running a first-of-its kind study exploring the effects of plant nutrients on human aging through epigenetic modulation. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Researchers around the world are looking at the role of a mechanism, inflammation, in what makes a good brain go bad, and specifically in diseases like Alzheimer’s. Dr. Jack Auty is a Tasmanian researcher who is focused on this process and is exploring a variety of inroads to inflammation, including, zinc deficiency, as well as the possible role of our ever-increasing exposure to microplastics in amplifying this mechanism. Dr. Auty has a very expansive social media exposure, bringing this information to the public awareness. He’s a very interesting researcher on a number of levels, including fieldwork looking at animals exposed to microplastics as well as translational research from the lab to humans again focused on inflammation and its damaging role throughout the body, and specifically the brain.  Currently, Dr. Auty is a lecturer in the Medical Sciences division in the School of Medicine at the University of Tasmania. He, in addition, serves as a collaborator with an organization called the Adrift Lab, and we will learn more about their mission on our podcast as well.   ==== 0:00 Intro 3:16 Studying the Mechanism of Inflammation 13:12 Optimizing Our Microglia 16:46 Polygenic Influences on Alzheimer’s 21:16 Accumulation of Microplastics  34:35 Avoiding Microplastics 36:53 Zinc’s Impact on Alzheimer’s  43:20 Removing the Blame From Lifestyle Choices 52:00 The Adrift Lab: Studying Microplastics 57:23 Conclusion ==== Jack completed a Bachelor of Science in anatomy with a neuroscience focus at the southernmost university in the world – the University of Otago. During his degree Jack took several botany papers and fell in love with the subject, so Jack continued studies at Otago with a post graduate diploma in botany followed by a Ph.D. which combined botany and neuroscience by investigating the effects of marijuana-like synthetic cannabinoids on inflammation in the ischemic brain, combining botany and neuroscience. After completing his Ph.D., Jack continued his research at the University of Otago with projects on hydrogen sulphide as an inflammatory signaling molecule and kamikaze neutrophils that release their DNA contents onto bacteria. He then moved to the University of Manchester, where he primarily investigated the role of the inflammasome in Alzheimer's disease and age-related cognitive decline. Jack was fortunate to have inspiring, supportive, and scientifically proficient supervisors and collaborators in Dr. Catherine Lawrence and Prof. David Brough, under whose guidance he was able to make significant contributions to the field of inflammation research. Currently, Jack is a lecturer in Medical Sciences at the University of Tasmania, where he investigates inflammation. He is focused on establishing the inflammatory properties of environmental microplastics and identifying the cellular mechanisms that mediate microplastic-induced inflammation. Additionally, he aims to understand how peripheral and central inflammatory responses contribute to Alzheimer's disease. https://jackauty.com ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 In this episode of The Empowering Neurologist Podcast, we had the profound pleasure of reconnecting with my longtime friend and now filmmaker, Max Lugavere, the creative force behind the deeply moving documentary Little Empty Boxes. Max, who is as articulate as he is passionate, took us through the deeply personal journey that led to the making of his film—a narrative woven from love, loss, and the quest for understanding dementia. The genesis of Little Empty Boxes is as poignant as it is inspiring. Max shared the moment his life changed during what was meant to be a serene summer vacation: his mother, Kathy, was unable to recall the current year, a lapse that signaled the onset of her cognitive decline. This incident wasn't just a fleeting moment of forgetfulness; it was the beginning of a challenging journey through the landscape of dementia, a condition affecting over 55 million people worldwide. Moved by his mother's struggle, Max returned to New York City, transitioning from a concerned son to a determined researcher, diving deep into the complexities of dementia. The film follows his exploration of innovative approaches beyond conventional medication, aiming to slow the progression of his mother's illness. Max described Little Empty Boxes as a project that "crept in, claws out." It wasn’t a film he planned, but one that emerged from necessity. His mother's worsening condition was harrowing to witness, but it birthed a purpose that transcended personal pain. Max emphasized that the film isn’t centered on definitive medical answers or miraculous recoveries. Instead, it presents a raw, messy, and intimately personal look into the life of a dementia patient and the daily realities of their caretakers. One of the most touching moments in our conversation was Max’s reflection on the film as a tribute to his mother and a love letter to the science of dementia prevention. He hopes that by sharing his mother's story, the film will not only shine a light on ways to delay or prevent this devastating condition but also encourage viewers to cherish every memory. "It's about making the most of what remains, together," Max remarked, highlighting the film’s focus on the human elements of love, memory, and resilience. Our discussion with Max was more than just an interview; it was an exploration of the emotional and scientific facets of dementia through the lens of a devoted son's experience. For anyone who has witnessed the impacts of dementia firsthand, or for those interested in the intersections of film and real-world issues, Little Empty Boxes offers a compelling narrative that is both educational and deeply moving. Watch Little Empty Boxes here: https://littleemptyboxes.com/ ==== 0:00 Intro 3:49 The Diagnosis That Changed Everything 8:09 How Medicine Failed Max’s Mom 12:07 How Fraudulent Research Clouded Our Knowledge 18:14 Making “Little Empty Boxes” 26:06 Bringing the Prevention Conversation to the Masses 35:50 Conclusion ==== Max Lugavere is a health and science journalist, filmmaker, and bestselling author. He is the author of the Genius trilogy of books, including the New York Times bestseller Genius Foods and the Wall Street Journal bestseller Genius Kitchen. He hosts The Genius Life podcast, one of the top health and wellness podcasts in the U.S, and has an audience of over 1.5 million followers across social media. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Alzheimer’s disease can be reversed. Need I state that again? That is the subject of our podcast featuring an interview with Dr. Heather Sandison. Dr. Sandison is a renowned naturopathic doctor and a leading expert in neurodegenerative diseases. She has dedicated her career to understanding and reversing cognitive decline, with a particular focus on Alzheimer's disease. In this episode, we will be discussing her groundbreaking new book, Reversing Alzheimer's. This transformative work offers a comprehensive approach to preventing and reversing Alzheimer’s disease through personalized medicine, lifestyle changes, and cutting-edge therapies. Dr. Sandison’s insights provide hope and practical strategies for those affected by this devastating condition. Tune in as we explore the innovative methods outlined in her book, the latest research in brain health, and how you can take proactive steps to maintain cognitive function. Whether you’re a caregiver, a healthcare professional, or someone concerned about your brain health, this episode is packed with invaluable information and inspiration. ==== 0:00 Intro 2:49 Promising Alzheimer’s Breakthrough 7:57 Where We’re Getting it Wrong with Alzheimer’s Prevention 11:00 Solving the Complex Problem of Alzheimer’s  13:33 How Infections & Covid 19 Plays a Role 18:34 A Different View of Beta Amyloid 22:10 Studying the Treatment Plan  26:50 Contrast Oxygen Therapy 33:21 Praise for Dale Bredesen’s Work 35:15 Conclusion ==== Dr. Heather Sandison, a distinguished naturopathic doctor, has devoted her career to providing compassionate care and innovative solutions to those affected by dementia. Renowned for her pioneering work, Dr. Sandison has integrated groundbreaking, holistic, and multimodal interventions, seamlessly creating clinical, residential, research, and educational platforms. Her relentless dedication has not only transformed the lives of patients and caregivers she has also set new standards in the field of dementia care. She is the author of Reversing Alzheimer's: The New Toolkit to Improve Cognition and Protect Brain Health, out with HarperCollins June 11th, 2024. Learn more about brain health by signing up for our mailing list at: drheathersandison.com ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 There’s certainly a lot of interest these days in the idea of having a “total body MRI scan.” And with good reason. This turns out to be a highly sensitive study as it relates to detecting a variety of issues, even including early cancers. I wanted to learn more about this technique so I traveled to Vancouver, Canada to meet with Dr. Raj Attariwala, developer of the Prenuvo Scan, a popular total body MRI here in America and the scan that I myself underwent. In this interview we explore the need and utility of total body MRI, its limitations, what the future will likely bring in this area of imaging, as well as Dr. Attariwala’s more recent research dealing with metabolic imaging of the brain. ==== 0:00 Intro  2:46 How & Why MRIs Work 7:37 Effectiveness for Early Detection 13:13 Cost/ Benefit Ratio of MRI 16:49 The Future of MRI & Metabolic Signature 21:27 Brain Health & Body Mass: Findings From Total Body MRI 27:20 Pushbacks on this Protocol 31:27 Total Body vs Regional MRI 34:00 Who Can't Have an MRI 36:00 Standardization in Interpretation of Scans 45:32 Success Stories 47:25 Detecting Colon Cancer 48:29 Best Protocol for Cancer Detection 51:53 Conclusion ==== Dr Rajpaul Attariwala, M.D., PhD, FRCPC Nuclear Medicine Radiologist & Biomedical Engineer Dr Attariwala holds a doctorate in Biomedical Engineering from Northwestern University (Evanston, IL) prior to becoming a double board-certified radiologist and nuclear medicine physician certified in both Canada and USA. He received his formal training at UBC, along with specialized training at Memorial Sloan Kettering Cancer Centre (New York), UCLA, and USC. He is the creator of the Prenuvo scan and report which were developed at his MRI facility, AIM Medical Imaging in Vancouver Canada. His passion is to create and advance technology to help patients understand how their body changes in both health and disease. Currently he is working to develop and implement critical tools to promote healthspan in Medicine 3.0 with leading scientists and physicians from around the world.  ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 In this installment in The Empowering Neurologist Podcast we are thrilled to have a very special guest, and longtime friend, Dr. Casey Means, co-author of the groundbreaking book, Good Energy. Good Energy is not just a book; it's a movement. It invites us to reconsider our day-to-day choices and their profound impact on our body's energy systems. Dr. Means, a Stanford-trained physician, has beautifully woven her medical expertise with cutting-edge research to craft a guide that’s indispensable for anyone looking to enhance their physical and mental well-being through sustainable energy management. In this episode, Dr. Means shares insights into how our everyday habits—what we eat, how we sleep, and even how we think—can significantly influence our metabolic processes, mental clarity, and overall vitality. The book delves into the concept of mitochondrial health, a topic we frequently explore, explaining how these tiny powerhouses in our cells are not just biological entities, but pivotal in shaping our health destiny by influencing all manner of our physiology. Our conversation covers key themes from the book, including: The Role of Diet in Energy Production: How can the right foods transform your health by optimizing energy production at a cellular level? Mindfulness and Mental Energy: Exploring the link between mental practices like mindfulness and physical energy levels. Innovative Health Tracking: Dr. Means is a proponent of leveraging technology (like the continuous glucose monitor) to monitor health markers. We discuss how modern tools can help personalize our health strategies for better energy. Listeners will come away with practical advice on integrating the principles of Good Energy into their lives. This episode is a must-watch for anyone interested in stepping up their energy game, enhancing cognitive function, and ultimately taking charge of their health in a holistic and informed manner. If you want to try Levels today click this link for 2 months free on an annual membership: levels.link/perlmutter ==== 0:00 Intro 3:27 Where We’re Missing the Mark on Health 8:56 Correlation of Movement and Alzheimer’s 11:34 Learn How to Trust Yourself 18:04 Linking Metabolism & Health: How Levels Health Began 27:18 How to Interpret Levels Data to Optimize Your Wellbeing 31:34 American Children’s Health Crisis 35:56 Take Your Health Back 41:16 How This Information is Helping People 53:03 Conclusion ==== Casey Means, MD is the co-founder of Levels, a health technology company with the mission of reversing the world’s metabolic health crisis. She received her BA with honors and MD from Stanford, was President of her Stanford class, and has served on Stanford faculty. She trained in Head & Neck Surgery at Oregon Health and Science University before leaving traditional medicine to devote her life to tackling the root cause of why Americans are sick. She has been featured in The New York Times, The New Yorker, The Wall Street Journal, Forbes, Women’s Health, and more.  Calley Means is the co-founder of Truemed - a company that enables Americans to purchase healthy food and exercise tax-free. He is an advocate/whistleblower about the corruption of the food and pharma industries and need to change incentives - and appeared on over 100 major media outlets to advocate for change. Calley is a graduate of Stanford and Harvard Business School. Make sure to tune in and join us for this enlightening conversation. Your journey towards better health and Good Energy starts here! This episode will equip you with the knowledge and tools to make a profound impact on your health. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Without question, a pivotal player in our health is the adequate and balanced functioning of the immune system. No matter what disease state you can consider, the immune system is playing an important role. We now recognize that our metabolic health is hugely influential in determining the functionality of our immune system. As such, we know that our lifestyles influence metabolic health and therefore, with this understanding, we can influence immune function by paying attention to these decisions we make each day that are so influential as it relates to human metabolism. On today's program, we are going to explore the concept of immune modulation and the relationship between immunity and metabolic health. We are also going to take a deep dive into new some very exciting discoveries as it relates to ancient foods that powerfully influence immune function including Himalayan tartary buckwheat, a modern day superfood that’s getting a lot of attention. There couldn't be anyone better to walk us through this exciting new science than my longtime friend, Dr. Jeffrey Bland.  This is a fascinating and thought provoking interview. To further explore this science, visit Big Bold Health: https://bigboldhealth.com/the-science ==== 0:00 Intro 4:25 The Immune System Connects Everything 13:27 Soil Health & Agricultural Toxins 19:01 Looking at the True Quality of Our Food 22:33 Discovering Himalayan Tartary Buckwheat 28:38 Polyphenols & Benefits of HTB 33:38 Longevity & Blue Zones 37:43 Forming a Super Superfood: Sprouting HTB 39:49 The True Interconnected Nature of the Body & Immune System 54:07 The Mystery of Ancient Medicine & Nature’s Intelligence 1:00:01 Taking a Closer Look at Functions 1:02:03 Conclusion ==== Jeff Bland, PhD is the founder of Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations — the immune system. Through Big Bold Health, Jeff is advocating for the power of Immuno-Rejuvenation to enhance immunity at a global level, often through the rediscovery of ancient food crops and superfoods. To get there, Jeff is building a network of small farms and suppliers throughout the US that take a clear stance on regenerative agriculture, environmental stewardship, and planetary health. Jeff’s career in health spans more than 40 years. A nutritional biochemist by training, he began in academia as a university professor. Jeff then spent three decades in the natural products industry, working alongside other pioneers. A lifelong educator, Jeff has traveled the world many times over in his role as the “father of functional medicine.” In 1991, he and his wife, Susan, founded The Institute for Functional Medicine. In 2012, Jeff founded another educational nonprofit called the Personalized Lifestyle Medicine Institute. Jeff is the author of The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life, as well as countless additional books and research papers. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 As many of you are aware, much of our information that we present deals with problems of the brain and spinal cord. These have been described as being parts of the central nervous system. However, there is another part of the nervous system called the peripheral nervous system that is basically made up of the peripheral nerves. Peripheral neuropathy is a term that describes an abnormality with peripheral nerves. This can cause loss of sensation, pain, or even loss of autonomic function. Here in America some 20 million people suffer from peripheral neuropathy. In fact more than half of the people with diabetes will develop prayerful neuropathy at some point in their lifetimes. We are at increased risk for peripheral neuropathy not only as a consequence of diabetes but also as we age. Pray for neuropathy can be caused by chemotherapy and fully 1/4 of all peripheral neuropathy patients do not have an identifiable cost. There aren't really any FDA approved treatments to actually treat purple neuropathy in terms of the underlying cause of the nerve damage. While we do have drugs that treat, pain for example, again we need to find a way of treating the fire, not just focusing on the smoke. Having said that, there is an exciting new development in this field using drugs that are already available and are called muscarinic antagonists. Basically, they block the transmission of acetylcholine. In today's podcast, we are going to explore deeply, the mechanisms whereby this approach, using these muscarinic antagonists seems to be incredibly effective in growing new nerve fibers as well as increasing metabolism in the nerve itself leading to improvement ultimately in the manifestation of peripheral neuropathy. === 0:00 Intro 5:35 The Scope of the Problem 8:09 Diabetic Neuropathy  11:49 Neuropathy Following Chemotherapy  14:21 Viral Infections: HIV Treatment & Covid 16:56 Why Mitochondria are Essential in This 19:44 Pharmaceutical Study of Neuropathy  24:57 Aldose reductase inhibitor 29:31 Why This Approach is Different 37:44 How Antimuscarinics Work 48:10 Metrics for Getting FDA Approval 58:42 Funding the Research 1:01:53 Conclusion  ==== Nigel A. Calcutt, Ph.D. ook both his B.Sc. in Zoology and Ph.D. Physiology and Pharmacology at Nottingham University, England. Dr. Calcutt first began studying nerve damage caused by diabetes as an undergraduate, with a largely unsuccessful but nevertheless entertaining and informative attempt to generate diabetic chickens in the laboratory of the esteemed ornithologist Professor David Tomlinson. Undeterred by the pitiful paucity of pre-diabetic poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his academic career, with a particular interest in translational studies. Dr. Calcutt is also a co-founder of the biotechnology company WinSanTor Inc. and the non-profit organization Diabetes Research Connection. Paul Fernyhough PhD received his PhD in biochemistry from the department of Biochemistry at University of Sheffield. He then carried out postdoctoral research at Colorado State University, Kings College London and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College. Dr. Fernyhough’s research interest is in the cell biology underlying neurodegenerative disorders of the peripheral nervous system with a focus on the impact of diabetes. A biotech start-up, WinSanTor Inc, has been established and is directing phase 2 clinical trials in diabetic neuropathy and chemotherapy-induced peripheral neuropathy. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 In a groundbreaking development, an international team of researchers has unveiled a remarkable advancement in the fight against progressive multiple sclerosis (MS). Their study, led by scientists from the University of Cambridge, the University of Milan Bicocca, and Hospital Casa Sollievo della Sofferenza in Italy, demonstrates the safety, tolerance, and long-lasting effectiveness of injecting a specific type of stem cell directly into the brains of patients living with progressive MS. This breakthrough paves the way for the development of advanced cell therapy treatments for this debilitating disease that affects over 2 million people worldwide. Multiple sclerosis is a complex autoimmune disease that targets the central nervous system, leading to severe disruption in the transmission of nerve signals. While there are treatments available to alleviate some of the symptoms and reduce the frequency of relapses, many patients still progress into a secondary phase of the disease, which steadily worsens over time, causing severe disability. This secondary progressive phase has long been a significant challenge in the treatment of MS. In progressive forms of MS, a type of immune cell known as macrophages, specifically microglial cells, plays a crucial role in attacking and damaging the central nervous system. This relentless assault leads to chronic inflammation and extensive nerve cell damage. Recent advances in stem cell therapies have raised hope that they could help mitigate this damage by replacing damaged cells with healthy ones. Before the current study, the University of Cambridge team had already demonstrated in mouse models that reprogrammed skin cells into brain stem cells, transplanted into the central nervous system, could reduce inflammation and potentially aid in repairing MS-related damage. This groundbreaking study marks a significant step forward in the pursuit of effective treatments for secondary progressive MS. Although the study is relatively small and may have confounding effects from immunosuppressant drugs, its safety and long-lasting effects over the 12-month trial period have paved the way for further clinical trials. The research team's cautious optimism fuels hope for the development of cell therapy as a potential solution for this debilitating condition. This exciting progress holds the promise of a brighter future for the millions of people living with progressive MS, offering renewed hope for a more effective treatment approach. Our interview today is with the lead researcher involved in this study at the University of Cambridge, Stefano Pluchino, MD, PhD. ==== 0:00 Intro 2:46 Why Stem Cell Therapy Works 5:10 Studying Stem Cells on the Brain 9:15 MS Patients Studied in This Trial  13:43 What the Results Mean for the Public 17:40 The Specifics of the Study 26:18 Rigorous Testing that Sets this Trail Apart 28:25 Findings: Feasibility, Safety, and Biomarkers  34:32 Looking at the Results over 12 months 40:11 Correlation of Metabolic Health and MS 44:55 What Exosomes Reveal About Disease 49:01 Senolytic Therapy & Neurodegenerative Diseases 53:36 Conclusion  ==== Stefano Pluchino received his MD and PhD degrees at the University of Siena, Italy, and additional training at Cambridge University, UK. He is currently Professor of Regenerative Neuroimmunology (2021) and Honorary Consultant in Neurology, within the Department of Clinical Neurosciences at Cambridge University. Twitter: @Pluchinolab Research: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00393-4 ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 In this episode of The Empowering Neurologist, we're diving into two topics that are gaining significant attention in the worlds of men's health and weight loss: the importance of testosterone replacement therapy and the emerging role of GLP-1 agonists in weight loss as well as in diabetes treatment. Joining us is an esteemed expert in this field, Dr. Tracy Gapin, a renowned urologist and men's health specialist. Why is this topic so crucial? Testosterone, often hailed as the cornerstone of male vitality, plays a central role in various aspects of men's health. It's not just about physical strength or libido; testosterone impacts mood, energy levels, bone density, muscle mass, cognitive function, and overall well-being. However, as men age, testosterone levels naturally decline, leading to a condition known as hypogonadism or low testosterone. This decline can have profound effects on a man's health and quality of life. Dr. Gapin, with his extensive experience and research in the field, sheds light on how testosterone replacement therapy can be a game-changer for men experiencing the effects of low testosterone. He delves into the nuances of identifying candidates for this therapy, the benefits, and the misconceptions surrounding it. His insights are particularly valuable in a time when discussions about men's hormonal health are often overshadowed or misunderstood. Further, as he explains, age-matched testosterone levels in men have plummeted over the past several decades, and we discuss why. In addition, Dr. Gapin takes us through the exciting world of GLP-1 agonists, a class of drugs initially developed for diabetes management but now having a major impact in the weight loss arena. Obesity is a mounting concern globally, and its impact on men's health is undeniable. With cardiovascular disease, diabetes, and a host of other conditions linked to obesity, finding effective weight management solutions is paramount. Dr. Gapin explains how GLP-1 agonists work, their benefits, their potential risks, and their role in revolutionizing weight loss treatments. This episode is not just for those directly experiencing these issues but also for anyone interested in the broader conversation about men's health. Whether you're a healthcare professional, someone exploring options for personal health improvement, or simply curious about the latest in medical advancements, Dr. Gapin's insights offer valuable knowledge and perspective. ==== 0:00 Intro 3:04 The Issues of Low Testosterone 7:07 Why Testosterone Levels are Falling 10:00 What Indicates Low Testosterone 15:00 The Holistic Approach to This 17:28 Why Testosterone Replacement Therapy May Be Essential 19:53 Addressing Potential Risks 28:20 How TRT Works & What to Expect 35:49 Looking at Estrogen and Progesterone  37:23 LDL Medication and Low Testosterone 39:55 Addressing Thyroid Functionality 40:56 Honest Thoughts on Ozempic 50:28 Conclusion ==== Tracy Gapin, MD, is a board-certified urologist, men’s health and performance expert. and founder of the Gapin Institute, a global leader in high performance medicine. He has over 20 years of experience focused on providing executives, entrepreneurs and athletes a personalized path to optimizing their health so they can have exceptional energy, laser-focused mind and a better body. Text HEALTH to 26786 to receive an electronic copy of the High Performance Health Handbook for Men ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Hello everyone. I am delighted to let you all know about this episode of The Empowering Neurologist. We discuss fundamentally important new book, The Autoimmune Cure, by one of my dearest friends on the planet, New York Times bestselling author, Dr. Sara Gottfried. In this interview, Dr. Gottfried enlightens us as to what is really underlying the vast array of autoimmune conditions. Yes, we do get into the weeds, but the information she provides is not just fascinating, but fully empowering as well. Prepare to be enlightened as she sheds light on how trauma can intricately rewire our bodies, ultimately becoming the catalyst for autoimmune diseases. With a prevalence that's skyrocketing globally, autoimmune conditions affect millions, yet the root cause often remains elusive. Conventional medicine's approach often falls short in effectively diagnosing and treating autoimmune disorders. Many individuals grapple with baffling symptoms ranging from fatigue to brain fog, from aches and pains to anxiety, unaware that their immune system is the culprit behind their distress. Drawing from her wealth of experience in precision medicine, Dr. Gottfried has uncovered a compelling correlation between autoimmune disease and a history of trauma, a revelation that's shaping the future of autoimmune care. But here's the exciting and empowering part—there's hope. Dr. Gottfried's revolutionary program outlined in he Autoimmune Cure offers a beacon of hope for those navigating the treacherous waters of autoimmune ailments. By addressing the root cause head-on and providing a comprehensive roadmap to reset the immune system, this program empowers individuals to reclaim their health and vitality. So,  join us as we embark on a transformative journey towards autoimmune liberation. Whether you're grappling with autoimmune symptoms yourself or seeking to deepen your understanding of immune health, this podcast episode promises to be a beacon of insight and inspiration. ==== 0:00 Intro 2:15 We’re Looking at Autoimmune Wrong 8:04 Using Psychedelics for Healing Trauma  12:58 Long Covid’s Impact on the Body 16:11 Thyroid Disruption 19:03 The Microbiome’s Impact on Immune Function 24:55 Symptoms Checklist & MS 30:26 Why Women have a Higher Risk  37:19 Praise for Dr. Gottfried’s World 44:29 Conclusion ==== Sara Szal Gottfried MD is a physician, researcher, author, and educator. She graduated from Harvard Medical School and MIT, and completed residency at UCSF, but is more likely to prescribe a CGM and personalized nutrition plan than the latest pharmaceutical. Dr. Gottfried is a global keynote speaker and the author of four New York Times bestselling books about hormones, nutrition, and health. Her latest book is called THE AUTOIMMUNE CURE (March 2024). She is Clinical Assistant Professor in Dept. of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University, and Director of Precision Medicine at the Marcus Institute of Integrative Health. She takes care of executives and professional athletes. Her focus is at the interface of mental and physical health, N-of-1 trial design, personalized molecular profiling, use of wearables, and how to leverage these tools to improve health outcomes. Learn more at SaraGottfriedMD.com ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 With so much discussion these days centered on metabolic health and issues like overweight, obesity, diabetes, and the downstream consequences of these health challenges, I think it's important to spend some time looking at what may be one of the pivotal  causes of metabolic disturbances, the consumption of fructose sugar. As such, I reached out to Dr. Richard Johnson, a world’s authority on the role of fructose in human metabolism, to share with us his latest thoughts not only related to fructose, but also including the various types of sweeteners that are available and have become very popular.  This discussion will take us into the world of GLP-1, a receptor that is stimulated by drugs like Ozempic. And no doubt, that is an area of discussion that is interesting for so many people. We begin our discussion however with Dr. Johnson describing his recent trip to Dubai where he attended the COP 28 climate conference which, interestingly, includes his insights related to the threats posed by climate change on human metabolism. Let me tell you a little bit more about Dr. Richard Johnson.He was formerly the chief of the Renal Division and Hypertension at the University of Colorado for nine years. He’s a physician, trained in internal medicine, infectious disease, and nephrology. Dr. Johnson is a widely cited NIH-funded scientist who has lectured in over 40 countries and has authored three books, The Sugar Fix, The Fat Switch, and the new Nature Wants Us to Be Fat. Rick has a special interest in the role of sugar and especially fructose and its byproduct uric acid in driving metabolic and kidney disorders. And most recently he has been exploring the biological properties of a unique sugar, allulose, a topic we discuss in great depth. ==== 0:00 Intro  1:56 Climate Change and Rising Health Concerns  12:53 Correlation of Uric Acid and Impulsivity 20:50 The Mechanics of Obesity as a Low Energy State 26:12 How Our Biology Supports Weight Gain 28:38 Impact of Sugar and Carbs on the Body 31:50 Should you avoid fruit? 33:09 What We should Be Doing 35:03 The World of Low Calorie Sugars 37:55 Disadvantages of Artificial Sweeteners  41:32 Allulose: The Next Best Thing?  54:19 How CGMs Will Change Your Perspective 55:10 The Role of Quercetin on Mitophagy  58:20 Conclusion ==== Dr. Johnson has performed medical research since the early 1980s and has been funded by the NIH since 1987. Most of  his research has focused on the pathogenesis of kidney diseases, but during the last 12 years his studies have also included studies of the pathogenesis of primary hypertension, insulin resistance and diabetes, diabetic nephropathy, and obesity. Much of his work has involved a combination of cell culture and animal models with a strong translational component, but he has also been involved in a number of clinical trials and epidemiology-based studies. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

Interested in an Apollo device? Click the following link and use code PERLMUTTER for a 15% OFF discount. https://apolloneuroscience.pxf.io/c/4460811/1861953/12331 🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Clearly, we've communicated a lot of information indicating that it's really fundamentally important for our health and ability to resist disease that we gain control over things like anxiety, lack of restorative sleep, lack of exercise, and certainly make other good choices like eating appropriately as well. These are powerful modulators of our metabolic health I have wide ranging implication not just as it relates to the brain, but our entire physiology.  How exciting is that we live in the day and age of wearable devices. And, importantly, we now see the development of a wearable device that specifically allows us in a non pharmaceutical way to deal with anxiety, help us through the days it relates to our decision making ability, and even help us in the night as a relates to sleep, and it’s called Apollo. I thought it would be a great idea to interview the creator of this device, Dr. David Ravin. Dr. David Rabin, MD, PhD, a board-certified psychiatrist and neuroscientist, is the co-founder & chief medical officer at Apollo Neuroscience, the first scientifically-validated wearable system to improve heart rate variability, focus, relaxation, and access to meditative states by delivering gentle layered vibrations to the skin. In addition to his clinical psychiatry practice, Dr. Rabin is also the co-founder & executive director of The Board of Medicine, and a psychedelic clinical researcher currently evaluating the mechanism  of psychedelic-assisted psychotherapy in treatment-resistant mental illnesses. This is a very interesting podcast about a very interesting and clearly beneficial wearable device. I have found that using this device my heart rate variability has gone up dramatically, which is a good thing, and something I have been trying to accomplish for quite some time. This has huge implications for health. I hope you enjoy this information. ==== 0:00 Intro 3:09 Where It All Began - Searching for Stress Solutions 7:18 MDMA Therapy for PTSD 9:52 Why the Pushback on Psychedelic Therapy?  12:20 New Wearable Tech that Simulates MDMA Benefits 19:56 Creating the Apollo  24:53 Key Metric: Heart Rate Variability  29:10 Dr. Perlmutter’s Success Story with the Apollo 34:32 Perceived vs Real Threat in Anxiety 36:53 Other Success Stories with Apollo 42:51 Solving the Problems of Sleep 50:04 Conclusion ==== Dr. David Rabin, MD, PhD, a board-certified psychiatrist and neuroscientist, is the co-founder & chief medical officer at Apollo Neuroscience, the first scientifically-validated wearable system to improve heart rate variability, focus, relaxation, and access to meditative states by delivering gentle layered vibrations to the skin. In addition to his clinical psychiatry practice, Dr. Rabin is also the co-founder & executive director of The Board of Medicine, and a psychedelic clinical researcher currently evaluating the mechanism  of psychedelic-assisted psychotherapy in treatment-resistant mental illnesses.  Socials: Drdave.io Apolloneuro.com Boardofmedicine.org Twitter: @daverabin Instagram: @drdavidrabin ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

To save 15% off an Apollo device, click THIS LINK and use code PERLMUTTER at checkout. 🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 One area that we spend a lot of time exploring focuses on the role of lifestyle choices as they relate to brain, health, functionality, and resistance to disease. I have to admit, over the years I have perhaps somewhat neglected a very important tool that offers up incredible utility as a relates to doing good things for the brain, and that is art. With that in mind, I felt it would be a great idea to interview the authors of an exciting new book that explores this very topic entitled, Your Brain on Art by Susan Magsamen and Ivy Ross. Your Brain on Art explores the vital role of arts in our lives, beyond mere entertainment. The book reveals a cultural evolution where arts emerge as powerful, accessible solutions for overall well-being. The authors present robust research highlighting the health benefits of art engagement. They illustrate how just 45 minutes of an art activity can significantly reduce stress hormones regardless of skill level, and regular artistic engagement could potentially extend life expectancy by a decade. The book delves into how music fosters cognitive abilities, the therapeutic effects of sound vibrations, the innovative use of virtual reality in therapy, and how interactive art experiences enhance memory and sensory engagement. It also discusses how art is being integrated into medical prescriptions for various health issues like loneliness and dementia. Your Brain on Art serves as a gateway to understanding the intersection of arts, aesthetics, and wellness. It includes discussions with renowned figures like David Byrne, Renée Fleming, and E. O. Wilson, offering a comprehensive view of neuroaesthetics. This guide combines cutting-edge research, multidisciplinary expert insights, and inspirational stories, showcasing how arts significantly improve life quality. ==== 0:00 Intro  3:07 How Susan & Ivy Began Studying Art 9:20 Why Art is Necessary for Humanity  14:22 Your Brain on Art 18:50 How Observing Art Helps Us  20:34 Reducing Amygdala Actions 22:16 The Healing Power of Sound and Vibration  25:18 The Role of Aesthetics & Awe of Nature  32:06 Poetry: the Oldest Art Form  34:48 Treating Mental Illness with Art 40:06 Why Talent Doesn’t Matter 44:14 Creative Flow & Mindfulness 45:34 Theatre & Connecting to Our Emotions 51:04 Psychedelics for Healing 57:30 The Art of Food 1:00:51 Conclusion ==== Susan Magsamen is the founder and executive director of the International Arts + Mind Lab (IAM Lab), Center for Applied Neuroaesthetics, a pioneering neuroaesthetics initiative from the Pedersen Brain Science Institute at Johns Hopkins University School of Medicine. Susan’s work focuses on how the arts and aesthetic experiences measurably change the brain, body and behavior and how this knowledge can be translated to inform health, wellbeing and learning programs in medicine, public health and education.   Magsamen is also the co-author of the New York Times Bestseller, Your Brain on Art: How the Arts Transform Us written for the general public.  === Ivy Ross is the Vice President of Design for the Hardware organization at Google. Over the past six years, she and her team have launched 50+ products winning over 240 global design awards. This collection of hardware established a new Google design aesthetic that is tactile, colorful, and bold. Most recently, Ivy co-authored with SusanMagsamen Your Brain on Art: How the ArtsTransform Us. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1

Get up to 53% off the P600 cookware and a FREE set of silicone utensils: https://chefsfoundry.com/DrPerlmutter   🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Loneliness is pervasive in our modern world. The sense of isolation and lack of connection, clearly made worse by the COVID pandemic, is associated with a wide scope of health issues and even mortality. So what do we do?   Some important steps are presented in our podcast, an interview with the author of Project Unlonely - Healing Our Crisis of Disconnection, Dr. Jeremy Nobel.   Jeremy Nobel, M.D., MPH, is a primary-care physician, public health practitioner, and award-winning poet with faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Medical School. He is the founder and president of the Foundation for Art & Healing (www.ArtandHealing.org), whose signature initiative, Project UnLonely, addressing the personal and public health challenges of loneliness and social isolation, has gained national visibility.   This is an important topic, not just for the elderly, living alone, but for all of us. For it is clear that any of us can feel lonely and disconnected, even in the midst of our busy lives.   ==== TIMESTAMPS: 0:00 Intro 2:10 Our Epidemic of Loneliness 6:11 Leveraging the Creative Arts for Healing 12:21 Evaluating Loneliness in Studies 16:31 How Loneliness Equates to Heightened Disease Risk 19:43 The Loneliness Spiral 21:56 Inflammation 24:38 How World Events Impact Well-Being 26:45 What You Can Do: Art as a Medium for Healing 31:05 How Psychedelics Overlap with Creativity 35:44 Cultural Norms Impact Loneliness 38:31 The Biggest Challenge for Moving Forward 40:57 The Potential of Awe and Nature-Connection 44:24 Correlation Between Loneliness and FMRI Imaging 50:00 Conclusion ====   JEREMY NOBEL, M.D., MPH, is a primary-care physician, public health practitioner, and award-winning poet with faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Medical School. He is the founder and president of the Foundation for Art & Healing (www.ArtandHealing.org), whose signature initiative, Project UnLonely, addressing the personal and public health challenges of loneliness and social isolation, has gained national visibility.   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Who knew? The same mechanisms that are involved in brain degeneration, cardiovascular disease, and virtually any other chronic degenerative decline that we experience in our bodies is also at play on our bodies, meaning affecting our skin. Yes, free radical mediated stress and inflammation are the pillars of what causes good skin to go bad. So, with that in mind I felt it would be terrific to interview a leader in holistic approaches to skin care and plastic surgery, Dr. Anthony Youn. Let me tell you more about him.   Known as America's Holistic Plastic Surgeon®, Anthony Youn, M.D. F.A.C.S is a nationally-recognized, board-certified plastic surgeon. Recognized as a leader in his field, he is the author of the best-selling books “The Age Fix," "In Stitches," and “Playing God.” His public television special, The Age Fix with Dr. Anthony Youn, has been viewed by millions.  Dr. Youn also hosts the popular podcast The Holistic Plastic Surgery Show.  He is the most followed plastic surgeon on social media, with over 4.5 million subscribers on his YouTube Channel and 8 million followers on TikTok. His new book, “Younger for Life” is a complete holistic guide to turning back the clock using the process of Autojuvenation®.   I learned an awful lot today on this podcast and hope you do too.     ==== TIMESTAMPS: 0:00 Intro 3:00 Dr. Youn’s Wake-up Call From Plastic Surgery 7:05 5 Accelerates for Skin Aging 10:44 What Causes Loss of Collagen 14:59 Healing the Skin Microbiome 17:38 Challenging the Dogma of Plant-Based Collagen 20:24 How to Supplement Collagen 21:29 Skin Cancer, Sun Exposure & Healthy Sunscreens 30:18 How Our Food Choices Cause Skin Inflammation 34:39 Autophagy: Small Steps that Lead to Big Changes 41:03 Botox & Fillers: What You Should Know 43:46 Conclusion ====   Known as America's Holistic Plastic Surgeon®, Anthony Youn, M.D. F.A.C.S is a nationally-recognized, board-certified plastic surgeon. Recognized as a leader in his field, he is the author of the best-selling books “The Age Fix," "In Stitches," and “Playing God.” His public television special, The Age Fix with Dr. Anthony Youn, has been viewed by millions.  Dr. Youn also hosts the popular podcast The Holistic Plastic Surgery Show.  He is the most followed plastic surgeon on social media, with over 4.5 million subscribers on his YouTube Channel and 8 million followers on TikTok. His new book, “Younger for Life” is a complete holistic guide to turning back the clock using the process of Autojuvenation®.   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Get a special sneak peek of Calm Your Mind with Food here if you join Dr. Uma’s weekly email list: https://umanaidoomd.com/pages/calmyourmindwithfoodsneakpeek   Want even more? Get a special introduction to Nutritional Psychiatry for reducing anxiety and depression symptoms in a special 6-lesson mini-course from Dr. Uma, bundled with a copy of her book: https://umanaidoomd.com/products/calm-your-mind-with-food-anti-anxiety-course-book-bundle   ====   Anxiety issues are certainly pervasive, and becoming much more common in our very stressful world. Generally, to go to therapy for dealing with anxiety seems to be pharmacotherapy, in other words, drugs. And while drugs may take the edge off and prove to be effective, it's good to know there are other ideas that are being considered. One important inroad into treating anxiety focuses on dietary change. We know that the consumption of the typical standard American diet is fraught with issues including posing a threat to metabolism by virtue of our consumption of large amount of ultra process foods which actually make up between 52 to 54% of of the calories consumed every day in American adults. This is a diet that has been associated with a dramatic increase risk for metabolic issues, cardiovascular disease, and even threatens the brain. As we will learn today, our consumption of these highly refined foods plays a role in creating anxiety as well.   Our guest today is Dr. Uma Naidoo, and we will be discussing her new book, Calm Your Mind with Food - A Revolutionary Guide to Controlling Your Anxiety.   Please enjoy the podcast.   ==== 0:00 Intro 3:42 The Rising Problem of Anxiety 6:37 Nutritional Psychiatry: Eating for Mental Health 9:51 Foods that Cause Anxiety 13:20 The Process of Healing Through Food 16:50 How We Can Gauge Progress 19:40 Helpful Lab Studies & Food Allergies 23:22 The Benefits of Supplements & Which to Take 28:04 Metabolic Issues & Anxiety 30:23 Bringing Medical Specialities Together 34:16 Starting Small and Regaining Control 37:35 Commonly Used Drugs that Impact Mood Disorders 39:33 Leptin Levels and Anxiety 42:13 The Future of Nutritional Psychiatry 45:20 Conclusion ====   Michelin-starred chef David Bouley described Dr. Uma Naidoo as the world’s first “triple threat” in the food and medicine space: a Harvard-trained psychiatrist, professional chef graduating with her culinary schools’ most coveted award, and a trained Nutrition Specialist. Her nexus of interests have found their niche in Nutritional Psychiatry.   Dr. Naidoo founded and directs the first hospital-based Nutritional Psychiatry Service in the United States. She is the Director of Nutritional and Lifestyle Psychiatry at Massachusetts General Hospital (MGH) & Director of Nutritional Psychiatry at MGH Academy while serving on the faculty at Harvard Medical School.   She is considered Harvard’s Mood Food Expert and has been featured in the Wall Street Journal, Goop, Live with Kelly & Ryan, and more. Dr. Naidoo is also the national bestselling author of This Is Your Brain on Food: https://umanaidoomd.com/collections/this-is-your-brain-on-food, and the upcoming title that we will discuss today, Calm Your Mind With Food https://umanaidoomd.com/collections/calm-your-mind-with-food ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

Get up to 53% off the P600 cookware and a FREE set of silicone utensils: https://chefsfoundry.com/DrPerlmutter   🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: https://www.drperlmutter.com/ ✉️🌱   Allulose as a sugar is getting a lot of well deserved attention. We are seeing some pretty remarkable science with respect to allulose as it relates to metabolic health and specifically, weight loss. I felt, as such, that it would be a good idea to interview Dr. Benjamin Bikman on the Empowering Neurologist program today. Let me tell you more about Dr. Bikman.   Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders.  Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the role of elevated insulin and nutrient metabolism in regulating obesity, diabetes, and dementia.   In our time together, we discuss the important science of allulose as it relates to fat distribution in the body, insulin resistance, heart disease, fatty liver disease, cognitive decline, and even how allulose is able to lower uric acid, an area that I'm certainly interested in.   I hope you enjoy this fascinating interview with Dr. Benjamin Bikman.   ==== TIMESTAMPS: 0:00 Intro 2:08 The Study of Metabolism 4:53 Dr. Bikman's Insulin Research 7:08 Why People's Bodys Aren’t Able to Use Insulin Correctly 10:12 What Causes Spikes in Insulin Levels 14:59 Problem with Annual Fasting Blood Sugar Test 17:24 Merits of a Continuous Glucose Monitor 19:53 New Sugar Replacement: Allulose 30:43 Bringing Down Uric Acid with Allulose 33:17 Allulose & Insulin Resistance 35:52 Reducing Fatty-Liver Disease Risk 38:48 Protecting Mitochondria Against Cardiovascular Disease 42:00 Cognitive Decline & Allulose 44:42 Preventing Alzheimers 51:28 Conclusion ====   Benjamin Bikman earned his Ph.D. in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore in metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the role of elevated insulin and nutrient metabolism in regulating obesity, diabetes, and dementia.   Dr. Bikman is the author of the book: Why We Get Sick Dr. Bikman’s education platform: https://www.insuliniq.com/     ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

Visit puritycoffee.com/empoweringneurologist for more information on Balance and use code PERLMUTTER for 30% off a one-time purchase of Balance. Applies to both 12oz bags and 5lb bags.   🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱   Without question, melatonin may well be the most popular nutritional supplement that people are talking about these days, and with good reason. There is an extensive body of science that looks at the use of melatonin in humans and the results of the research are certainly intriguing.   Dr. Deanna Minich has been at the forefront of melatonin research for the past several years. She brings to our attention some interesting new insights as a relates to using melatonin, including ways to optimize and personalize its use. Today on this podcast, we will discuss how melatonin interacts with our light exposure and how we can adjust our blue light exposure, especially at night, to maximize the effectiveness of melatonin. We will learn how to enhance melatonin functionality by making sure our vitamin D levels are where they need to be. We will explore melatonin in the wider context of our overall antioxidant status and our discussion will reveal differences in melatonin availability between men and women.   When should we take melatonin, what's your dosage be, and how do we adjust our dosage based upon the cycles of the moon? These are interesting questions, for sure. Dr. Minich does exemplary job in explaining these and other questions, and offers up some intriguing information as a relates to possible interactions between melatonin habits like caffeine consumption.   I hope you enjoy the program today. I know I found it very informative.   ====   TIMESTAMPS: 0:00 Intro 2:20 The Origin on Melatonin Supplements 9:24 Understanding Receptors: Time of Day & Dosages 13:07 Purity Coffee: Better For You Energy 14:15 How Light & Darkness Affects Melatonin 21:13 Setting a Caffeine Curfew 25:38 Antioxidants & Melatonin 28:58 Gender Specificities for Melatonin 31:28 Impact on the Gut Microbiome 33:19 How to Get Started on Supplements 36:10 Why Plants Make Melatonin 37:25 How the Moon Cycle Affects Melatonin 39:25 Melatonin: A Molecule of Consciousness 45:14 How Stress Impacts Melatonin 47:40 Wearable Technology 49:01 Rebound: Waking Up in the Middle of the Night 57:33 Conclusion   ====   Deanna Minich, MS, PhD, CNS, Certified Functional Medicine Practitioner (IFMCP), is a nutrition scientist, international lecturer, teacher, and author, with over twenty years of experience in academia and in the food and dietary supplement industries. Throughout the years, she has been active as a functional medicine clinician in clinical trials and in her own practice (Food & Spirit™), which has now become oriented towards groups, workshops, and retreats. She is the author of six consumer books on wellness topics, four book chapters, and fifty scientific publications. Her academic background is in nutrition science, including a Master of Science (M.S.) degree in Human Nutrition and Dietetics from the University of Illinois at Chicago (1995) and a Doctorate (Ph.D.) in Medical Sciences (nutrition focus) from the University of Groningen in the Netherlands (1999).   Review article on melatonin authored by Dr. Minich: https://www.mdpi.com/2072-6643/14/19/3934/htm Published article comparing plant melatonin to synthetic melatonin: https://www.mdpi.com/1420-3049/26/19/6087 Research website on melatonin: https://www.phytomelatonin.com/   ====   Visit puritycoffee.com/empoweringneurologist for more information on Balance and use code PERLMUTTER for 30% off a one-time purchase of Balance. Applies to both 12oz bags and 5lb bags. ___________________________ Instagram: https://www.instagram.com/davidperlmutter/ Website: https://www.drperlmutter.com/ Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

Welcome one and all to another enlightening episode of The Empowering Neurologist. Joining us is Dr. Ray Dorsey, Professor of Neurology at the University of Rochester, a stalwart advocate for Parkinson's disease, and a renowned researcher in the field. With a profound belief in the power of awareness and knowledge, Dr. Dorsey dedicates his life to a cause that is impacting millions globally. He stands at the forefront of the fight against Parkinson's disease, a fight that is becoming increasingly critical as we see a staggering rise in the incidence of this condition.   Dr. Dorsey is not just an accomplished physician but also an engaging author. His groundbreaking book, Ending Parkinson’s Disease, is a critical exploration that sheds light on this global health crisis. It offers an enlightening perspective on Parkinson's disease and, so importantly as we discuss in this episode, its modifiable risk factors, raising consciousness and hope about this life-altering condition.   His book is an earnest appeal to policymakers, researchers, physicians, and the general public to recognize the escalating crisis and join the battle to end Parkinson's. It also serves as a testament to his belief in our collective ability to mitigate this crisis, beginning with understanding the risk factors that we can change.   We delve into the comprehensive world of Ending Parkinson’s Disease, discuss the modifiable risk factors, and explore ways to curb the skyrocketing incidences of Parkinson's. It is our shared responsibility, and understanding is the first step.   So, please enjoy this fascinating interview.   ====   Timestamps   0:00 Intro 0:50 Rise in Parkinson’s 3:20 MPTP 8:10 Trichloroethylene (TCE) 13:14 Call to Action 16:19 Prevention of Parkinson’s 32:00 Caffeine and Smoking 37:25 Head Trauma 39:27 Conclusion     Dr. Ray Dorsey is the David M. Levy Professor of Neurology at the University of Rochester.  Ray is working to identify and eliminate the root causes of Parkinson’s disease.  His research on brain diseases and digital health has been published in leading academic journals and featured in multiple news outlets.  In 2020, Ray and his colleagues wrote Ending Parkinson’s Disease, a book that provides a prescription for ending the world’s fastest growing brain disease.   Ray previously directed the movement disorders division and neurology telemedicine at Johns Hopkins and worked as a consultant for McKinsey & Company. In 2015, the White House recognized him as a “Champion for Change” for Parkinson’s disease.   Dr. Dorsey is the co-author of the book Ending Parkinson's Disease - A Prescription for Action available at retailers everywhere. The authors are all devoting their proceeds to efforts to prevent and end Parkinson’s. If you cannot afford a copy, they will send you one for free. You can just email them at [email protected] with your preferred mailing address. They are also happy to hear their stories or field questions that you may have.   ___________________________   Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.

In this installment of The Empowering Neurologist we are privileged to welcome Dr. Nathan Bryan, a trailblazer in the realm of biomedical research, with a specific focus on the life-sustaining molecule, nitric oxide.  As a globally recognized pioneer in nitric oxide biochemistry and physiology, Dr. Bryan’s contributions have significantly shifted our understanding of the role of nitric oxide in overall human health. I had the privilege of attending a lecture given by Dr. Bryan recently and learned that he is a tenacious advocate for understanding nitric oxide not as a mere molecule, but as a vital bioactive substance with a profound influence on numerous physiological processes. His extensive research has elucidated nitric oxide's pivotal roles in areas like maintaining vascular health, bolstering the immune system, and regulating the cardiovascular system. These insights have been instrumental in revolutionizing therapeutic strategies and disease management methods. In a world beset by increasing health challenges, understanding the critical role of nitric oxide is paramount. This molecule is the very fulcrum of our well-being, influencing how cells communicate and interact, determining disease resistance, and even dictating our longevity. Dr. Bryan's invaluable work unveils the importance of maintaining nitric oxide balance for optimum health and wellbeing. And interestingly, the nitric oxide story fully dovetails with our work in the area of uric acid as we discuss. I’m certain you will be fascinated by this interview as we do a deep dive into the world of nitric oxide with Dr. Bryan, whose pioneering work continues to enlighten us on the intricate mechanisms that drive human health. This conversation promises to challenge preconceived notions, inspire new health perspectives, and fundamentally reshape how we approach wellness in the 21st century.   Timestamps   0:00 Intro 3:14 Nitric Oxide 5:29 Measuring Nitric Oxide “interestingly” 8:36 Oral Health and Nitric Oxide 15:02 Acid Blocking Drugs 18:00 Dietary Sources of Nitrates 19:55 Oxygen Availability 23:14 MTFHR 27:46 Age and Nitric Oxide 30:42 Viagra 35:46 Wound Healing 43:27 Latest Findings 46:27 Nathan’s Book Release 48:23 Conclusion   ====   Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research.  He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute.  After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology.  Dr. Bryan has been involved in nitric oxide research for the past 20 years and has made many seminal discoveries in the field.  His many seminal discoveries have resulted dozens of issued US and International patents and the product technology resulting from his discoveries and inventions has improved patient care worldwide.  Dr. Bryan is a successful entrepreneur and Founder of HumanN, Inc, Pneuma Nitric Oxide, LLC, Nitric Oxide Innovations, LLC and Bryan Nitriceuticals, LLC.  His product technology is responsible for hundreds of millions of product sales worldwide.  Most recently, Dr. Bryan serves as Founder and CEO of Nitric Oxide Innovations, LLC, a privately-held, clinical-stage biopharmaceutical company that is actively engaged in the discovery and development of nitric oxide based therapies.  Their lead drug candidate NOviricid is currently in phase 3 clinical trials for the treatment of COVID19 in African Americans and Hispanics.  Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry.     www.N1O1.com www.drnathansbryan.com www.NO2U.com www.nitricoxideinnovations.com   ___________________________ Instagram: https://www.instagram.com/davidperlmutter/   Website: https://www.drperlmutter.com/   Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1See omnystudio.com/listener for privacy information.