1-Methyl-2-iodo-LSD

rWotD Episode 3380: 1-Methyl-2-iodo-LSD Welcome to random Wiki of the Day, your journey through Wikipedia's vast and varied content, one random article at a time.The random article for Wednesday, 5 August 2026, is 1-Methyl-2-iodo-LSD.1-Methyl-2-iodo-LSD (MIL) is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD). It is the 1-methyl derivative of 2-iodo-LSD (IOL). Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed. The properties and effects of MIL in humans are unknown. However, a radiolabeled form of MIL, 1-methyl-2-[125I]iodo-LSD ([125I]-MIL), as well as the analogue 1-ethyl-2-[125I]iodo-LSD ([125I]-EIL), have been developed for use as presumably non-hallucinogenic agents in imaging of serotonin receptors. [125I]-MIL has much greater selectivity for serotonin 5-HT2 receptors over dopamine receptors compared to LSD. MIL and [125I]-MIL were first described in the scientific literature by Beth J. Hoffman and colleagues by 1985.This recording reflects the Wikipedia text as of 00:48 UTC on Wednesday, 5 August 2026.For the full current version of the article, see 1-Methyl-2-iodo-LSD on Wikipedia.This podcast uses content from Wikipedia under the Creative Commons Attribution-ShareAlike License.Visit our archives at wikioftheday.com and subscribe to stay updated on new episodes.Follow us on Bluesky at @wikioftheday.com.Also check out Curmudgeon's Corner, a current events podcast.Until next time, I'm neural Kendra.