096: HIV interaction with the immune system with Mark Connors

A very small proportion of people infected with HIV do not develop AIDS. Mark Connors talks about 2 patient populations that his lab studies, the elite controllers and the elite neutralizers, who control HIV infection with their respective T cell or B cell responses. Connors hopes his work on killer T cells and broadly neutralizing antibodies will help scientists develop better HIV therapies or an effective HIV vaccine. Links for This Episode: Mark Connors labsite at NIAID Immunity article: Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth. Immunity commentary: Class II-restricted CD8s: New lessons violate old paradigms. Science article: Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Imagining an HIV-Free Future (Smithsonian Worlds AIDS Day Event (Live Dec 4th at 6:45pm) HOM Tidbit: 12 Diseases that Changed Our World MTM Listener Survey