1 27 2025

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer

A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest

Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest

Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation

 Journal of  American Medical Association

Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial

Question  Is transanal total mesorectal excision (TME) noninferior to laparoscopic   Annals of Internal Medicine

Census Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities

Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine

 British Medical Journal

Dapagliflozin plus calorie restriction for remission of type 2 diabetes

  Lancet

Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study

 Journal of Clinical Oncology

Efficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study

  journal of Hepatology

Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy

 Gastroenterology

Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction

 Clinical Gastroenterology

 Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant

Association Between Different Types of Physical Activity and Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study Based on NHANES

  Journal of Clinical Rheumatology 

Preliminary Evaluation for the Development of a Scoring System to Predict Homozygous M694V Genotype in Familial Mediterranean Fever Patients: A Single-Center Study

 Circulation

A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand

   Journals of the American College of Cardiology

Optimal Strategy for Complete Revascularization in ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A Network Meta-Analysis

  JAMA Cardiology

Cost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population

  Journal of Clinical Endocrinology & Metabolism

Personalized Medicine in Acromegaly: The ACROFAST Study 

 Diabetes care

Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study

  Chest

Neutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis

 The American Journal of Respiratory and Critical Care Medicine

Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations

 Clinical Journal of American Society of Nephrology

Fracture in Association with Anticoagulant Therapy in Patients with CKD and Atrial Fibrillation

Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus

 Kidney International reports

Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients