This Medical Life

Ancient Egyptians called it podagra (foot-trap), Hippocrates the unwalkable disease, and the 17th and 18th century it became known as the Disease of Kings. Gout has long been associated with rich foods and an affluent lifestyle. Yet, its significance in the modern era cannot be overstated. Commonly thought of a joint disease, the systemic impact are becoming increasingly apparent. Join us as we discuss the significance of gout for patients and the importance of diet, treatment and management. Our special guests include: Professor Richard Johnson is a physician in internal medicine, renal, and infectious diseases. Professor Johnson is involved in research and published over 260 journal articles, ‘The Fat Switch’ in 2012, and ‘Nature wants us to be fat’ in 2022. He also is popular on youtube: https://www.youtube.com/watch?v=gAjC_BWMElk Professor Ken Sikaris is a chemical pathologist and the Director of Chemical Pathology at Melbourne Pathology. Professor Sikaris is a NATA assessor, Founding Fellow of the RCPA Faculty of Science and principle examiner in Pathology Informatics. He is also an advocate of the low carb diet on YouTube (with over half a million views) and was Professor Blood in the Australian documentary ‘That Sugar Film’. This is the story of gout.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Marijuana has a complex history. It seems every society has grappled with balancing the positive and negative effects. Historical records indicate that Ancient Chinese farmers were the first to grow this plant but also were the first to reject it as a socially acceptable drug. In the middle ages, Pope Innocent VIII took this fight to the extreme associating it with witchcraft and sorcery labelling marijuana an existential threat. Those who cultivated it were imprisoned, exiled or executed. Alternatively, in the 1790s, the British saw it as a great source of tax revenue out of India. Today we recognised there is a number of benefits of medicinal cannabis. Our special guest is Professor Jennifer Martin who is a clinical pharmacologist and physician with vast experience and research in this field. Australian registered medical practitioners who would like to access to medicinal cannabis products for the treatment of appropriate patients may apply through the following links: Accessing medicinal cannabis for a patient: https://www.tga.gov.au/accessing-medicinal-cannabis-patient Special Access Scheme: https://www.tga.gov.au/form/special-access-scheme Authorised Prescriber Scheme: https://www.tga.gov.au/form/authorised-prescribers This is the story of medicinal cannabis.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

In 1770, in the small German town of Bonn, a child was born that would impact the world on a par with great emperors and conquerors. Yet, it was not with a sword or bloodshed but with imagination and composition. This man was Ludwig van Beethoven and his influence is possibly even more important today than when he was alive. Ludwig was one of seven children but only three of them survived beyond infancy. Ludwig’s musical gifts were apparent at a very young age but he had an abusive and alcoholic father who demanded performances at any time he desired (often back from the pub with his similarly inebriated friends). At the age of 16, Ludwig’s mother died of tuberculosis. At the age of 21, his father died. Beethoven’s life was beset with poor health including gastrointestinal problems and headaches. He was not fond of doctors but he loved his wine, his women and his music. Unfortunately, in his late twenties, Ludwig experienced progressive hearing loss which eventually led to complete deafness in his late 40’s and 50’s. At the age of 56 years, on the 26 March 1827, Beethoven died. His final words ‘Pity, pity, too late’. This is the story of Ludwig van Beethoven’s death.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

In the 1930s, outbreaks of a mysterious febrile illness occurred with abattoir workers in Queensland in Australia. Physicians investigated these patients but no cause was able to be identified. To complicate matters, there wasn’t any consistency between those who got sick, the area where they worked in the abattoir nor the animals with which they worked with. Hence, the name has come to us as ‘Q’ (meaning ‘Query’) fever. It would take significant investigative skills and an outbreak in the United States to confirm the diagnosis. Today, the causative agent is called Coxiella burnetti. This is the story of Q fever.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Pauline Gross was a seamstress in 1895 who had seen family members die at an early age from cancer. At the time, one of her clients was a pathologist by the name of Dr Aldred Scott Warthin and confided in him her fear that that this would be her fate too. The two combined to record the most comprehensive family history ever created. Dr Warthin called them ‘Family G’. In the 1960s, Dr Henry T Lynch who revived the search for the members of Family G. Through family gatherings and meetings, he managed to track down over 650 family members, of which, 95 had a history of cancer. He noted that they had an Autosomal Dominant disorder that increased their incidence of uterine and gastrointestinal cancers. Dr Lynch called it a ‘Cancer Family Syndrome’. Today, it is known as Lynch syndrome. Our special guests include: Ami McKay: an award winning novelist who has written ‘Daughter of Family G/Before my time: a memoir of love & fate’. Ami has also produced the radio documentary ‘Daughter of Family G’ available at amimckay.com Dr Tristan Rutland: Anatomical pathologists at Liverpool hospital and based at Western Sydney University with a PhD in colorectcal cancer. Dr Rutland was the recipient of the Konrad Muller RCPA Outstanding Teaching Award Professor Graeme Suthers: National Director of Genetics for Sonic Pathology Australia who trained in clinical and laboratory genetics in Sydney, Adelaide, and Oxford. This is the story of Lynch syndrome.See omnystudio.com/listener for privacy information.

In 1951, Australian anthropologists reported on a unique neurodegenerative disease from Papua New Guinea. The natives called it ‘Kuru’ which meant to tremble or to be afraid and it certainly struck fear into those who saw it. Through amazing investigative work and serendipity, a veterinary pathologist in the United States saw the histology of a Kuru from the brain and noted it looked a lot like ‘Scrapie’ (a neurodegenerative disease in sheep) and the link was made. It would not be until 1980s that the causative agent for these diseases was identified: Prion’s. And then in the 1990s, cows in the United Kingdom began showing symptoms… This is the story of Prion diseaseSupport the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

In 1924, a previously well 20 year old woman presented to hospital with a headache and general fatigue. Her condition rapidly deteriorated and she died in 6 days. Over 6000 cases occurred within 1924. The search was on to find the cause. Fortunately, in 1935, a breakthrough occurred. We know the virus today as the Japanese Encephalitis Virus. The vast majority of people who become infected with JEV are either oblivious (asymptomatic) or only have mild non-specific viral symptoms (ie. fever). However, those who are very unwell and require hospitalisation have significant risks of morbidity and mortality. In 2022, cases of JEV have been identified in Queensland, New South Wales, Victoria and South Australia. This is the first time cases have been recorded this far south. We know that JEV is endemic in at least 24 countries around Asia. Is Australia going to become the 25th? This is the story of Japanese Encephalitis Virus.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

In 1951, two Haematology fellows, Dr William Harrington and Dr James Hollingsworth, agreed upon an experiment. They would ask the next patient with Idiopathic Thrombocytopenia Purpura (ITP) to donate 500ml of blood. Then, whoever was a blood-type match would get the transfusion and see if they got the disease. The results were immediate and dramatic.Surprisingly, the fact that platelets are the foundation of coagulation and derived from megakaryocytes have only been known for just over a century. Our understanding during this time has been exponential but the key to ITP remains in its name: idiopathic. Yes, we actually don't know the cause of this disease. Fortunately, there is a lot about ITP that we do know.Our special guest is Dr Nicholas Myles who is a General Haematologist and Senior lecturer at the University of Adelaide.This is the story of ITP.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

In 1347, the European world encountered one of history’s greatest tragedies: the great plague. Today, it is known by many names: the black death, the black plague, or the great mortality. Whatever name we give it though, one thing is clear: those who lived through this time genuinely believed this disease would eradicate of humanity The true toll of this plague is unknown. Tens of millions of people were killed and those that weren’t, were scarred in every way imaginable. This disease would ravage European cities and countries for 7 years before it finally relented. Amazingly, it would only be 9 years before another plague epidemic appeared. They called this one the ‘Children’s plague’. Join us with this episode to study the disease that is responsible for millions of deaths in history and still exists with us today. This is the story of the black plague and Yersinia pestis.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Familial Hypercholesterolaemia (FH) is an under-recognised genetic condition that causes elevated cholesterol in patients and affects approximately 1/250 people in Australia. Approximately 100,000 Australians have FH but only ~5% are diagnosed. This needs to change. FH causes early cardiovascular disease and can be a significant cause of morbidity and mortality in those affect. How do I know? Because a few years ago my brother with no significant co-morbidities and a healthy lifestyle had a life-threatening acute myocardial infarct (heart-attack) at the age of 43. Our special guests for this episode include: Dr Gavin Brown (brother of the co-host) A/Professor Damon Bell (Chemical pathologist for Clinipath, PhD in FH, A/Prof at the School of Medicine at the University of Western Australia) Professor Graeme Suthers (Director of Sonic Genetics Australia) This is our story of Familial Hypercholesterolaemia.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Scattered throughout history are epidemics of catarrhal or campaign jaundice (the latter was experienced during military campaigns). The pivotal moment was during World War II where troops became sick with jaundice due to a contaminated Yellow Fever vaccine and sporadic jaundice outbreaks in different countries. While the symptoms appeared similar (ie jaundice), one did not confer immunity to the other and further investigation was needed. This discovery of Hepatitis A and B lead to the discovery of Non-hepatitis A and Non-hepatitis B: other illnesses that caused jaundice and liver damage. This lead to the identification of Hepatitis C, D, and E. Although they have similar names, these are 5 separate virus and require different tests for identification. This is the story of hepatitis.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

King Henry VIII was both a literal and a historical giant but his reputation of brutality and malevolence has few equals. He took power at the start of the English renaissance and was responsible for the English reformation. He had inroads into public health and regulated medical practitioners but also oversaw the enactment of vicious traitorous laws where could be jailed or executed for actions (including speaking out) against the crown. Henry was touted as being a tall and striking young man who was gifted in athletic sports. However, his health deteriorated during his mid-30s apparently as a result of a significant accident in a jousting event. At the age of 55, he died. Legend had it that after his death, he was so large that his coffin exploded. Is this true? This is the story of King Henry VIII historical autopsySupport the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

How we teach those who come after us is as important as the knowledge we learn for ourselves. Medicine throughout the ages has been an apprenticeship style model, but over the last few hundred years this has changed to tertiary education. However, is this the right model? Our special guest is Dr Tristan Rutland who is an Anatomical Pathologist at Liverpool hospital and teaches at Western Sydney University. He was the recipient of the Konrad Muller RCPA award for Outstanding Teaching in 2020. He is also very active on Twitter (@TristanRutland7) posting #Tweetorials and Pathology Education. This is a story of Medical Education.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

At the end of the 14th century, a young woman is skating on a frozen canal and suddenly falls injuring herself. Her name is Lidwina. Over the next 30 years her body deteriorated due to a disease we know today as Multiple Sclerosis. Lidwina faced this illness admirably and was canonized in the late 19th century for her fortitude and faith. The breakthrough for MS is attributed to Jean-Martin Charcot. Known as the Father of Neurology, he called this condition ‘sclerose en plaque disseminee’ and even watched as his servant ‘Luc’ developed symptoms. He confirmed as her disease when he performed her autopsy and found sclerotic plaques on her spinal cord and brain.   Our special guest is Dr James Leyden from Leyden Neurology who has been practicing in Adelaide for 12 years. Links to the MS Society of Australia have been provided in the show notes. This is the story of Multiple Sclerosis.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Ancient Egyptians hold a special place in history. Their civilization, religions, gods, conquests, traditions and rituals are some of the most well documented and fascinating. Throughout the centuries, we have been able to piece together the health and medicine of our ancient ancestors and the mummification process plays a significant part in this. Which brings us to story the of Ramesses III and the Judicial papyrus of Turin. This tells a story of the Harem conspiracy to assassinate Ramesses III and ‘overturn the royal bark’. Through modern imaging techniques, the body of Ramesses III has given up its secrets about this conspiracy and the punishment of those responsible. This is the story of Egyptian mummification and the trial of a millennia.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

If there is one constant throughout all of medical history, it is the value of urine. Our ancient ancestors believed they predict a patient’s recovery (or not) upon examination of their urine to the middle ages where they used a scale of colour, thickness, and sediment. Urine was also used in a range of non-medical and even commercial uses that boggles the modern mind. This episode examines the history of urine, its uses, and its modern-day medical uses. The range of testing we have available for urine is staggering and it raises the question: is urine liquid gold? This is the story of urine.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

SLE is a chronic relapsing autoimmune disease. ‘Lupus’ is latin for wolf and glimpses of it can be seen throughout history. However, it is often obscured by the complexity of the disease and the conglomeration of other conditions. Over time, our understanding of SLE has dramatically improved but it still remains a complex condition to diagnose and a significant challenge to interpret pathology results. Anti-nuclear antibodies (ANA) are commonly ordered but are commonly misunderstood. Our special guest is Dr Daman Langguth who is a clinical immunologist and Head of the Immunology Department at Sullivan Nicolaides Pathology. We discuss diagnosing, testing, and management of patients with Systemic Lupus Erythematosus. This is the story of SLE.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

The emergence of syphilis in 15th century Europe caused widespread panic and finger-pointing as to the cause and origin of this disease. Unfortunately, the treatment at the time was as dangerous as it was ineffectual. Many historical figures have been associated with syphilis; some will have certainly had it but others will be to cast aspersions against one’s character. This is because it is a disease of rare distinction that sits at the historical nexus of a sex, disease, moral depravity, and mental illness. It would take centuries before the cause of syphilis (Treponema pallidum) would be known. However, despite all of our knowledge and available treatment of syphilis, we see the prevalence of this on the rise. This is the story of syphilis.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Modern day surgery is synonymous with anaesthetic. Yet, it has only been that way since the mid-1800s. Prior to this, people either resided to their fate without surgery or faced the knife with little to nothing to numb any pain. The story about the discovery of anaesthetic is both hopeful and tragic. Ether, the first widespread anaesthetic used, was a blessing to the world but a curse to those who discovered its use. However, it would revolutionise the care of patients and open the door to disciplines of surgery previously unimaginable. This is the moment surgery changed forever. This is the story about the discovery of anaesthetic. Welcome to This Medical Life.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.

Aug 27, 2021 2:32 PM ** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** One of the important jobs of a doctor is to prescribe medications. Unfortunately, it also happens to be one of the most challenging. Pharmacokinetics, physiology, and drug-to-drug interactions are just some of the challenges that doctors deal with every day. It is becoming more apparent that for medications and one size (dose) does not fit them all. In addition, it the role of genetics is also becoming increasingly important for the drugs that suit, and don’t suit, individual patients. Our special guest for this episode is Professor Graeme Suthers to help us shed light on this area of Pharmacogenetics.   SPECIAL GUEST Professor Graeme SuthersBSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD Prof Suthers is Sonic Healthcare’ Director of Genetics. He is one of Australia’s most respected experts in the field of genetics, and is nationally and internationally recognised for his expertise in genetic disorders, testing and clinical service provision.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** In the 1920’s, Pearl Buck searched for an answer to her 3 year old daughters intellectually disability. Unfortunately, no-one could help her because her daughter's condition was not yet known. From the mid 1930s to the 1960s, a remarkable sequence of events led to the discovery of Phenylketonuria (PKU), accurate testing and widespread screening that revolutionised early detection of childhood disease(s) It was also around the same time (mid 1930s) that some young children were believed to be dying of Coeliac disease. One child had an unusual findings in their pancreas. Further investigation revealed other children with the same finding. This was not Coeliac disease, it was Cystic Fibrosis (of the pancreas). As more was learnt about this disease, children began to live longer with improved quality of life. Over the span of 90 years, the average life expectance for a person with Cystic Fibrosis went from 6 months to close to 50 years. Our special guest for this episode is Professor Graeme Suthers. The voice of Pearl Buck was generously recorded by Christine Helen Coombe. We appreciate all submissions via our social media request.   SPECIAL GUEST Professor Graeme SuthersBSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD Prof Suthers is Sonic Healthcare’ Director of Genetics. He is one of Australia’s most respected experts in the field of genetics, and is nationally and internationally recognised for his expertise in genetic disorders, testing and clinical service provision.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** The computing world has come a long way in less than 100 years. Since Alan Turing introduced his paper ‘Computing Machinery and Intelligence’ in 1950, we have not only achieved the ‘Turing Test’ of Artificial Intelligence, but exceeded it. This episode takes a look at Digital Pathology and the prospects of Artificial Intelligence particularly in relation to Anatomical Pathology. Our special guest is Dr Joseph Anderson   Dr Joseph Anderson BioConnect on LinkedIn  Dr. Joseph Anderson, the host of Digital Pathology Today, is a consultant to early stage and mature companies in the digital pathology and molecular diagnostics space.Previously, he oversaw the clinical pathology group at Genomic Health as the Oncotype Dx Breast Cancer Assay grew to a volume of over half a million tests. He was also involved in the development of new products, including assays for DCIS, Colon Cancer and one of the first commercially available liquid biopsies.He served the College of American Pathologists on the Molecular Oncology Committee, with responsibility for proficiency testing in biomarkers for lung cancer in the United States and across the world and as a member of the House of Delegates representing the State of California. He has served on several working groups and committees for the American Medical Association for CPT coding and reimbursement and assessment of new technologies such as next generation sequencing.Upon graduating from the University of Minnesota Medical School, Dr. Anderson completed residency in Anatomic and Clinical Pathology at Rush University, fellowship in Oncologic Pathology at Fox Chase Cancer Center and post-doctoral training in Molecular Diagnostics at UCSF. He initially worked in private practice, credentialed at 17 various hospitals and surgery centers. Digital pathology Today Link: https://www.digitalpathologytoday.comDigital Pathology Today™ is your podcast all about the world of digital pathology.   See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Cholesterol is an essential component of our cells. It is synthesized by our cells and affected by dietary, lifestyle, and genetic factors. Unfortunately, cholesterol for doctors can feel like a moving target as different guidelines have different recommendations, new measurements can appear on reports (ie Non-HDL), and it is a constantly evolving topic for research In this episode, we talk to one of Australia’s foremost expert in Cholesterol, Professor Ken Sikaris. This podcast is eligible for 1 RACGP CPD point – self reporting. Associate Professor Ken Sikaris Bio KEN trained in science then medicine at Melbourne university before becoming a pathologist in 1992. He worked for several years at St Vincent’s hospital in Melbourne including running a specialist lipid/cholesterol laboratory performing research as well as seeing hundreds of patients in the lipid/cholesterol clinic. Since then he has worked in private pathology and currently in his job as chemical pathology director he supervises testing on thousands of patients each day - including thousands of cholesterol tests. He is well known internationally in the fields of pathology Quality and how we define the decision limits we use to interpret blood tests. Ken has several YouTube’s on the low carb down under site (with a total of over half a million views) and some may have seen him as Professor Blood in the Australian documentary ‘That Sugar Film’. Bio Link: https://www.mps.com.au/about-us/pathologists/assoc-prof-ken-sikaris/ YouTube: https://www.youtube.com/watch?v=OyzPEii-wo0 That Sugar Film: https://www.youtube.com/watch?v=lsnk8s6JNIQSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** “I die before my time, killed by the English oligarchy and its hired assassins.” These are the words of Napoleon Bonaparte dictated in his last will and testament on his death bed. Napoleon is undoubtedly one of the world’s greatest Generals. During his life, France become a global power. The man responsible for the Napoleonic wars and had previously escaped exile before, was captured again following the defeat at the Battle of Waterloo and exiled a second time to the island of St Helena in the Pacific. The official cause of death concluded by an autopsy was stomach cancer. However, his death is surrounded by controversy. Did the British have him killed? Was he poisoned with arsenic? Was his body swapped before or after his death? In this episode we discuss the life & death of Napoleon Bonaparte, gastric cancer and some of the conspiracy theories surrounding the Great General’s demise.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Multiple Endocrine Neoplasia is a difficult diagnosis for patients, families, and clinicians. The vast array of symptoms, affected organs, and complex genetics often mean that it can take years (if not longer) for it to be diagnosed. In addition, the impact for the patient is significant as it is a familial disease that is autosomal dominant with very high penetrance. These syndromes were only identified around the 1960s. However, clinical suspicions were unable to be confirmed as the molecular/genetic techniques only in its infancy. It is a rare condition but one that is critical to recognise early to ensure we provide the best care and management for patients and their families. Special GuestMark A. Lewis, MD, is director of gastrointestinal oncology at Intermountain Healthcare in Utah. Specializing in cancers of the gastrointestinal tract and accessory organs, his interests focus on hereditary cancer syndromes and young-onset cancers, shared decision-making, and patient-physician communication. The death of his father not only took a huge emotional toll on Lewis, but also piqued his intellectual curiosity. Lewis’ paternal uncle and grandfather both died of rare cancer types and then Lewis was diagnosed with a suspicious symptom himself – hypercalcemia, or high levels of calcium – something his father had also experienced. As Lewis completed his medical training and established his current position as a haematologist/oncologist at Intermountain Healthcare in Utah, his PNETs were serially monitored. After the dominant PNET changed, crossing a threshold of concern, he had surgery and has documented the experience. Lewis had another special person in mind though and says, “I wanted my son, who has inherited MEN1 from me and may one day require pancreatic surgery himself, to have a record of my own operation.” Quote: “Pancreatic cancer need not be viewed as a death sentence.” REFERENCEpancan.org/news/quest-understand-fathers-illness-young-doctor-discovers/See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Coeliac disease has been recognised since the times of Ancient Greece. This is a malabsorption disease that causes abdominal pain, nausea, vomiting, bloating, diarrhoea, and leaves sufferers starved of nutrients. The offending protein is Gluten which is found in wheat, rye, and barley. It was a Dutch Paediatrician by the name of Dr Willem Dicke who discovered the link between Gluten and Coeliac disease around the 1940s. This arose from the keen observation of a young patient’s mother to the devastation and starvation of the Hunger Winter in World War 2. This is a story like no other.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Leprosy the disease, is rife with myths and false beliefs. In 1863, Hawaii recognised leprosy an official public health threat. In 1865, a law of segregation was enacted forcing sufferers to Kalaupapa on Molokai island. As fate would have it, St Damien of Molokai (canonized in 2009) was there to serve. His role was that of a model Priest and his feats were super-human. However, local legends are not always a perfect reflection of historical events, and Damien the man can be lost in St Damien the hero. Leprosy is a terrible disease but it is much less contagious than commonly thought. Its historical significance may have heightened due to inter-language Biblical translation over centuries. In any event, it is a fascinating disease and one worth knowing more about.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Lead has been used for thousands of years. And why not? This is a metal that is abundant, pliable, has a low melting point, and does not easily corrode. However, even our ancestors knew that those who worked closely with it often became sick. Called Saturnism by the Ancient Romans, lead poisoning was known to cause a pale appearance, intestinal problems, paralysis, delirium, and even death. We have not escaped the perils of lead in our modern times. Petrol, paint, construction, ammunition, cosmetics, toys, etc. have at all included lead at some point in time. Recent regulations have reduced the exposure of the general population. However, we are not immune from contamination and outbreaks as recent history has shown. GUEST INTERVIEW This episode includes an interview with special guest, Dennis Strenk, Milwaukee Pathologists' Assistant, CFO and Board of Trustees member of the AAPA and People of Pathology Podcast host [peopleofpathology.podbean.com]See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** In June 1981, the CDC reported an article of 5 men who presented with Pneumocystis pneumonia (PCP). PCP is an opportunistic infection more commonly found immunosuppressed patients (ie. patients receiving chemotherapy for cancer). The 5 men were young and otherwise healthy. They were also all homosexual. In July 1981, another CDC article reported 26 men who presented with PCP as well as Kaposi sarcoma. Kaposi sarcoma is a rare blood vessel tumour. This could not be a coincidence and the world was on the precipice of a pandemic that would kill millions and unleash a wave of homophobia, prejudice and demonization. Fortunately, today, HIV is a manageable disease and patients can continue to live productive and healthy lives which could not be further from this once terminal diagnosis. This is the story of HIV.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** The rise of the tobacco industry and prevalence of smoking has significantly shaped the health (or lack of) in the last century. In 1900s, lung cancer was rare. 60 years later, it was the top cause of cancer deaths in men and second in women. This remains the case to this day. However, as the evidence mounted against smoking, the tobacco industry was not going to let studies, public health or facts get in the way of such a promising albeit fatal product. Fortunately, the risks and diseases associated with cigarettes are well known today. Unfortunately, the rates of smoking worldwide are still very high and accounts for approximately 8 million deaths per year. However, the a new product has emerged in the last two decades called ‘heated tobacco’ and Vaping. We explore what we know, and what we don’t about this new trend. Every disease has a story to tell - Dr Travis Brown This Pathological Life podcast is brought to you by Clinpath Pathology in South AustraliaSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Hodgkin Lymphoma, formerly known as Hodgkin disease, is a cancer of the lymph node(s). First described by Thomas Hodgkin (1832) where he wrote a paper titled ‘On Some Morbid Appearances of the Absorbent (now Lymphatic) Glands and Spleen’. However, the significance of this did not become apparent until decades later. Hodgkin Lymphoma is the most common malignancy of adolescents and young adults. This used to be a fatal disease but because of meticulous studies, research, modern medicine and advances in treatment, the prognosis is excellent. Our interview is with Dr Bradley Webster, Histopathologist specialising in Uropathology and Lymphoid Pathology and this section of the podcast is eligible for 1 RACGP CPD point – self reporting.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Fragile X is the most common form of inherited intellectually disability. It is a sex-linked chromosomal disorder that affects boys much more commonly than girls. However, it took some ingenious foresight combined with advancing genetic techniques in the 1970s and 1980s to isolate the exact cause of this condition. This is a challenging diagnosis for General Practitioners, Specialists, Patients and their families. A multi-disciplinary approach is essential and, as Professor Graeme Suthers always says ‘listen to your patients and don’t be afraid to seek advice’. This podcast is eligible for 1 RACGP CPD point – self reporting.   GUEST HOST & INTERVIEW Professor Graeme SuthersBSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD Prof Suthers is Sonic Healthcare' Director of Genetics. He is one of Australia’s most respected experts in the field of genetics, and is nationally and internationally recognised for his expertise in genetic disorders, testing and clinical service provision.clinpath.com.au/about-us/clinpath-leadership/our-pathologists/professor-graeme-suthers/ This Pathological Life is produced by Clinpath Pathology in South Australia.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Information in the past (ergo knowledge) was restricted to the few. However, the social media landscape provides individuals with their personal megaphone to the world. As most are aware, there are numerous benefits this provides, such as engaging directly with an audience. However, these benefits have to be balanced with a price, namely personal data and professional boundaries. Traditionally, Medical Practitioners, Doctors, and Specialists have approached social media cautiously. We discuss the pros and cons of medical practitioners accessing/using social media with Lee Aase, Director, Mayo Clinic Social Media Network and Mayo Clinic’s Social & Digital Innovation team. For Lee, he has been working in the social medial field for over twenty years from politics to medical institutions. We discuss what information is being collected, how that can be used, and the best way Doctors can use social media.   GUEST INTERVIEW Lee Aase Director, Mayo Clinic Social Media Network [email protected] | @LeeAase Lee Aase is director of the Mayo Clinic Social Media Network, which provides training resources, educational and networking events and a collaboration platform for health care professionals who want to safely and effectively apply social and digital strategies to fight disease, promote health and improve health care. Lee also leads Mayo Clinic’s Social & Digital Innovation team, which manages Mayo Clinic’s presence on general purpose social networks like Facebook, YouTube and Twitter as well as its owned blog and community platform. Key sites include Mayo Clinic Connect, an online patient community, Mayo Clinic News Network, and Sharing Mayo Clinic, a patient stories blog. Prior to joining Mayo Clinic in 2000, Lee spent more than a decade in political and government communications at the local, state and federal level. He was elected to Mayo Clinic’s Voting Staff in 2016. In 2018 he received VitalSmarts certification as a trainer in the Getting Things Done (GTD) methodology for stress-free productivity.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** In 1901, an experiment when horribly wrong when Doctors attempted to induce tolerance in to a group of dogs by repeated injections of poison. The results were reproducible. Furthermore, the substance did not even need to be poisonous. In 1902, the reaction was called Anaphylaxis. In the 1920s, a spate of Scientists and Doctors self-experimentation led to a range of discoveries about food allergies and reactions. Injecting skin, injecting nasal turbinates, and injection volunteers (including children) helped us to understand the different types of reactions the gastrointestinal tract can have to different foods allergens. Join us as we discuss Part Two to our Allergies Podcast with Dr Daman Langguth and learn our current understanding of Anaphylaxis and food allergies. This podcast is eligible for 1 RACGP CPD point – self reporting.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Our immune system provides the means for us to live in a world full of pathogens. However, sometimes it gets it wrong and we can find ourselves debilitated because of our own immune system. Allergies and hypersensitivies fall into this category, with symptoms ranging from the mildly irritating, to the life-threatening anaphylaxis. Our knowledge of these ailments come from a variety of observational and experimental studies. In the late 1800’s and early 1900’s, they did not understand the immune system nor allergies. Terms used to describe these diseases (that we know today as allergies) were Summer colds, Summer flu, Hay-asthma, and Hay-fever. The causes were unknown, the treatment ranged from experimental to dangerous and the Scientists often used themselves as the study subjects/volunteers. However, it took some clever minds and quite a bit of courage (not to mention a lot of dogs and other experimental animals) to gather the understanding of these conditions that we have today. Our special guest is Dr Daman Langguth Head of Immunology Department Sullivan Nicolaides Pathology (SNP), Chair of SNP Partners, Member of Executive Advisory Committee, Chair of the Data Request Committee. Daman has particular expertise in the investigation of auto-immune disease, allergy, and immune deficiency and has special interests in idiopathic inflammatory myositis, vasculitis, IgG4-related systemic disease and e-Health. SNP’s Immunology Department is the largest laboratory of its kind in Australia.See omnystudio.com/listener for privacy information.

Published: Feb 19, 2021 2:30 PM ** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** In 1952, George Papanicolaou with the National Cancer Institute embarked on the first ever cervical screening trial. The results were remarkable and the first demonstration of the power of screening an asymptomatic population. However, the path to this point took decades of perseverance and self-belief. This feat changed the course of medicine and can be attributed to two people: George and Mary Papanicolaou. Cervical screening is one of the most effective screening programs ever initiated. Combined with the recent advancements of HPV molecular testing and the HPV vaccine, Cervical cancer is now relatively uncommon and has an excellent prognosis.   SPECIAL GUEST Dr Cos FuscoDoctor of Health Science, Master of Medical Science (Pathology)Fellow of the International Academy of CytologyCT(ASC) Australian Society of Cytology Currently Supervising Cytologist Clinpath Pathology Additionally, Dr Fusco is a current committee member of the RCPAQAP Cytopathology advisory committee 2019-2023 and Scientific coordinator (SA) for The IMPACT National HPV study. He started his cytology training in 1986 at the then Gribbles Pathology. He worked in Cytology and Histology at Gribbles, IMVS, Clinpath and Adelaide Pathology Partners. In 2006, Dr Fusco started the Cytology laboratory at Adelaide Pathology Partners at the invitation of Dr Fergus Whitehead, and continued with this role post merger with Clinpath Pathology. His Doctoral Thesis was based on HPV HR DNA testing, HPV vaccination and molecular biomarkers and the potential impacts, on the Australian cervical screening program. Cervical cancer and HPV related cancers are an interest and a focus for research. He has a strong interest and involvement in Endobronchial Ultrasound FNA (EBUS FNA) collection for lung cancer staging and diagnosis. Contents Andromachi Papanikolaou - WikipediaSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Health records are arguably the single most important and personal collection of data anyone can have. With records containing doctor visits, consultation notes, pathology results, radiology reports, medications, allergies, etc., it is hard to overstate its significance. In fact, these records can save lives. The Australian Government has implemented an opt-out arrangement for MyHealthRecord and as such, there has been a rise in the number of records available. However, this venture has not been without its stumbles, detractors, and challenges. We discuss medical records with Dr Chris Moy, who has been a national leader in developing and promoting My Health Record, the electronic ‘filing system’ of Australians’ individual health histories.  GUEST INTERVIEW AMA(SA) President Dr Chris MoyMBBS, FRACGP, FAMA sa.ama.com.au/council digitalhealth.gov.au/dr-chris-moy See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** COVID-19: Testing the strength of nations As the pandemic continues to rage, we take a snapshot in time about our current understanding from an epidemiological, pathological, microbiological and immunological viewpoint of COVID-19. This pandemic has tested the Governments, Politicians and the Public Health of nations; some have responded valiantly; others have been found lacking. The deviation from our regular style podcast is because we are living the COVID story. Our special guest is Dr Daman Langguth Head of Immunology Department Sullivan Nicolaides Pathology (SNP), Chair of SNP Partners, Member of Executive Advisory Committee, Chair of the Data Request Committee. Daman has particular expertise in the investigation of auto-immune disease, allergy, and immune deficiency and has special interests in idiopathic inflammatory myositis, vasculitis, IgG4-related systemic disease and e-Health. SNP’s Immunology Department is the largest laboratory of its kind in Australia. Known for pushing the boundaries and pioneering new technologies it is acknowledged as the most advanced flow cytometry lab in diagnostic practice. With Australia's most diverse range of autoantibody assays, the lab is also at the forefront of autoantibody testing. In a partnership with a UQ engineering research team it is breaking new ground in digital pathology and image analysis. See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Caitlan Davis starts Episode 26 with, "In the spirit of reconciliation Clinpath Pathology acknowledges the Traditional Custodians of country throughout Australia and their connections to land, sea and community. We pay our respect to their elders past and present and extend that respect to all Aboriginal and Torres Strait Islander peoples today. Today's episode of This Pathological Life, looks at Indigenous Health and its intersection with Pathology, along with health issues and challenges among Australia's first European settlers. But first... First Australians meet the First Fleet The American revolution forced the British to investigate alternate destinations for penal colonies. The answer came from a Botanist who travelled with Captain James Cook in 1770 to a land they called New South Wales. With the decision made, this ‘new’ land would be forever changed. The First Fleet took a year to prepare and eight months to voyage to New South Wales and suffered from a variety of ailments (which we examine) on the way. What we now call Australia, is a hard, dry unexpected land, which proved difficult for Europeans to manage and adjust.  Yet Indigenous/Aboriginals survived and thrived in this land.  This episode explores Aboriginal medical knowledge with Dan Tyson, Chief Executive Officer at Desert Knowledge Australia from the year 1788, when the land was quite diverse in geographical areas and Aboriginal people were quite diverse in their technologies to survive. We ponder the recurring question of how when bush medicine and food is still used in many places today, why the health of the Australian Indigenous Communities remains so poor. This is the tale of two worlds.   GUEST INTERVIEWDan Tyson, CEO Desert Knowledge Australia Twitter: @dka_connect LinkedIn Dan: linkedin.com/in/dan-tyson-8215636/ LinkedIn DKA: linkedin.com/company/dkaconnect/ Dan is currently member of the AMSANT Research Committee and a member of the Central Region Executive of the Chamber of Commerce however, and has also been a director of the Aboriginal Medical Services Alliance of the NT (AMSANT), and previously director and vice-chair of Katherine Regional Aboriginal Health and Related Services. He co-founded the Aboriginal Business Industry Chamber of South Australia (ABICSA) and the Mental Health Coalition of SA. Dan holds a PhD in the field of medical anthropology and has worked extensively in the mainstream and Indigenous health sectors.   OTHER VOICES Doris Pilkington, author, Follow The Rabbit Proof Fence Joylene Koolmatrie, Aboriginal Healer and Psychologist Kenneth Branagh, Rabbit Proof Fence Rev John Brown, co-chair, National Sorry Day Committee Sir Ronald Wilson, co-author, Bringing Them Home ReportSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** From our first Episode #1 "What is Pathology?", we have enjoyed the journey we have travelled and feedback to date is encouraging. In these (pandemic) times, remaining connected is as important as ongoing education and from here at Clinpath Pathology, providing this channel has been as good for us, as it has been for our listeners.  In this episode #25 we reflect over 12 different pathology (pathological) podcasts and what each of these 12 has given us - whether this be an eye opening story, an honoured guest, a realisation of the 'Dunning–Kruger effect', a stumbling over big words, big personalities and big guests, or the unravelling of tales behind the useful things discovered through science that end up being not so good for humans. Steve reflects, "A spoonful of podcast helps the medicine go down."  There have been many where the pathologist's lens to a topic really shines, such as alcohol (a good one to listen to before the Christmas period). We hope everyone has a safe Christmas and look forward to Season #2 SPECIAL GUESTProducer Charlie-Helen RobinsonSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** The discovery of radiation was a monumental achievement in human history. Marie Curie isolated Radium and Polonium from the mineral pitchblende, and received two Nobel Prizes for this achievement (Physics 1903 and Chemistry 1911). She was clearly a genius, however, not even Marie anticipated the dangers inherent with this material. The interest in Radium exploded and it became a key ingredient in medicine, make-up, and toothpaste. The most notable was for the ‘Undark’ paint that literally glowed. The women workers, now known as the Radium girls, used this paint in the early twentieth century to paint the hands of watches/clocks. The results were devastating and fatal. Our episode’s final destination, takes us into the remote region of South Australia, where 7 atomic bombs were detonated by the British between 1956 and 1963… destroying the land and killing indigenous and non-indigenous people alike. A human history we must remember for the sheer tragedy of it.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** The implications for Healthcare to lose control or access to the IT systems is literally life threatening. The first confirmed fatality occurred when a Ransomware attack unintentionally struck a German University Hospital in September 2020. There have been over 80 public cases of Ransomware attacks occurred in the US targeting Healthcare institutions in 2020. These are on the rise as Healthcare provides an attractive target with dated IT software, time critical data, and private patient information that can be used and leveraged, even if the target reverts to back-ups. With hospitals left in a no-win situation, they will often pay the ransom to (hopefully) restore access to their systems/data but also increases the likelihood of future attacks. Our special guests: Dr Nick TellisMBBS, FRACGPGP and Owner PartridgeGPAdjunct Senior Lecturer at Flinders University College of Medicine and Public Healthhttps://partridgegp.me/DrNickTellisLinkedIn  John StronnerChief Executive Officer | Loftus Technology GroupCertified Data Protection Officerhttps://www.linkedin.com/in/johnstronnar/   Dr Nick tellis Bio: Dr Nick Tellis is a specialist GP who has been working in General Practice since 2002 and has owned general practices since 2007.  Every Australian should have their own GP and General Practice, and use them regularly and appropriately. If that is PartridgeGP and one of our helping GPs that's even better. We can help! Here to Help - 3 ways!1. You’re a patient wanting a Great GP! Book one of the caring PartridgeGPs online: http://partridgegp.me/makeanappointment  You’re a great GP/Allied Health Professional wanting PartridgeGP to provide you awesome services, facilities, and team so you can serve patients to the best of your ability: www.partridgegp.com.auhttps://partridgegp.me/DrNickTellisFB call Mrs Hayley Roberts 08 8295 3200 You’re a small business owner looking to network and grow your amazing business! Coffee and chat with Dr Nick Tellis: https://partridgegp.me/DrNickTellisLinkedIn http://partridgegp.me/networkwithdrnick See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Humans have always had a complex relationship with drugs: some help us; some heal us; and some hurt us. The problem with the drugs of addiction is they can do all of three. However, long term use of these inevitably leads to dependence where, once ceased, will lead to withdraw symptoms. The ‘highs’ and addictiveness combined with the potency of the drugs can have fatal consequences. In this podcast we delve into these Drugs of Addiction (namely Opioids, Amphetamines, Cannabinoids, Cocaine, and Benzodiazepines) to explore their sordid history and discuss how we test for them today. Our special guest: Dr Devika ThomasBSc (Hons), MBBS, M Surg, MAACB, CCD, FRCPA, PhD Clinpath Pathology Medical Director, Executive TeamDirector of Chemical Pathology https://www.clinpath.com.au/about-us/clinpath-leadership/our-pathologists/dr-devika-thomas/ This podcast is eligible for 1 RACGP CPD point – self reporting.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Health data is the most personal official records we will ever have. It can contain everything from the medications we regularly take, all the way through to documenting discussions about some of our most troubling times. It does not get any more personal than our own Health Data. This is part of a series of podcasts we are undertaking on Health Information Technology. We look at Governmental Regulation of Health Data and get a sneak peek at the advances in A.I. embryology. The song quoted was written by Mark Hoppus and Tom Delonge, Blink-182. Our special guests: Andrew AndrewsVice PresidentData Management Association Australiahttps://au.linkedin.com/in/andrewandrews Dr Michelle PeruginiCo-Founder & CEOPresagen www.Presagen.comhttps://au.linkedin.com/in/michelleperuginiSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** In 1983, Dr Robin Warren and Dr Barry Marshall embarked upon a study to investigate the significance of bacterial found in the stomachs of ulcer patients. This journey would take them over a decade to complete and was riddled with self-doubt, persistent scepticism, and challenging centuries of medical dogma but their persistence ultimately led to the highest accolade in Medicine. Oh, and a bout of bad breath.Helicobacter pylori is a gram-negative bacteria that has evolved with humans. With an estimated worldwide prevalence of up to 50%, this organism has found a survival niche where it is perfectly suited to thrive in the stomach’s highly acidic environment. Unfortunately for those of us who have it, it will cause inflammation (gastritis) but can eventually lead to cancer (gastric adenocarcinoma).Our interview is with Professor Barry Marshall who navigates the lows of persistent knockbacks through to the worldwide tour that lead to the Nobel Prize in 2005. Professor Barry MarshallNobel Prize Laureate and Professor of Clinical Microbiology The discovery by Dr Warren and Professor Marshall has benefited millions of people, maybe saving a million lives over the last 10 or 20 years. Barry James Marshall AC FRACP FRS FAA is an Australian physician, Nobel Prize Laureate in Physiology or Medicine, and Professor of Clinical Microbiology at the University of Western Australia. https://www.uwa.edu.au/profile/barry-marshall Additional links of interest: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67587-3/fulltext  https://www.science.org.au/learning/general-audience/history/interviews-australian-scientists/professor-barry-marshall/teacher See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Since ancient times, all manner of diseases have been attributed to the uterus. Theories range from a wandering womb yearning for motherhood to the psychological disorder of hysteria that was contagious. The treatment of women with these 'diseases' were reprehensible and the some of the outcomes were nothing short of tragic. Fortunately, we have come a long way to understanding the plethora of gynaecological conditions and treatments. In this episode, we examine the pathology of endometriosis. What the world needs more of right now, is everyone talking about women's health. Steve Davis and Dr Travis Brown discuss this history from antiquity to the twenty-first century. However, they did call on special guest Dr Nicole Sladden to keep them in check. This podcast episode is eligible for 1 RACGP CPD point – self reporting. Dr Nicole SladdenMBBS, FRCPA Bio Link: https://www.clinpath.com.au/about-us/clinpath-leadership/our-pathologists/dr-nicole-sladden/See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** 'You have cancer' It must be the most dreaded sentence in modern society. Our fear of cancer is well founded and for those suffering from Chronic Myeloid Leukaemia (CML), before 1999, there was only a slim chance of survival. Caused by a single translocation called the Philadelphia chromosome, it took only 40 years to go from a chemotherapy resistant and often fatal disease to a manageable condition with an oral tablet. This is a remarkable story of science, persistence and triumph. As Dr Travis Brown says, "When chromosomes were discovered in the late 1800’s, their nature and function was unclear.In 1910, Thomas Hunt Morgan identified the link between chromosomes and inheritance.In 1959, Peter Nowell & David Hungerford discovered CMLs Philadelphia chromosome, but where had the segment of chr 22 gone?In 1973, Dr Janet Rowley found it.In 1999, Dr Brian Druker treated it."See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Our love affair with alcohol is as old as civilization itself. Every culture and religion have traditions, attitudes and laws that ranges from governing celebrations to issuing punishments. With only have sporadic cases of excessive drinking from historical figures, it becomes apparent that alcohol use disorder and dependency are modern diagnoses. The urgency for testing alcohol intoxication arrived with the increasing popularity of cars that shifted the automobile from a form of transport to a potential weapon. This led to a revolution in public health measures and has saved countless lives. However, it is not until one starts to examine the prevalence of risky alcohol drinking behaviour and alcohol use disorder in modern society that we realise this love affair comes with a price. Image Interference – The Animal "Though you can guess what temperance should be, You know not what it is"ShakespeareSee omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Tuberculosis has had many names throughout human history: Phthisis, Robber of youth, the white plague, consumption. It wasn’t until 1865 that Jean Antonine Villemin proved it was an infectious disease and 1882 that Robert Koch identified the causative agent: Mycobacterium tuberculosis (he called it Tubercle bacillus). Via the first ever Pathology Report from Melbourne Hospital (now Royal Melbourne Hospital), we explore this infectious disease that continues to have a devastating impact to this day.See omnystudio.com/listener for privacy information.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode ** Sugar is as addictive as nicotine and as toxic as … well, sugar. Diabetes mellitus is the fastest growing chronic disease and the not-so-silent potentially ignorable epidemic sweeping our nation. This is a disease known about since antiquity and often fatal to those afflicted in history. With the discovery of insulin in 1922 and exponential growth in our understanding, we now have the resources to manage and even potentially prevent this disease; but will we choose to do so? The Episode has a special guest collaboration with Dr James Meucke AM “AUSTRALIAN OF THE YEAR”. Wiki: https://en.wikipedia.org/wiki/James_Muecke LinkedIn and bio: www.linkedin.com/in/james-muecke-am-a1621812 This Episode includes an interview with Dr Devika Thomas Bio: www.clinpath.com.au/about-us/clinpath-leadership/our-pathologists/dr-devika-thomas/   and is eligible for 1 RACGP CPD point – self reporting.See omnystudio.com/listener for privacy information.