#0070 - AI Is Reshaping Startups, Digg, Colossal Bioscience's Mammoth Mice, Private Moon Landing, and More - Somewhat Frank Podcast

On this episode of the Somewhat Frank Podcast, Frank Gruber (X and IG: @FrankGruber), John Guidos (IG: jgoodtimes83), and Simon Kahan (IG: @simonkahan) discuss the following topics:   We are hosting the Established House in Austin on Friday, March 7th, with a couple of featured conversations, a barista spinning our delightful lattes and teas and lots of opportunities to connect with one another. If you'll be in Austin, please join us! RSVP at: est.us/house25    AI Is Changing How Silicon Valley Builds Startups - The traditional Silicon Valley model of heavy fundraising and large headcounts is being replaced by AI-driven efficiency, with companies like Anysphere and ElevenLabs reaching $100M revenue with under 50 workers. Also, here is Frank's take on it: https://www.linkedin.com/feed/update/urn:li:activity:7299885251869196288/    Mice have been genetically engineered to look like mammoths - Colossal Biosciences genetically engineered mice with mammoth-like fur by altering up to five genes, though only one matches the mammoth genome exactly. Here are some more thoughts on the animal/human hybrid topic: https://www.scientificamerican.com/article/japan-approves-first-human-animal-embryo-experiments/   Digg is coming back, thanks to its founder Kevin Rose — and Reddit's success - Digg is relaunching with Kevin Rose as chair, Alexis Ohanian as an adviser, and Justin Mezzell as CEO, aiming to revive its "homepage of the internet" legacy.   A Private Space Mission Just Successfully Landed on the Moon for the First Time - Firefly Aerospace's Blue Ghost lunar module became the first private company's lander to successfully touch down on the moon, landing on March 2, 2025.   We also upload our episodes to YouTube in video format so you can see us now. Check it out on Established YouTube, where you can subscribe to get updates when we drop a new episode at: https://soty.link/ESTYouTube    As always, thank you for listening, and feel free to reach out and let us know what you think at: [email protected]