1 27 2025

Hi, This Week in Medicine, we will be discussing New England Journal of MedicinePerioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation Journal of  American Medical AssociationTransanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical TrialQuestion  Is transanal total mesorectal excision (TME) noninferior to laparoscopic   Annals of Internal MedicineCensus Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine British Medical JournalDapagliflozin plus calorie restriction for remission of type 2 diabetes  LancetTransarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study Journal of Clinical OncologyEfficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study  journal of HepatologyInduction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy Gastroenterology Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction Clinical Gastroenterology Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant Association Between Different Types of Physical Activity and Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study Based on NHANES   Journal of Clinical Rheumatology Preliminary Evaluation for the Development of a Scoring System to Predict Homozygous M694V Genotype in Familial Mediterranean Fever Patients: A Single-Center Study CirculationA Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand   Journals of the American College of CardiologyOptimal Strategy for Complete Revascularization in ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A Network Meta-Analysis  JAMA CardiologyCost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population  Journal of Clinical Endocrinology & MetabolismPersonalized Medicine in Acromegaly: The ACROFAST Study  Diabetes careDiabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study  ChestNeutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis  The American Journal of Respiratory and Critical Care MedicineLung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations Clinical Journal of American Society of NephrologyFracture in Association with Anticoagulant Therapy in Patients with CKD and Atrial Fibrillation Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus Kidney International reportsMuscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients